{"id":"https://openalex.org/W4240198657","doi":"https://doi.org/10.1002/9780470015902.a0000711.pub4","title":"Lipids","display_name":"Lipids","publication_year":2020,"publication_date":"2020-07-20","ids":{"openalex":"https://openalex.org/W4240198657","doi":"https://doi.org/10.1002/9780470015902.a0000711.pub4"},"language":"en","primary_location":{"id":"doi:10.1002/9780470015902.a0000711.pub4","doi":"https://doi.org/10.1002/9780470015902.a0000711.pub4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470015902.a0000711.pub4","pdf_url":null,"source":{"id":"https://openalex.org/S4363604175","display_name":"Encyclopedia of Life Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Life Sciences","raw_type":"other"},"volume":{"id":"https://openalex.org/W1905439276","display_name":"Encyclopedia of Life Sciences"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049880042","display_name":"Philip L. Y\u00e8agle","orcid":"https://orcid.org/0000-0003-4157-8506","observed_orcids":["https://orcid.org/0000-0003-4157-8506"]},"institutions":[{"id":"https://openalex.org/I140172145","display_name":"University of Connecticut","ror":"https://ror.org/02der9h97","country_code":"US","type":"education","lineage":["https://openalex.org/I140172145"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip L Yeagle","raw_affiliation_strings":["University of Connecticut, Storrs, Connecticut, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Connecticut, Storrs, Connecticut, USA","institution_ids":["https://openalex.org/I140172145"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049880042"],"corresponding_institution_ids":["https://openalex.org/I140172145"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"10"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10407","display_name":"Lipid Membrane Structure and Behavior","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12793","display_name":"Caveolin-1 and cellular processes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipids","display_name":"lipids","score":0.9919999837875366},{"id":"https://openalex.org/keywords/lipid-bilayers","display_name":"lipid bilayers","score":0.9739999771118164},{"id":"https://openalex.org/keywords/biological-membranes","display_name":"biological membranes","score":0.9480000138282776},{"id":"https://openalex.org/keywords/phospholipids","display_name":"phospholipids","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hydrophobic-effect","display_name":"hydrophobic effect","score":0.8629999756813049},{"id":"https://openalex.org/keywords/liquid-crystal-state","display_name":"liquid crystal state","score":0.9150000214576721},{"id":"https://openalex.org/keywords/membrane-fluidity","display_name":"membrane fluidity","score":0.6830000281333923},{"id":"https://openalex.org/keywords/membrane-permeability","display_name":"membrane permeability","score":0.7490000128746033},{"id":"https://openalex.org/keywords/lipid-unsaturation","display_name":"lipid unsaturation","score":0.7850000262260437},{"id":"https://openalex.org/keywords/membrane-fusion","display_name":"membrane fusion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/endocytosis","display_name":"endocytosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/viral-infection","display_name":"viral infection","score":0.7889999747276306},{"id":"https://openalex.org/keywords/membrane-proteins","display_name":"membrane proteins","score":0.4950000047683716},{"id":"https://openalex.org/keywords/lipid-signaling","display_name":"lipid signaling","score":0.5189999938011169},{"id":"https://openalex.org/keywords/second-messengers","display_name":"second messengers","score":0.7300000190734863},{"id":"https://openalex.org/keywords/lipoproteins","display_name":"lipoproteins","score":0.7609999775886536},{"id":"https://openalex.org/keywords/hormone-precursors","display_name":"hormone precursors","score":0.6669999957084656}],"concepts":[{"id":"https://openalex.org/C125501631","wikidata":"https://www.wikidata.org/wiki/Q1587185","display_name":"Biological membrane","level":3,"score":0.7655818462371826},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.6942605376243591},{"id":"https://openalex.org/C39944091","wikidata":"https://www.wikidata.org/wiki/Q423279","display_name":"Lipid bilayer","level":3,"score":0.660723090171814},{"id":"https://openalex.org/C103038307","wikidata":"https://www.wikidata.org/wiki/Q6556360","display_name":"Lipid bilayer fusion","level":3,"score":0.6116805672645569},{"id":"https://openalex.org/C560191","wikidata":"https://www.wikidata.org/wiki/Q417736","display_name":"Peripheral membrane protein","level":5,"score":0.47788798809051514},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4586150646209717},{"id":"https://openalex.org/C96347405","wikidata":"https://www.wikidata.org/wiki/Q16863771","display_name":"Membrane biophysics","level":4,"score":0.4502708613872528},{"id":"https://openalex.org/C107565407","wikidata":"https://www.wikidata.org/wiki/Q6815134","display_name":"Membrane lipids","level":3,"score":0.4405042827129364},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.35963910818099976},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.331622838973999},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.33043745160102844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32071492075920105},{"id":"https://openalex.org/C161200384","wikidata":"https://www.wikidata.org/wiki/Q1757382","display_name":"Integral membrane protein","level":4,"score":0.19632825255393982}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9780470015902.a0000711.pub4","doi":"https://doi.org/10.1002/9780470015902.a0000711.pub4","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9780470015902.a0000711.pub4","pdf_url":null,"source":{"id":"https://openalex.org/S4363604175","display_name":"Encyclopedia of Life Sciences","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Life Sciences","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1541778702","https://openalex.org/W1560423324","https://openalex.org/W1979166300","https://openalex.org/W2035442025","https://openalex.org/W2054167577","https://openalex.org/W2057220797","https://openalex.org/W2076542263","https://openalex.org/W2102335249","https://openalex.org/W2145450694","https://openalex.org/W2162796423","https://openalex.org/W2598303470","https://openalex.org/W2907189725","https://openalex.org/W2921960717","https://openalex.org/W2992838111"],"related_works":["https://openalex.org/W2495625122","https://openalex.org/W7100722990","https://openalex.org/W2489906594","https://openalex.org/W4245693181","https://openalex.org/W2427906825","https://openalex.org/W2481108801","https://openalex.org/W7095604411","https://openalex.org/W42543059","https://openalex.org/W7021004069","https://openalex.org/W2338280521"],"abstract_inverted_index":{"Abstract":[0],"Lipids":[1,80,104,126],"are":[2,105,127,171,178,220,263,271,301],"molecular":[3],"building":[4],"blocks":[5],"that":[6],"form":[7,34,149],"the":[8,15,18,26,37,67,86,92,95,107,128,157,163,180,206,238,245,255,268],"most":[9],"fundamental":[10,38,164],"structures":[11,58,68,151],"in":[12,54,76,83,137,152,175,179,222,237,251,267,286,304],"biology,":[13,252],"including":[14,189,211],"serum":[16],"lipoproteins,":[17],"membranes":[19,27,73,170,177,210],"of":[20,28,41,49,63,71,88,94,109,121,131,187,205,208,216,241,249,258],"cells":[21,122],"and":[22,25,69,74,98,118,134,191,193],"cellular":[23],"organelles":[24],"enveloped":[29,124],"viruses.":[30,125],"Many":[31],"lipids":[32,281,300],"spontaneously":[33,148],"lipid":[35,50,96,218,234,242],"bilayers,":[36],"architectural":[39],"feature":[40],"all":[42,77,168],"biological":[43,72,89,169,176,209,223,284],"membranes.":[44],"A":[45],"nearly":[46],"uncountable":[47],"catalogue":[48],"molecules":[51,136],"is":[52],"found":[53,221],"nature,":[55],"their":[56,212],"individual":[57],"imparting":[59],"a":[60,231],"wide":[61],"variety":[62],"properties":[64,93,207],"essential":[65,113,196,253],"to":[66,101,197,254,273,296],"functions":[70],"lipoproteins":[75],"life":[78],"forms.":[79],"regulate,":[81],"often":[82],"specific":[84,283],"ways,":[85],"functionality":[87],"membranes,":[90,224],"through":[91,294],"bilayer":[97,150,269],"by":[99,123,156,289],"binding":[100,295],"membrane":[102,110,198,259,276,280,287,291,297],"proteins.":[103,298],"at":[106],"centre":[108],"fusion":[111,277],"events":[112],"for":[114],"intracellular":[115,305],"transport,":[116],"endocytosis":[117],"viral":[119],"infection":[120],"metabolic":[129],"precursors":[130],"some":[132],"hormones":[133],"signalling":[135,306],"cells.":[138],"Key":[139],"Concepts":[140],"Phospholipids,":[141],"as":[142,144,154],"well":[143],"many":[145,204],"other":[146],"lipids,":[147,192],"water,":[153],"governed":[155],"hydrophobic":[158],"effect.":[159],"Lipid":[160,173,201],"bilayers":[161,174,202,243,250,262],"provide":[162],"architecture":[165],"upon":[166],"which":[167],"built.":[172],"liquid":[181,246],"crystal":[182,247],"state,":[183],"permitting":[184],"lateral":[185],"diffusion":[186],"components":[188],"proteins":[190],"internal":[194],"flexibility":[195],"enzyme":[199,292],"function.":[200],"determine":[203],"limited":[213],"permeability.":[214],"Thousands":[215],"different":[217],"species":[219],"but":[225],"they":[226],"can":[227],"be":[228],"organised":[229],"into":[230],"few":[232],"major":[233],"classes.":[235],"Unsaturation":[236],"hydrocarbon":[239],"chains":[240],"supports":[244],"state":[248],"proper":[256],"functioning":[257],"enzymes.":[260],"Although":[261],"inherently":[264],"stable,":[265],"defects":[266],"structure":[270],"required":[272],"initiate":[274],"critical":[275],"events.":[278],"Individual":[279],"play":[282],"roles":[285],"biology":[288],"modulating":[290],"activity":[293],"Some":[299],"second":[302],"messengers":[303],"systems.":[307]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}