{"id":"https://openalex.org/W4240168978","doi":"https://doi.org/10.1002/anie.200704093","title":"Desymmetrization\u2010like Catalytic Enantioselective Fluorination of Malonates and Its Application to Pharmaceutically Attractive Molecules","display_name":"Desymmetrization\u2010like Catalytic Enantioselective Fluorination of Malonates and Its Application to Pharmaceutically Attractive Molecules","publication_year":2007,"publication_date":"2007-11-13","ids":{"openalex":"https://openalex.org/W4240168978","doi":"https://doi.org/10.1002/anie.200704093"},"language":"en","primary_location":{"id":"doi:10.1002/anie.200704093","doi":"https://doi.org/10.1002/anie.200704093","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200704093","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042577230","display_name":"Dhande Sudhakar Reddy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197274945","display_name":"Nagoya Institute of Technology","ror":"https://ror.org/055yf1005","country_code":"JP","type":"education","lineage":["https://openalex.org/I197274945"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Dhande\u2005Sudhakar Reddy","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan","institution_ids":["https://openalex.org/I197274945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077654635","display_name":"Norio Shibata","orcid":"https://orcid.org/0000-0002-3742-4064","observed_orcids":["https://orcid.org/0000-0002-3742-4064"]},"institutions":[{"id":"https://openalex.org/I197274945","display_name":"Nagoya Institute of Technology","ror":"https://ror.org/055yf1005","country_code":"JP","type":"education","lineage":["https://openalex.org/I197274945"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Norio Shibata","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan,","institution_ids":["https://openalex.org/I197274945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102900260","display_name":"Jun Nagai","orcid":"https://orcid.org/0000-0003-4720-5065","observed_orcids":["https://orcid.org/0000-0003-4720-5065"]},"institutions":[{"id":"https://openalex.org/I197274945","display_name":"Nagoya Institute of Technology","ror":"https://ror.org/055yf1005","country_code":"JP","type":"education","lineage":["https://openalex.org/I197274945"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Jun Nagai","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan,","institution_ids":["https://openalex.org/I197274945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037788901","display_name":"Shuichi Nakamura","orcid":"https://orcid.org/0000-0001-5633-8367","observed_orcids":["https://orcid.org/0000-0001-5633-8367"]},"institutions":[{"id":"https://openalex.org/I197274945","display_name":"Nagoya Institute of Technology","ror":"https://ror.org/055yf1005","country_code":"JP","type":"education","lineage":["https://openalex.org/I197274945"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuichi Nakamura","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan,","institution_ids":["https://openalex.org/I197274945"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109513909","display_name":"Takeshi Toru","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I197274945","display_name":"Nagoya Institute of Technology","ror":"https://ror.org/055yf1005","country_code":"JP","type":"education","lineage":["https://openalex.org/I197274945"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takeshi Toru","raw_affiliation_strings":["Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan,","institution_ids":["https://openalex.org/I197274945"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004068447","display_name":"Shuji Kanemasa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135598925","display_name":"Kyushu University","ror":"https://ror.org/00p4k0j84","country_code":"JP","type":"education","lineage":["https://openalex.org/I135598925"]},{"id":"https://openalex.org/I4405286310","display_name":"Institute for Materials Chemistry and Engineering, Kyushu University","ror":"https://ror.org/01s8eag11","country_code":"JP","type":"facility","lineage":["https://openalex.org/I135598925","https://openalex.org/I4405286310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shuji Kanemasa","raw_affiliation_strings":["Institute for Materials Chemistry and Engineering, Kyushu University, 6\u20131 Kasugakoen, Kasuga 816-8580, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Materials Chemistry and Engineering, Kyushu University, 6\u20131 Kasugakoen, Kasuga 816-8580, Japan","institution_ids":["https://openalex.org/I135598925","https://openalex.org/I4405286310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5510,"currency":"USD","value_usd":5510},"apc_paid":null,"fwci":9.9292,"has_fulltext":false,"cited_by_count":159,"citation_normalized_percentile":{"value":0.99262709,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"47","issue":"1","first_page":"164","last_page":"168"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10947","display_name":"Fluorine in Organic Chemistry","score":0.8300999999046326,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10013","display_name":"Asymmetric Synthesis and Catalysis","score":0.15690000355243683,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.002300000051036477,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enantioselective-fluorination","display_name":"enantioselective fluorination","score":0.9789999723434448},{"id":"https://openalex.org/keywords/malonate","display_name":"malonate","score":0.8230000138282776},{"id":"https://openalex.org/keywords/desymmetrization","display_name":"desymmetrization","score":0.9150000214576721},{"id":"https://openalex.org/keywords/zinc-acetate-catalyst","display_name":"zinc acetate catalyst","score":0.7480000257492065},{"id":"https://openalex.org/keywords/asymmetric-synthesis","display_name":"asymmetric synthesis","score":0.47999998927116394},{"id":"https://openalex.org/keywords/pharmaceutical-compounds","display_name":"pharmaceutical compounds","score":0.47099998593330383}],"concepts":[{"id":"https://openalex.org/C2777190055","wikidata":"https://www.wikidata.org/wiki/Q3045251","display_name":"Desymmetrization","level":4,"score":0.976504921913147},{"id":"https://openalex.org/C146686406","wikidata":"https://www.wikidata.org/wiki/Q898628","display_name":"Enantioselective synthesis","level":3,"score":0.9343867301940918},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.6333351731300354},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5392554998397827},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.47156020998954773},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.43927350640296936}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/anie.200704093","doi":"https://doi.org/10.1002/anie.200704093","is_oa":false,"landing_page_url":"https://doi.org/10.1002/anie.200704093","pdf_url":null,"source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1549889872","https://openalex.org/W1966955621","https://openalex.org/W1968710126","https://openalex.org/W1971764355","https://openalex.org/W1973110679","https://openalex.org/W1976807900","https://openalex.org/W1978155954","https://openalex.org/W1985942780","https://openalex.org/W1992531506","https://openalex.org/W1992578571","https://openalex.org/W1993535745","https://openalex.org/W1997892247","https://openalex.org/W1999886355","https://openalex.org/W2002303729","https://openalex.org/W2002656822","https://openalex.org/W2008777623","https://openalex.org/W2014335924","https://openalex.org/W2015156413","https://openalex.org/W2019445932","https://openalex.org/W2020482148","https://openalex.org/W2020851444","https://openalex.org/W2022624267","https://openalex.org/W2022974353","https://openalex.org/W2038110885","https://openalex.org/W2044822033","https://openalex.org/W2051601643","https://openalex.org/W2051912110","https://openalex.org/W2052183426","https://openalex.org/W2054857449","https://openalex.org/W2057076538","https://openalex.org/W2060813784","https://openalex.org/W2069193306","https://openalex.org/W2071795006","https://openalex.org/W2072105121","https://openalex.org/W2074182043","https://openalex.org/W2076003490","https://openalex.org/W2080830650","https://openalex.org/W2083402105","https://openalex.org/W2086885624","https://openalex.org/W2088141349","https://openalex.org/W2088419468","https://openalex.org/W2090470812","https://openalex.org/W2092617271","https://openalex.org/W2098441813","https://openalex.org/W2102182663","https://openalex.org/W2105724107","https://openalex.org/W2106354376","https://openalex.org/W2107528653","https://openalex.org/W2116578592","https://openalex.org/W2149446147","https://openalex.org/W2151656086","https://openalex.org/W2155664589","https://openalex.org/W2165172030","https://openalex.org/W2165411663","https://openalex.org/W2166176365","https://openalex.org/W2175322377","https://openalex.org/W2316540311","https://openalex.org/W2321279877","https://openalex.org/W2324721161","https://openalex.org/W2738313407","https://openalex.org/W2949466601","https://openalex.org/W2950040707","https://openalex.org/W2950391863","https://openalex.org/W2950582713","https://openalex.org/W2950612029","https://openalex.org/W2950617695","https://openalex.org/W2950738401","https://openalex.org/W2951168823","https://openalex.org/W2951233585","https://openalex.org/W2951263354","https://openalex.org/W2951953897","https://openalex.org/W2952035564","https://openalex.org/W2952346333","https://openalex.org/W2952360245","https://openalex.org/W2952856210","https://openalex.org/W2952867605","https://openalex.org/W3210392154","https://openalex.org/W4244957154","https://openalex.org/W4249979235","https://openalex.org/W4252388688","https://openalex.org/W4255559941"],"related_works":["https://openalex.org/W2949376678","https://openalex.org/W1988669879","https://openalex.org/W2952745951","https://openalex.org/W2399268378","https://openalex.org/W3160792021","https://openalex.org/W2952035564","https://openalex.org/W2091977412","https://openalex.org/W2054098266","https://openalex.org/W2284218729","https://openalex.org/W1972766887"],"abstract_inverted_index":{"At":[0],"the":[1,37],"leading":[2],"edge:":[3],"Chiral":[4],"fluoromalonates":[5],"can":[6],"be":[7],"prepared":[8,49],"with":[9],"very":[10],"high":[11],"stereocontrol":[12],"by":[13,50],"enantioselective":[14],"fluorination":[15],"of":[16,39],"racemic":[17],"malonates":[18],"and":[19],"using":[20,51],"a":[21],"Zn(OAc)2/DBFOX\uf8ffPh":[22],"catalyst":[23],"(see":[24],"scheme),":[25],"thus":[26],"providing":[27],"an":[28],"efficient":[29],"alternative":[30],"route":[31],"to":[32],"conventional":[33],"microbial":[34],"desymmetrization":[35],"for":[36],"preparation":[38],"fluorinated":[40],"chiral":[41],"building":[42],"blocks.":[43],"Several":[44],"pharmaceutically":[45],"attractive":[46],"compounds":[47],"were":[48],"this":[52],"method.":[53]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":10},{"year":2014,"cited_by_count":15},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":15}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}