{"id":"https://openalex.org/W4240148226","doi":"https://doi.org/10.1385/1-59259-063-2:209","title":"Using Self-Assembled Monolayers to Pattern ECM Proteins and Cells on Substrates","display_name":"Using Self-Assembled Monolayers to Pattern ECM Proteins and Cells on Substrates","publication_year":2003,"publication_date":"2003-11-14","ids":{"openalex":"https://openalex.org/W4240148226","doi":"https://doi.org/10.1385/1-59259-063-2:209","pmid":"https://pubmed.ncbi.nlm.nih.gov/10840789"},"language":"en","primary_location":{"id":"doi:10.1385/1-59259-063-2:209","doi":"https://doi.org/10.1385/1-59259-063-2:209","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-063-2:209","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracellular Matrix Protocols","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W1604245084","display_name":"Extracellular Matrix Protocols"},"type":"book-chapter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100609547","display_name":"Christopher S. Chen","orcid":"https://orcid.org/0000-0003-2445-8449","observed_orcids":["https://orcid.org/0000-0003-2445-8449"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Chen","raw_affiliation_strings":["Childrens Hospital, Harvard Medical School, Boston, MA, USA","Childrens Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Childrens Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034684168","display_name":"Emanuele Ostuni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuele Ostuni","raw_affiliation_strings":["Childrens Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051537916","display_name":"George M. Whitesides","orcid":"https://orcid.org/0000-0001-9451-2442","observed_orcids":["https://orcid.org/0000-0001-9451-2442","https://orcid.org/0000-0003-1184-6573"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"George M. Whitesides","raw_affiliation_strings":["Childrens Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005669988","display_name":"Donald E. Ingber","orcid":"https://orcid.org/0000-0002-4319-6520","observed_orcids":["https://orcid.org/0000-0002-4319-6520"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald E. Ingber","raw_affiliation_strings":["Childrens Hospital, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Childrens Hospital, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.2943,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.93073593,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"139","issue":null,"first_page":"209","last_page":"219"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9291999936103821,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12224","display_name":"Nanofabrication and Lithography Techniques","score":0.04899999871850014,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/self-assembled-monolayers","display_name":"self-assembled monolayers","score":0.9639999866485596},{"id":"https://openalex.org/keywords/microcontact-printing","display_name":"microcontact printing","score":0.8579999804496765},{"id":"https://openalex.org/keywords/alkanethiols","display_name":"alkanethiols","score":0.8119999766349792},{"id":"https://openalex.org/keywords/gold-substrate","display_name":"gold substrate","score":0.9679999947547913},{"id":"https://openalex.org/keywords/extracellular-matrix-proteins","display_name":"extracellular matrix proteins","score":0.7950000166893005},{"id":"https://openalex.org/keywords/micropatterning","display_name":"micropatterning","score":0.8519999980926514},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cell-spreading","display_name":"cell spreading","score":0.9620000123977661},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cell-shape","display_name":"cell shape","score":0.7789999842643738},{"id":"https://openalex.org/keywords/cell-matrix-interactions","display_name":"cell-matrix interactions","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.6990000009536743}],"concepts":[{"id":"https://openalex.org/C2859760","wikidata":"https://www.wikidata.org/wiki/Q6839807","display_name":"Micropatterning","level":2,"score":0.9700644016265869},{"id":"https://openalex.org/C58943365","wikidata":"https://www.wikidata.org/wiki/Q6839191","display_name":"Microcontact printing","level":2,"score":0.9102271795272827},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.661054790019989},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5725218057632446},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.5692113041877747},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.5519855618476868},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.48479145765304565},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4525068700313568},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4257127046585083},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3649316132068634},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28120744228363037},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14964476227760315},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002448","descriptor_name":"Cell Adhesion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016326","descriptor_name":"Extracellular Matrix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1385/1-59259-063-2:209","doi":"https://doi.org/10.1385/1-59259-063-2:209","is_oa":false,"landing_page_url":"https://doi.org/10.1385/1-59259-063-2:209","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Extracellular Matrix Protocols","raw_type":"book-chapter"},{"id":"pmid:10840789","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10840789","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Methods in molecular biology (Clifton, N.J.)","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.668.8925","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.668.8925","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://gmwgroup.unix.fas.harvard.edu/pubs/pdf/623.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8479709372","display_name":"Growth Genes, Extracellular Matrix and Angiogenesis","funder_award_id":"R01CA055833","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G8947089381","display_name":null,"funder_award_id":"HL57699","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2166987361","https://openalex.org/W1590328827","https://openalex.org/W1421587871","https://openalex.org/W2109707676","https://openalex.org/W2169391121","https://openalex.org/W1983352401","https://openalex.org/W2080218770","https://openalex.org/W3112527142","https://openalex.org/W7101094017","https://openalex.org/W1967060076"],"abstract_inverted_index":{"We":[0,38],"present":[1],"a":[2,149,164],"method":[3],"that":[4,27,46,86,94,137],"uses":[5],"microcontact":[6],"printing":[7],"of":[8,18,60,63,79,100,117,130,184],"alkanethiols":[9],"on":[10,34],"gold":[11],"to":[12,44,153],"generate":[13],"patterned":[14],"substrates":[15],"presenting":[16],"\u201cislands\u201d":[17],"extracellular":[19],"matrix":[20],"(ECM)":[21],"surrounded":[22],"by":[23,66,107,133,147,200,204],"nonadhesive":[24],"regions":[25],"such":[26,121],"single":[28],"cells":[29,48,142],"attach":[30],"and":[31,54,92,124,173,179,187,202,211],"spread":[32],"only":[33],"the":[35,58,77,87,98,115,128,138,182,205,212,218],"adhesive":[36,139],"regions.":[37],"have":[39],"used":[40],"this":[41],"micropatterning":[42],"technology":[43,161],"demonstrate":[45],"mammalian":[47],"can":[49,143],"be":[50,105,144,215],"switched":[51],"between":[52],"growth":[53,64,91],"apoptosis":[55],"programs":[56],"in":[57,90,110,151,168,180],"presence":[59],"saturating":[61],"concentrations":[62],"factors":[65,156],"either":[67],"promoting":[68],"or":[69],"preventing":[70],"cell":[71,81,118,131,134,174,177],"spreading":[72],"(":[73,157,191],"1":[74],").":[75,159,195],"From":[76],"perspective":[78],"fundamental":[80],"biology,":[82],"these":[83],"results":[84],"suggested":[85],"local":[88,108],"differentials":[89],"viability":[93],"are":[95],"critical":[96],"for":[97],"formation":[99],"complex":[101],"tissue":[102,188],"patterns":[103],"may":[104,214],"generated":[106],"changes":[109],"cell-":[111],"ECM":[112,172],"interactions.":[113],"In":[114],"context":[116],"culture":[119],"technologies,":[120],"as":[122,217],"bioreactors":[123],"cellular":[125,185],"engineering":[126,189],"applications,":[127],"regulation":[129],"function":[132],"shape":[135,175],"indicates":[136],"microenvironment":[140],"around":[141],"carefully":[145],"optimized":[146],"patterning":[148],"substrate":[150],"addition":[152],"using":[154],"soluble":[155],"2":[158],"Micropatterning":[160],"will":[162],"play":[163],"central":[165],"role":[166],"both":[167],"our":[169],"understanding":[170],"how":[171],"regulate":[176],"physiology":[178],"facilitating":[181],"development":[183],"biosensor":[186],"applications":[190],"3":[192],"-":[193],"5":[194],"These":[196],"keywords":[197,213],"were":[198],"added":[199],"machine":[201],"not":[203],"authors.":[206],"This":[207],"process":[208],"is":[209],"experimental":[210],"updated":[216],"learning":[219],"algorithm":[220],"improves.":[221]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2022-05-12T00:00:00"}
