{"id":"https://openalex.org/W4240141057","doi":"https://doi.org/10.1016/b978-012466044-1/50362-8","title":"Keratin 14","display_name":"Keratin 14","publication_year":1998,"publication_date":"1998-01-01","ids":{"openalex":"https://openalex.org/W4240141057","doi":"https://doi.org/10.1016/b978-012466044-1/50362-8"},"language":"en","primary_location":{"id":"doi:10.1016/b978-012466044-1/50362-8","doi":"https://doi.org/10.1016/b978-012466044-1/50362-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-012466044-1/50362-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Gene Knockout FactsBook","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W564011763","display_name":"The Gene Knockout FactsBook"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000800493","display_name":"Tak W. Mak","orcid":"https://orcid.org/0000-0001-6766-861X","observed_orcids":["https://orcid.org/0000-0001-6766-861X","https://orcid.org/0000-0002-0459-4112"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Tak W. Mak","raw_affiliation_strings":["Amgen Institute, Department of Medicial Biophysics, University of Toronto, Toronto, Canada","Department of Immunology, University of Toronto, Toronto, Canada","Editor-in-chief Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Institute, Department of Medicial Biophysics, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Editor-in-chief Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059310975","display_name":"Josef Martin Penninger","orcid":"https://orcid.org/0000-0002-8194-3777","observed_orcids":["https://orcid.org/0000-0002-8194-3777"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Josef Penninger","raw_affiliation_strings":["Amgen Institute, Department of Medical Biophysics, University of Toronto, Canada","Department of Immunology, University of Toronto, Toronto, Canada","Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Amgen Institute, Department of Medical Biophysics, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Immunology, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Ontario Cancer Institute/Princess Margaret Hospital, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111715744","display_name":"John Roder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"John Roder","raw_affiliation_strings":["Department of Immunology, University of Toronto, Canada","Department of Molecular and Medical Genetics, University of Toronto, Canada","Program in Development and Fetal Health, Samuel Lunenfeld. Research Institute, Mount Sinai Hospital, University of Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Molecular and Medical Genetics, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Program in Development and Fetal Health, Samuel Lunenfeld. Research Institute, Mount Sinai Hospital, University of Toronto, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011985445","display_name":"Janet Rossant","orcid":"https://orcid.org/0000-0002-3731-5466","observed_orcids":["https://orcid.org/0000-0002-3731-5466"]},"institutions":[{"id":"https://openalex.org/I1291836623","display_name":"Mount Sinai Hospital","ror":"https://ror.org/05deks119","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1291836623","https://openalex.org/I4210130843"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I210557978","display_name":"Lunenfeld-Tanenbaum Research Institute","ror":"https://ror.org/01s5axj25","country_code":"CA","type":"facility","lineage":["https://openalex.org/I1291836623","https://openalex.org/I210557978","https://openalex.org/I4210130843"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Janet Rossant","raw_affiliation_strings":["Department of Molecular and Medical Genetics, University of Toronto, Canada","Department of Obstetrics/Gynaecology, University of Toronto, Canada","Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital University of Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Medical Genetics, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Department of Obstetrics/Gynaecology, University of Toronto, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Program in Development and Fetal Health, Samuel Lunenfeld Research Institute, Mount Sinai Hospital University of Toronto, Canada","institution_ids":["https://openalex.org/I1291836623","https://openalex.org/I185261750","https://openalex.org/I210557978"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023514711","display_name":"Mary E. Saunders","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mary Saunders","raw_affiliation_strings":["Senior Scientist/Scientific Editor Amgen Institute, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Senior Scientist/Scientific Editor Amgen Institute, Toronto, Canada","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.36758893,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"647","last_page":"648"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11650","display_name":"Skin and Cellular Biology Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12355","display_name":"Genetic and rare skin diseases.","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keratin-14","display_name":"keratin 14","score":1.0},{"id":"https://openalex.org/keywords/keratin-5","display_name":"keratin 5","score":0.9269999861717224},{"id":"https://openalex.org/keywords/keratin-15","display_name":"keratin 15","score":0.9490000009536743},{"id":"https://openalex.org/keywords/keratin-filaments","display_name":"keratin filaments","score":0.8299999833106995},{"id":"https://openalex.org/keywords/blistering","display_name":"blistering","score":0.5540000200271606},{"id":"https://openalex.org/keywords/keratinocyte-cytoskeleton","display_name":"keratinocyte cytoskeleton","score":0.5920000076293945},{"id":"https://openalex.org/keywords/basal-layer","display_name":"basal layer","score":0.5080000162124634},{"id":"https://openalex.org/keywords/hemidesmosomes","display_name":"hemidesmosomes","score":0.8399999737739563},{"id":"https://openalex.org/keywords/desmosomes","display_name":"desmosomes","score":0.9990000128746033},{"id":"https://openalex.org/keywords/keratinocyte-differentiation","display_name":"keratinocyte differentiation","score":0.5960000157356262},{"id":"https://openalex.org/keywords/keratinocyte-proliferation","display_name":"keratinocyte proliferation","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C81241287","wikidata":"https://www.wikidata.org/wiki/Q189474","display_name":"Keratin","level":2,"score":0.9543602466583252},{"id":"https://openalex.org/C78383274","wikidata":"https://www.wikidata.org/wiki/Q421987","display_name":"Intermediate filament","level":4,"score":0.8719315528869629},{"id":"https://openalex.org/C170178370","wikidata":"https://www.wikidata.org/wiki/Q14907905","display_name":"Keratin 5","level":3,"score":0.8239174485206604},{"id":"https://openalex.org/C108335385","wikidata":"https://www.wikidata.org/wiki/Q14864155","display_name":"Keratin 6A","level":5,"score":0.7787805795669556},{"id":"https://openalex.org/C147075424","wikidata":"https://www.wikidata.org/wiki/Q1604780","display_name":"Hemidesmosome","level":3,"score":0.7056493759155273},{"id":"https://openalex.org/C50548948","wikidata":"https://www.wikidata.org/wiki/Q14907896","display_name":"Keratin 8","level":3,"score":0.6929486989974976},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.6899333000183105},{"id":"https://openalex.org/C189689871","wikidata":"https://www.wikidata.org/wiki/Q14864152","display_name":"Keratin 7","level":4,"score":0.6044365167617798},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5690705180168152},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5155960917472839},{"id":"https://openalex.org/C2778266373","wikidata":"https://www.wikidata.org/wiki/Q14864175","display_name":"Keratin 14","level":5,"score":0.45872020721435547},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.429744154214859},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.37759897112846375},{"id":"https://openalex.org/C87555872","wikidata":"https://www.wikidata.org/wiki/Q3141316","display_name":"Ultrastructure","level":2,"score":0.3328559398651123},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3244500756263733},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.320591539144516},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.27634066343307495},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21226951479911804},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.16073724627494812},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1510467529296875},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.12902861833572388},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11913737654685974},{"id":"https://openalex.org/C2779012181","wikidata":"https://www.wikidata.org/wiki/Q2750567","display_name":"Cytokeratin","level":3,"score":0.10877656936645508},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.08595651388168335},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/b978-012466044-1/50362-8","doi":"https://doi.org/10.1016/b978-012466044-1/50362-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/b978-012466044-1/50362-8","pdf_url":null,"source":{"id":"https://openalex.org/S4306463230","display_name":"Elsevier eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Gene Knockout FactsBook","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":1,"referenced_works":["https://openalex.org/W2141021726"],"related_works":["https://openalex.org/W2110516509","https://openalex.org/W2141021726","https://openalex.org/W2045255180","https://openalex.org/W1973031977","https://openalex.org/W2149827167","https://openalex.org/W2155507850","https://openalex.org/W2091382241","https://openalex.org/W1602235258","https://openalex.org/W2073852580","https://openalex.org/W2069714982"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-05-12T00:00:00"}