{"id":"https://openalex.org/W4240112809","doi":"https://doi.org/10.1007/s13238-013-3911-2","title":"Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes","display_name":"Global DNA methylation and transcriptional analyses of human ESC-derived cardiomyocytes","publication_year":2013,"publication_date":"2013-08-27","ids":{"openalex":"https://openalex.org/W4240112809","doi":"https://doi.org/10.1007/s13238-013-3911-2","pmid":"https://pubmed.ncbi.nlm.nih.gov/23982742"},"language":"en","primary_location":{"id":"doi:10.1007/s13238-013-3911-2","doi":"https://doi.org/10.1007/s13238-013-3911-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13238-013-3911-2","pdf_url":"https://academic.oup.com/proteincell/article-pdf/5/1/59/47215833/13238_2013_article_16.pdf","source":{"id":"https://openalex.org/S126440360","display_name":"Protein & Cell","issn_l":"1674-800X","issn":["1674-800X","1674-8018"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein & Cell","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/proteincell/article-pdf/5/1/59/47215833/13238_2013_article_16.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067874194","display_name":"Ying Gu","orcid":"https://orcid.org/0000-0001-7822-0570","observed_orcids":["https://orcid.org/0000-0001-7822-0570"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying Gu","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA","Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I1307098950"]},{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100654857","display_name":"Guang\u2010Hui Liu","orcid":"https://orcid.org/0000-0001-9289-8177","observed_orcids":["https://orcid.org/0000-0001-9289-8177"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guang-Hui Liu","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]},{"raw_affiliation_string":"State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203, Shanghai, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051198855","display_name":"Nongluk Plongthongkum","orcid":"https://orcid.org/0000-0002-1305-285X","observed_orcids":["https://orcid.org/0000-0002-1305-285X"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nongluk Plongthongkum","raw_affiliation_strings":["Department of Bioengineering, University of California at San Diego, 92093, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California at San Diego, 92093, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060761396","display_name":"Christopher W. Benner","orcid":"https://orcid.org/0000-0002-4618-0719","observed_orcids":["https://orcid.org/0000-0002-4618-0719"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher Benner","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036770398","display_name":"Fei Yi","orcid":"https://orcid.org/0000-0002-2464-3655","observed_orcids":["https://orcid.org/0000-0002-2464-3655"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fei Yi","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069869323","display_name":"Jing Tao Qu","orcid":"https://orcid.org/0000-0002-3988-5067","observed_orcids":["https://orcid.org/0000-0002-3988-5067"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Qu","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089926733","display_name":"Keiichiro Suzuki","orcid":"https://orcid.org/0000-0001-5603-9105","observed_orcids":["https://orcid.org/0000-0001-5603-9105"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keiichiro Suzuki","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082911266","display_name":"Jiping Yang","orcid":"https://orcid.org/0000-0001-6332-8693","observed_orcids":["https://orcid.org/0000-0001-6332-8693"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiping Yang","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100646599","display_name":"Weiqi Zhang","orcid":"https://orcid.org/0000-0002-8885-5104","observed_orcids":["https://orcid.org/0000-0002-8885-5104"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112540","display_name":"Institute of Biophysics","ror":"https://ror.org/01tyv8576","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiqi Zhang","raw_affiliation_strings":["National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 100101, Beijing, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112540"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100361471","display_name":"Mo Li","orcid":"https://orcid.org/0000-0003-0827-8907","observed_orcids":["https://orcid.org/0000-0003-0827-8907","https://orcid.org/0000-0002-5133-3935","https://orcid.org/0000-0001-7005-7545"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mo Li","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026937459","display_name":"N\u00faria Montserrat","orcid":"https://orcid.org/0000-0002-1603-1755","observed_orcids":["https://orcid.org/0000-0002-1603-1755"]},"institutions":[{"id":"https://openalex.org/I4210105141","display_name":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine","ror":"https://ror.org/01gm5f004","country_code":"ES","type":"other","lineage":["https://openalex.org/I4210105141"]},{"id":"https://openalex.org/I4210138155","display_name":"Center of Regenerative Medicine in Barcelona","ror":"https://ror.org/03q0p7c86","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210138155","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Nuria Montserrat","raw_affiliation_strings":["Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Poeta Mariano Esquillor s/n, 50018, Sargossa, Spain","Center of Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003, Barcelona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER-BBN), Poeta Mariano Esquillor s/n, 50018, Sargossa, Spain","institution_ids":["https://openalex.org/I4210105141"]},{"raw_affiliation_string":"Center of Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003, Barcelona, Spain","institution_ids":["https://openalex.org/I4210138155"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017913780","display_name":"Isaac Crespo","orcid":"https://orcid.org/0000-0003-3151-3901","observed_orcids":["https://orcid.org/0000-0003-3151-3901"]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]},{"id":"https://openalex.org/I4405257232","display_name":"Luxembourg Centre for Systems Biomedicine","ror":"https://ror.org/051tr1y59","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577","https://openalex.org/I4405257232"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Isaac Crespo","raw_affiliation_strings":["Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Walferdange, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Walferdange, Luxembourg","institution_ids":["https://openalex.org/I186903577","https://openalex.org/I4405257232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075664103","display_name":"Antonio del Sol","orcid":"https://orcid.org/0000-0002-9926-617X","observed_orcids":["https://orcid.org/0000-0002-9926-617X"]},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]},{"id":"https://openalex.org/I4405257232","display_name":"Luxembourg Centre for Systems Biomedicine","ror":"https://ror.org/051tr1y59","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577","https://openalex.org/I4405257232"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Antonio Sol","raw_affiliation_strings":["Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Walferdange, Luxembourg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Walferdange, Luxembourg","institution_ids":["https://openalex.org/I186903577","https://openalex.org/I4405257232"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029674899","display_name":"Concepci\u00f3n Rodr\u0131\u0301guez Esteban","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Concepcion Rodriguez Esteban","raw_affiliation_strings":["Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100342359","display_name":"Kun Zhang","orcid":"https://orcid.org/0000-0002-7596-5224","observed_orcids":["https://orcid.org/0000-0002-7596-5224"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kun Zhang","raw_affiliation_strings":["Department of Bioengineering, University of California at San Diego, 92093, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, University of California at San Diego, 92093, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050690657","display_name":"Juan Carlos Izpis\u00faa Belmonte","orcid":"https://orcid.org/0000-0003-0557-8875","observed_orcids":["https://orcid.org/0000-0003-0557-8875"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]},{"id":"https://openalex.org/I4210138155","display_name":"Center of Regenerative Medicine in Barcelona","ror":"https://ror.org/03q0p7c86","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210138155","https://openalex.org/I4387153040"]}],"countries":["ES","US"],"is_corresponding":true,"raw_author_name":"Juan Carlos Izpisua Belmonte","raw_affiliation_strings":["Center of Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003, Barcelona, Spain","Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center of Regenerative Medicine in Barcelona, Dr. Aiguader 88, 08003, Barcelona, Spain","institution_ids":["https://openalex.org/I4210138155"]},{"raw_affiliation_string":"Gene Expression Laboratory, Salk Institute for Biological Studies, 10010, North Torrey Pines Road, 92037, La Jolla, CA, USA","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5050690657","https://openalex.org/A5100342359","https://openalex.org/A5100654857"],"corresponding_institution_ids":["https://openalex.org/I1307098950","https://openalex.org/I19820366","https://openalex.org/I36258959","https://openalex.org/I4210112540","https://openalex.org/I4210112820","https://openalex.org/I4210138155","https://openalex.org/I4391767758"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":{"value":2700,"currency":"USD","value_usd":2700},"fwci":0.596,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.69044793,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":null,"issue":null,"first_page":"","last_page":""},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-embryonic-stem-cells","display_name":"human embryonic stem cells","score":0.8859999775886536},{"id":"https://openalex.org/keywords/cardiomyocytes","display_name":"cardiomyocytes","score":0.8980000019073486},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/epigenetics","display_name":"epigenetics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/cardiac-transcription-factors","display_name":"cardiac transcription factors","score":0.6340000033378601},{"id":"https://openalex.org/keywords/gene-disease-networks","display_name":"gene-disease networks","score":0.7620000243186951},{"id":"https://openalex.org/keywords/functional-association-networks","display_name":"functional association networks","score":0.718999981880188},{"id":"https://openalex.org/keywords/cardiac-disease-models","display_name":"cardiac disease models","score":0.41499999165534973}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.8354560136795044},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8011542558670044},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7473719120025635},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5689942836761475},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5631900429725647},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5538828372955322},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5320497751235962},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5199059844017029},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4587978720664978},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41423362493515015},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.39613524079322815}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s13238-013-3911-2","doi":"https://doi.org/10.1007/s13238-013-3911-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13238-013-3911-2","pdf_url":"https://academic.oup.com/proteincell/article-pdf/5/1/59/47215833/13238_2013_article_16.pdf","source":{"id":"https://openalex.org/S126440360","display_name":"Protein & Cell","issn_l":"1674-800X","issn":["1674-800X","1674-8018"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein & Cell","raw_type":"journal-article"},{"id":"pmid:23982742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23982742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein & cell","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s13238-013-3911-2","doi":"https://doi.org/10.1007/s13238-013-3911-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s13238-013-3911-2","pdf_url":"https://academic.oup.com/proteincell/article-pdf/5/1/59/47215833/13238_2013_article_16.pdf","source":{"id":"https://openalex.org/S126440360","display_name":"Protein & Cell","issn_l":"1674-800X","issn":["1674-800X","1674-8018"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Protein & Cell","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1118969332","display_name":null,"funder_award_id":"2014CB964600","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G326723367","display_name":null,"funder_award_id":"XDA01020312","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G5226670311","display_name":null,"funder_award_id":"SIMM1302KF","funder_id":"https://openalex.org/F4320335657","funder_display_name":"State Key Laboratory of Drug Research"},{"id":"https://openalex.org/G579332670","display_name":null,"funder_award_id":"2014CB910500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5952284444","display_name":null,"funder_award_id":"2014CB910500","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"},{"id":"https://openalex.org/G6391271827","display_name":null,"funder_award_id":"No. 2014CB910500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320306135","display_name":"Ellison Medical Foundation","ror":"https://ror.org/01pqy3846"},{"id":"https://openalex.org/F4320306171","display_name":"California Institute for Regenerative Medicine","ror":"https://ror.org/033m8b439"},{"id":"https://openalex.org/F4320309446","display_name":"Leona M. and Harry B. Helmsley Charitable Trust","ror":"https://ror.org/011x6n313"},{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320323089","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Bioingenier\u00eda, Biomateriales y Nanomedicina","ror":"https://ror.org/01gm5f004"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335657","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null},{"id":"https://openalex.org/F4320338022","display_name":"National Laboratory of Biomacromolecules","ror":"https://ror.org/03twns208"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4240112809.pdf","grobid_xml":"https://content.openalex.org/works/W4240112809.grobid-xml"},"referenced_works_count":22,"referenced_works":["https://openalex.org/W1977025496","https://openalex.org/W2010417854","https://openalex.org/W2015313458","https://openalex.org/W2024133736","https://openalex.org/W2059065706","https://openalex.org/W2073610802","https://openalex.org/W2083342911","https://openalex.org/W2088778610","https://openalex.org/W2109261272","https://openalex.org/W2112395856","https://openalex.org/W2122902176","https://openalex.org/W2140601463","https://openalex.org/W2147418473","https://openalex.org/W2147898718","https://openalex.org/W2157232603","https://openalex.org/W2158128644","https://openalex.org/W2159675211","https://openalex.org/W2160238006","https://openalex.org/W2166305181","https://openalex.org/W2166542841","https://openalex.org/W2171030481","https://openalex.org/W2171942713"],"related_works":["https://openalex.org/W2890769067","https://openalex.org/W1979842175","https://openalex.org/W2024133736","https://openalex.org/W2106478731","https://openalex.org/W2942442690","https://openalex.org/W2099754256","https://openalex.org/W2024799581","https://openalex.org/W2282483835","https://openalex.org/W2015313458","https://openalex.org/W2171942713"],"abstract_inverted_index":{"With":[0],"defined":[1],"culture":[2],"protocol,":[3],"human":[4,22,44],"embryonic":[5],"stem":[6],"cells":[7],"(hESCs)":[8],"are":[9],"able":[10],"to":[11,55,122,137],"generate":[12],"cardiomyocytes":[13,45],"in":[14,141],"vitro,":[15],"therefore":[16],"providing":[17,127],"a":[18,39,128],"great":[19,27],"model":[20],"for":[21,29,101],"heart":[23],"development,":[24],"and":[25,57,67,75,93,98,106,115],"holding":[26],"potential":[28],"cardiac":[30,103],"disease":[31,107],"therapies.":[32],"In":[33],"this":[34],"study,":[35],"we":[36,110],"successfully":[37],"generated":[38],"highly":[40],"pure":[41],"population":[42],"of":[43,79,89,131],"(hCMs)":[46],"(>95%":[47],"cTnT+)":[48],"from":[49],"hESC":[50],"line,":[51],"which":[52],"enabled":[53],"us":[54],"identify":[56],"characterize":[58],"an":[59,96],"hCM-specific":[60],"signature,":[61],"at":[62],"both":[63],"the":[64,87,133],"gene":[65,104,125,139],"expression":[66,140],"DNA":[68],"methylation":[69],"levels.":[70],"Gene":[71],"functional":[72],"association":[73],"network":[74,77],"gene-disease":[76],"analyses":[78],"these":[80],"hCM-enriched":[81],"genes":[82,114],"provide":[83],"new":[84],"insights":[85],"into":[86],"mechanisms":[88,121],"hCM":[90],"transcriptional":[91],"regulation,":[92],"stand":[94],"as":[95],"informative":[97],"rich":[99],"resource":[100],"investigating":[102],"functions":[105],"mechanisms.":[108],"Moreover,":[109],"show":[111],"that":[112],"cardiac-structural":[113],"cardiac-transcription":[116],"factors":[117],"have":[118],"distinct":[119],"epigenetic":[120,134],"regulate":[123,138],"their":[124],"expression,":[126],"better":[129],"understanding":[130],"how":[132],"machinery":[135],"coordinates":[136],"different":[142],"cell":[143],"types.":[144]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}