{"id":"https://openalex.org/W4239808304","doi":"https://doi.org/10.1161/hyp.70.suppl_1.146","title":"Abstract 146: MicroRNA-216a Promotes M1 Macrophages Polarization Through the Activation of Telomerase","display_name":"Abstract 146: MicroRNA-216a Promotes M1 Macrophages Polarization Through the Activation of Telomerase","publication_year":2017,"publication_date":"2017-09-01","ids":{"openalex":"https://openalex.org/W4239808304","doi":"https://doi.org/10.1161/hyp.70.suppl_1.146"},"language":"en","primary_location":{"id":"doi:10.1161/hyp.70.suppl_1.146","doi":"https://doi.org/10.1161/hyp.70.suppl_1.146","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.70.suppl_1.146","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101830007","display_name":"Shujun Yang","orcid":"https://orcid.org/0000-0002-5419-4416","observed_orcids":["https://orcid.org/0000-0002-5419-4416"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujun Yang","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","Shujun Yang State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]},{"raw_affiliation_string":"Shujun Yang State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100402608","display_name":"Jian Li","orcid":"https://orcid.org/0000-0003-3320-7924","observed_orcids":["https://orcid.org/0000-0003-3320-7924","https://orcid.org/0000-0001-9289-8177"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Li","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","Jian Li State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]},{"raw_affiliation_string":"Jian Li State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100740490","display_name":"Yu Chen","orcid":"https://orcid.org/0000-0003-0277-6614","observed_orcids":["https://orcid.org/0000-0003-0277-6614"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Chen","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","Yu Chen State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]},{"raw_affiliation_string":"Yu Chen State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102215365","display_name":"Rutai Hui","orcid":"https://orcid.org/0000-0001-7393-2544","observed_orcids":["https://orcid.org/0000-0001-7393-2544"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rutai Hui","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","Rutai Hui State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]},{"raw_affiliation_string":"Rutai Hui State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100610347","display_name":"Weili Zhang","orcid":"https://orcid.org/0000-0002-1862-1492","observed_orcids":["https://orcid.org/0000-0002-1862-1492","https://orcid.org/0000-0003-4703-3486","https://orcid.org/0009-0007-8646-1500"]},"institutions":[{"id":"https://openalex.org/I200296433","display_name":"Chinese Academy of Medical Sciences & Peking Union Medical College","ror":"https://ror.org/02drdmm93","country_code":"CN","type":"education","lineage":["https://openalex.org/I200296433"]},{"id":"https://openalex.org/I4210161896","display_name":"Fu Wai Hospital","ror":"https://ror.org/0590dnz19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210161896"]},{"id":"https://openalex.org/I4391767941","display_name":"State Key Laboratory of Cardiovascular Disease","ror":"https://ror.org/00t7sjs72","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210087153","https://openalex.org/I4391767941"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weili Zhang","raw_affiliation_strings":["State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","Weili Zhang State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]},{"raw_affiliation_string":"Weili Zhang State Key Laboratory of Cardiovascular Disease, Fuwai Hosp, National Cntr for Cardiovascular Diseases, Peking Union Med College &Chinese Academy of Med Sciences, Beijing, China","institution_ids":["https://openalex.org/I200296433","https://openalex.org/I4210161896","https://openalex.org/I4391767941"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"70","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.7856000065803528,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.1860000044107437,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-216a","display_name":"miR-216a","score":0.9359999895095825},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.7960000038146973},{"id":"https://openalex.org/keywords/m2-macrophage-polarization","display_name":"M2 macrophage polarization","score":0.6970000267028809},{"id":"https://openalex.org/keywords/telomerase-activation","display_name":"telomerase activation","score":0.7070000171661377},{"id":"https://openalex.org/keywords/tert","display_name":"telomerase reverse transcriptase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9900000095367432},{"id":"https://openalex.org/keywords/atherosclerotic-plaque","display_name":"atherosclerotic plaque","score":0.8849999904632568},{"id":"https://openalex.org/keywords/type-iii-collagen","display_name":"type III collagen","score":0.8109999895095825},{"id":"https://openalex.org/keywords/col3a1","display_name":"COL3A1","score":0.9079999923706055},{"id":"https://openalex.org/keywords/macrophage-plasticity","display_name":"macrophage plasticity","score":0.6790000200271606},{"id":"https://openalex.org/keywords/carotid-stenosis","display_name":"carotid artery stenosis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/apoe-deficient-mice","display_name":"ApoE-deficient mice","score":0.8059999942779541}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5439039468765259},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.5432360172271729},{"id":"https://openalex.org/C2779770810","wikidata":"https://www.wikidata.org/wiki/Q23069155","display_name":"Sirius Red","level":3,"score":0.5388969779014587},{"id":"https://openalex.org/C94581717","wikidata":"https://www.wikidata.org/wiki/Q331839","display_name":"Telomerase","level":3,"score":0.5237317681312561},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.49752262234687805},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4972718060016632},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4103567898273468},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4101422131061554},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4047943949699402},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3887864053249359},{"id":"https://openalex.org/C74864618","wikidata":"https://www.wikidata.org/wiki/Q2332446","display_name":"Staining","level":2,"score":0.33640599250793457},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3209998607635498},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2879183292388916},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28666865825653076},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28014689683914185},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.259146511554718},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.24477618932724},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09129780530929565},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07777085900306702},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/hyp.70.suppl_1.146","doi":"https://doi.org/10.1161/hyp.70.suppl_1.146","is_oa":false,"landing_page_url":"https://doi.org/10.1161/hyp.70.suppl_1.146","pdf_url":null,"source":{"id":"https://openalex.org/S67880631","display_name":"Hypertension","issn_l":"0194-911X","issn":["0194-911X","1524-4563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Hypertension","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2810250321","https://openalex.org/W2887785294","https://openalex.org/W2731656009","https://openalex.org/W2765827324","https://openalex.org/W2433898765","https://openalex.org/W3193247589","https://openalex.org/W4206837420","https://openalex.org/W3214887096","https://openalex.org/W4288034139","https://openalex.org/W2076800531"],"abstract_inverted_index":{"Background:":[0],"Macrophages":[1],"display":[2],"significant":[3,124],"phenotypic":[4],"heterogeneity":[5],"and":[6,17,31,81,87,164,184,214,220,235,239,257,278,286],"plasticity.":[7],"Two":[8],"subtypes":[9],"exist":[10],"in":[11,56,63,78,83,140,229,282],"atherosclerotic":[12,143],"plaques:":[13],"M1":[14,150,230,247,255,261,270],"pro-inflammatory":[15],"subtype":[16,151,158],"M2":[18,157,259],"anti-inflammatory":[19],"subtype,":[20],"which":[21],"can":[22],"be":[23],"converted":[24],"to":[25,34,72,94,105,205,260],"each":[26],"other":[27],"under":[28],"certain":[29],"conditions":[30],"therefore":[32],"contribute":[33],"the":[35,39,52,60,67,74,95,116,123,135,141,147,176,186,200,207,215,240,250,274,289],"plaque":[36,129],"progression.":[37],"But":[38],"underlying":[40],"mechanisms":[41],"remain":[42],"unclear.":[43],"Our":[44,264],"previous":[45],"work":[46],"showed":[47,137,217,242],"that":[48,138,172,218,243,267],"m":[49],"iR-216a":[50],"mediates":[51],"activation":[53,275],"of":[54,76,99,115,126,149,178,189,209,276,291],"telomerase":[55,221,277],"macrophages":[57,79,202,212,271],"differentiation":[58],"via":[59],"Smad3/NF-\u03baB":[61],"pathway":[62],"vitro":[64],".":[65,85],"In":[66,168],"present":[68],"study,":[69],"we":[70,170],"aimed":[71],"examine":[73],"role":[75],"miR-216a":[77,117,127,139,173,210,219,268],"polarization":[80,256,272],"atherosclerosis":[82],"vivo":[84],"Methods":[86],"Results:":[88],"We":[89],"applied":[90],"a":[91],"tandem":[92],"stenosis":[93],"right":[96],"carotid":[97,142,284],"artery":[98],"apolipoprotein":[100],"E-deficient":[101],"mice":[102,283],"model":[103],"according":[104],"doctor":[106],"Chen\u2019s":[107],"method":[108],"(Circ":[109],"Res.":[110],"2013;113(3):252-65.),":[111],"with":[112],"local":[113],"infiltration":[114],"lentivirus.":[118],"At":[119],"4":[120],"weeks":[121],"postoperatively,":[122],"effect":[125],"on":[128,211,249],"area":[130],"was":[131],"not":[132],"observed;":[133],"however,":[134],"results":[136,216,241],"plaques":[144],"markedly":[145],"increased":[146,228],"numbers":[148],"by":[152,159,161,181,197],"1.8-fold":[153],"whereas":[154],"simultaneously":[155],"decreased":[156],"2.1-fold":[160],"applying":[162],"CD16/32":[163],"Arg1":[165],"immuno-fluorescent":[166],"staining.":[167],"addition,":[169],"found":[171],"significantly":[174],"reduced":[175],"amounts":[177],"collagen":[179,190,280],"III":[180,192,281],"Sirius-Red":[182],"staining":[183],"downregulated":[185],"mRNA":[187],"expression":[188,225],"type":[191],"alpha":[193],"1":[194],"chain":[195],"(COL3A1)":[196],"70%.":[198],"Furthermore,":[199],"THP-1":[201],"were":[203,226,237],"used":[204],"explore":[206],"mechanism":[208],"polarization,":[213],"reverse":[222],"transcriptase":[223],"(TERT)":[224],"only":[227],"macrophages.":[231],"Next,":[232],"TERT":[233,244,253],"lentivirus":[234],"siRNA":[236],"transfected,":[238],"overexpression":[245],"promoted":[246],"polarization;":[248],"contrary,":[251],"silencing":[252],"inhibited":[254],"suppressed":[258],"conversion.":[262],"Conclusions:":[263],"data":[265],"indicated":[266],"promotes":[269],"through":[273],"reduces":[279],"lesions,":[285],"ultimately":[287],"accelerates":[288],"development":[290],"atherosclerosis.":[292]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-12T00:00:00"}