{"id":"https://openalex.org/W4239749157","doi":"https://doi.org/10.1016/j.jalz.2015.06.686","title":"P2\u2010148: An early Alzheimer's disease functional imaging marker: Olfactory deficits in Alzheimer's disease and MCI reflect degeneration of central olfactory system","display_name":"P2\u2010148: An early Alzheimer's disease functional imaging marker: Olfactory deficits in Alzheimer's disease and MCI reflect degeneration of central olfactory system","publication_year":2015,"publication_date":"2015-07-01","ids":{"openalex":"https://openalex.org/W4239749157","doi":"https://doi.org/10.1016/j.jalz.2015.06.686"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2015.06.686","doi":"https://doi.org/10.1016/j.jalz.2015.06.686","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.06.686","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2015.06.686","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2015.06.686","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101843283","display_name":"Qing X. Yang","orcid":"https://orcid.org/0000-0003-0530-9915","observed_orcids":["https://orcid.org/0000-0003-0530-9915","https://orcid.org/0000-0003-3161-8439"]},"institutions":[{"id":"https://openalex.org/I130769515","display_name":"Pennsylvania State University","ror":"https://ror.org/04p491231","country_code":"US","type":"education","lineage":["https://openalex.org/I130769515"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qing X. Yang","raw_affiliation_strings":["The Pennsylvania State University - College of Medicine, Hershey, PA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Pennsylvania State University - College of Medicine, Hershey, PA, USA","institution_ids":["https://openalex.org/I130769515"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101843283"],"corresponding_institution_ids":["https://openalex.org/I130769515"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.33951802,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"7S_Part_11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10971","display_name":"Olfactory and Sensory Function Studies","score":0.9779999852180481,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0210999995470047,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mild-cognitive-impairment","display_name":"mild cognitive impairment","score":0.9980000257492065}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6939964890480042},{"id":"https://openalex.org/C2778916471","wikidata":"https://www.wikidata.org/wiki/Q485537","display_name":"Odor","level":2,"score":0.6760843992233276},{"id":"https://openalex.org/C130959647","wikidata":"https://www.wikidata.org/wiki/Q7086515","display_name":"Olfactory memory","level":4,"score":0.6745924949645996},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.65592360496521},{"id":"https://openalex.org/C201792869","wikidata":"https://www.wikidata.org/wiki/Q1054094","display_name":"Olfactory system","level":2,"score":0.5874760746955872},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.5400121808052063},{"id":"https://openalex.org/C163214680","wikidata":"https://www.wikidata.org/wiki/Q1541064","display_name":"Olfaction","level":2,"score":0.4868466258049011},{"id":"https://openalex.org/C2983526489","wikidata":"https://www.wikidata.org/wiki/Q133500","display_name":"Associative learning","level":2,"score":0.44351285696029663},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3433228135108948},{"id":"https://openalex.org/C2780496858","wikidata":"https://www.wikidata.org/wiki/Q644945","display_name":"Olfactory bulb","level":3,"score":0.21403515338897705}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2015.06.686","doi":"https://doi.org/10.1016/j.jalz.2015.06.686","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.06.686","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2015.06.686","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jalz.2015.06.686","doi":"https://doi.org/10.1016/j.jalz.2015.06.686","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jalz.2015.06.686","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1016/j.jalz.2015.06.686","source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4239749157.pdf","grobid_xml":"https://content.openalex.org/works/W4239749157.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2252458449","https://openalex.org/W2731879746","https://openalex.org/W2040016312","https://openalex.org/W2538015683","https://openalex.org/W2539358685","https://openalex.org/W4213386378","https://openalex.org/W1448960299","https://openalex.org/W2160401304","https://openalex.org/W4256268128","https://openalex.org/W2168353204"],"abstract_inverted_index":{"Olfactory":[0],"deficits":[1,18],"are":[2,19],"present":[3],"in":[4,38,103,140,174,201,217],"early":[5],"AD":[6,39,155,218],"and":[7,40,55,72,109,142,147,166,176,219],"MCI":[8,41,54,153,220],"(1-4).":[9],"It":[10],"is":[11,178],"critical,":[12],"however,":[13],"to":[14,21],"determine":[15],"whether":[16],"these":[17],"due":[20],"degeneration":[22],"of":[23,33,66,82,182],"the":[24,34,64,92,104,113,152,164,192,209,214],"central":[25,35,210],"or":[26,154],"peripheral":[27],"olfactory":[28,36,45,75,106,125,167,211,215],"system.":[29],"We":[30],"investigated":[31],"involvement":[32],"system":[37],"with":[42,61,86,163,196],"an":[43,97],"implicit":[44,124,183],"associative":[46,76,126],"learning":[47,77,127],"paradigm.":[48],"Sixty-three":[49],"subjects":[50,135,156],"(15":[51],"AD,":[52],"21":[53],"27":[56],"age-matched":[57],"CN)":[58],"were":[59],"studied":[60],"cognitive":[62,165],"tests,":[63],"University":[65],"Pennsylvania":[67],"Smell":[68],"Identification":[69],"Test":[70],"(UPSIT)":[71],"fMRI.":[73],"The":[74,133,169,198],"paradigm":[78,130],"(Fig.":[79,131],"1)":[80],"consisted":[81],"visual":[83,94,193],"cues":[84],"paired":[85,195],"lavender":[87],"odor":[88,98],"(visual+odor)":[89],"followed":[90],"by":[91,171,191],"same":[93],"cue":[95,101,116,173,194],"without":[96],"(visual-only).":[99],"Visual-only":[100],"activated":[102,138],"primary":[105],"cortex":[107],"(POC)":[108],"hippocampus":[110,141,177],"as":[111],"did":[112],"preceded":[114,190],"visual+odor":[115,146],"for":[117,230],"each":[118],"group":[119],"(p<0.05),":[120],"suggesting":[121],"a":[122,180,225],"rapid":[123],"under":[128,204],"this":[129,205],"2).":[132],"CN":[134],"had":[136],"greater":[137],"volume":[139],"POC":[143,175],"during":[144],"both":[145],"visual-only":[148,172],"conditions":[149,161],"than":[150],"either":[151],"(P":[157],"<":[158],"0.05).":[159],"Both":[160],"correlated":[162],"tests.":[168],"activation":[170,203],"likely":[179],"result":[181],"learning/memory":[184],"since":[185],"it":[186],"occurs":[187],"only":[188],"when":[189],"odor.":[197],"significant":[199],"decline":[200],"brain":[202],"condition":[206],"suggests":[207],"that":[208],"processing":[212],"contributed":[213],"dysfunction":[216],"patients,":[221],"which":[222],"could":[223],"lead":[224],"sensitive":[226],"functional":[227],"imaging":[228],"marker":[229],"AD.":[231]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}