{"id":"https://openalex.org/W4239707487","doi":"https://doi.org/10.1093/neuonc/now212.605","title":"PDCT-01. TOXICITY AND OUTCOME IN ADOLESCENT AND YOUNG ADULTS TREATED FOR MEDULLOBLASTOMA AND PRIMITIVE NEUROECTODERMAL TUMORS ON STUDIES COG-A9961 AND CCG-99701: A REPORT FROM THE CHILDREN\u2019S ONCOLOGY GROUP (COG)","display_name":"PDCT-01. TOXICITY AND OUTCOME IN ADOLESCENT AND YOUNG ADULTS TREATED FOR MEDULLOBLASTOMA AND PRIMITIVE NEUROECTODERMAL TUMORS ON STUDIES COG-A9961 AND CCG-99701: A REPORT FROM THE CHILDREN\u2019S ONCOLOGY GROUP (COG)","publication_year":2016,"publication_date":"2016-11-01","ids":{"openalex":"https://openalex.org/W4239707487","doi":"https://doi.org/10.1093/neuonc/now212.605"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/now212.605","doi":"https://doi.org/10.1093/neuonc/now212.605","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/now212.605","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi145/9643726/now212.605.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi145/9643726/now212.605.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090588180","display_name":"Shadi Farzingohar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210166294","display_name":"Loma Linda University Children's Hospital","ror":"https://ror.org/05htjfp05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210166294"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shadi Farzingohar","raw_affiliation_strings":["Loma Linda University Children\u2019s Hospital, Loma Linda, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loma Linda University Children\u2019s Hospital, Loma Linda, CA, USA,","institution_ids":["https://openalex.org/I4210166294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104232241","display_name":"Caihong Xia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210134079","display_name":"Children's Oncology Group","ror":"https://ror.org/03yyg2352","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210134079"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Caihong Xia","raw_affiliation_strings":["Children\u2019s Oncology Group, Monrovia, CA, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Oncology Group, Monrovia, CA, USA,","institution_ids":["https://openalex.org/I4210134079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047701227","display_name":"Richard Sposto","orcid":"https://orcid.org/0000-0002-2729-2360","observed_orcids":["https://orcid.org/0000-0002-2729-2360"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Sposto","raw_affiliation_strings":["Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087224572","display_name":"David R. Freyer","orcid":"https://orcid.org/0000-0001-5280-990X","observed_orcids":["https://orcid.org/0000-0001-5280-990X"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Freyer","raw_affiliation_strings":["Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066253784","display_name":"Girish Dhall","orcid":"https://orcid.org/0000-0002-4918-0167","observed_orcids":["https://orcid.org/0000-0002-4918-0167"]},"institutions":[{"id":"https://openalex.org/I1336910626","display_name":"Children's Hospital Los Angeles","ror":"https://ror.org/00412ts95","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336910626"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Girish Dhall","raw_affiliation_strings":["Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s Hospital Los Angeles, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1336910626"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5132,"currency":"USD","value_usd":5132},"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"suppl_6","first_page":"vi145","last_page":"vi145"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9711999893188477,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11141","display_name":"Childhood Cancer Survivors' Quality of Life","score":0.014499999582767487,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/medulloblastoma","display_name":"medulloblastoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/primitive-neuroectodermal-tumor","display_name":"primitive neuroectodermal tumor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/adolescent-and-young-adult-cancer","display_name":"adolescent and young adult cancer","score":0.9340000152587891},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.8029999732971191},{"id":"https://openalex.org/keywords/event-free-survival","display_name":"event-free survival","score":0.8240000009536743},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9959999918937683},{"id":"https://openalex.org/keywords/age-related-outcomes","display_name":"age-related outcomes","score":0.5329999923706055},{"id":"https://openalex.org/keywords/chemoradiotherapy","display_name":"chemoradiotherapy","score":0.781000018119812},{"id":"https://openalex.org/keywords/maintenance-chemotherapy","display_name":"maintenance chemotherapy","score":0.9769999980926514},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.968999981880188}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8583040237426758},{"id":"https://openalex.org/C4661277","wikidata":"https://www.wikidata.org/wiki/Q1054157","display_name":"Cog","level":2,"score":0.8337832093238831},{"id":"https://openalex.org/C2780789225","wikidata":"https://www.wikidata.org/wiki/Q1333608","display_name":"Medulloblastoma","level":2,"score":0.8005097508430481},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6229891777038574},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.5972266793251038},{"id":"https://openalex.org/C2776891213","wikidata":"https://www.wikidata.org/wiki/Q618660","display_name":"Primitive neuroectodermal tumor","level":3,"score":0.5841534733772278},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.5450766682624817},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.47726649045944214},{"id":"https://openalex.org/C205545832","wikidata":"https://www.wikidata.org/wiki/Q17156455","display_name":"Young adult","level":2,"score":0.4752333462238312},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.44874048233032227},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14102834463119507},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/neuonc/now212.605","doi":"https://doi.org/10.1093/neuonc/now212.605","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/now212.605","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi145/9643726/now212.605.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1093/neuonc/now212.605","doi":"https://doi.org/10.1093/neuonc/now212.605","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/now212.605","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/18/suppl_6/vi145/9643726/now212.605.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7699999809265137,"display_name":"No poverty","id":"https://metadata.un.org/sdg/1"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4239707487.pdf","grobid_xml":"https://content.openalex.org/works/W4239707487.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4232476700","https://openalex.org/W1997799378","https://openalex.org/W7165762936","https://openalex.org/W4415532915","https://openalex.org/W7172265494","https://openalex.org/W4401809727","https://openalex.org/W2346555090","https://openalex.org/W3014007830","https://openalex.org/W2092339150","https://openalex.org/W4387207119"],"abstract_inverted_index":{"Adolescent":[0],"and":[1,19,30,43,111,165,224,245],"young":[2],"adults":[3],"(AYA)":[4],"with":[5,11,23,27,69,74,89,148,178],"cancer":[6],"have":[7],"inferior":[8],"outcomes":[9,53],"compared":[10,180],"younger":[12,59,225],"patients.":[13,226],"We":[14],"explored":[15],"whether":[16],"treatment-related":[17],"toxicity":[18],"survival":[20,109,113,174,198],"were":[21,72,116],"associated":[22],"age":[24,186],"in":[25,137,151,197,218,241,247],"patients":[26,60,66,88,120,153,177,182,202],"medulloblastoma":[28,201],"(MB)":[29],"primitive":[31],"neuroectodermal":[32],"tumor":[33,248],"(PNET)":[34],"enrolled":[35],"on":[36],"children\u2019s":[37],"oncology":[38],"group":[39,230],"(COG)":[40],"studies":[41,236],"COG-A9961":[42],"CCG-99701.":[44],"A":[45],"retrospective":[46],"analysis":[47],"was":[48,139,145,169,193,206,215],"conducted":[49],"to":[50,172,181],"compare":[51],"the":[52,134,228,238],"between":[54,222],"AYA":[55,119,176,209,223,229],"(15-21":[56],"years)":[57],"vs.":[58],"(3-14":[61],"years).":[62],"On":[63,84,104,131,212],"CCG-99701,":[64,105],"161":[65],"(16":[67],"AYA)":[68,93],"high-risk":[70,200],"MB/PNET":[71],"treated":[73],"chemoradiotherapy":[75,95],"followed":[76,96],"by":[77,97],"six":[78],"cycles":[79,99],"of":[80,100,163,185,243],"maintenance":[81,101],"chemotherapy":[82,102,244],"cyclophosphamide/cisplatin/vincristine).":[83],"A9961":[85],"study,":[86],"379":[87],"standard-risk":[90],"MB":[91],"(25":[92],"received":[94],"eight":[98],"(cisplatin/CCNU/vincristine).":[103],"estimated":[106],"5-year":[107],"event-free":[108],"(EFS)":[110],"overall":[112],"(OS)":[114],"rates":[115],"lower":[117],"for":[118,161,175,199],"(EFS:":[121],"37.5%":[122],"versus":[123,128,188],"60.3%,":[124],"p=0.05;":[125],"OS:":[126],"50.0%":[127],"70.8%,":[129],"p=0.005).":[130],"multivariate":[132],"analysis,":[133],"observed":[135],"difference":[136,168,196,217],"EFS":[138,219],"not":[140],"statistically":[141],"significant":[142,195],"(p=0.12)":[143],"but":[144],"still":[146],"consistent":[147],"poorer":[149,173],"outcome":[150],"older":[152],"(HR":[154],"1.75,":[155],"95%":[156],"CI":[157],"0.89-3.45)":[158],"after":[159],"adjustment":[160],"extent":[162],"resection":[164],"pathology.":[166],"This":[167],"mainly":[170],"due":[171],"PNET":[179],"3-14":[183],"years":[184],"(55.7%":[187],"9.1%;":[189],"p=.002)":[190],"as":[191,210],"there":[192,214],"no":[194,216],"(p=0.26).":[203],"Peripheral":[204],"neuropathy":[205],"higher":[207],"among":[208],"well.":[211],"A9961,":[213],"or":[220],"OS":[221],"Interestingly,":[227],"experienced":[231],"less":[232],"hearing":[233],"loss.":[234],"Future":[235],"examining":[237],"age-related":[239],"differences":[240,246],"pharmacokinetics":[242],"molecular":[249],"biology":[250],"are":[251],"necessary.":[252]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2022-05-12T00:00:00"}
