{"id":"https://openalex.org/W4239677006","doi":"https://doi.org/10.1158/1538-7445.am2019-4265","title":"Abstract 4265: Transient versus permanent autophagy inhibition in pancreatic ductal adenocarcinoma","display_name":"Abstract 4265: Transient versus permanent autophagy inhibition in pancreatic ductal adenocarcinoma","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4239677006","doi":"https://doi.org/10.1158/1538-7445.am2019-4265"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-4265","doi":"https://doi.org/10.1158/1538-7445.am2019-4265","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4265","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054470861","display_name":"Jane B. Pearce","orcid":"https://orcid.org/0009-0001-2970-0743","observed_orcids":["https://orcid.org/0009-0001-2970-0743"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jane B. Pearce","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022170125","display_name":"Ciara H. O\u2019Flanagan","orcid":"https://orcid.org/0000-0001-9467-1291","observed_orcids":["https://orcid.org/0000-0001-9467-1291"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ciara H. O'Flanagan","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5036400845","display_name":"Stephen David Hursting","orcid":"https://orcid.org/0000-0003-3605-2833","observed_orcids":["https://orcid.org/0000-0003-3605-2833"]},"institutions":[{"id":"https://openalex.org/I114027177","display_name":"University of North Carolina at Chapel Hill","ror":"https://ror.org/0130frc33","country_code":"US","type":"education","lineage":["https://openalex.org/I114027177"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen D. Hursting","raw_affiliation_strings":["UNC Chapel Hill, Chapel Hill, NC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNC Chapel Hill, Chapel Hill, NC","institution_ids":["https://openalex.org/I114027177"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I114027177"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"4265","last_page":"4265"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10587","display_name":"Autophagy in Disease and Therapy","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.008500000461935997,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9980000257492065},{"id":"https://openalex.org/keywords/autophagy-inhibition","display_name":"autophagy inhibition","score":0.9959999918937683},{"id":"https://openalex.org/keywords/atg5","display_name":"ATG5","score":0.7540000081062317},{"id":"https://openalex.org/keywords/chloroquine","display_name":"chloroquine","score":0.8970000147819519},{"id":"https://openalex.org/keywords/nutrient-restriction","display_name":"nutrient restriction","score":0.8389999866485596},{"id":"https://openalex.org/keywords/glucose-restriction","display_name":"glucose restriction","score":0.7419999837875366},{"id":"https://openalex.org/keywords/kras-driven-cancers","display_name":"KRAS-driven cancers","score":0.7450000047683716},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7229999899864197},{"id":"https://openalex.org/keywords/mesenchymal-markers","display_name":"mesenchymal markers","score":0.7450000047683716},{"id":"https://openalex.org/keywords/n-cadherin","display_name":"N-cadherin","score":0.7850000262260437},{"id":"https://openalex.org/keywords/snails","display_name":"snails","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anchorage-independent-growth","display_name":"anchorage-independent growth","score":0.7329999804496765},{"id":"https://openalex.org/keywords/compensatory-mechanisms","display_name":"compensatory mechanisms","score":0.49799999594688416}],"concepts":[{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.8872633576393127},{"id":"https://openalex.org/C2781000418","wikidata":"https://www.wikidata.org/wiki/Q18034312","display_name":"ATG5","level":4,"score":0.6636599898338318},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5734341740608215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.518534243106842},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4686182141304016},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.45360100269317627},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4121132791042328},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.27892303466796875},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21537217497825623},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09921726584434509},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-4265","doi":"https://doi.org/10.1158/1538-7445.am2019-4265","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4265","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3005786922","https://openalex.org/W4309108430","https://openalex.org/W7166524517","https://openalex.org/W2783887386","https://openalex.org/W7148854296","https://openalex.org/W2590338185","https://openalex.org/W2995063209","https://openalex.org/W4402551873","https://openalex.org/W4393087513","https://openalex.org/W6925204815"],"abstract_inverted_index":{"Abstract":[0],"Pancreatic":[1],"ductal":[2,327],"adenocarcinoma":[3,328],"(PDAC)":[4],"is":[5],"one":[6],"of":[7,18,62,72,83,114,124,184,196,200,247,332],"the":[8,70,81,112,125,189,281,333],"deadliest":[9],"cancers":[10],"worldwide,":[11],"with":[12,45,94,121],"a":[13,31,182,267,298],"5-":[14],"year":[15],"survival":[16],"rate":[17],"less":[19],"than":[20],"5":[21,163],"percent.":[22],"KRAS-driven":[23],"PDACs":[24],"often":[25],"exhibit":[26],"increased":[27],"dependence":[28],"on":[29,209],"autophagy,":[30],"process":[32],"by":[33],"which":[34],"cells":[35,118,169,220,230,271,291],"degrade":[36],"internal":[37],"components":[38],"to":[39,59,187,277,288],"mobilize":[40],"energy":[41],"stores.":[42],"When":[43],"faced":[44],"cellular":[46,210,237],"stress,":[47],"such":[48],"as":[49,138,140,253,255],"nutrient":[50,84,90,141,203,305],"deprivation,":[51],"tumor":[52,77,108,274],"growth":[53,63,78,135,275],"may":[54],"initially":[55],"slow":[56],"in":[57,80,92,150,167,181,212,236,239,244,266,285,292,307,325],"response":[58],"decreasing":[60],"supplies":[61],"factors":[64],"and":[65,103,145,193,202,215,222,251,258,304],"cytokines.":[66],"Under":[67],"these":[68,290],"conditions,":[69],"induction":[71],"autophagy":[73,95,116,154,161,302,323],"can":[74],"enable":[75],"continued":[76],"even":[79],"presence":[82],"stress.":[85],"Therefore,":[86],"we":[87],"posited":[88],"that":[89],"restriction":[91,147],"combination":[93,199],"inhibition":[96,303,324],"would":[97],"synergistically":[98],"disrupt":[99],"aberrant":[100],"metabolic":[101],"pathways":[102],"more":[104],"effectively":[105],"stunt":[106],"PDAC":[107,174,219],"progression.":[109],"To":[110,133],"determine":[111,188],"impact":[113],"transient":[115],"inhibition,":[117],"were":[119,148,179],"treated":[120],"10":[122],"\u03bcM":[123],"pharmaceutical":[126],"agent":[127],"chloroquine":[128],"(CQ)":[129],"for":[130,336],"48":[131],"hours.":[132],"modulate":[134],"factor/cytokine":[136],"signaling":[137,143],"well":[139,254],"sensing":[142],"serum":[144],"glucose":[146],"used":[149],"vitro.":[151,240],"Next,":[152],"permanent":[153,322],"ablation":[155],"was":[156,165],"achieved":[157],"through":[158],"CRISPR/Cas9":[159],"technology,":[160],"related":[162],"(Atg5)":[164],"deleted":[166],"Panc02":[168,229],"generating":[170],"an":[171,206],"autophagy-deficient":[172],"(Atg-/-)":[173],"cell":[175],"line.":[176],"Growth":[177],"kinetics":[178],"determined":[180],"range":[183],"culture":[185],"matrixes":[186],"proliferation":[190,211,238],"rate,":[191],"invasiveness,":[192],"anchorage":[194,259],"independence":[195],"cells.":[197],"The":[198],"CQ":[201],"stress":[204,306],"elicited":[205],"additive":[207],"effect":[208],"both":[213],"murine":[214],"human-derived":[216],"KRAS":[217],"mutant":[218],"(Panc02":[221],"MIA":[223],"PaCa-2":[224],"respectively).":[225],"In":[226],"contrast,":[227],"Atg5-/-":[228],"did":[231],"not":[232],"display":[233],"any":[234],"alteration":[235],"Atg5":[241],"deletion":[242],"resulted":[243],"decreased":[245,256],"expression":[246],"mesenchymal":[248],"markers":[249],"N-Cadherin":[250],"Snail":[252],"invasiveness":[257],"independent":[260],"colony":[261],"formation.":[262],"Upon":[263],"intrapancreatic":[264],"injection":[265],"syngeneic":[268],"model,":[269],"Atg-/-":[270],"exhibited":[272],"reduced":[273],"relative":[276],"control":[278],"Atg5+/+cells,":[279],"indicating":[280],"compensatory":[282],"mechanisms":[283],"effective":[284],"vitro":[286],"failed":[287],"protect":[289],"vivo.":[293],"Thus,":[294],"our":[295],"findings":[296],"reveal":[297],"potential":[299],"synergism":[300],"between":[301],"PDAC.":[308],"Citation":[309],"Format:":[310],"Jane":[311],"B.":[312],"Pearce,":[313],"Ciara":[314],"H.":[315],"O'Flanagan,":[316],"Stephen":[317],"D.":[318],"Hursting.":[319],"Transient":[320],"versus":[321],"pancreatic":[326],"[abstract].":[329],"In:":[330],"Proceedings":[331],"American":[334],"Association":[335],"Cancer":[337,351],"Research":[338],"Annual":[339],"Meeting":[340],"2019;":[341],"2019":[342],"Mar":[343],"29-Apr":[344],"3;":[345],"Atlanta,":[346],"GA.":[347],"Philadelphia":[348],"(PA):":[349],"AACR;":[350],"Res":[352],"2019;79(13":[353],"Suppl):Abstract":[354],"nr":[355],"4265.":[356]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-05-12T00:00:00"}
