{"id":"https://openalex.org/W4239628774","doi":"https://doi.org/10.1002/(sici)1097-0142(19981201)83:11<2259::aid-cncr5>3.3.co;2-k","title":"Current evaluation of the tissue localization and diagnostic utility of prostate specific membrane antigen","display_name":"Current evaluation of the tissue localization and diagnostic utility of prostate specific membrane antigen","publication_year":1998,"publication_date":"1998-12-01","ids":{"openalex":"https://openalex.org/W4239628774","doi":"https://doi.org/10.1002/(sici)1097-0142(19981201)83:11<2259::aid-cncr5>3.3.co;2-k","mag":"2003624089","pmid":"https://pubmed.ncbi.nlm.nih.gov/9840525"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0142(19981201)83:11<2259::aid-cncr5>3.3.co;2-k","doi":"https://doi.org/10.1002/(sici)1097-0142(19981201)83:11<2259::aid-cncr5>3.3.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19981201)83:11<2259::aid-cncr5>3.3.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111368983","display_name":"Gerald P. Murphy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gerald P. Murphy","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110863918","display_name":"Abdel\u2010Aziz A. Elgamal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Abdel\u2010Aziz A. Elgamal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111449109","display_name":"Sai L. Su","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sai L. Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111726165","display_name":"David G. Bostwick","orcid":"https://orcid.org/0009-0006-9613-8144","observed_orcids":["https://orcid.org/0009-0006-9613-8144"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G. Bostwick","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5111754017","display_name":"Eric H. Holmes","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Eric H. Holmes","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":8.4574,"has_fulltext":false,"cited_by_count":171,"citation_normalized_percentile":{"value":0.98100161,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"83","issue":"11","first_page":"2259","last_page":"2269"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.08569999784231186,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-specific-membrane-antigen","display_name":"prostate-specific membrane antigen","score":0.925000011920929},{"id":"https://openalex.org/keywords/tissue-localization","display_name":"tissue localization","score":0.8240000009536743},{"id":"https://openalex.org/keywords/diagnostic-value","display_name":"diagnostic value","score":0.9330000281333923},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.765999972820282},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8546957969665527},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.6762752532958984},{"id":"https://openalex.org/C148043351","wikidata":"https://www.wikidata.org/wiki/Q4456944","display_name":"Current (fluid)","level":2,"score":0.6617809534072876},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5791047811508179},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5556179285049438},{"id":"https://openalex.org/C20417620","wikidata":"https://www.wikidata.org/wiki/Q4140229","display_name":"Glutamate carboxypeptidase II","level":4,"score":0.5501813888549805},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4134265184402466},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2176377773284912},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.21467164158821106},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18778854608535767},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000954","descriptor_name":"Antigens, Surface","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002268","descriptor_name":"Carboxypeptidases","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005069","descriptor_name":"Evaluation Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016719","descriptor_name":"Radioimmunodetection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043425","descriptor_name":"Glutamate Carboxypeptidase II","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/(sici)1097-0142(19981201)83:11<2259::aid-cncr5>3.3.co;2-k","doi":"https://doi.org/10.1002/(sici)1097-0142(19981201)83:11<2259::aid-cncr5>3.3.co;2-k","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19981201)83:11<2259::aid-cncr5>3.3.co;2-k","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},{"id":"pmid:9840525","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9840525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"Journal Article"},{"id":"mag:2003624089","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9840525","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":71,"referenced_works":["https://openalex.org/W1491459754","https://openalex.org/W1492336771","https://openalex.org/W1495043122","https://openalex.org/W1552193435","https://openalex.org/W1558144205","https://openalex.org/W1573450491","https://openalex.org/W1765255767","https://openalex.org/W1783280884","https://openalex.org/W1814183605","https://openalex.org/W1834558432","https://openalex.org/W1872291407","https://openalex.org/W1911230960","https://openalex.org/W1916477575","https://openalex.org/W1933088330","https://openalex.org/W1970137322","https://openalex.org/W1973114712","https://openalex.org/W1973274321","https://openalex.org/W1974211977","https://openalex.org/W1975969719","https://openalex.org/W1981214901","https://openalex.org/W1989578247","https://openalex.org/W1991928498","https://openalex.org/W1994240919","https://openalex.org/W2010805980","https://openalex.org/W2013989151","https://openalex.org/W2014145760","https://openalex.org/W2014247337","https://openalex.org/W2016973566","https://openalex.org/W2033327605","https://openalex.org/W2035068824","https://openalex.org/W2035137050","https://openalex.org/W2043041181","https://openalex.org/W2043745789","https://openalex.org/W2049276029","https://openalex.org/W2049582148","https://openalex.org/W2051891947","https://openalex.org/W2053554578","https://openalex.org/W2055028529","https://openalex.org/W2063649715","https://openalex.org/W2066697968","https://openalex.org/W2068776651","https://openalex.org/W2069867210","https://openalex.org/W2075133582","https://openalex.org/W2075518898","https://openalex.org/W2075601928","https://openalex.org/W2085258079","https://openalex.org/W2089372512","https://openalex.org/W2089897387","https://openalex.org/W2096395857","https://openalex.org/W2097103508","https://openalex.org/W2103117450","https://openalex.org/W2113083743","https://openalex.org/W2114040719","https://openalex.org/W2115615594","https://openalex.org/W2116511683","https://openalex.org/W2118722884","https://openalex.org/W2134247556","https://openalex.org/W2147136637","https://openalex.org/W2161715331","https://openalex.org/W2169699370","https://openalex.org/W2230262546","https://openalex.org/W2315455891","https://openalex.org/W2394669656","https://openalex.org/W2395381058","https://openalex.org/W2402915313","https://openalex.org/W2413726205","https://openalex.org/W2417896762","https://openalex.org/W2419299220","https://openalex.org/W2423706968","https://openalex.org/W2468722314","https://openalex.org/W4300813546"],"related_works":["https://openalex.org/W2612876780","https://openalex.org/W2947083611","https://openalex.org/W4236220843","https://openalex.org/W2993772258","https://openalex.org/W2918834889","https://openalex.org/W2906687445","https://openalex.org/W7099256159","https://openalex.org/W2437285759","https://openalex.org/W1522369185","https://openalex.org/W3032472356"],"abstract_inverted_index":{"BACKGROUND:":[0],"Current":[1],"statistics":[2],"indicate":[3,105],"that":[4,34,96,106],"prostate":[5,70,124,164,174,216],"carcinoma":[6,165,175],"is":[7,36,69,92,97,108,119,210,229],"the":[8,20,101,115,147,161,198,252],"most":[9],"common":[10],"form":[11],"of":[12,50,85,88,111,114,155,163,197,239],"cancer":[13,23,262],"diagnosed":[14],"in":[15,19,121,127,160,205,221,226],"American":[16],"men,":[17],"resulting":[18],"second":[21],"highest":[22],"death":[24],"rate.":[25],"Early":[26],"diagnosis":[27,62,263],"and":[28,63,264],"accurate":[29],"staging":[30],"are":[31,158,177,202,248],"imperative":[32],"given":[33],"there":[35],"little":[37],"effective":[38],"treatment":[39],"for":[40,54,61,141,188,194,215,231],"metastatic":[41],"disease,":[42],"especially":[43],"after":[44],"androgen":[45],"deprivation":[46],"therapy":[47],"fails.":[48],"Identification":[49],"new":[51],"biochemical":[52],"markers":[53],"disease":[55],"progression":[56],"will":[57],"provide":[58],"important":[59,259],"tools":[60],"monitoring.":[64],"One":[65],"such":[66],"potential":[67],"marker":[68,110,140,214],"specific":[71,187,193],"membrane":[72],"antigen":[73,157],"(PSMA).":[74],"METHODS:":[75],"A":[76,237],"review":[77],"was":[78],"conducted":[79],"to":[80,100,256],"identify":[81],"reports":[82],"concerning":[83],"evaluation":[84],"diagnostic":[86],"applications":[87,242],"PSMA.":[89,189],"RESULTS:":[90],"PSMA":[91,107,134,199,209,244],"a":[93,109,139,211,234],"membrane-bound":[94,132],"glycoprotein":[95],"highly":[98],"restricted":[99],"prostate.":[102,116],"Immunohistochemical":[103],"findings":[104],"epithelial":[112,217],"cells":[113,176],"This":[117],"expression":[118],"increased":[120],"association":[122,222],"with":[123,146,168,179,185,223],"carcinoma,":[125],"particularly":[126,225],"hormone-refractory":[128],"disease.":[129],"Given":[130],"its":[131],"character,":[133],"has":[135],"been":[136,246],"exploited":[137],"as":[138,233],"tumor":[142],"detection":[143],"by":[144],"immunoscintiscanning":[145],"111In-labeled":[148],"anti-PSMA":[149],"monoclonal":[150,191],"antibody":[151],"7E11.C5.":[152],"Increased":[153],"concentrations":[154],"7E11.C5-reactive":[156],"present":[159],"serum":[162],"patients":[166],"compared":[167],"healthy":[169],"individuals;":[170],"also,":[171],"hematogenous":[172],"circulating":[173],"detectable":[178],"reverse":[180],"transcriptase-polymerase":[181],"chain":[182],"reaction":[183],"analysis":[184],"primers":[186],"New":[190],"antibodies":[192],"extracellular":[195],"portions":[196],"molecule":[200],"currently":[201],"being":[203,249],"utilized":[204],"applied":[206],"studies.":[207],"CONCLUSIONS:":[208],"widely":[212],"used":[213],"cells.":[218],"Its":[219],"up-regulation":[220],"cancer,":[224,228],"advanced":[227],"ideal":[230],"application":[232],"prognostic":[235],"marker.":[236],"variety":[238],"promising":[240],"clinical":[241],"utilizing":[243],"have":[245,257],"or":[247],"developed.":[250],"In":[251],"future,":[253],"these":[254],"promise":[255],"an":[258],"impact":[260],"on":[261],"patient":[265],"treatment.":[266]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-05-12T00:00:00"}