{"id":"https://openalex.org/W4239496898","doi":"https://doi.org/10.1161/circ.132.suppl_3.14664","title":"Abstract 14664: Reduced Activin Like Kinase 1 Activity Promotes Cardiac Fibrosis in Heart Failure","display_name":"Abstract 14664: Reduced Activin Like Kinase 1 Activity Promotes Cardiac Fibrosis in Heart Failure","publication_year":2015,"publication_date":"2015-11-10","ids":{"openalex":"https://openalex.org/W4239496898","doi":"https://doi.org/10.1161/circ.132.suppl_3.14664"},"language":"en","primary_location":{"id":"doi:10.1161/circ.132.suppl_3.14664","doi":"https://doi.org/10.1161/circ.132.suppl_3.14664","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.132.suppl_3.14664","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084212280","display_name":"Kevin Morine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin Morine","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108569468","display_name":"Vikram Paruchuri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vikram Paruchuri","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109372858","display_name":"Xiaoying Qiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoying Qiao","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Emily Mackey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Mackey","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110152621","display_name":"Mark J. Aronovitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Aronovitz","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041772967","display_name":"Pilar Alcaide","orcid":"https://orcid.org/0000-0003-3013-3982","observed_orcids":["https://orcid.org/0000-0003-3013-3982"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pilar Alcaide","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045311058","display_name":"Robert M. Blanton","orcid":"https://orcid.org/0000-0002-6837-2076","observed_orcids":["https://orcid.org/0000-0002-6837-2076"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Blanton","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102904713","display_name":"Richard H. Karas","orcid":"https://orcid.org/0000-0001-7799-091X","observed_orcids":["https://orcid.org/0000-0001-7799-091X"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard Karas","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000653485","display_name":"Navin Kumar Kapur","orcid":"https://orcid.org/0000-0002-8302-6796","observed_orcids":["https://orcid.org/0000-0002-8302-6796"]},"institutions":[{"id":"https://openalex.org/I1290900354","display_name":"Tufts Medical Center","ror":"https://ror.org/002hsbm82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1290900354"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Navin K Kapur","raw_affiliation_strings":["MCRI, Tufts Med Cntr, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MCRI, Tufts Med Cntr, Boston, MA","institution_ids":["https://openalex.org/I1290900354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1290900354"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"132","issue":"suppl_3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alk1","display_name":"ALK1","score":0.7900000214576721},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.656000018119812},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tgf-beta1-signaling","display_name":"TGF-\u03b21 signaling","score":0.9179999828338623},{"id":"https://openalex.org/keywords/smad3","display_name":"Smad3","score":0.6100000143051147},{"id":"https://openalex.org/keywords/collagen-synthesis","display_name":"collagen synthesis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/thoracic-aortic-constriction","display_name":"thoracic aortic constriction","score":0.9789999723434448},{"id":"https://openalex.org/keywords/left-ventricular-function","display_name":"left ventricular function","score":0.6930000185966492},{"id":"https://openalex.org/keywords/sirna-knockdown","display_name":"siRNA knockdown","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cardiac-fibroblasts","display_name":"cardiac fibroblasts","score":0.8339999914169312}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.7570854425430298},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7552247047424316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.533811628818512},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5105958580970764},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.49800705909729004},{"id":"https://openalex.org/C2778649528","wikidata":"https://www.wikidata.org/wiki/Q4677603","display_name":"Activin receptor","level":3,"score":0.4285743534564972},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4170488715171814},{"id":"https://openalex.org/C2777420927","wikidata":"https://www.wikidata.org/wiki/Q5038318","display_name":"Cardiac fibrosis","level":3,"score":0.41568413376808167},{"id":"https://openalex.org/C2775915353","wikidata":"https://www.wikidata.org/wiki/Q1571529","display_name":"Natriuretic peptide","level":3,"score":0.41552847623825073},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4113960564136505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18096813559532166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07807084918022156},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/circ.132.suppl_3.14664","doi":"https://doi.org/10.1161/circ.132.suppl_3.14664","is_oa":false,"landing_page_url":"https://doi.org/10.1161/circ.132.suppl_3.14664","pdf_url":null,"source":{"id":"https://openalex.org/S116251202","display_name":"Circulation","issn_l":"0009-7322","issn":["0009-7322","1524-4539"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2734919425","https://openalex.org/W4387615302","https://openalex.org/W2587839922","https://openalex.org/W2601883063","https://openalex.org/W2588604744","https://openalex.org/W2472710576","https://openalex.org/W4389489791","https://openalex.org/W1989296211","https://openalex.org/W2167263842","https://openalex.org/W2761287177"],"abstract_inverted_index":{"Introduction:":[0],"Activin":[1],"receptor":[2],"like":[3],"kinase":[4],"1":[5,232],"(ALK1)":[6,156],"mediates":[7],"signaling":[8],"via":[9],"transforming":[10],"growth":[11],"factor":[12],"beta-1":[13],"(TGFb1),":[14],"a":[15,22,147,288],"pro-fibrogenic":[16],"cytokine.":[17],"No":[18],"studies":[19,295],"have":[20],"defined":[21],"role":[23,148,298],"for":[24,149],"ALK1":[25,35,47,83,104,117,120,143,150,154,176,183,193,218,241,259,268,300,302],"in":[26,41,54,90,110,151,182,192,216,258,275,287],"heart":[27,42,63,93,152,273,292],"failure.":[28,43,94,293],"We":[29],"tested":[30,101],"the":[31,73,297],"hypothesis":[32],"that":[33],"reduced":[34,87,103,119,215],"expression":[36,49,266],"promotes":[37,278],"maladaptive":[38],"cardiac":[39,112,285,305],"remodeling":[40,306],"Methods":[44],"and":[45,65,132,138,157,187,199,206,219,230,235,253,277,284,301],"Results:":[46],"mRNA":[48,84,121,177,201,234],"was":[50],"quantified":[51],"by":[52,88,123],"RT-PCR":[53],"left":[55],"ventricular":[56],"(LV)":[57],"tissue":[58,70],"from":[59,72],"patients":[60,91],"with":[61,92,115,271],"end-stage":[62],"failure":[64,274],"compared":[66],"to":[67,80,126,172,225,244],"control":[68],"LV":[69,82,175,186,200,227,246,265,282],"obtained":[71],"National":[74],"Disease":[75],"Research":[76],"Interchange":[77],"(n=8/group).":[78],"Compared":[79,125,171,224,243],"controls,":[81],"levels":[85,105,122,135,178,202,213,237],"were":[86,136,162,179,190,208,214,238,256],"85%":[89],"Next,":[95],"using":[96],"an":[97,116],"siRNA":[98,118],"approach,":[99],"we":[100],"whether":[102],"promote":[106],"TGFb1-mediated":[107,128],"collagen":[108,131],"production":[109],"human":[111],"fibroblasts.":[113],"Treatment":[114],"75%.":[124],"control,":[127],"Type":[129,231],"I":[130],"pSmad-3":[133],"protein":[134,236],"2.5-fold":[137],"1.7-fold":[139],"higher,":[140],"respectively,":[141],"after":[142,166,195,222,261],"depletion.":[144],"To":[145],"explore":[146],"failure,":[153],"haploinsufficient":[155],"wild-type":[158],"mice":[159,194,221,260],"(WT;":[160],"n=8/group)":[161],"studied":[163],"2":[164],"weeks":[165],"thoracic":[167],"aortic":[168],"constriction":[169],"(TAC).":[170],"WT,":[173,226,245],"baseline":[174],"50%":[180],"lower":[181,257],"mice.":[184,242],"Both":[185],"lung":[188],"weights":[189],"higher":[191,239],"TAC.":[196,223,262],"Cardiomyocyte":[197],"area":[198],"of":[203,267,291,299],"BNP,":[204],"RCAN,":[205],"b-MHC":[207],"increased":[209],"similarly,":[210],"while":[211],"SERCa":[212],"both":[217],"WT":[220],"fibrosis":[228,286],"(Figure)":[229,255],"Collagen":[233],"among":[240],"fractional":[247],"shortening":[248],"(48\u00b112":[249],"vs":[250],"26\u00b110%,":[251],"p=0.01)":[252],"survival":[254],"Conclusions:":[263],"Reduced":[264],"is":[269],"associated":[270],"advanced":[272],"humans":[276],"early":[279],"mortality,":[280],"impaired":[281],"function,":[283],"murine":[289],"model":[290],"Further":[294],"examining":[296],"inhibitors":[303],"on":[304],"are":[307],"required.":[308]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-05-12T00:00:00"}