{"id":"https://openalex.org/W4239458214","doi":"https://doi.org/10.3410/f.1158839.620083","title":"Faculty Opinions recommendation of Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma.","display_name":"Faculty Opinions recommendation of Thalidomide-dexamethasone compared with melphalan-prednisolone in elderly patients with multiple myeloma.","publication_year":2009,"publication_date":"2009-04-14","ids":{"openalex":"https://openalex.org/W4239458214","doi":"https://doi.org/10.3410/f.1158839.620083"},"language":"en","primary_location":{"id":"doi:10.3410/f.1158839.620083","doi":"https://doi.org/10.3410/f.1158839.620083","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.1158839.620083","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056698355","display_name":"Arati V. Rao","orcid":"https://orcid.org/0009-0004-2922-710X","observed_orcids":["https://orcid.org/0009-0004-2922-710X"]},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Arati Rao","raw_affiliation_strings":["Cellular Therapy Division, Department of Medicine, Duke University, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cellular Therapy Division, Department of Medicine, Duke University, USA","institution_ids":["https://openalex.org/I170897317"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056698355"],"corresponding_institution_ids":["https://openalex.org/I170897317"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multiple-myeloma","display_name":"multiple myeloma","score":0.9169999957084656},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9649999737739563},{"id":"https://openalex.org/keywords/interferon-alpha-2b","display_name":"interferon alfa-2b","score":0.8349999785423279},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/complete-remission","display_name":"complete remission","score":0.6710000038146973},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8970000147819519},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C2779609412","wikidata":"https://www.wikidata.org/wiki/Q203174","display_name":"Thalidomide","level":3,"score":0.9253281950950623},{"id":"https://openalex.org/C2778684742","wikidata":"https://www.wikidata.org/wiki/Q2298283","display_name":"Melphalan","level":3,"score":0.8747063875198364},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8352607488632202},{"id":"https://openalex.org/C2776715498","wikidata":"https://www.wikidata.org/wiki/Q11426176","display_name":"Prednisolone","level":2,"score":0.8238756656646729},{"id":"https://openalex.org/C2780401358","wikidata":"https://www.wikidata.org/wiki/Q422252","display_name":"Dexamethasone","level":2,"score":0.7989044189453125},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.7131915092468262},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5782523155212402},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5255374312400818},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.47094783186912537},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3262391686439514}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.1158839.620083","doi":"https://doi.org/10.3410/f.1158839.620083","is_oa":false,"landing_page_url":"https://doi.org/10.3410/f.1158839.620083","pdf_url":null,"source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1988092780","https://openalex.org/W2243908240","https://openalex.org/W2947048522","https://openalex.org/W2980309900","https://openalex.org/W1970078294","https://openalex.org/W2112942216","https://openalex.org/W2146199517","https://openalex.org/W1991603735","https://openalex.org/W2034634002","https://openalex.org/W2078752778"],"abstract_inverted_index":{"We":[0],"compared":[1,128],"thalidomide-dexamethasone":[2],"(TD)":[3],"with":[4,11,81,129,170,179],"melphalan-prednisolone":[5],"(MP)":[6],"in":[7,105,157,173],"289":[8],"elderly":[9],"patients":[10,174],"multiple":[12],"myeloma":[13],"(MM).":[14],"Patients":[15,69],"received":[16],"either":[17,82],"thalidomide":[18,83],"200":[19],"mg":[20,85],"plus":[21],"dexamethasone":[22],"40":[23],"mg,":[24],"days":[25,37,59],"1":[26,38,60],"to":[27,31,39,49,61,66,78,95,132],"4":[28,40,62],"and":[29,36,53,87,111,120,140],"15":[30],"18":[32],"on":[33,41,58],"even":[34],"cycles":[35],"odd":[42],"cycles,":[43],"during":[44,63],"a":[45,64,106],"28-day":[46],"cycle":[47],"or":[48,73,94],"melphalan":[50],"0.25":[51],"mg/kg":[52,56],"prednisolone":[54],"2":[55],"orally":[57],"28-":[65],"42-day":[67],"cycle.":[68],"achieving":[70],"stable":[71],"disease":[72],"better":[74],"were":[75],"randomly":[76],"assigned":[77],"maintenance":[79],"therapy":[80],"100":[84],"daily":[86],"3":[88,96],"MU":[89,97],"interferon":[90,98],"alpha-2b":[91,99],"thrice":[92,100],"weekly":[93,101],"only.":[102],"TD":[103,159],"resulted":[104],"higher":[107,169],"proportion":[108],"of":[109],"complete":[110],"very":[112],"good":[113],"remissions":[114],"(26%":[115],"vs":[116,124,135,146,162],"13%;":[117],"P=":[118,126,138,149,165],".006)":[119],"overall":[121,152],"responses":[122],"(68%":[123],"50%;":[125],".002)":[127],"MP.":[130],"Time":[131],"progression":[133],"(21.2":[134],"29.1":[136],"months;":[137,148,164],".2),":[139],"progression-free":[141],"survival":[142,153],"was":[143,154,168,185],"similar":[144],"(16.7":[145],"20.7":[147],".1),":[150],"but":[151],"significantly":[155],"shorter":[156],"the":[158],"group":[160],"(41.5":[161],"49.4":[163],".024).":[166],"Toxicity":[167],"TD,":[171],"particularly":[172],"older":[175],"than":[176],"75":[177],"years":[178],"poor":[180],"performance":[181],"status.":[182],"The":[183],"study":[184],"registered":[186],"at":[187],"ClinicalTrials.gov":[188],"as":[189],"NCT00205751.":[190],"PMID:":[191],"18955563":[192]},"counts_by_year":[],"updated_date":"2026-10-01T08:54:57.152042","created_date":"2022-05-12T00:00:00"}