{"id":"https://openalex.org/W4239344252","doi":"https://doi.org/10.1042/0264-6021:3410139","title":"An aromatic, but not a basic, residue is involved in the toxicity of group-II phospholipase A2 neurotoxins","display_name":"An aromatic, but not a basic, residue is involved in the toxicity of group-II phospholipase A2 neurotoxins","publication_year":1999,"publication_date":"1999-06-24","ids":{"openalex":"https://openalex.org/W4239344252","doi":"https://doi.org/10.1042/0264-6021:3410139","mag":"2065416079","pmid":"https://pubmed.ncbi.nlm.nih.gov/10377255","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1220340"},"language":"en","primary_location":{"id":"doi:10.1042/0264-6021:3410139","doi":"https://doi.org/10.1042/0264-6021:3410139","is_oa":true,"landing_page_url":"https://doi.org/10.1042/0264-6021:3410139","pdf_url":"https://portlandpress.com/biochemj/article-pdf/341/1/139/634871/bj3410139.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://portlandpress.com/biochemj/article-pdf/341/1/139/634871/bj3410139.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004552048","display_name":"Jo\u017ee Punger\u010dar","orcid":"https://orcid.org/0000-0001-7228-336X","observed_orcids":["https://orcid.org/0000-0001-7228-336X"]},"institutions":[{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Jo\u017ee PUNGER\u010cAR","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Jo\u01ceef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Jo\u01ceef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034321058","display_name":"Igor Kri\u017eaj","orcid":"https://orcid.org/0000-0003-0203-0708","observed_orcids":["https://orcid.org/0000-0003-0203-0708"]},"institutions":[{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Igor KRI\u017dAJ","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Jo\u01ceef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Jo\u01ceef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109597118","display_name":"Liang Ning-sheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ning-Sheng LIANG","raw_affiliation_strings":["Laboratory of Pharmacology, Cancer Institute, Guangxi Medical College, P.O. Box 530027, Nanning, Guangxi, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Pharmacology, Cancer Institute, Guangxi Medical College, P.O. Box 530027, Nanning, Guangxi, People's Republic of China","institution_ids":["https://openalex.org/I160354086"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010893774","display_name":"Franc Guben\u0161ek","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153976015","display_name":"University of Ljubljana","ror":"https://ror.org/05njb9z20","country_code":"SI","type":"education","lineage":["https://openalex.org/I153976015"]},{"id":"https://openalex.org/I3006985408","display_name":"Jo\u017eef Stefan Institute","ror":"https://ror.org/05060sz93","country_code":"SI","type":"facility","lineage":["https://openalex.org/I3006985408"]}],"countries":["SI"],"is_corresponding":false,"raw_author_name":"Franc GUBEN\u0160EK","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Jo\u01ceef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia","Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Jo\u01ceef Stefan Institute, Jamova 39, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I3006985408"]},{"raw_affiliation_string":"Faculty of Chemistry and Chemical Technology, University of Ljubljana, SI-1000 Ljubljana, Slovenia","institution_ids":["https://openalex.org/I153976015"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.7907,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.89935065,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"341","issue":"1","first_page":"139","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11274","display_name":"Botulinum Toxin and Related Neurological Disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12477","display_name":"Toxin Mechanisms and Immunotoxins","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phospholipase-a2","display_name":"phospholipase A2","score":0.878000020980835},{"id":"https://openalex.org/keywords/vipera-ammodytes-ammodytes","display_name":"Vipera ammodytes ammodytes","score":0.8999999761581421},{"id":"https://openalex.org/keywords/snake-neurotoxins","display_name":"snake venom neurotoxins","score":0.8840000033378601},{"id":"https://openalex.org/keywords/aromatic-residues","display_name":"aromatic residues","score":0.6010000109672546},{"id":"https://openalex.org/keywords/basic-residues","display_name":"basic residues","score":0.828000009059906},{"id":"https://openalex.org/keywords/enzyme-activity","display_name":"enzyme activity","score":0.32899999618530273},{"id":"https://openalex.org/keywords/interfacial-adsorption","display_name":"interfacial adsorption","score":0.7860000133514404},{"id":"https://openalex.org/keywords/toxin-mutants","display_name":"toxin mutants","score":0.5789999961853027},{"id":"https://openalex.org/keywords/neurotoxicity","display_name":"neurotoxicity","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8117521405220032},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6369004249572754},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.5741830468177795},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5015292167663574},{"id":"https://openalex.org/C2776330855","wikidata":"https://www.wikidata.org/wiki/Q650187","display_name":"Phosphatidylcholine","level":4,"score":0.43930473923683167},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43304935097694397},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.14270564913749695},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009498","descriptor_name":"Neurotoxins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010649","descriptor_name":"Phenylalanine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D013570","descriptor_name":"Synaptic Membranes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014757","descriptor_name":"Viper Venoms","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018675","descriptor_name":"Toxicity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054467","descriptor_name":"Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054501","descriptor_name":"Group II Phospholipases A2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1042/0264-6021:3410139","doi":"https://doi.org/10.1042/0264-6021:3410139","is_oa":true,"landing_page_url":"https://doi.org/10.1042/0264-6021:3410139","pdf_url":"https://portlandpress.com/biochemj/article-pdf/341/1/139/634871/bj3410139.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"doi:10.1042/bj3410139","doi":"https://doi.org/10.1042/bj3410139","is_oa":false,"landing_page_url":"https://doi.org/10.1042/bj3410139","pdf_url":null,"source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1220340","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/1220340","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochem J","raw_type":"Text"},{"id":"pmid:10377255","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10377255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Biochemical journal","raw_type":"Comparative Study"},{"id":"mag:2065416079","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10377255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"doi:10.1042/0264-6021:3410139","doi":"https://doi.org/10.1042/0264-6021:3410139","is_oa":true,"landing_page_url":"https://doi.org/10.1042/0264-6021:3410139","pdf_url":"https://portlandpress.com/biochemj/article-pdf/341/1/139/634871/bj3410139.pdf","source":{"id":"https://openalex.org/S44425019","display_name":"Biochemical Journal","issn_l":"0264-6021","issn":["0264-6021","1470-8728"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310311608","host_organization_name":"Portland Press","host_organization_lineage":["https://openalex.org/P4310311608","https://openalex.org/P4310311715"],"host_organization_lineage_names":["Portland Press","Biochemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.428600013256073}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4239344252.pdf","grobid_xml":"https://content.openalex.org/works/W4239344252.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W39220136","https://openalex.org/W148319113","https://openalex.org/W1028073060","https://openalex.org/W1505902561","https://openalex.org/W1514236298","https://openalex.org/W1544437272","https://openalex.org/W1591927080","https://openalex.org/W1828105334","https://openalex.org/W1863914224","https://openalex.org/W1891984009","https://openalex.org/W1965116143","https://openalex.org/W1968985054","https://openalex.org/W1972149163","https://openalex.org/W1980284911","https://openalex.org/W1983657150","https://openalex.org/W1985878975","https://openalex.org/W2003608396","https://openalex.org/W2004948034","https://openalex.org/W2011830623","https://openalex.org/W2017296679","https://openalex.org/W2018289835","https://openalex.org/W2019589446","https://openalex.org/W2030294033","https://openalex.org/W2031423487","https://openalex.org/W2034410496","https://openalex.org/W2037151486","https://openalex.org/W2040101665","https://openalex.org/W2042308296","https://openalex.org/W2042374733","https://openalex.org/W2044711182","https://openalex.org/W2055347511","https://openalex.org/W2067887192","https://openalex.org/W2074152861","https://openalex.org/W2079486383","https://openalex.org/W2080388832","https://openalex.org/W2083785905","https://openalex.org/W2093182937","https://openalex.org/W2093396859","https://openalex.org/W2093679322","https://openalex.org/W2100837269","https://openalex.org/W2129228470","https://openalex.org/W2138270253","https://openalex.org/W2162193325","https://openalex.org/W2169674918","https://openalex.org/W2231988228","https://openalex.org/W2313031353","https://openalex.org/W2319243736","https://openalex.org/W3023699636","https://openalex.org/W6604074603","https://openalex.org/W6609384966","https://openalex.org/W6814302381","https://openalex.org/W6837820049"],"related_works":["https://openalex.org/W2056284574","https://openalex.org/W2132119418","https://openalex.org/W2009464368","https://openalex.org/W2158207999","https://openalex.org/W1978332134","https://openalex.org/W7096513301","https://openalex.org/W2169674918","https://openalex.org/W2044339893","https://openalex.org/W2018780041","https://openalex.org/W2141572434"],"abstract_inverted_index":{"Ammodytoxins":[0],"(Atxs)":[1],"A,":[2],"B":[3],"and":[4,16,49,104],"C":[5],"are":[6],"basic":[7,86,174],"phospholipase":[8],"A2s":[9],"from":[10],"Vipera":[11],"ammodytes":[12,13],"snake":[14],"venom,":[15],"they":[17],"exhibit":[18],"presynaptic":[19,208],"toxicity.":[20],"The":[21,51,72,125,212],"most":[22],"toxic":[23],"is":[24,35,64,191,205,223],"AtxA,":[25,144,222],"followed":[26],"by":[27,88],"AtxC,":[28,157,219],"its":[29],"naturally":[30],"occurring":[31],"F124-->I/K128-->E":[32],"mutant,":[33,74,196],"which":[34,158],"17":[36],"times":[37],"less":[38],"toxic.":[39],"Two":[40],"mutants":[41],"of":[42,55,68,78,83,96,122,128,143,148,156,164,169,171,184,210,218,226,229,251],"AtxA":[43],"have":[44],"been":[45],"produced":[46],"in":[47,109,136,240],"bacteria":[48],"characterized.":[50],"specific":[52,134],"enzymic":[53,111],"activity":[54,112],"the":[56,69,79,84,93,97,100,114,129,133,146,149,167,181,187,194,200,227,241,249],"K128-->E":[57],"mutant":[58,131,151,189],"on":[59,92],"mixed":[60],"phosphatidylcholine/Triton":[61],"X-100":[62],"micelles":[63],"similar":[65,140,153,253],"to":[66,99,119,141,154,193],"that":[67,142,155,163,199],"wild":[70],"type.":[71],"K108-->N/K111-->N":[73],"however,":[75],"possesses":[76],"160%":[77],"wild-type":[80],"activity.":[81],"Replacement":[82],"two":[85],"residues":[87,91,176,239],"uncharged,":[89],"polar":[90],"opposite":[94],"side":[95],"protein":[98],"enzyme":[101],"active":[102],"site":[103],"interfacial":[105],"adsorption":[106],"surface":[107,175],"results":[108],"increased":[110],"at":[113,202],"water/lipid":[115],"aggregate":[116],"interface,":[117],"due":[118],"a":[120,224],"redistribution":[121],"electrostatic":[123],"charge.":[124],"binding":[126],"affinity":[127,147],"double":[130],"for":[132,207,248],"acceptor":[135],"bovine":[137],"brain":[138],"was":[139,152,159],"whereas":[145],"single":[150,188],"slightly":[160],"weaker":[161],"than":[162,214],"AtxA.":[165,185],"Interestingly,":[166],"substitution":[168,228],"any":[170],"these":[172],"three":[173],"did":[177],"not":[178],"significantly":[179],"change":[180],"lethal":[182],"potency":[183],"Since":[186],"AtxA(K128-->E)":[190],"equivalent":[192],"AtxC(I124-->F)":[195],"this":[197],"indicates":[198],"residue":[201],"position":[203],"124":[204],"important":[206,247],"toxicity":[209,217],"Atxs.":[211],"more":[213],"10-fold":[215],"lower":[216],"compared":[220],"with":[221,233],"consequence":[225],"Phe-124":[230],"(aromatic":[231],"ring)":[232],"Ile":[234],"(aliphatic":[235],"chain).":[236],"Exposed":[237],"aromatic":[238],"C-terminal":[242],"region":[243],"may":[244],"also":[245],"be":[246],"neurotoxicity":[250],"other":[252],"toxins.":[254]},"counts_by_year":[{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}