{"id":"https://openalex.org/W4239194162","doi":"https://doi.org/10.1182/blood.v112.11.1806.1806","title":"The PIM1 Oncogene Accelerates TCL1 Driven Lymphomagenesis in a Double-Transgenic Murine Model.","display_name":"The PIM1 Oncogene Accelerates TCL1 Driven Lymphomagenesis in a Double-Transgenic Murine Model.","publication_year":2008,"publication_date":"2008-11-16","ids":{"openalex":"https://openalex.org/W4239194162","doi":"https://doi.org/10.1182/blood.v112.11.1806.1806"},"language":"en","primary_location":{"id":"doi:10.1182/blood.v112.11.1806.1806","doi":"https://doi.org/10.1182/blood.v112.11.1806.1806","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.1806.1806","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048995932","display_name":"Matthew I. Schrage","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew I. Schrage","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, David Geffen School of Med. at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, David Geffen School of Med. at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007693528","display_name":"David Dongkyung Kim","orcid":"https://orcid.org/0000-0002-6375-2846","observed_orcids":["https://orcid.org/0000-0002-6375-2846"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David Kim","raw_affiliation_strings":["Div. of Hematology/Oncology, David Geffen School of Med. at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Div. of Hematology/Oncology, David Geffen School of Med. at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058975051","display_name":"Jeffrey Calimlim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Calimlim","raw_affiliation_strings":["Div. of Hematology/Oncology, David Geffen School of Med. at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Div. of Hematology/Oncology, David Geffen School of Med. at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054956722","display_name":"Evelena P. Ontiveros","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Evelena Ontiveros","raw_affiliation_strings":["Div. of Hematology/Oncology, David Geffen School of Med. at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Div. of Hematology/Oncology, David Geffen School of Med. at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045356809","display_name":"Michael A. Teitell","orcid":"https://orcid.org/0000-0002-4495-8750","observed_orcids":["https://orcid.org/0000-0002-4495-8750"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael A. Teitell","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, David Geffen School of Med. at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, David Geffen School of Med. at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083115147","display_name":"JONATHAN W. SAID","orcid":"https://orcid.org/0000-0001-9474-2563","observed_orcids":["https://orcid.org/0000-0001-9474-2563"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan W. Said","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, David Geffen School of Med. at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, David Geffen School of Med. at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081213752","display_name":"Sven de Vos","orcid":"https://orcid.org/0000-0002-6715-4851","observed_orcids":["https://orcid.org/0000-0002-6715-4851"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sven de Vos","raw_affiliation_strings":["Div. of Hematology/Oncology, David Geffen School of Med. at UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Div. of Hematology/Oncology, David Geffen School of Med. at UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52372133,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"112","issue":"11","first_page":"1806","last_page":"1806"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pim-1","display_name":"PIM-1","score":0.7829999923706055},{"id":"https://openalex.org/keywords/tcl1a","display_name":"TCL1","score":0.9769999980926514},{"id":"https://openalex.org/keywords/lymphomagenesis","display_name":"lymphomagenesis","score":0.9559999704360962},{"id":"https://openalex.org/keywords/mantle-cell-lymphoma","display_name":"mantle cell lymphoma","score":0.8500000238418579},{"id":"https://openalex.org/keywords/double-transgenic-mice","display_name":"double transgenic mice","score":0.6970000267028809},{"id":"https://openalex.org/keywords/t-lymphoblastic-lymphoma","display_name":"T-cell lymphoblastic lymphoma","score":0.8299999833106995},{"id":"https://openalex.org/keywords/burkitt-like-lymphoma","display_name":"Burkitt-like lymphoma","score":0.8600000143051147},{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.7720000147819519},{"id":"https://openalex.org/keywords/oncogenic-cooperation","display_name":"oncogene cooperation","score":0.5740000009536743},{"id":"https://openalex.org/keywords/b-cell-malignancies","display_name":"B-cell malignancies","score":0.5419999957084656},{"id":"https://openalex.org/keywords/lymphoma-progression","display_name":"lymphoma progression","score":0.4880000054836273},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7289999723434448},{"id":"https://openalex.org/keywords/serine-threonine-kinase","display_name":"serine/threonine kinase","score":0.6899999976158142},{"id":"https://openalex.org/keywords/murine-lymphoma-model","display_name":"murine lymphoma model","score":0.47999998927116394}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.716632068157196},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6053546071052551},{"id":"https://openalex.org/C98175054","wikidata":"https://www.wikidata.org/wiki/Q18030550","display_name":"PIM1","level":4,"score":0.5987606644630432},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.5938756465911865},{"id":"https://openalex.org/C2777525834","wikidata":"https://www.wikidata.org/wiki/Q268713","display_name":"Mantle cell lymphoma","level":3,"score":0.5543199181556702},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.4639797806739807},{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.45797109603881836},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.4499526619911194},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.42316702008247375},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.37596216797828674},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37014466524124146},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.16423025727272034},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C2776414213","wikidata":"https://www.wikidata.org/wiki/Q183290","display_name":"Serine","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1182/blood.v112.11.1806.1806","doi":"https://doi.org/10.1182/blood.v112.11.1806.1806","is_oa":false,"landing_page_url":"https://doi.org/10.1182/blood.v112.11.1806.1806","pdf_url":null,"source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2034442000","https://openalex.org/W2052133201","https://openalex.org/W148861686","https://openalex.org/W2140764496","https://openalex.org/W2016548691","https://openalex.org/W2333352978","https://openalex.org/W2504657517","https://openalex.org/W105608943","https://openalex.org/W2980219065","https://openalex.org/W4250894669"],"abstract_inverted_index":{"Abstract":[0],"Previously,":[1],"we":[2,20,94],"identified":[3],"and":[4,45,56,69,88,140,143,160,189,192,215,241,253,292,311,325,360],"validated":[5],"PIM-1":[6,23,32,75,101,113,118,168,240,279,382],"as":[7,82,407,434],"a":[8,26,145,218,248,347,435],"differentially":[9],"expressed":[10],"gene":[11],"in":[12,30,54,60,72,78,97,104,137,175,235,266,346,368,384,401,408,424],"mantle":[13],"cell":[14,350,369],"lymphoma":[15,154,332,349],"(MCL)":[16],"patient":[17],"samples.":[18],"Further,":[19],"have":[21,212],"shown":[22],"to":[24,133,195,237,365,440],"be":[25,366,432,446],"significant":[27,262],"prognostic":[28],"biomarker":[29],"MCL.":[31],"is":[33,39,76],"an":[34],"oncogenic":[35],"serine/threonine":[36],"kinase":[37,341,421,429],"that":[38,167,427],"transcriptionally":[40],"regulated":[41],"by":[42,107,187,354],"cytokines,":[43],"mitogens,":[44],"numerous":[46],"growth":[47],"factors.":[48],"It":[49],"cooperates":[50],"with":[51,102,247,273,305,320],"other":[52],"oncogenes":[53],"tumorigenesis":[55],"has":[57],"been":[58,213],"implicated":[59],"the":[61,83,89,96,120,123,176,196,230,267,389,397,450],"development":[62,177,390],"of":[63,86,91,100,122,178,199,221,229,251,264,287,297,308,330,339,376,391,399,417,438,449],"leukemias,":[64],"lymphomas,":[65,80,180,234],"late":[66,293],"progression":[67],"events,":[68],"most":[70],"recently":[71],"prostate":[73],"cancer.":[74],"overexpressed":[77,367],"aggressive":[79],"such":[81],"blastoid":[84],"variant":[85],"MCL,":[87],"ABC-type":[90],"DLBCL.":[92,299,414],"Here":[93],"tested":[95],"vivo":[98],"cooperation":[99],"TCL1":[103,127,135,244,275,300,385,409],"murine":[105,111,117],"lymphomagenesis":[106,265],"producing":[108],"double":[109,208],"transgenic":[110,114,128,209,245,269,276,280,301,315,386,411],"strains.":[112],"mice":[115,129,210,232,270,277,281,302,316,387,403],"overexpress":[116],"under":[119],"control":[121],"immunoglobulin":[124],"enhancer":[125],"E\u03bc.":[126],"(pE\u03bc":[130],"-B29-TCL1)":[131],"fail":[132],"downregulate":[134],"expression":[136,338,416],"mature":[138,149,392],"B":[139],"T":[141],"cells":[142],"provide":[144],"unique":[146],"model":[147],"for":[148,217],"B-cell":[150,161,393],"malignancies,":[151],"including":[152],"Burkitt-like":[153],"(BLL),":[155],"DLBCL,":[156,304,318],"marginal":[157],"zone":[158],"lymphoma,":[159],"chronic":[162],"lymphocytic":[163,310],"leukemia.":[164],"We":[165],"hypothesized":[166],"would":[169],"either":[170],"accelerate":[171],"TCL1-driven":[172],"lymphomagenesis,":[173],"result":[174],"immature":[179],"or":[181],"both.":[182],"Lymphoid":[183],"malignancies":[184,375],"were":[185,363],"examined":[186],"immunohistochemistry":[188],"flow":[190],"cytometry":[191],"classified":[193],"according":[194],"mouse":[197],"models":[198],"human":[200,348,373],"cancer":[201],"consortium":[202],"(MMHCC)":[203],"\u2018Bethesda\u2019":[204],"classification":[205,398],"scheme.":[206],"Forty":[207],"(PIM-1/TCL1)":[211],"generated":[214],"observed":[216],"median":[219,249],"follow-up":[220,250],"9":[222],"months.":[223],"To":[224,395],"date,":[225,396],"8/40":[226],"(20":[227],"%)":[228],"PIM-1/TCL1":[231,268,314,402],"developed":[233,282,303,317,433],"contrast":[236],"9/88":[238],"(10%)":[239],"11/49":[242],"(22%)":[243],"mice,":[246,412],"7":[252,285],"15":[254],"months,":[255],"respectively.":[256],"A":[257,327],"Kaplan-Meyer":[258],"plot":[259],"demonstrated":[260],"statistically":[261],"acceleration":[263],"when":[271],"compared":[272],"single":[274,306,328,410],"(p=0.037).":[278],"early":[283],"(<":[284],"months":[286,296],"age)":[288,298],"T-cell":[289],"lymphoblastic":[290],"lymphomas":[291,400,425],"(>":[294],"20":[295],"occurrences":[307],"lymphoblastic,":[309],"Burkitt":[312],"lymphomas.":[313,394],"frequently":[319],"extranodal":[321],"involvement":[322],"(spleen,":[323],"liver":[324],"lung).":[326],"case":[329],"follicular":[331],"was":[333,344],"seen.":[334],"In":[335,379],"addition,":[336],"endogenous":[337],"PIM":[340,420,443],"family":[342,422,452],"members":[343,423],"investigated":[345],"line":[351],"bank":[352],"(n=40)":[353],"quantitative":[355],"real-time":[356],"PCR.":[357],"PIM-1,":[358],"PIM-2,":[359],"also":[361],"PIM-3":[362],"found":[364],"lines":[370],"derived":[371],"from":[372],"lymphoid":[374],"multiple":[377],"histologies.":[378],"summary,":[380],"aberrant":[381],"overexpression":[383,448],"accelerated":[388],"revealed":[404],"similar":[405],"histologies":[406],"mainly":[413],"The":[415],"all":[418],"3":[419],"implies":[426],"pan-PIM":[428],"inhibitors":[430,444],"should":[431],"potential":[436],"mechanism":[437],"resistance":[439],"more":[441],"restricted":[442],"could":[445],"compensatory":[447],"non-targeted":[451],"members.":[453]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-05-12T00:00:00"}