{"id":"https://openalex.org/W4239047337","doi":"https://doi.org/10.3410/f.718039861.793480610","title":"Faculty Opinions recommendation of A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.","display_name":"Faculty Opinions recommendation of A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.","publication_year":2013,"publication_date":"2013-07-19","ids":{"openalex":"https://openalex.org/W4239047337","doi":"https://doi.org/10.3410/f.718039861.793480610"},"language":"en","primary_location":{"id":"doi:10.3410/f.718039861.793480610","doi":"https://doi.org/10.3410/f.718039861.793480610","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.718039861.793480610","pdf_url":"https://facultyopinions.com/download/718039861","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://facultyopinions.com/download/718039861","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100715040","display_name":"Marc E. Rothenberg","orcid":"https://orcid.org/0000-0001-9790-6332","observed_orcids":["https://orcid.org/0000-0001-9790-6332"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc Rothenberg","raw_affiliation_strings":["Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Allergy and Immunology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, USA","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100715040"],"corresponding_institution_ids":["https://openalex.org/I1285204247"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.6327999830245972,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.2184000015258789,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10877","display_name":"Allergic Rhinitis and Sensitization","score":0.12680000066757202,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allergic-diseases","display_name":"allergic diseases","score":0.7739999890327454},{"id":"https://openalex.org/keywords/cat-allergy","display_name":"cat allergy","score":0.7379999756813049},{"id":"https://openalex.org/keywords/house-dust-mite-allergy","display_name":"house dust mite allergy","score":0.871999979019165},{"id":"https://openalex.org/keywords/allergic-rhinitis","display_name":"allergic rhinitis","score":1.0},{"id":"https://openalex.org/keywords/self-reported-allergy","display_name":"self-reported allergy","score":0.75},{"id":"https://openalex.org/keywords/susceptibility-loci","display_name":"genetic susceptibility loci","score":0.8939999938011169},{"id":"https://openalex.org/keywords/shared-genetic-effects","display_name":"shared genetic effects","score":0.6330000162124634},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.597000002861023},{"id":"https://openalex.org/keywords/hla-class-ii-region","display_name":"HLA class II region","score":0.7979999780654907},{"id":"https://openalex.org/keywords/ep4-receptor","display_name":"EP4 receptor","score":0.781000018119812},{"id":"https://openalex.org/keywords/lpp","display_name":"LPP","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nfatc2","display_name":"NFATc2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/foxa1","display_name":"FOXA1","score":0.9319999814033508}],"concepts":[{"id":"https://openalex.org/C207480886","wikidata":"https://www.wikidata.org/wiki/Q42982","display_name":"Allergy","level":2,"score":0.6357309818267822},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.5867571234703064},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.4659496247768402},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4243966341018677},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4111817479133606},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32701587677001953},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.32171928882598877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2877175807952881},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.24763402342796326},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.18029388785362244},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11690935492515564},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.08428692817687988}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.718039861.793480610","doi":"https://doi.org/10.3410/f.718039861.793480610","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.718039861.793480610","pdf_url":"https://facultyopinions.com/download/718039861","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":{"id":"doi:10.3410/f.718039861.793480610","doi":"https://doi.org/10.3410/f.718039861.793480610","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.718039861.793480610","pdf_url":"https://facultyopinions.com/download/718039861","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1153816297","display_name":null,"funder_award_id":"74882","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G1659787205","display_name":null,"funder_award_id":"74882","funder_id":"https://openalex.org/F4320320360","funder_display_name":"University of Bristol"},{"id":"https://openalex.org/G4182683118","display_name":null,"funder_award_id":"092731","funder_id":"https://openalex.org/F4320320360","funder_display_name":"University of Bristol"},{"id":"https://openalex.org/G4884678108","display_name":null,"funder_award_id":"092731","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G5278080124","display_name":"The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support 2011-2013.","funder_award_id":"092731","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"},{"id":"https://openalex.org/G6737906592","display_name":null,"funder_award_id":"092731","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"},{"id":"https://openalex.org/G7042387311","display_name":null,"funder_award_id":"74882","funder_id":"https://openalex.org/F4320311904","funder_display_name":"Wellcome Trust"}],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320360","display_name":"University of Bristol","ror":"https://ror.org/0524sp257"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4239047337.pdf","grobid_xml":"https://content.openalex.org/works/W4239047337.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1593596752","https://openalex.org/W1747499909","https://openalex.org/W1950067960","https://openalex.org/W1980725116","https://openalex.org/W1982042604","https://openalex.org/W1983754832","https://openalex.org/W1984939442","https://openalex.org/W1990142540","https://openalex.org/W1993745762","https://openalex.org/W1999690368","https://openalex.org/W2002169500","https://openalex.org/W2008797950","https://openalex.org/W2008844540","https://openalex.org/W2017199648","https://openalex.org/W2019512405","https://openalex.org/W2019966611","https://openalex.org/W2020304403","https://openalex.org/W2024027763","https://openalex.org/W2024931422","https://openalex.org/W2026061492","https://openalex.org/W2040063114","https://openalex.org/W2055500885","https://openalex.org/W2057593547","https://openalex.org/W2058792575","https://openalex.org/W2065119658","https://openalex.org/W2078586457","https://openalex.org/W2085258093","https://openalex.org/W2086075223","https://openalex.org/W2105842551","https://openalex.org/W2106070528","https://openalex.org/W2109130469","https://openalex.org/W2110633408","https://openalex.org/W2110878879","https://openalex.org/W2111307685","https://openalex.org/W2112409097","https://openalex.org/W2117446594","https://openalex.org/W2119279196","https://openalex.org/W2122329447","https://openalex.org/W2123077897","https://openalex.org/W2123411711","https://openalex.org/W2126930838","https://openalex.org/W2127715317","https://openalex.org/W2128885802","https://openalex.org/W2132993315","https://openalex.org/W2133520037","https://openalex.org/W2134700932","https://openalex.org/W2141665982","https://openalex.org/W2143509157","https://openalex.org/W2145762862","https://openalex.org/W2149349277","https://openalex.org/W2149860264","https://openalex.org/W2156459362","https://openalex.org/W2157087957","https://openalex.org/W2158489424","https://openalex.org/W2161416069","https://openalex.org/W2165277651","https://openalex.org/W2166501262","https://openalex.org/W2170069789","https://openalex.org/W2171777347","https://openalex.org/W2259938310","https://openalex.org/W2326927070","https://openalex.org/W2471754418","https://openalex.org/W2915985519","https://openalex.org/W4230174249","https://openalex.org/W6631984995","https://openalex.org/W6759401175"],"related_works":["https://openalex.org/W2045008815","https://openalex.org/W4230804439","https://openalex.org/W2394910030","https://openalex.org/W2128738903","https://openalex.org/W1981877495","https://openalex.org/W2163175229","https://openalex.org/W2070024531","https://openalex.org/W2028275896","https://openalex.org/W2800432568","https://openalex.org/W4308640991"],"abstract_inverted_index":{"Allergic":[0],"disease":[1],"is":[2],"very":[3],"common":[4],"and":[5,21,34,61,70,111,115,160],"carries":[6],"substantial":[7,125],"public":[8],"health":[9],"burdens.We":[10],"conducted":[11],"a":[12],"meta-analysis":[13],"of":[14,158],"genome-wide":[15],"association":[16],"with":[17,43,52,124,147],"self-reported":[18],"cat,":[19],"dust-mite,":[20],"pollen":[22],"allergy":[23],"in":[24,84,91,98,105,129,135],"53,862":[25],"individuals.We":[26],"used":[27],"generalized":[28],"estimating":[29],"equations":[30],"to":[31],"model":[32],"shared":[33,40,156],"allergy-specific":[35],"genetic":[36],"effects.We":[37],"identified":[38,121],"16":[39],"susceptibility":[41],"loci":[42,49],"P<5\u00d710":[44],"-8":[45,109,119],",":[46],"including":[47],"8":[48],"previously":[50],"associated":[51,146],"asthma,":[53],"as":[54,56],"well":[55],"4p14":[57],"near":[58,68,77,113],"TLR1,":[59],"TLR6,":[60],"TLR10":[62],"(rs2101521:":[63],"P=5.3\u00d7":[64],"-21":[65],");":[66,75,82,89,96,103,110],"6p21.33":[67],"HLA-C":[69],"MICA":[71],"(rs9266772:":[72],"P=3.2\u00d710":[73],"-12":[74,143],"5p13.1":[76],"PTGER4":[78],"(rs7720838:":[79],"P=8.2\u00d710":[80],"-11":[81],"2q33.1":[83],"PLCL1":[85],"(rs10497813:":[86],"P=6.1\u00d710":[87],"-10":[88],"3q28":[90],"LPP":[92],"(rs9860547:":[93],"P=1.2\u00d710":[94],"-9":[95,102],"20q13.2":[97],"NFATC2":[99],"(rs6021270:":[100],"P=6.9\u00d710":[101],"4q27":[104],"ADAD1":[106],"(rs17388568:":[107],"P=3.9\u00d710":[108],"14q21.1":[112],"FOXA1":[114],"TTC6":[116],"(rs1998359:":[117],"P=4.8\u00d710":[118],").We":[120],"one":[122],"locus":[123],"evidence":[126],"for":[127],"differences":[128],"effects":[130],"across":[131],"allergies,":[132],"at":[133],"6p21.32":[134],"the":[136,155],"class":[137],"II":[138],"HLA":[139],"region":[140],"(rs17533090:":[141],"P=1.7\u00d710":[142],"),":[144],"strongly":[145],"cat":[148],"allergy.Our":[149],"study":[150],"sheds":[151],"new":[152],"light":[153],"on":[154],"etiology":[157],"immune":[159],"autoimmune":[161],"disease.":[162]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}