{"id":"https://openalex.org/W4238933966","doi":"https://doi.org/10.1002/9781119951438.eibc0520","title":"Calsequestrin","display_name":"Calsequestrin","publication_year":2004,"publication_date":"2004-03-05","ids":{"openalex":"https://openalex.org/W4238933966","doi":"https://doi.org/10.1002/9781119951438.eibc0520"},"language":"en","primary_location":{"id":"doi:10.1002/9781119951438.eibc0520","doi":"https://doi.org/10.1002/9781119951438.eibc0520","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781119951438.eibc0520","pdf_url":null,"source":{"id":"https://openalex.org/S4306509365","display_name":"Encyclopedia of Inorganic and Bioinorganic Chemistry","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Inorganic and Bioinorganic Chemistry","raw_type":"other"},"volume":{"id":"https://openalex.org/W2621193951","display_name":"Encyclopedia of Inorganic and Bioinorganic Chemistry"},"type":"reference-entry","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071667418","display_name":"ChulHee Kang","orcid":"https://orcid.org/0000-0002-0693-7860","observed_orcids":["https://orcid.org/0000-0002-0693-7860"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"ChulHee Kang","raw_affiliation_strings":["Washington State University, School of Molecular Biosciences, Pullman, WA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Washington State University, School of Molecular Biosciences, Pullman, WA, USA","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5071667418"],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.7250999808311462,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.10679999738931656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calsequestrin","display_name":"calsequestrin","score":1.0},{"id":"https://openalex.org/keywords/calcium-binding","display_name":"calcium binding","score":0.8360000252723694},{"id":"https://openalex.org/keywords/sarcoplasmic-reticulum","display_name":"sarcoplasmic reticulum","score":0.9750000238418579},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"muscle contraction","score":0.7049999833106995},{"id":"https://openalex.org/keywords/thioredoxin-fold","display_name":"thioredoxin fold","score":0.8849999904632568},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.7900000214576721},{"id":"https://openalex.org/keywords/cooperative-calcium-binding","display_name":"cooperative calcium binding","score":0.8349999785423279},{"id":"https://openalex.org/keywords/calcium-storage","display_name":"calcium storage","score":0.41999998688697815},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.6269999742507935}],"concepts":[{"id":"https://openalex.org/C2775953344","wikidata":"https://www.wikidata.org/wiki/Q24774223","display_name":"Calsequestrin","level":4,"score":0.9608569741249084},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7207024097442627},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6457207202911377},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.5421328544616699},{"id":"https://openalex.org/C44228677","wikidata":"https://www.wikidata.org/wiki/Q181898","display_name":"Polymerization","level":3,"score":0.5362898707389832},{"id":"https://openalex.org/C158617107","wikidata":"https://www.wikidata.org/wiki/Q79927","display_name":"Endoplasmic reticulum","level":2,"score":0.5178742408752441},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.35360151529312134},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3152468502521515},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.17641681432724},{"id":"https://openalex.org/C113217602","wikidata":"https://www.wikidata.org/wiki/Q416781","display_name":"Ryanodine receptor","level":3,"score":0.11177322268486023},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.09093675017356873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.07690349221229553}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9781119951438.eibc0520","doi":"https://doi.org/10.1002/9781119951438.eibc0520","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781119951438.eibc0520","pdf_url":null,"source":{"id":"https://openalex.org/S4306509365","display_name":"Encyclopedia of Inorganic and Bioinorganic Chemistry","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Encyclopedia of Inorganic and Bioinorganic Chemistry","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":112,"referenced_works":["https://openalex.org/W162876264","https://openalex.org/W964655812","https://openalex.org/W1480415840","https://openalex.org/W1487568705","https://openalex.org/W1500397819","https://openalex.org/W1509611865","https://openalex.org/W1510616039","https://openalex.org/W1515292518","https://openalex.org/W1520052960","https://openalex.org/W1527461658","https://openalex.org/W1531532159","https://openalex.org/W1531765690","https://openalex.org/W1543140440","https://openalex.org/W1546431662","https://openalex.org/W1549666314","https://openalex.org/W1556184133","https://openalex.org/W1563267809","https://openalex.org/W1563422013","https://openalex.org/W1574440719","https://openalex.org/W1591998251","https://openalex.org/W1640776676","https://openalex.org/W1795611968","https://openalex.org/W1804840144","https://openalex.org/W1941910566","https://openalex.org/W1965095855","https://openalex.org/W1965233966","https://openalex.org/W1966972600","https://openalex.org/W1970395634","https://openalex.org/W1971833900","https://openalex.org/W1982765384","https://openalex.org/W1983240254","https://openalex.org/W1985783132","https://openalex.org/W1987523382","https://openalex.org/W1989553550","https://openalex.org/W1991605997","https://openalex.org/W1994693592","https://openalex.org/W1999167809","https://openalex.org/W2003187190","https://openalex.org/W2005145242","https://openalex.org/W2005908710","https://openalex.org/W2007098899","https://openalex.org/W2007709380","https://openalex.org/W2014214317","https://openalex.org/W2016850966","https://openalex.org/W2018558127","https://openalex.org/W2018599257","https://openalex.org/W2022114235","https://openalex.org/W2024391217","https://openalex.org/W2028421228","https://openalex.org/W2029790439","https://openalex.org/W2031602261","https://openalex.org/W2032415450","https://openalex.org/W2032894671","https://openalex.org/W2034113803","https://openalex.org/W2036701273","https://openalex.org/W2036970859","https://openalex.org/W2039932112","https://openalex.org/W2040737229","https://openalex.org/W2041768145","https://openalex.org/W2044699197","https://openalex.org/W2045001619","https://openalex.org/W2045049365","https://openalex.org/W2045720972","https://openalex.org/W2050761691","https://openalex.org/W2051132821","https://openalex.org/W2051542346","https://openalex.org/W2053330560","https://openalex.org/W2055619329","https://openalex.org/W2059647854","https://openalex.org/W2060728728","https://openalex.org/W2063150400","https://openalex.org/W2065700132","https://openalex.org/W2067392556","https://openalex.org/W2068696047","https://openalex.org/W2069396614","https://openalex.org/W2070130144","https://openalex.org/W2071234680","https://openalex.org/W2072198852","https://openalex.org/W2072980596","https://openalex.org/W2075970710","https://openalex.org/W2078144327","https://openalex.org/W2078794355","https://openalex.org/W2079245978","https://openalex.org/W2080955459","https://openalex.org/W2087412907","https://openalex.org/W2090820454","https://openalex.org/W2091991849","https://openalex.org/W2094186244","https://openalex.org/W2095224851","https://openalex.org/W2095409224","https://openalex.org/W2096716204","https://openalex.org/W2100310965","https://openalex.org/W2101370748","https://openalex.org/W2108764665","https://openalex.org/W2121096033","https://openalex.org/W2122005870","https://openalex.org/W2128826241","https://openalex.org/W2131516732","https://openalex.org/W2136530494","https://openalex.org/W2136716105","https://openalex.org/W2138348928","https://openalex.org/W2138450406","https://openalex.org/W2150075279","https://openalex.org/W2158325136","https://openalex.org/W2160025963","https://openalex.org/W2161957047","https://openalex.org/W2166016354","https://openalex.org/W2342404863","https://openalex.org/W2409521202","https://openalex.org/W2414022827","https://openalex.org/W4234988580","https://openalex.org/W4245915136"],"related_works":["https://openalex.org/W1971833900","https://openalex.org/W2072531353","https://openalex.org/W2025514694","https://openalex.org/W3035824151","https://openalex.org/W2043586697","https://openalex.org/W1858204783","https://openalex.org/W1989553550","https://openalex.org/W1509611865","https://openalex.org/W2005686655","https://openalex.org/W2794255873"],"abstract_inverted_index":{"Abstract":[0],"The":[1,78,102,192,228],"contraction/relaxation":[2],"of":[3,13,18,33,36,44,49,57,71,98,105,113,147,155,168,183,194,220,230],"the":[4,10,26,31,42,45,86,90,99,125,145,169,181,218,221],"muscle":[5],"cell":[6],"is":[7,83,110,205],"controlled":[8],"by":[9,30,81,165],"transient":[11],"increase/decrease":[12],"Ca2+concentration.":[14],"A":[15,207],"large":[16,55],"fraction":[17],"this":[19],"Ca2+is":[20],"stored":[21],"in":[22,41,135],"and":[23,53,85,128,150,188,240],"released":[24],"from":[25,144],"sarcoplasmic":[27],"reticulum":[28],"(SR)":[29],"presence":[32],"high":[34],"concentrations":[35],"an":[37],"acidic":[38,92],"protein,":[39],"calsequestrin,":[40],"lumen":[43],"junctional":[46],"terminal":[47],"cisternae":[48],"SR.":[50],"Calsequestrin":[51],"binds":[52],"releases":[54],"quantities":[56],"Ca2+ion":[58],"rapidly:":[59],"about":[60,174],"40":[61],"to":[62,160,162,172,215,233],"50":[63],"ions":[64],"per":[65],"molecule":[66],"with":[67,117],"a":[68,118,139,198,224,242],"binding":[69,80,179],"constant":[70],"approximately":[72],"1":[73],"mM":[74],"under":[75],"physiological":[76],"conditions.":[77],"cation":[79],"calsequestrin":[82,106,136,184,195,232],"nonspecific":[84],"Ca2+binding":[87,149],"sites":[88],"incorporate":[89],"numerous":[91],"residues":[93],"that":[94,108],"comprise":[95],"over":[96,217],"one\u2010third":[97],"total":[100],"residues.":[101],"crystal":[103],"structure":[104],"shows":[107],"it":[109],"made":[111],"up":[112],"three":[114],"domains,":[115],"each":[116],"thioredoxin":[119],"fold.":[120],"Ca2+ions":[121],"are":[122],"bound":[123],"on":[124],"protein":[126,151],"surface":[127,201,219],"between":[129],"domains.":[130],"Two":[131],"distinct":[132],"dimerization":[133,163],"contacts":[134],"crystals":[137],"suggested":[138],"mechanism":[140],"for":[141],"Ca2+regulation":[142],"resulting":[143],"occurrence":[146],"coupled":[148],"polymerization.":[152,175],"Ca2+\u2010induced":[153,166],"formation":[154,167],"one":[156],"contact":[157,171],"was":[158],"proposed":[159],"lead":[161],"followed":[164],"second":[170],"bring":[173],"Strong":[176],"cooperative":[177],"calcium":[178,204],"accompanies":[180],"polymerization":[182,193],"into":[185],"insoluble,":[186],"extended,":[187],"often":[189],"needle\u2010like":[190],"structures.":[191],"also":[196],"provides":[197],"highly":[199],"charged":[200],"onto":[202],"which":[203],"adsorbed.":[206],"sparingly":[208],"soluble":[209],"ion":[210],"such":[211],"as":[212],"Ca2+would":[213],"tend":[214],"spread":[216],"polymer,":[222],"forming":[223],"readily":[225],"exchangeable":[226],"film.":[227],"propensity":[229],"Ca2+\u2010bound":[231],"form":[234],"linear":[235],"structures":[236],"would":[237],"make":[238],"Ca2+dissociation":[239],"diffusion":[241],"more":[243],"rapid":[244],"event.":[245]},"counts_by_year":[],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2022-05-12T00:00:00"}
