{"id":"https://openalex.org/W4238909204","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2391","title":"Abstract 2391: DR5 agonist activity of HexaBody\u00ae-DR5/DR5 (GEN1029) is potentiated by C1q and independent of Fc-gamma receptor binding in preclinical tumor models","display_name":"Abstract 2391: DR5 agonist activity of HexaBody\u00ae-DR5/DR5 (GEN1029) is potentiated by C1q and independent of Fc-gamma receptor binding in preclinical tumor models","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4238909204","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2391"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-2391","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2391","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2391","pdf_url":null,"source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073137809","display_name":"Marije B. Overdijk","orcid":"https://orcid.org/0009-0006-5295-2339","observed_orcids":["https://orcid.org/0009-0006-5295-2339"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marije B. Overdijk","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056241266","display_name":"Kristin Strumane","orcid":"https://orcid.org/0009-0009-5910-9477","observed_orcids":["https://orcid.org/0009-0009-5910-9477"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kristin Strumane","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017301184","display_name":"Antonio Ortiz Buijsse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Antonio Ortiz Buijsse","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087845767","display_name":"Claudine Vermot\u2010Desroches","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Claudine Vermot-Desroches","raw_affiliation_strings":["IDD Biotech, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IDD Biotech, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055289383","display_name":"Thessa Kroes","orcid":"https://orcid.org/0000-0003-1416-5407","observed_orcids":["https://orcid.org/0000-0003-1416-5407"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Thessa Kroes","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110715182","display_name":"Bart de Jong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Bart de Jong","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055233279","display_name":"Naomi Hoevenaars","orcid":"https://orcid.org/0000-0002-3336-7453","observed_orcids":["https://orcid.org/0000-0002-3336-7453"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Naomi Hoevenaars","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013693987","display_name":"Frank J M Beurskens","orcid":"https://orcid.org/0000-0002-7165-5771","observed_orcids":["https://orcid.org/0000-0002-7165-5771"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Frank J. Beurskens","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016951786","display_name":"Rob N. de Jong","orcid":"https://orcid.org/0000-0002-9300-6633","observed_orcids":["https://orcid.org/0000-0002-9300-6633"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rob N. de Jong","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andreas Lingnau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Andreas Lingnau","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039190287","display_name":"Paul W.H.I. Parren","orcid":"https://orcid.org/0000-0002-4365-3859","observed_orcids":["https://orcid.org/0000-0002-4365-3859"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Paul W. Parren","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030866619","display_name":"Ulf Forssmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ulf Forssmann","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015733850","display_name":"Amy Kate Sasser","orcid":"https://orcid.org/0009-0009-2804-1684","observed_orcids":["https://orcid.org/0009-0009-2804-1684"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"A Kate Sasser","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069729938","display_name":"Janine Schuurman","orcid":"https://orcid.org/0000-0002-9738-9926","observed_orcids":["https://orcid.org/0000-0002-9738-9926"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Janine Schuurman","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014666198","display_name":"Esther C.W. Breij","orcid":"https://orcid.org/0000-0002-5368-6849","observed_orcids":["https://orcid.org/0000-0002-5368-6849"]},"institutions":[{"id":"https://openalex.org/I4210102253","display_name":"Genmab (Netherlands)","ror":"https://ror.org/01ajp8153","country_code":"NL","type":"company","lineage":["https://openalex.org/I4210102253","https://openalex.org/I4210163256"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Esther C. Breij","raw_affiliation_strings":["Genmab, Utrecht, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genmab, Utrecht, Netherlands","institution_ids":["https://openalex.org/I4210102253"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"2391","last_page":"2391"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.8881999850273132,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.09910000115633011,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dr5","display_name":"DR5","score":0.7620000243186951},{"id":"https://openalex.org/keywords/trail","display_name":"TRAIL","score":0.8050000071525574},{"id":"https://openalex.org/keywords/c1q","display_name":"C1q","score":0.6949999928474426},{"id":"https://openalex.org/keywords/complement-activation","display_name":"complement activation","score":0.46399998664855957},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.5109999775886536},{"id":"https://openalex.org/keywords/tumor-xenografts","display_name":"tumor xenografts","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cancer-cell-lines","display_name":"cancer cell lines","score":0.5080000162124634},{"id":"https://openalex.org/keywords/antibody-drug-conjugates","display_name":"antibody-drug conjugates","score":0.4749999940395355},{"id":"https://openalex.org/keywords/humanized-antibody","display_name":"humanized monoclonal antibody","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6663307547569275},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.6355986595153809},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6120771169662476},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5674233436584473},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5461533665657043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5433865189552307},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4868728220462799},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.4662543535232544},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.46604812145233154},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4127761125564575},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32426780462265015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26998090744018555},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2494233250617981},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.20458778738975525},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-2391","doi":"https://doi.org/10.1158/1538-7445.sabcs18-2391","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-2391","pdf_url":null,"source":{"id":"https://openalex.org/S89865888","display_name":"Immunology","issn_l":"0019-2805","issn":["0019-2805","1365-2567"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Immunology","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2991791481","https://openalex.org/W3081464583","https://openalex.org/W2488139719","https://openalex.org/W3082037134","https://openalex.org/W2563543071","https://openalex.org/W2481590007","https://openalex.org/W2976239299","https://openalex.org/W2741535348","https://openalex.org/W2058776690","https://openalex.org/W2953948502"],"abstract_inverted_index":{"Hyperclustering":[0],"of":[1,8,25,30,114,146,168,185,193,267,336,350,369,377,382,401,451,460,471],"Death":[2],"Receptor":[3],"5":[4],"(DR5)":[5],"after":[6],"binding":[7,62,102,324,358,463],"its":[9],"ligand":[10],"TRAIL":[11],"induces":[12],"apoptosis.":[13],"Targeting":[14],"DR5":[15,47,143,235,344,362,448],"with":[16,87],"agonistic":[17],"antibodies":[18,34],"has":[19,36],"been":[20,37],"evaluated":[21],"for":[22,142,220,231,279,297,475],"the":[23,41,57,93,160,183,265,365,375,472],"treatment":[24],"cancer,":[26],"however":[27],"clinical":[28,395,399],"efficacy":[29],"conventional":[31],"DR5-targeting":[32],"monoclonal":[33],"(mAbs)":[35],"disappointing.":[38],"We":[39,126],"applied":[40],"HexaBody\u00ae":[42],"technology":[43,53],"to":[44,63,103,159,214,329,359,397],"improve":[45],"antibody-mediated":[46],"clustering":[48],"on":[49,56,65,364],"cancer":[50,256,311],"cells.":[51],"This":[52],"is":[54,110,333,405,454],"based":[55],"natural":[58],"concept":[59],"that,":[60],"upon":[61,101,357],"antigens":[64],"a":[66,88,111,165,176,190,199,229,277,309,315,334,348],"cell":[67,200,244,366],"surface,":[68],"immunoglobulin":[69],"G":[70],"(IgG)":[71],"molecules":[72,83,86,163,340],"can":[73],"organize":[74],"into":[75],"ordered":[76],"hexamers":[77,211],"through":[78,137,353],"intermolecular":[79],"Fc-Fc":[80,99,138],"interactions.":[81],"HexaBody":[82,162,339],"are":[84,140,212],"IgG1":[85],"single":[89,161],"point":[90],"mutation":[91],"in":[92,148,173,187,189,204,206,233,241,247,261,291,308,319,347,374,389,392,403,464],"Fc":[94],"domain":[95],"that":[96,129,152,341],"enhances":[97],"these":[98],"interactions":[100,139],"membrane-bound":[104],"targets,":[105],"while":[106,314],"retaining":[107],"solution-monomericity.HexaBody-DR5/DR5":[108],"(Hx-DR5-01/05)":[109],"1:1":[112,166],"mixture":[113,167,335],"two":[115,337,360],"humanized":[116],"non-competing":[117],"DR5-specific":[118,338],"mAbs,":[119],"each":[120],"carrying":[121],"an":[122,216],"E430G":[123],"hexamerization-enhancing":[124],"mutation.":[125],"previously":[127],"demonstrated":[128],"both":[130,298],"dual":[131],"epitope":[132],"targeting":[133],"and":[134,203,246,300,379,391,458],"enhanced":[135,354],"hexamerization":[136,356],"required":[141,264],"agonist":[144,236,345,449],"activity":[145,157,307,327,346,450],"Hx-DR5-01/05":[147,153,186,263,294,316,332,370,402],"vitro.Here,":[149],"we":[150,181,224],"confirmed":[151,290],"showed":[154,303,325],"superior":[155],"anti-tumor":[156,306,326],"compared":[158],"or":[164,269,386],"their":[169],"wild":[170],"type":[171],"counterparts":[172],"vivo,":[174],"using":[175,198],"mouse":[177],"xenograft":[178,207,251,312],"model.":[179],"Furthermore,":[180],"screened":[182],"potency":[184],"vitro":[188,390],"broad":[191],"panel":[192],"human":[194],"tumor":[195,243,466],"cells":[196],"lines":[197,245],"viability":[201],"assay,":[202],"vivo":[205],"models.":[208],"As":[209],"IgG":[210,275,355],"known":[213],"provide":[215],"optimal":[217,259,373],"docking":[218],"site":[219],"complement":[221],"component":[222],"C1q,":[223],"studied":[225],"if":[226],"there":[227],"was":[228,371],"role":[230],"C1q":[232,299,323,378,457],"Hx-DR5-01/05-dependent":[234],"activity.Hx-DR5-01/05":[237],"induced":[238],"potent":[239,343],"cytotoxicity":[240,260],"104":[242],"more":[248],"than":[249],"ten":[250],"models":[252,352,467],"representing":[253],"many":[254],"solid":[255],"lineages.":[257],"For":[258],"vitro,":[262],"presence":[266,376],"serum":[268],"purified":[270],"C1q.":[271],"In":[272],"contrast,":[273],"polyclonal":[274],"crosslinking,":[276,282],"mimic":[278],"Fc\u03b3R-mediated":[280,383],"antibody":[281,384],"did":[283],"not":[284,322],"enhance":[285],"potency.":[286],"These":[287],"data":[288],"were":[289],"vivo.":[292,393],"A":[293,394,440],"variant":[295,317],"deficient":[296,318],"Fc\u03b3R":[301,320],"binding,":[302],"significantly":[304],"reduced":[305],"colon":[310],"model,":[313],"but":[321],"comparable":[328],"Hx-DR5-01/05.In":[330],"summary,":[331],"shows":[342],"multitude":[349],"preclinical":[351,465],"different":[361],"epitopes":[363],"surface.":[367],"Cytotoxicity":[368],"most":[372],"completely":[380],"independent":[381,459],"crosslinking":[385],"effector":[387],"functions":[388],"trial":[396],"assess":[398],"safety":[400],"patients":[404],"currently":[406],"ongoing.Citation":[407],"Format:":[408],"Marije":[409],"B.":[410],"Overdijk,":[411],"Kristin":[412],"Strumane,":[413],"Antonio":[414],"Ortiz":[415],"Buijsse,":[416],"Claudine":[417],"Vermot-Desroches,":[418],"Thessa":[419],"Kroes,":[420],"Bart":[421],"de":[422,431],"Jong,":[423,432],"Naomi":[424],"Hoevenaars,":[425],"Frank":[426],"J.":[427],"Beurskens,":[428],"Rob":[429],"N.":[430],"Andreas":[433],"Lingnau,":[434],"Paul":[435],"W.":[436],"Parren,":[437],"Ulf":[438],"Forssmann,":[439],"Kate":[441],"Sasser,":[442],"Janine":[443],"Schuurman,":[444],"Esther":[445],"C.":[446],"Breij.":[447],"HexaBody\u00ae-DR5/DR5":[452],"(GEN1029)":[453],"potentiated":[455],"by":[456],"Fc-gamma":[461],"receptor":[462],"[abstract].":[468],"In:":[469],"Proceedings":[470],"American":[473],"Association":[474],"Cancer":[476,490],"Research":[477],"Annual":[478],"Meeting":[479],"2019;":[480],"2019":[481],"Mar":[482],"29-Apr":[483],"3;":[484],"Atlanta,":[485],"GA.":[486],"Philadelphia":[487],"(PA):":[488],"AACR;":[489],"Res":[491],"2019;79(13":[492],"Suppl):Abstract":[493],"nr":[494],"2391.":[495]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-05-12T00:00:00"}
