{"id":"https://openalex.org/W4238883595","doi":"https://doi.org/10.1200/jco.2016.34.2_suppl.308","title":"Optimal sequencing of enzalutamide and abiraterone in men with metastatic castration-resistant prostate cancer (mCRPC).","display_name":"Optimal sequencing of enzalutamide and abiraterone in men with metastatic castration-resistant prostate cancer (mCRPC).","publication_year":2016,"publication_date":"2016-01-10","ids":{"openalex":"https://openalex.org/W4238883595","doi":"https://doi.org/10.1200/jco.2016.34.2_suppl.308"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2016.34.2_suppl.308","doi":"https://doi.org/10.1200/jco.2016.34.2_suppl.308","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.2_suppl.308","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022744341","display_name":"Benjamin Louis Maughan","orcid":"https://orcid.org/0000-0002-0010-8551","observed_orcids":["https://orcid.org/0000-0002-0010-8551"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Louis Maughan","raw_affiliation_strings":["Johns Hopkins Medcl Ctr, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins Medcl Ctr, Baltimore, MD","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040090615","display_name":"Daniel L. Suzman","orcid":"https://orcid.org/0000-0002-1702-6114","observed_orcids":["https://orcid.org/0000-0002-1702-6114"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel L. Suzman","raw_affiliation_strings":["Johns Hopkins, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104856552","display_name":"Rosa Maria Nadal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rosa Maria Nadal","raw_affiliation_strings":["National Institutes of Health, Bethesda, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health, Bethesda, MD","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082891875","display_name":"Sunakshi Bassi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunakshi Bassi","raw_affiliation_strings":["Johns Hopkins University, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018645768","display_name":"Emmanuel S. Antonarakis","orcid":"https://orcid.org/0000-0003-0031-9655","observed_orcids":["https://orcid.org/0000-0003-0031-9655","https://orcid.org/0000-0003-3531-3851"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emmanuel S. Antonarakis","raw_affiliation_strings":["Johns Hopkins University School of Medicine, Baltimore, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Johns Hopkins University School of Medicine, Baltimore, MD","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"34","issue":"2_suppl","first_page":"308","last_page":"308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metastatic-castration-resistant-prostate-cancer","display_name":"metastatic castration-resistant prostate cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/enzalutamide","display_name":"enzalutamide","score":0.9739999771118164},{"id":"https://openalex.org/keywords/abiraterone-acetate","display_name":"abiraterone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/treatment-sequencing","display_name":"treatment sequencing","score":0.7919999957084656},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9990000128746033},{"id":"https://openalex.org/keywords/androgen-receptor-antagonists","display_name":"androgen receptor antagonists","score":0.6169999837875366},{"id":"https://openalex.org/keywords/visceral-disease","display_name":"visceral disease","score":0.5879999995231628},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"hemoglobin","score":0.7269999980926514},{"id":"https://openalex.org/keywords/psa-levels","display_name":"PSA levels","score":0.6489999890327454},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.6890000104904175},{"id":"https://openalex.org/keywords/metastatic-hormone-sensitive-prostate-cancer","display_name":"metastatic hormone-sensitive prostate cancer","score":0.6299999952316284}],"concepts":[{"id":"https://openalex.org/C2776551883","wikidata":"https://www.wikidata.org/wiki/Q1996756","display_name":"Enzalutamide","level":5,"score":0.9599366188049316},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7852765917778015},{"id":"https://openalex.org/C2776421732","wikidata":"https://www.wikidata.org/wiki/Q27888393","display_name":"Abiraterone","level":5,"score":0.6818637251853943},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6220391988754272},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6032475233078003},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5602850914001465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5435559153556824},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4850730001926422},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4151993989944458},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.35909152030944824},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.34896770119667053},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.11633408069610596},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.08682358264923096},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.05660998821258545}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2016.34.2_suppl.308","doi":"https://doi.org/10.1200/jco.2016.34.2_suppl.308","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2016.34.2_suppl.308","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2509917335","https://openalex.org/W2603427132","https://openalex.org/W3119442987","https://openalex.org/W2601963594","https://openalex.org/W3010512320","https://openalex.org/W2995441292","https://openalex.org/W2589011220","https://openalex.org/W2809274368","https://openalex.org/W2997776811","https://openalex.org/W2608121362"],"abstract_inverted_index":{"308":[0],"Background:":[1],"Both":[2],"enzalutamide":[3,52,293,296],"and":[4,39,162,184,250,262,284],"abiraterone":[5,57,291],"are":[6],"approved":[7],"for":[8,151],"the":[9,26,60,91,96,99,110,119,122,128,147,201,223,228,273,308],"treatment":[10],"of":[11,29,68,98,121,167,186,312,317],"mCRPC,":[12],"each":[13],"demonstrating":[14],"improved":[15,270],"overall":[16],"survival":[17],"(OS)":[18],"versus":[19],"placebo.":[20],"However,":[21],"it":[22],"is":[23,320],"unclear":[24],"what":[25],"optimal":[27],"sequencing":[28],"these":[30],"two":[31],"therapies":[32],"should":[33],"be":[34,302],"to":[35,139,227,295,304],"maximize":[36],"clinical":[37,44],"outcomes":[38,45,271],"survival.":[40],"Here,":[41],"we":[42],"compare":[43],"among":[46],"patients":[47,71,156],"with":[48,76,272,288],"mCRPC":[49,70,289],"who":[50],"received":[51,160,164],"first":[53,100,123],"followed":[54],"immediately":[55],"by":[56],"(enza-to-abi)":[58],"or":[59,78,104,114,307],"opposite":[61],"sequence":[62,143],"(abi-to-enza).":[63],"Methods:":[64],"A":[65],"retrospective":[66],"review":[67],"consecutive":[69],"treated":[72],"at":[73],"Johns":[74],"Hopkins":[75],"enza-to-abi":[77,202,229],"abi-to-enza":[79,161,193,224,274],"was":[80,90,127,137,144,215],"conducted.":[81],"The":[82,116,192],"combined":[83,198,255],"PFS":[84,199,256,283],"(PFS":[85],"=":[86,178,190,212,260],"PFS1":[87],"+":[88],"PFS2)":[89],"primary":[92],"endpoint,":[93],"measured":[94],"from":[95,118],"start":[97,120],"therapy":[101,112,124],"(i.e.":[102],"enza":[103],"abi)":[105],"until":[106,125],"disease":[107,188,249],"progression":[108],"on":[109],"subsequent":[111],"(i.e.abi":[113],"enza).":[115],"OS":[117,221,263,285],"death":[126],"secondary":[129],"endpoint.":[130],"Cox":[131],"proportional":[132],"hazards":[133],"multivariable":[134,242],"regression":[135],"analysis":[136],"performed":[138],"determine":[140],"whether":[141],"one":[142],"better":[145],"than":[146,200],"other":[148],"after":[149],"adjusting":[150],"baseline":[152,168,305],"characteristics.":[153],"Results:":[154],"71":[155],"were":[157],"identified:":[158],"58":[159],"13":[163],"enza-to-abi.":[165],"Comparisons":[166],"characteristics":[169],"between":[170],"groups":[171],"identified":[172],"differences":[173],"in":[174,220,222,286],"PSA":[175,245],"levels":[176],"(P":[177,181,189],"0.007),":[179],"hemoglobin":[180],"<":[182,239,267],"0.001),":[183],"presence":[185],"visceral":[187,248],"0.035).":[191],"group":[194,225],"had":[195],"a":[196,217],"longer":[197],"group:":[203,230],"median":[204,231],"16.3":[205],"vs":[206,233],"12.5":[207],"mo":[208,235],"(HR":[209,236,257,264],"0.53,":[210],"P":[211,238,259,266],"0.04).":[213],"There":[214],"also":[216],"numeric":[218],"improvement":[219],"compared":[226],"29.0":[232],"21.0":[234],"0.51,":[237],"0.10).":[240],"In":[241],"analyses":[243],"incorporating":[244],"level,":[246],"hemoglobin,":[247],"prior":[251],"docetaxel":[252],"use,":[253],"both":[254],"2.59,":[258],"0.03)":[261],"4.59,":[265],"0.01)":[268],"demonstrated":[269],"sequence.":[275],"Conclusions:":[276],"This":[277],"hypothesis-generating":[278],"study":[279],"potentially":[280],"suggests":[281],"superior":[282],"men":[287],"receiving":[290],"then":[292,297],"(compared":[294],"abiraterone),":[298],"although":[299],"this":[300,313,318],"could":[301],"due":[303],"imbalances":[306],"small":[309],"sample":[310],"size":[311],"study.":[314],"Prospective":[315],"validation":[316],"concept":[319],"ongoing":[321],"(NCT02125357).":[322]},"counts_by_year":[],"updated_date":"2026-09-24T07:57:37.273135","created_date":"2022-05-12T00:00:00"}