{"id":"https://openalex.org/W4238575808","doi":"https://doi.org/10.1007/978-1-59259-100-8_15","title":"The Utility of Transgenic Mouse Models for Cancer Prevention Research","display_name":"The Utility of Transgenic Mouse Models for Cancer Prevention Research","publication_year":2002,"publication_date":"2002-01-01","ids":{"openalex":"https://openalex.org/W4238575808","doi":"https://doi.org/10.1007/978-1-59259-100-8_15"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-59259-100-8_15","doi":"https://doi.org/10.1007/978-1-59259-100-8_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-100-8_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Models in Cancer Research","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4406312002","display_name":"Tumor Models in Cancer Research"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036400845","display_name":"Stephen David Hursting","orcid":"https://orcid.org/0000-0003-3605-2833","observed_orcids":["https://orcid.org/0000-0003-3605-2833"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stephen D. Hursting","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5014024059","display_name":"Ronald A. Lubet","orcid":"https://orcid.org/0000-0003-1957-7945","observed_orcids":["https://orcid.org/0000-0003-1957-7945"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald A. Lubet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.3115,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.84507042,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"263","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.576200008392334,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.1712999939918518,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.15639999508857727,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transgenic-mouse-model","display_name":"transgenic mouse model","score":0.9789999723434448},{"id":"https://openalex.org/keywords/cancer-prevention","display_name":"cancer prevention","score":0.9950000047683716},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8899999856948853},{"id":"https://openalex.org/keywords/tumor-suppression","display_name":"tumor suppression","score":0.4000000059604645},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"carcinogenesis","score":0.35499998927116394}],"concepts":[{"id":"https://openalex.org/C141035611","wikidata":"https://www.wikidata.org/wiki/Q5532934","display_name":"Genetically modified mouse","level":4,"score":0.6630436778068542},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.5454438924789429},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.45103156566619873},{"id":"https://openalex.org/C2780234812","wikidata":"https://www.wikidata.org/wiki/Q1787013","display_name":"Cancer prevention","level":3,"score":0.422366201877594},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37400466203689575},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3221537470817566},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32092729210853577},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1501196026802063},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10337170958518982},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.043921470642089844}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/978-1-59259-100-8_15","doi":"https://doi.org/10.1007/978-1-59259-100-8_15","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-59259-100-8_15","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Models in Cancer Research","raw_type":"book-chapter"},{"id":"doi:10.1385/1-59259-100-0:263","doi":"https://doi.org/10.1385/1-59259-100-0:263","is_oa":false,"landing_page_url":"http://doi.org/10.1385/1-59259-100-0:263","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tumor Models in Cancer Research","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W8347340","https://openalex.org/W173096480","https://openalex.org/W1521853181","https://openalex.org/W1542940668","https://openalex.org/W1868796410","https://openalex.org/W1918998896","https://openalex.org/W1963322127","https://openalex.org/W1965179084","https://openalex.org/W1968625769","https://openalex.org/W1974958661","https://openalex.org/W1976934772","https://openalex.org/W1982928787","https://openalex.org/W1988707015","https://openalex.org/W1989970624","https://openalex.org/W1990606472","https://openalex.org/W2001258296","https://openalex.org/W2010013468","https://openalex.org/W2020636054","https://openalex.org/W2023068350","https://openalex.org/W2024575518","https://openalex.org/W2026897120","https://openalex.org/W2042316019","https://openalex.org/W2049296953","https://openalex.org/W2051686420","https://openalex.org/W2056785620","https://openalex.org/W2074584160","https://openalex.org/W2075074994","https://openalex.org/W2093187453","https://openalex.org/W2094009758","https://openalex.org/W2095278911","https://openalex.org/W2103816786","https://openalex.org/W2108126051","https://openalex.org/W2109776329","https://openalex.org/W2126679757","https://openalex.org/W2130639027","https://openalex.org/W2132628938","https://openalex.org/W2138582617","https://openalex.org/W2138960847","https://openalex.org/W2141299449","https://openalex.org/W2142576177","https://openalex.org/W2145925849","https://openalex.org/W2150183586","https://openalex.org/W2161363642","https://openalex.org/W2166568482","https://openalex.org/W2167327503","https://openalex.org/W2170720047","https://openalex.org/W2402255383"],"related_works":["https://openalex.org/W4233698464","https://openalex.org/W2499880418","https://openalex.org/W2598892797","https://openalex.org/W2437458611","https://openalex.org/W4244386812","https://openalex.org/W1983017536","https://openalex.org/W2501671076","https://openalex.org/W4210663054","https://openalex.org/W2404249662","https://openalex.org/W2472779879"],"abstract_inverted_index":{"Humans":[0],"are":[1,59,140],"exposed":[2],"to":[3,22,31,83,105,116],"a":[4,112],"wide":[5],"variety":[6],"of":[7,25,39,78,101,127,136],"carcinogenic":[8],"insults,":[9],"including":[10],"chemicals,":[11],"radiation,":[12],"physical":[13],"agents,":[14],"and":[15,29,52,63,147,171],"viruses.":[16],"Animal":[17],"models":[18],"have":[19],"contributed":[20],"significantly":[21],"our":[23],"understanding":[24],"the":[26,55,99,102,134,152],"carcinogenesis":[27,40],"process":[28],"ways":[30],"interfere":[32],"with":[33,72,111,142,167],"that":[34,79,96],"process.":[35],"The":[36,119],"major":[37],"stages":[38],"(Fig.":[41],"1),":[42],"deduced":[43],"primarily":[44],"from":[45,76],"chemically":[46],"induced":[47],"tumor":[48],"studies":[49],"in":[50,70,93,133],"mice":[51],"rats":[53],"over":[54],"past":[56],"fifty":[57],"years,":[58],"termed":[60],"initiation,":[61],"promotion,":[62],"progression":[64],"(1)":[65],".":[66,150,181],"Tumor":[67],"initiation":[68],"begins":[69],"cells":[71,104,129,156],"DNA":[73,90],"damage,":[74],"resulting":[75],"exposure":[77],"cell\u2019s":[80],"genetic":[81,94,173],"material":[82],"exogenous":[84],"or":[85],"endogenous":[86],"carcinogens.":[87],"Unless":[88],"repaired,":[89],"damage":[91,174],"results":[92],"mutations":[95],"can":[97],"alter":[98],"responsiveness":[100],"mutated":[103],"their":[106],"microenvironment,":[107],"eventually":[108],"providing":[109],"them":[110],"growth":[113],"advantage":[114],"relative":[115],"normal":[117],"cells.":[118],"tumor-promotion":[120],"stage":[121],"is":[122],"characterized":[123],"by":[124,131,176],"clonal":[125,163],"expansion":[126],"initiated":[128],"caused":[130,175],"alterations":[132],"expression":[135,170],"genes":[137],"whose":[138],"products":[139],"associated":[141,166],"hyperproliferation,":[143],"apoptosis,":[144],"tissue":[145],"remodeling,":[146],"inflammation":[148],"(2)":[149],"During":[151],"tumor-progression":[153],"stage,":[154],"preneoplastic":[155],"develop":[157],"into":[158],"invasive":[159],"tumors":[160],"through":[161],"further":[162],"expansion,":[164],"usually":[165],"altered":[168],"gene":[169],"additional":[172],"progressive":[177],"genomic":[178],"instability":[179],"(3)":[180]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-05-12T00:00:00"}
