{"id":"https://openalex.org/W4238564380","doi":"https://doi.org/10.1101/2021.10.25.465800","title":"Dissecting the Roles of the Tuberin Protein in the Subcellular Localization of the G2/M Cyclin, Cyclin B1","display_name":"Dissecting the Roles of the Tuberin Protein in the Subcellular Localization of the G2/M Cyclin, Cyclin B1","publication_year":2021,"publication_date":"2021-10-25","ids":{"openalex":"https://openalex.org/W4238564380","doi":"https://doi.org/10.1101/2021.10.25.465800"},"language":"en","primary_location":{"id":"doi:10.1101/2021.10.25.465800","doi":"https://doi.org/10.1101/2021.10.25.465800","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.25.465800","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/25/2021.10.25.465800.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/25/2021.10.25.465800.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089750529","display_name":"Jessica Dare-Shih","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jessica Dare-Shih","raw_affiliation_strings":["Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028047494","display_name":"Adam Pillon","orcid":"https://orcid.org/0009-0002-2511-2108","observed_orcids":["https://orcid.org/0009-0002-2511-2108"]},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Adam Pillon","raw_affiliation_strings":["Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071465103","display_name":"Jackie Fong","orcid":"https://orcid.org/0000-0002-7500-102X","observed_orcids":["https://orcid.org/0000-0002-7500-102X"]},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jackie Fong","raw_affiliation_strings":["Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070307394","display_name":"Elizabeth Fidalgo da Silva","orcid":"https://orcid.org/0000-0003-3540-9335","observed_orcids":["https://orcid.org/0000-0003-3540-9335"]},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Elizabeth Fidalgo da Silva","raw_affiliation_strings":["Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4","institution_ids":["https://openalex.org/I74413500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082524181","display_name":"Lisa Ann Porter","orcid":"https://orcid.org/0000-0002-9234-1712","observed_orcids":["https://orcid.org/0000-0002-9234-1712"]},"institutions":[{"id":"https://openalex.org/I74413500","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370","country_code":"CA","type":"education","lineage":["https://openalex.org/I74413500"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Lisa A. Porter","raw_affiliation_strings":["Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4"],"raw_orcid":"https://orcid.org/0000-0002-9234-1712","affiliations":[{"raw_affiliation_string":"Department of Biomedical Sciences, University of Windsor, 401 Sunset Ave., Windsor, Ontario, Canada N9B 3P4","institution_ids":["https://openalex.org/I74413500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5082524181"],"corresponding_institution_ids":["https://openalex.org/I74413500"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12049","display_name":"Tuberous Sclerosis Complex Research","score":0.9839000105857849,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tuberin","display_name":"tuberin","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tsc2","display_name":"TSC2","score":0.871999979019165},{"id":"https://openalex.org/keywords/tuberous-sclerosis-complex","display_name":"tuberous sclerosis complex","score":0.9150000214576721},{"id":"https://openalex.org/keywords/cyclin-b1","display_name":"cyclin B1","score":0.8899999856948853},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.8420000076293945},{"id":"https://openalex.org/keywords/nuclear-accumulation","display_name":"nuclear accumulation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/truncated-protein","display_name":"truncated protein","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cell-cycle-regulation","display_name":"cell cycle regulation","score":0.6679999828338623},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.949999988079071}],"concepts":[{"id":"https://openalex.org/C2779422105","wikidata":"https://www.wikidata.org/wiki/Q21109261","display_name":"TSC2","level":4,"score":0.9463980197906494},{"id":"https://openalex.org/C2778980267","wikidata":"https://www.wikidata.org/wiki/Q1362721","display_name":"Tuberous sclerosis","level":2,"score":0.8662317991256714},{"id":"https://openalex.org/C2776773979","wikidata":"https://www.wikidata.org/wiki/Q898669","display_name":"TSC1","level":4,"score":0.7473417520523071},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6703425645828247},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5590328574180603},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5170984268188477},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5108356475830078},{"id":"https://openalex.org/C120089663","wikidata":"https://www.wikidata.org/wiki/Q59250999","display_name":"Cyclin","level":4,"score":0.503523051738739},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.47155237197875977},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4617474377155304},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.339816689491272},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.20815393328666687},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.15409022569656372},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14152371883392334},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08741438388824463}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1101/2021.10.25.465800","doi":"https://doi.org/10.1101/2021.10.25.465800","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.25.465800","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/25/2021.10.25.465800.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.1101/2021.10.25.465800","doi":"https://doi.org/10.1101/2021.10.25.465800","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2021.10.25.465800","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/10/25/2021.10.25.465800.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9074000120162964,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.5699999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2082072623","display_name":null,"funder_award_id":"RGPIN/06636-2014","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320311065","display_name":"University of Windsor","ror":"https://ror.org/01gw3d370"},{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4238564380.pdf","grobid_xml":"https://content.openalex.org/works/W4238564380.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W133571668","https://openalex.org/W1592476226","https://openalex.org/W1594998876","https://openalex.org/W1601465996","https://openalex.org/W1980939920","https://openalex.org/W1982992093","https://openalex.org/W1983115702","https://openalex.org/W1993431258","https://openalex.org/W1996556344","https://openalex.org/W1996847747","https://openalex.org/W2001568034","https://openalex.org/W2013787505","https://openalex.org/W2042192373","https://openalex.org/W2049776717","https://openalex.org/W2052570373","https://openalex.org/W2059765843","https://openalex.org/W2060441112","https://openalex.org/W2066234603","https://openalex.org/W2076174029","https://openalex.org/W2079569906","https://openalex.org/W2085024359","https://openalex.org/W2086934839","https://openalex.org/W2087812126","https://openalex.org/W2103304405","https://openalex.org/W2118659567","https://openalex.org/W2122025343","https://openalex.org/W2124487642","https://openalex.org/W2128732250","https://openalex.org/W2139052077","https://openalex.org/W2139752122","https://openalex.org/W2155487101","https://openalex.org/W2235106477","https://openalex.org/W2901242178","https://openalex.org/W2909028814","https://openalex.org/W4210953366","https://openalex.org/W4232786548"],"related_works":["https://openalex.org/W1931685279","https://openalex.org/W3032641101","https://openalex.org/W2134100931","https://openalex.org/W4213043570","https://openalex.org/W3202266851","https://openalex.org/W2417624839","https://openalex.org/W2070399526","https://openalex.org/W2313951357","https://openalex.org/W2037371174","https://openalex.org/W1533346947"],"abstract_inverted_index":{"Abstract":[0],"Tuberin":[1,32,91,134,146],"is":[2],"a":[3,19,71,116,132,156],"major":[4],"component":[5],"of":[6,40,74,119,145,152,188,194],"the":[7,13,31,38,49,63,87,97,104,120,125,163,168,178,189],"protein":[8,27],"regulatory":[9],"complex":[10],"known":[11],"as":[12],"Tuberous":[14,50,171],"Sclerosis":[15,51,172],"Complex":[16,52,173],"and":[17,26,47,92,155,191],"plays":[18],"crucial":[20],"role":[21],"in":[22,30,43,62,115,126,159,167,200],"cell":[23,98,160],"cycle":[24,99],"progression":[25],"synthesis.":[28],"Mutations":[29],"gene,":[33],"TSC2":[34,64,179],",":[35],"lead":[36],"to":[37,59,79,95,103],"formation":[39],"benign":[41],"tumors":[42,78],"many":[44],"organ":[45],"systems":[46],"causes":[48],"disorder.":[53],"Genotypes":[54],"ranging":[55],"from":[56,76,131],"point":[57],"mutations":[58],"large":[60,80],"deletions":[61,176],"gene":[65],"have":[66],"been":[67],"clinically":[68,141],"characterized":[69],"with":[70,170],"wide":[72],"range":[73],"phenotypes":[75],"skin":[77],"brain":[81],"tumors.":[82],"Our":[83],"current":[84],"work":[85],"investigates":[86],"molecular":[88,192],"mechanisms":[89],"behind":[90],"its":[93,101],"ability":[94],"regulate":[96],"through":[100],"binding":[102],"G2/M":[105],"cyclin,":[106],"Cyclin":[107,153],"B1.":[108],"After":[109],"creating":[110],"an":[111,148,184],"early":[112],"stop":[113],"codon":[114],"critical":[117],"region":[118],"Tuberin,":[121],"our":[122],"results":[123],"show":[124],"vitro":[127],"phenotype":[128],"that":[129,139,197],"occurs":[130],"truncated":[133,143,195],"protein.":[135],"Herein":[136],"we":[137],"demonstrate":[138],"this":[140],"relevant":[142],"form":[144],"promotes":[147],"increased":[149],"nuclear":[150],"accumulation":[151],"B1":[154],"subsequent":[157],"increase":[158],"proliferation":[161],"supporting":[162],"phenotypic":[164],"data":[165,182],"seen":[166,199],"clinic":[169],"patients":[174],"showing":[175],"within":[177],"gene.":[180],"This":[181],"provides":[183],"insight":[185],"into":[186],"some":[187],"functional":[190],"consequences":[193],"proteins":[196],"are":[198],"clinical":[201],"patients.":[202]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2025-10-10T00:00:00"}