{"id":"https://openalex.org/W4238499005","doi":"https://doi.org/10.1002/ange.201000329","title":"A Left\u2010Handed Solution to Peptide Inhibition of the p53\u2013MDM2 Interaction","display_name":"A Left\u2010Handed Solution to Peptide Inhibition of the p53\u2013MDM2 Interaction","publication_year":2010,"publication_date":"2010-04-01","ids":{"openalex":"https://openalex.org/W4238499005","doi":"https://doi.org/10.1002/ange.201000329"},"language":"en","primary_location":{"id":"doi:10.1002/ange.201000329","doi":"https://doi.org/10.1002/ange.201000329","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201000329","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042963227","display_name":"Min Liu","orcid":"https://orcid.org/0000-0003-2420-2769","observed_orcids":["https://orcid.org/0000-0003-2420-2769"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I4210121771","display_name":"First Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/02tbvhh96","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210121771"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Min Liu","raw_affiliation_strings":["Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine (China)","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"The First Affiliated Hospital, Xi'an Jiaotong University School of Medicine (China)","institution_ids":["https://openalex.org/I4210121771","https://openalex.org/I87445476"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043383923","display_name":"Marzena Pazgier","orcid":"https://orcid.org/0000-0003-0594-5057","observed_orcids":["https://orcid.org/0000-0003-0594-5057"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marzena Pazgier","raw_affiliation_strings":["Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108051172","display_name":"Changqing Li","orcid":"https://orcid.org/0000-0002-4254-7974","observed_orcids":["https://orcid.org/0000-0002-4254-7974"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Changqing Li","raw_affiliation_strings":["Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102300462","display_name":"Weirong Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Weirong Yuan","raw_affiliation_strings":["Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","institution_ids":["https://openalex.org/I126744593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100424938","display_name":"Chong Li","orcid":"https://orcid.org/0009-0000-3015-181X","observed_orcids":["https://orcid.org/0009-0000-3015-181X"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chong Li","raw_affiliation_strings":["Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","These authors contributed equally to this work"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","institution_ids":["https://openalex.org/I126744593"]},{"raw_affiliation_string":"These authors contributed equally to this work","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068243367","display_name":"Wuyuan Lu","orcid":"https://orcid.org/0000-0003-1318-9968","observed_orcids":["https://orcid.org/0000-0003-1318-9968"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wuyuan Lu","raw_affiliation_strings":["Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Human Virology, University of Maryland School of Medicine, 725 W. Lombard St., Baltimore, MD 21201 (USA)","institution_ids":["https://openalex.org/I126744593"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5790,"currency":"USD","value_usd":5790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"122","issue":"21","first_page":"3731","last_page":"3734"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6621000170707703,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.3303000032901764,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-mdm2-interaction","display_name":"p53-MDM2 interaction","score":0.8709999918937683},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.800000011920929},{"id":"https://openalex.org/keywords/p53-activation","display_name":"p53 activation","score":0.7480000257492065},{"id":"https://openalex.org/keywords/peptide-inhibitors","display_name":"peptide inhibitors","score":0.5419999957084656},{"id":"https://openalex.org/keywords/phage-display","display_name":"phage display","score":0.8550000190734863},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.6430000066757202},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6322812438011169},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5991510152816772},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5823901295661926},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.4894970655441284},{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.43256402015686035},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.17352277040481567},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.12117356061935425},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/ange.201000329","doi":"https://doi.org/10.1002/ange.201000329","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ange.201000329","pdf_url":null,"source":{"id":"https://openalex.org/S4210200754","display_name":"Angewandte Chemie","issn_l":"0044-8249","issn":["0044-8249","0932-2140","1521-3757"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1976261939","https://openalex.org/W1992947288","https://openalex.org/W1999253307","https://openalex.org/W2008845432","https://openalex.org/W2025476423","https://openalex.org/W2025686590","https://openalex.org/W2040576705","https://openalex.org/W2058947924","https://openalex.org/W2076060796","https://openalex.org/W2079945282","https://openalex.org/W2081184407","https://openalex.org/W2084156461","https://openalex.org/W2084374650","https://openalex.org/W2085948054","https://openalex.org/W2087682857","https://openalex.org/W2090696823","https://openalex.org/W2093775600","https://openalex.org/W2096950500","https://openalex.org/W2097933346","https://openalex.org/W2100589388","https://openalex.org/W2104017463","https://openalex.org/W2136646067","https://openalex.org/W2141224144","https://openalex.org/W2146837416","https://openalex.org/W2151785803","https://openalex.org/W2165337291","https://openalex.org/W2167398093","https://openalex.org/W4213262935","https://openalex.org/W4252881819","https://openalex.org/W4253743937"],"related_works":["https://openalex.org/W2120620959","https://openalex.org/W3193032301","https://openalex.org/W2108649505","https://openalex.org/W2100589388","https://openalex.org/W2321730050","https://openalex.org/W2044477380","https://openalex.org/W2076060796","https://openalex.org/W4253743937","https://openalex.org/W2321016560","https://openalex.org/W2581896988"],"abstract_inverted_index":{"Linker":[0],"Schwinger":[1],"f\u00fcr":[2,30],"Tumore:":[3],"Das":[4],"Onkoprotein":[5],"MDM2,":[6],"das":[7],"die":[8],"Aktivit\u00e4t":[9],"und":[10,38],"Stabilit\u00e4t":[11],"des":[12],"Tumorsuppressor-Proteins":[13],"p53":[14],"verringert,":[15],"ist":[16],"ein":[17],"wichtiges":[18],"Zielmolek\u00fcl":[19],"bei":[20],"der":[21,34],"Krebstherapie.":[22],"Ein":[23],"spiegelbildliches":[24],"Phagendisplay":[25],"identifizierte":[26],"einen":[27,36],"hochaffinen":[28],"D-Peptid-Ligand":[29],"MDM2":[31],"(siehe":[32],"Struktur),":[33],"in":[35],"wirksamen":[37],"proteasebest\u00e4ndigen":[39],"p53-Aktivator":[40],"mit":[41],"potenzieller":[42],"Antitumoraktivit\u00e4t":[43],"weiterentwickelt":[44],"wurde.":[45]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2022-05-12T00:00:00"}
