{"id":"https://openalex.org/W4237565484","doi":"https://doi.org/10.1016/j.jalz.2014.04.454","title":"O4\u201012\u201004: DETECTING COGNITIVE PROFILES IN THE BIOMARKER STAGES OF PRECLINICAL AD","display_name":"O4\u201012\u201004: DETECTING COGNITIVE PROFILES IN THE BIOMARKER STAGES OF PRECLINICAL AD","publication_year":2014,"publication_date":"2014-07-01","ids":{"openalex":"https://openalex.org/W4237565484","doi":"https://doi.org/10.1016/j.jalz.2014.04.454"},"language":"en","primary_location":{"id":"doi:10.1016/j.jalz.2014.04.454","doi":"https://doi.org/10.1016/j.jalz.2014.04.454","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.04.454","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076768887","display_name":"Dorene M. Rentz","orcid":"https://orcid.org/0000-0002-6318-9213","observed_orcids":["https://orcid.org/0000-0002-6318-9213"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dorene M. Rentz","raw_affiliation_strings":["Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070766714","display_name":"Kathryn V. Papp","orcid":"https://orcid.org/0000-0003-1687-4370","observed_orcids":["https://orcid.org/0000-0003-1687-4370"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kate V. Papp","raw_affiliation_strings":["Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078734759","display_name":"Elizabeth C. Mormino","orcid":"https://orcid.org/0000-0002-4542-6537","observed_orcids":["https://orcid.org/0000-0002-4542-6537","https://orcid.org/0009-0003-3321-8081"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elizabeth V. Mormino","raw_affiliation_strings":["Massachusetts General Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084568106","display_name":"Rebecca England Amariglio","orcid":"https://orcid.org/0009-0009-5878-8930","observed_orcids":["https://orcid.org/0009-0009-5878-8930"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca V. Amariglio","raw_affiliation_strings":["Brigham and Women's Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women's Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010168107","display_name":"John Alex Becker","orcid":"https://orcid.org/0000-0001-7435-1338","observed_orcids":["https://orcid.org/0000-0001-7435-1338"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John Alex Becker","raw_affiliation_strings":["Massachusetts General Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005435770","display_name":"Aaron P. Schultz","orcid":"https://orcid.org/0000-0002-0418-0999","observed_orcids":["https://orcid.org/0000-0002-0418-0999"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron P. Schultz","raw_affiliation_strings":["Massachusetts General Hospital, Charlestown, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Charlestown, Massachusetts, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090842068","display_name":"Keith A. Johnson","orcid":"https://orcid.org/0000-0002-5916-6043","observed_orcids":["https://orcid.org/0000-0002-5916-6043","https://orcid.org/0000-0002-3577-8299"]},"institutions":[{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith A. Johnson","raw_affiliation_strings":["Massachusetts General Hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Massachusetts General Hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001795846","display_name":"Reisa Anne Sperling","orcid":"https://orcid.org/0000-0003-1535-6133","observed_orcids":["https://orcid.org/0000-0003-1535-6133"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reisa A. Sperling","raw_affiliation_strings":["Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Alzheimer Research and Treatment, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076768887"],"corresponding_institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.47134636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"10","issue":"4S_Part_5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/preclinical-alzheimer-s-disease","display_name":"preclinical Alzheimer's disease","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cognitive-profile","display_name":"cognitive profile","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.7295602560043335},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.7127898931503296},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.516558051109314},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5066226124763489},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5025830268859863},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.5002412796020508},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4961443841457367},{"id":"https://openalex.org/C2779951007","wikidata":"https://www.wikidata.org/wiki/Q816798","display_name":"Amyloidosis","level":2,"score":0.4851115942001343},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.42953288555145264},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4254711866378784},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.42273736000061035},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41478797793388367},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.38945651054382324},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.36546775698661804},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.29604053497314453},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12944850325584412},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.12858086824417114},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.12735381722450256},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10644352436065674},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jalz.2014.04.454","doi":"https://doi.org/10.1016/j.jalz.2014.04.454","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jalz.2014.04.454","pdf_url":null,"source":{"id":"https://openalex.org/S108427512","display_name":"Alzheimer s & Dementia","issn_l":"1552-5260","issn":["1552-5260","1552-5279"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-3","ki-jl-3","medline","norway-1","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Alzheimer's &amp; Dementia","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2097152254","https://openalex.org/W2536921748","https://openalex.org/W2107064099","https://openalex.org/W1977054568","https://openalex.org/W2896432629","https://openalex.org/W2534804818","https://openalex.org/W2085722939","https://openalex.org/W1973526765","https://openalex.org/W4243315010","https://openalex.org/W1625746524"],"abstract_inverted_index":{"A":[0,155,275],"subset":[1],"of":[2,10,35,187,343],"clinically":[3],"normal":[4],"(CN)":[5],"individuals":[6],"has":[7],"biomarker":[8,22,40,315],"evidence":[9],"amyloidosis":[11,45,49,344],"and/or":[12],"neurodegeneration.":[13],"Whether":[14],"subtle":[15,308],"cognitive":[16,33,167,309],"changes":[17,310],"are":[18,311],"associated":[19,312,323,334],"with":[20,92,313,324,335],"these":[21],"stages":[23,316],"remains":[24],"to":[25,29,283],"be":[26],"elucidated.":[27],"Wesought":[28],"determine":[30],"if":[31],"baseline":[32],"profiles":[34],"CN":[36,59,318],"subjects":[37,42,60],"differ":[38],"between":[39,170],"negative":[41],"(Stage":[43,47,52],"0);":[44],"alone":[46,56],"1);":[48],"plus":[50],"neurodegeneration":[51,55,346],"2)":[53],"and":[54,82,84,106,146,163,193,220,241,250,264,268,277,288,301,330,345,354],"(SNAP).":[57],"158":[58],"(CDR=0,":[61],"MMSE":[62],">25;":[63],"LMIIa":[64],">7)":[65],"enrolled":[66],"in":[67,317,348,352],"the":[68,202,239],"Harvard":[69],"Aging":[70],"Brain":[71],"Study":[72],"underwent":[73],"neuropsychological":[74],"testing,":[75],"APOE":[76],"genotyping,":[77],"positron":[78],"emission":[79],"tomography":[80],"(PiB-PET":[81],"FDG-PET)":[83],"magnetic":[85],"resonance":[86],"imaging.":[87],"Amyloid":[88],"status":[89,165],"was":[90,95],"determined":[91],"PiB-PET.":[93],"Neurodegeneration":[94],"measured":[96],"using":[97],"two":[98],"a":[99],"priori":[100],"imaging":[101],"markers:":[102],"MRI":[103],"hippocampal":[104],"volume":[105],"FDG-PET":[107],"metabolism":[108],"extracted":[109],"from":[110],"AD-vulnerable":[111],"regions.":[112],"Subjects":[113],"were":[114],"classified":[115],"into":[116],"4":[117],"groups:":[118],"Stage":[119,128,137,176,182,224,230,253,284],"0":[120,183,231,285],"(n=76,":[121],"mean":[122,131,140,149],"age=71.0":[123],"\u00b1":[124,133,142,151],"4.8;":[125],"14.5%":[126],"APOE4);":[127,136],"1":[129,177,254],"(n=20,":[130],"age=73.8":[132],"5.3;":[134],"50.0%":[135],"2":[138,197,225],"(n=26,":[139],"age=76.5":[141],"6.3;":[143],"42.9%":[144],"APOE4)":[145],"SNAP":[147,280],"(n=36,":[148],"age=76.9":[150],"6.2;":[152],"12.9%":[153],"APOE4).":[154],"Multivariate":[156],"General":[157],"Linear":[158],"Model":[159],"controlling":[160],"for":[161,189],"age":[162],"APOE4":[164],"explored":[166],"test":[168],"performances":[169],"groups.":[171],"Pairwise":[172],"comparisons":[173],"revealed":[174],"that":[175,307],"performed":[178,226,281],"significantly":[179,227],"worse":[180,228,251,293],"than":[181,229,252,339],"on":[184,201,232,255,286,294,326],"challenging":[185,256,289,328],"tests":[186,236,271,291,296],"memory":[188,212,235,257,290,329,353],"names":[190],"(FNAME":[191,195],"p=0.042)":[192],"occupations":[194],"p=0.033),":[196],"nd":[198],"list":[199],"learning":[200],"Memory":[203],"Capacity":[204],"Test":[205,245],"(MCT":[206,258],"DR,":[207],"p=0.017),":[208],"executive":[209,269,295,331,337,355],"function":[210,270],"(working":[211],"WM,":[213],"p=0.016;":[214],"Letter":[215],"Number":[216],"Sequencing":[217],"LNSq,":[218],"p=0.027)":[219],"naming":[221],"(BNT":[222],"p=0.026).":[223],"more":[233,336,349],"standard":[234,287],"such":[237],"as":[238],"Free":[240],"Cued":[242],"Selective":[243],"Reminding":[244],"(FRsrt":[246],"p=0.015;":[247],"FCsrt":[248],"p=0.010)":[249],"IR":[259],"p=0.029,":[260],"MCT":[261,265],"DR":[262],"p=0.009":[263],"CR":[266],"p=0.002)":[267],"(LNSq":[272],"p=0.001,":[273],"Trails":[274],"p=0.034":[276],"WM":[278,299],"p=0.042).":[279],"similar":[282],"but":[292],"(fluency,":[297],"p=0.031,":[298],"p=0.012,":[300],"LNSq":[302],"p=0.030).":[303],"These":[304],"findings":[305],"suggest":[306],"different":[314],"older":[319],"adults.":[320],"Amyloidosis":[321],"is":[322,333],"impairment":[325],"both":[327],"tests.Neurodegeneration":[332],"dysfunction":[338],"memory.":[340],"The":[341],"combination":[342],"results":[347],"significant":[350],"decline":[351],"performance.":[356]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
