{"id":"https://openalex.org/W4237096071","doi":"https://doi.org/10.1134/s1990750821020116","title":"Molecular Mechanisms of the Cardiotoxic Action of Anthracycline Antibiotics and Statin-Induced Cytoprotective Reactions of Cardiomyocytes","display_name":"Molecular Mechanisms of the Cardiotoxic Action of Anthracycline Antibiotics and Statin-Induced Cytoprotective Reactions of Cardiomyocytes","publication_year":2021,"publication_date":"2021-04-01","ids":{"openalex":"https://openalex.org/W4237096071","doi":"https://doi.org/10.1134/s1990750821020116"},"language":"en","primary_location":{"id":"doi:10.1134/s1990750821020116","doi":"https://doi.org/10.1134/s1990750821020116","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1990750821020116","pdf_url":null,"source":{"id":"https://openalex.org/S4210194599","display_name":"Biochemistry (Moscow) Supplement Series B Biomedical Chemistry","issn_l":"1990-7508","issn":["1990-7508","1990-7516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111355924","display_name":"\u0422\u0443\u0440\u0441\u0443\u043d\u043e\u0432\u0430 \u041d\u0430\u0442\u0430\u043b\u044c\u044f \u0412\u043b\u0430\u0434\u0438\u043c\u0438\u0440\u043e\u0432\u043d\u0430","orcid":"https://orcid.org/0009-0003-7796-6292","observed_orcids":["https://orcid.org/0009-0003-7796-6292"]},"institutions":[{"id":"https://openalex.org/I4210128002","display_name":"Institute of Molecular Pathology and Pathomorphology","ror":"https://ror.org/02trrjx85","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210128002"]},{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"N. V. Tursunova","raw_affiliation_strings":["Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, ul. Timakova 2, 630117, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, ul. Timakova 2, 630117, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005986779","display_name":"\u041a\u043b\u0438\u043d\u043d\u0438\u043a\u043e\u0432\u0430 \u041c\u0430\u0440\u0438\u043d\u0430 \u0413\u0435\u043d\u043d\u0430\u0434\u044c\u0435\u0432\u043d\u0430","orcid":"https://orcid.org/0009-0008-5508-0411","observed_orcids":["https://orcid.org/0009-0008-5508-0411","https://orcid.org/0000-0001-9909-5027"]},"institutions":[{"id":"https://openalex.org/I4210128002","display_name":"Institute of Molecular Pathology and Pathomorphology","ror":"https://ror.org/02trrjx85","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210128002"]},{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"M. G. Klinnikova","raw_affiliation_strings":["Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, ul. Timakova 2, 630117, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, ul. Timakova 2, 630117, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029643162","display_name":"O. A. Babenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128002","display_name":"Institute of Molecular Pathology and Pathomorphology","ror":"https://ror.org/02trrjx85","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210128002"]},{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"O. A. Babenko","raw_affiliation_strings":["Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, ul. Timakova 2, 630117, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, ul. Timakova 2, 630117, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087166684","display_name":"Elena L. Lushnikova","orcid":"https://orcid.org/0000-0002-3269-2465","observed_orcids":["https://orcid.org/0000-0002-3269-2465"]},"institutions":[{"id":"https://openalex.org/I4210128002","display_name":"Institute of Molecular Pathology and Pathomorphology","ror":"https://ror.org/02trrjx85","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210128002"]},{"id":"https://openalex.org/I4210134550","display_name":"Federal Research Center of Fundamental and Translational Medicine","ror":"https://ror.org/04545k330","country_code":"RU","type":"facility","lineage":["https://openalex.org/I4210134550"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. L. Lushnikova","raw_affiliation_strings":["Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, ul. Timakova 2, 630117, Novosibirsk, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Pathomorphology, Federal Research Center of Fundamental and Translational Medicine, ul. Timakova 2, 630117, Novosibirsk, Russia","institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111355924"],"corresponding_institution_ids":["https://openalex.org/I4210128002","https://openalex.org/I4210134550"],"apc_list":null,"apc_paid":null,"fwci":0.3494,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.55998478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"15","issue":"2","first_page":"89","last_page":"104"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anthracycline-induced-cardiotoxicity","display_name":"anthracycline cardiotoxicity","score":0.9990000128746033},{"id":"https://openalex.org/keywords/statins","display_name":"statins","score":0.8059999942779541},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.902999997138977},{"id":"https://openalex.org/keywords/doxorubicin","display_name":"doxorubicin","score":0.8479999899864197},{"id":"https://openalex.org/keywords/free-radicals","display_name":"free radicals","score":0.6460000276565552},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mevalonate-pathway","display_name":"mevalonate pathway","score":0.7519999742507935},{"id":"https://openalex.org/keywords/topoisomerase-ii-inhibition","display_name":"topoisomerase II inhibition","score":0.7950000166893005},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7310000061988831},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.7250000238418579},{"id":"https://openalex.org/keywords/synergistic-antitumor-effect","display_name":"synergistic antitumor effect","score":0.6420000195503235},{"id":"https://openalex.org/keywords/chemotherapy-side-effects","display_name":"chemotherapy side effects","score":0.5690000057220459}],"concepts":[{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.7794985771179199},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6725713610649109},{"id":"https://openalex.org/C2776802502","wikidata":"https://www.wikidata.org/wiki/Q417589","display_name":"Anthracycline","level":4,"score":0.5578751564025879},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.5553605556488037},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.5403410196304321},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5210065841674805},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.519679844379425},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.3066152334213257},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16394495964050293},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.10035675764083862},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s1990750821020116","doi":"https://doi.org/10.1134/s1990750821020116","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1990750821020116","pdf_url":null,"source":{"id":"https://openalex.org/S4210194599","display_name":"Biochemistry (Moscow) Supplement Series B Biomedical Chemistry","issn_l":"1990-7508","issn":["1990-7508","1990-7516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":90,"referenced_works":["https://openalex.org/W161377529","https://openalex.org/W1072651658","https://openalex.org/W1120544291","https://openalex.org/W1915620309","https://openalex.org/W1930501916","https://openalex.org/W1951308530","https://openalex.org/W1963621262","https://openalex.org/W1964088193","https://openalex.org/W1966861594","https://openalex.org/W1969144125","https://openalex.org/W1973814322","https://openalex.org/W1978983696","https://openalex.org/W1982778125","https://openalex.org/W1983822030","https://openalex.org/W1991516806","https://openalex.org/W1991583073","https://openalex.org/W1998140849","https://openalex.org/W1999854541","https://openalex.org/W2008886404","https://openalex.org/W2011710975","https://openalex.org/W2013429872","https://openalex.org/W2015615030","https://openalex.org/W2016636623","https://openalex.org/W2028044362","https://openalex.org/W2031311519","https://openalex.org/W2039920784","https://openalex.org/W2044590638","https://openalex.org/W2049727461","https://openalex.org/W2051357882","https://openalex.org/W2052637997","https://openalex.org/W2064488040","https://openalex.org/W2070832781","https://openalex.org/W2080009224","https://openalex.org/W2084304742","https://openalex.org/W2086469250","https://openalex.org/W2088491250","https://openalex.org/W2096211999","https://openalex.org/W2098886952","https://openalex.org/W2112300595","https://openalex.org/W2120087347","https://openalex.org/W2125304966","https://openalex.org/W2125683592","https://openalex.org/W2132001873","https://openalex.org/W2132973959","https://openalex.org/W2133584350","https://openalex.org/W2134242032","https://openalex.org/W2134599751","https://openalex.org/W2136507649","https://openalex.org/W2136727847","https://openalex.org/W2136765652","https://openalex.org/W2142678310","https://openalex.org/W2148580947","https://openalex.org/W2150171020","https://openalex.org/W2151600204","https://openalex.org/W2153709731","https://openalex.org/W2162514244","https://openalex.org/W2165079456","https://openalex.org/W2165752493","https://openalex.org/W2170452186","https://openalex.org/W2212776653","https://openalex.org/W2253116428","https://openalex.org/W2267561229","https://openalex.org/W2285368761","https://openalex.org/W2317946219","https://openalex.org/W2394924032","https://openalex.org/W2396139649","https://openalex.org/W2422664499","https://openalex.org/W2517162981","https://openalex.org/W2524574476","https://openalex.org/W2556923697","https://openalex.org/W2559406810","https://openalex.org/W2570787279","https://openalex.org/W2577541469","https://openalex.org/W2587416719","https://openalex.org/W2604571360","https://openalex.org/W2748821417","https://openalex.org/W2749508920","https://openalex.org/W2765612046","https://openalex.org/W2793794684","https://openalex.org/W2802804112","https://openalex.org/W2803569339","https://openalex.org/W2885488580","https://openalex.org/W2935851573","https://openalex.org/W2953817630","https://openalex.org/W2966756181","https://openalex.org/W2992641315","https://openalex.org/W3005801915","https://openalex.org/W3007790435","https://openalex.org/W4249338315","https://openalex.org/W4290114218"],"related_works":["https://openalex.org/W4395004229","https://openalex.org/W2577541469","https://openalex.org/W4400608662","https://openalex.org/W1978983696","https://openalex.org/W2026652277","https://openalex.org/W982330761","https://openalex.org/W166021776","https://openalex.org/W2736135258","https://openalex.org/W2033538830","https://openalex.org/W2999269162"],"abstract_inverted_index":{"Abstract\u2014":[0],"Cardiotoxicity,":[1],"a":[2],"well-recognized":[3],"side":[4,238],"effect":[5,34,166,281],"of":[6,15,27,35,61,68,85,104,116,131,133,137,148,151,167,175,197,200,204,214,231,241,263,276,282],"anthracycline":[7,55,299,333],"antibiotics":[8,300],"limits":[9],"their":[10,125,142,179,254,284],"use":[11,60,98,230,331],"in":[12,18,57,64,189,259,269,311,332],"the":[13,24,28,32,59,65,81,86,134,146,152,162,170,190,195,201,205,215,221,229,251,279,288,296,323,330],"treatment":[14,67,291],"malignant":[16],"processes":[17],"some":[19,312,317],"patients.":[20],"The":[21,128,165],"review":[22,191],"considers":[23],"main":[25,129],"causes":[26],"cardiomyocyte":[29],"susceptibility":[30],"to":[31,50,53,79,97,100,144,194,286,290],"damaging":[33],"anthracyclines,":[36],"primarily":[37],"associated":[38],"with":[39,261,292],"increased":[40,242],"free":[41],"radical":[42],"processes.":[43],"Currently,":[44],"research":[45,268],"is":[46,95,141,192,272,303],"widely":[47],"carried":[48],"out":[49],"find":[51],"ways":[52],"reduce":[54,101],"cardiotoxicity,":[56],"particular,":[58],"cardioprotective":[62,126],"agents":[63],"complex":[66],"tumors.":[69],"Hydroxymethylglutaryl":[70],"coenzyme":[71],"A":[72],"reductase":[73],"inhibitors":[74],"(statins)":[75],"have":[76],"been":[77],"shown":[78],"improve":[80],"function":[82],"and":[83,110,120,139,156,172,184,245,301,327],"metabolism":[84],"cardiovascular":[87],"system":[88],"under":[89],"various":[90],"pathological":[91],"conditions,":[92],"therefore,":[93],"it":[94,224],"proposed":[96],"statins":[99,140,157,168,232,302,320],"cardiotoxic":[102,216],"complications":[103],"chemotherapy.":[105,219],"Statins":[106],"exhibit":[107],"direct":[108],"(hypolipidemic)":[109],"pleiotropic":[111],"effects":[112,160],"determined":[113],"by":[114,236,307,314],"inhibition":[115,199],"mevalonic":[117],"acid":[118],"synthesis":[119],"downstream":[121],"biochemical":[122],"cascades":[123],"mediating":[124],"properties.":[127],"point":[130],"intersection":[132],"pharmacological":[135],"activity":[136],"anthracyclines":[138,155],"ability":[143,285],"regulate":[145],"functioning":[147],"small":[149],"GTPases":[150],"Rho":[153,163,176],"family:":[154],"cause":[158],"opposite":[159],"on":[161,169,278],"proteins.":[164],"modification":[171],"membrane":[173],"dislocation":[174],"proteins":[177],"mediates":[178],"indirect":[180],"antioxidant,":[181],"anti-inflammatory,":[182],"endothelioprotective,":[183],"antiapoptotic":[185],"effects.":[186],"Special":[187],"attention":[188],"paid":[193],"mechanism":[196],"statin":[198],"doxorubicin":[202],"blockade":[203],"DNA-topoisomerase":[206],"complex,":[207],"which":[208,248],"may":[209],"be":[210,226,234],"important":[211],"for":[212,253,329],"prevention":[213],"damage":[217],"during":[218],"At":[220],"same":[222],"time,":[223],"should":[225],"noted":[227],"that":[228,295],"can":[233],"accompanied":[235],"adverse":[237,318],"effects:":[239],"provocation":[240],"insulin":[243],"resistance":[244],"glucose":[246],"tolerance,":[247],"often":[249],"becomes":[250],"reason":[252],"elimination":[255],"from":[256],"therapeutic":[257],"schemes":[258],"patients":[260],"disorders":[262],"carbohydrate":[264],"metabolism,":[265],"so":[266],"further":[267],"this":[270],"direction":[271],"clearly":[273],"needed.":[274],"Analysis":[275],"data":[277],"antitumor":[280],"statins,":[283],"sensitize":[287],"tumor":[289],"cytostatics":[293],"showed":[294],"relationship":[297],"between":[298],"characterized":[304],"not":[305],"only":[306],"antagonism,":[308],"but":[309],"also":[310],"cases":[313],"synergism.":[315],"Despite":[316],"effects,":[319],"are":[321],"among":[322],"most":[324],"promising":[325],"cardio-":[326],"vasoprotectors":[328],"cardiomyopathy.":[334]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-05-12T00:00:00"}