{"id":"https://openalex.org/W4236849067","doi":"https://doi.org/10.4061/2010/941419","title":"Sclerostin","display_name":"Sclerostin","publication_year":2010,"publication_date":"2010-01-01","ids":{"openalex":"https://openalex.org/W4236849067","doi":"https://doi.org/10.4061/2010/941419","pmid":"https://pubmed.ncbi.nlm.nih.gov/20981340","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2957275"},"language":"en","primary_location":{"id":"doi:10.4061/2010/941419","doi":"https://doi.org/10.4061/2010/941419","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2010/941419","pdf_url":"https://downloads.hindawi.com/journals/jos/2010/941419.pdf","source":{"id":"https://openalex.org/S150424892","display_name":"Journal of Osteoporosis","issn_l":"2042-0064","issn":["2042-0064","2090-8059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Osteoporosis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/jos/2010/941419.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064911759","display_name":"Stuart L. Silverman","orcid":"https://orcid.org/0000-0002-5313-1018","observed_orcids":["https://orcid.org/0000-0002-5313-1018"]},"institutions":[{"id":"https://openalex.org/I1282927834","display_name":"Cedars-Sinai Medical Center","ror":"https://ror.org/02pammg90","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1282927834"]},{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stuart L. Silverman","raw_affiliation_strings":["Cedars-Sinai, UCLA, OMC Clinical Research Center, 8641 Wilshire Boulevard, Suite 301, Beverly Hills, CA 90211, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cedars-Sinai, UCLA, OMC Clinical Research Center, 8641 Wilshire Boulevard, Suite 301, Beverly Hills, CA 90211, USA","institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064911759"],"corresponding_institution_ids":["https://openalex.org/I1282927834","https://openalex.org/I161318765"],"apc_list":{"value":1000,"currency":"USD","value_usd":1000},"apc_paid":{"value":1000,"currency":"USD","value_usd":1000},"fwci":0.6912,"has_fulltext":true,"cited_by_count":30,"citation_normalized_percentile":{"value":0.77223736,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2010","issue":null,"first_page":"1","last_page":"3"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.9829000234603882,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sclerostin","display_name":"sclerostin","score":1.0},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8339999914169312},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8560000061988831},{"id":"https://openalex.org/keywords/parathyroid-hormone","display_name":"parathyroid hormone","score":0.8640000224113464},{"id":"https://openalex.org/keywords/bone-formation","display_name":"bone formation","score":0.5630000233650208}],"concepts":[{"id":"https://openalex.org/C2779277721","wikidata":"https://www.wikidata.org/wiki/Q14887295","display_name":"Sclerostin","level":4,"score":0.9879688620567322},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8295029401779175},{"id":"https://openalex.org/C2781208988","wikidata":"https://www.wikidata.org/wiki/Q202476","display_name":"Parathyroid hormone","level":3,"score":0.6313248872756958},{"id":"https://openalex.org/C1008401","wikidata":"https://www.wikidata.org/wiki/Q184681","display_name":"Anabolism","level":2,"score":0.6246242523193359},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.5560539960861206},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48040297627449036},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.43264877796173096},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.42224496603012085},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.411364883184433},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2556535005569458},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16718971729278564},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.0940563976764679},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.08275318145751953},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06504574418067932},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.06464526057243347},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.06337133049964905}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.4061/2010/941419","doi":"https://doi.org/10.4061/2010/941419","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2010/941419","pdf_url":"https://downloads.hindawi.com/journals/jos/2010/941419.pdf","source":{"id":"https://openalex.org/S150424892","display_name":"Journal of Osteoporosis","issn_l":"2042-0064","issn":["2042-0064","2090-8059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Osteoporosis","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2957275","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2957275","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Osteoporos","raw_type":"Text"},{"id":"pmid:20981340","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20981340","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of osteoporosis","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.350.9046","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.350.9046","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/55/b9/J_Osteoporos_2010_Sep_29_2010_941419.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:24771db1ad0f407c84ff02e6d38c1e4c","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/24771db1ad0f407c84ff02e6d38c1e4c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Osteoporosis, Vol 2010 (2010)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.4061/2010/941419","doi":"https://doi.org/10.4061/2010/941419","is_oa":true,"landing_page_url":"https://doi.org/10.4061/2010/941419","pdf_url":"https://downloads.hindawi.com/journals/jos/2010/941419.pdf","source":{"id":"https://openalex.org/S150424892","display_name":"Journal of Osteoporosis","issn_l":"2042-0064","issn":["2042-0064","2090-8059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Osteoporosis","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4236849067.pdf","grobid_xml":"https://content.openalex.org/works/W4236849067.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1983220846","https://openalex.org/W2029361003","https://openalex.org/W2043991983","https://openalex.org/W2060336303","https://openalex.org/W2068916684","https://openalex.org/W2075220924","https://openalex.org/W2104119774","https://openalex.org/W2113263838","https://openalex.org/W2119934014","https://openalex.org/W2159374159","https://openalex.org/W3188170180","https://openalex.org/W4237458227"],"related_works":["https://openalex.org/W7097280714","https://openalex.org/W2036193886","https://openalex.org/W3188170180","https://openalex.org/W2753905927","https://openalex.org/W4299560020","https://openalex.org/W2792452334","https://openalex.org/W2090988863","https://openalex.org/W6885099961","https://openalex.org/W7100531063","https://openalex.org/W2533066994"],"abstract_inverted_index":{"The":[0],"striking":[1],"clinical":[2],"benefits":[3],"of":[4,15,31],"intermittent":[5],"parathyroid":[6],"hormone":[7],"in":[8],"osteoporosis":[9],"have":[10],"begun":[11],"a":[12,28],"new":[13,21],"era":[14],"skeletal":[16],"anabolic":[17],"agents.":[18],"One":[19],"potential":[20],"agent":[22],"is":[23],"monoclonal":[24],"antibody":[25],"to":[26],"sclerostin,":[27],"potent":[29],"inhibitor":[30],"osteoblastogenesis.":[32]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}