{"id":"https://openalex.org/W4236779668","doi":"https://doi.org/10.1089/hum.2019.118","title":"Effects of inhibition of miR-155-5p in neural stem cell subarachnoid transplant on rats with cerebral infarction","display_name":"Effects of inhibition of miR-155-5p in neural stem cell subarachnoid transplant on rats with cerebral infarction","publication_year":2019,"publication_date":"2019-10-04","ids":{"openalex":"https://openalex.org/W4236779668","doi":"https://doi.org/10.1089/hum.2019.118"},"language":"en","primary_location":{"id":"doi:10.1089/hum.2019.118","doi":"https://doi.org/10.1089/hum.2019.118","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2019.118","pdf_url":null,"source":{"id":"https://openalex.org/S2495496942","display_name":"Human Gene Therapy Methods","issn_l":"1946-6536","issn":["1946-6536","1946-6544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy Methods","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039561937","display_name":"Dong Wang","orcid":"https://orcid.org/0000-0002-5245-3074","observed_orcids":["https://orcid.org/0000-0002-5245-3074"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Wang","raw_affiliation_strings":["Second Hospital of Hebei Medical University, 71213, the Second Hospital of Hebei Medical University, Shijiazhuang, China, 050000;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Hospital of Hebei Medical University, 71213, the Second Hospital of Hebei Medical University, Shijiazhuang, China, 050000;","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100456473","display_name":"Liang Wang","orcid":"https://orcid.org/0000-0001-6047-5284","observed_orcids":["https://orcid.org/0000-0001-6047-5284"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Wang","raw_affiliation_strings":["Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Bai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Bai","raw_affiliation_strings":["Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052971827","display_name":"Yuanyuan Du","orcid":"https://orcid.org/0000-0002-8293-328X","observed_orcids":["https://orcid.org/0000-0002-8293-328X"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Du","raw_affiliation_strings":["Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048229466","display_name":"Luji Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luji Liu","raw_affiliation_strings":["Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100441917","display_name":"Xiang 'Anthony' Chen","orcid":"https://orcid.org/0000-0002-2499-8261","observed_orcids":["https://orcid.org/0000-0002-2499-8261"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Chen","raw_affiliation_strings":["Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Second Hospital of Hebei Medical University, 71213, Shijiazhuang, Hebei, China;","institution_ids":["https://openalex.org/I4210099373"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210099373"],"apc_list":null,"apc_paid":null,"fwci":0.0792,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.37326478,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5615000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.20900000631809235,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.09030000120401382,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mir-155-5p","display_name":"miR-155-5p","score":0.9940000176429749},{"id":"https://openalex.org/keywords/neural-stem-cell-transplantation","display_name":"neural stem cell transplantation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/cerebral-infarction","display_name":"cerebral infarction","score":0.9769999980926514},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.8610000014305115},{"id":"https://openalex.org/keywords/microrna-inhibition","display_name":"microRNA inhibition","score":0.6919999718666077},{"id":"https://openalex.org/keywords/middle-cerebral-artery-occlusion","display_name":"middle cerebral artery occlusion","score":0.9369999766349792},{"id":"https://openalex.org/keywords/infarct-size","display_name":"infarct size","score":0.8220000267028809},{"id":"https://openalex.org/keywords/neurobehavioral-recovery","display_name":"neurobehavioral recovery","score":0.8659999966621399},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7260000109672546},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.7587250471115112},{"id":"https://openalex.org/C2779450755","wikidata":"https://www.wikidata.org/wiki/Q1209150","display_name":"Cerebral infarction","level":3,"score":0.6161613464355469},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5648266673088074},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5467856526374817},{"id":"https://openalex.org/C2777798775","wikidata":"https://www.wikidata.org/wiki/Q207550","display_name":"Infarction","level":3,"score":0.5324574112892151},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5289167165756226},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4968600571155548},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.4211772382259369},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.403245747089386},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39515241980552673},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3765926957130432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3718402683734894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26661229133605957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.17237666249275208},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.08993765711784363},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.048048317432403564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1089/hum.2019.118","doi":"https://doi.org/10.1089/hum.2019.118","is_oa":false,"landing_page_url":"https://doi.org/10.1089/hum.2019.118","pdf_url":null,"source":{"id":"https://openalex.org/S2495496942","display_name":"Human Gene Therapy Methods","issn_l":"1946-6536","issn":["1946-6536","1946-6544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","poland-70"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Human Gene Therapy Methods","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":19,"referenced_works":["https://openalex.org/W1963719591","https://openalex.org/W1990914057","https://openalex.org/W1994569384","https://openalex.org/W1994687979","https://openalex.org/W1997966386","https://openalex.org/W2001500938","https://openalex.org/W2009389358","https://openalex.org/W2019408622","https://openalex.org/W2027637306","https://openalex.org/W2076677364","https://openalex.org/W2108687101","https://openalex.org/W2114032717","https://openalex.org/W2131872235","https://openalex.org/W2322509087","https://openalex.org/W2529878187","https://openalex.org/W2592268566","https://openalex.org/W2597660577","https://openalex.org/W2807261454","https://openalex.org/W2809390185"],"related_works":["https://openalex.org/W2888975567","https://openalex.org/W2507862591","https://openalex.org/W2594135991","https://openalex.org/W2998734092","https://openalex.org/W643111727","https://openalex.org/W4309504570","https://openalex.org/W7096433546","https://openalex.org/W4408370403","https://openalex.org/W2356738064","https://openalex.org/W2362451198"],"abstract_inverted_index":{"Cerebral":[0],"infarction":[1,28,190],"is":[2,21,62],"a":[3,22],"leading":[4],"cause":[5],"of":[6,16,38,51,60,74,82,106,146,156,166,170,180],"death,":[7],"which":[8],"calls":[9],"for":[10],"effective":[11],"prevention":[12],"and":[13,78,103,121,128,140,151,176],"treatment.":[14],"Transplant":[15,155,169],"neural":[17],"stem":[18,52],"cells":[19],"(NSCs)":[20],"potential":[23],"therapeutic":[24],"treatment":[25],"to":[26,34,46,64],"cerebral":[27,56,87,115,189],"although":[29],"its":[30,143],"efficacy":[31],"still":[32],"needs":[33],"be":[35,65],"improved.":[36],"Overexpression":[37],"Hypoxia-inducible":[39],"factor":[40],"1\u03b1":[41],"(HIF-1\u03b1)":[42],"has":[43],"been":[44],"shown":[45],"enhance":[47],"the":[48,72,80,104,113,122],"protective":[49],"effects":[50,81],"cell":[53,101,149,153],"transplant":[54,85],"on":[55,86],"infarction.":[57,88],"The":[58],"expression":[59,73,92,105],"HIF-1\u03b1":[61,99,139],"predicted":[63],"regulated":[66,71,142],"by":[67,95],"miR-155-5p.":[68],"Therefore,":[69],"we":[70],"miR-155-5p":[75,91,97,136,147,181],"in":[76,93,182,185],"NSCs":[77,94,158,172,183],"evaluated":[79,132],"miR-155-5p-regulated":[83],"NSC":[84,134,192],"We":[89,111],"inhibited":[90,174],"overexpressing":[96],"inhibitor.":[98],"expression,":[100],"viability":[102,150],"apoptosis":[107],"markers":[108],"were":[109,131],"examined.":[110],"established":[112],"middle":[114],"artery":[116],"occlusion":[117],"(MCAO)":[118],"rat":[119],"model,":[120],"infarct":[123,161],"volume,":[124,162],"neurobehavioral":[125,164],"outcomes,":[126],"inflammation":[127,175],"oxidative":[129,177],"stress":[130],"after":[133,191],"transplant.":[135,193],"directly":[137],"targeted":[138],"negatively":[141],"expression.":[144],"Inhibition":[145,179],"enhanced":[148,186],"prevented":[152],"apoptosis.":[154],"miR-155-5p-inhibited":[157,171],"significantly":[159,173],"decreased":[160],"improved":[163],"outcomes":[165],"MCAO":[167],"rats.":[168],"stress.":[178],"resulted":[184],"protection":[187],"against":[188]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}
