{"id":"https://openalex.org/W4236706267","doi":"https://doi.org/10.1002/(sici)1097-4695(200001)42:1<69::aid-neu7>3.3.co;2-r","title":"Genetic effects on an anesthetic\u2010sensitive pathway in the brain of drosophila","display_name":"Genetic effects on an anesthetic\u2010sensitive pathway in the brain of drosophila","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W4236706267","doi":"https://doi.org/10.1002/(sici)1097-4695(200001)42:1<69::aid-neu7>3.3.co;2-r","pmid":"https://pubmed.ncbi.nlm.nih.gov/10623902"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4695(200001)42:1<69::aid-neu7>3.3.co;2-r","doi":"https://doi.org/10.1002/(sici)1097-4695(200001)42:1<69::aid-neu7>3.3.co;2-r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4695(200001)42:1<69::aid-neu7>3.3.co;2-r","pdf_url":null,"source":{"id":"https://openalex.org/S68990794","display_name":"Journal of Neurobiology","issn_l":"0022-3034","issn":["0022-3034","1097-4695"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042398617","display_name":"Asikiya Walcourt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Asikiya Walcourt","raw_affiliation_strings":["Laboratory of Molecular Biology, Building 36, Room 1B08, National Institute of Mental Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Building 36, Room 1B08, National Institute of Mental Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113530452","display_name":"Howard A. Nash","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Howard A. Nash","raw_affiliation_strings":["Laboratory of Molecular Biology, Building 36, Room 1B08, National Institute of Mental Health, Bethesda, Maryland 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Biology, Building 36, Room 1B08, National Institute of Mental Health, Bethesda, Maryland 20892","institution_ids":["https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5113530452"],"corresponding_institution_ids":["https://openalex.org/I4210158500"],"apc_list":null,"apc_paid":null,"fwci":0.9036,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.70369573,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"42","issue":"1","first_page":"69","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12963","display_name":"Anesthesia and Neurotoxicity Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/general-anesthesia","display_name":"general anesthesia","score":0.6940000057220459},{"id":"https://openalex.org/keywords/halothane","display_name":"halothane","score":0.7979999780654907},{"id":"https://openalex.org/keywords/anesthetic-sensitivity","display_name":"anesthetic sensitivity","score":0.8629999756813049},{"id":"https://openalex.org/keywords/escape-behavior","display_name":"escape behavior","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mushroom-body","display_name":"mushroom body","score":0.8679999709129333},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.781000018119812},{"id":"https://openalex.org/keywords/genetic-background","display_name":"genetic background","score":0.6880000233650208},{"id":"https://openalex.org/keywords/anesthetic-targets","display_name":"anesthetic targets","score":0.7480000257492065},{"id":"https://openalex.org/keywords/central-brain","display_name":"central brain","score":0.5130000114440918},{"id":"https://openalex.org/keywords/heterozygotes","display_name":"heterozygotes","score":0.7620000243186951}],"concepts":[{"id":"https://openalex.org/C2778162923","wikidata":"https://www.wikidata.org/wiki/Q4990531","display_name":"Anesthetic","level":2,"score":0.8004834055900574},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6753548979759216},{"id":"https://openalex.org/C153471976","wikidata":"https://www.wikidata.org/wiki/Q2873354","display_name":"Heterozygote advantage","level":4,"score":0.6497272849082947},{"id":"https://openalex.org/C2776932660","wikidata":"https://www.wikidata.org/wiki/Q32921","display_name":"Halothane","level":2,"score":0.6442495584487915},{"id":"https://openalex.org/C2776038537","wikidata":"https://www.wikidata.org/wiki/Q1362803","display_name":"Mushroom bodies","level":4,"score":0.623992383480072},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.6022160053253174},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.5338042378425598},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.43216216564178467},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4242027997970581},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.40119627118110657},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.2400028109550476},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2197069525718689},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1115456223487854}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000033","qualifier_name":"anatomy & histology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004737","descriptor_name":"Enflurane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004924","descriptor_name":"Escape Reaction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004924","descriptor_name":"Escape Reaction","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006221","descriptor_name":"Halothane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D009412","descriptor_name":"Nerve Fibers","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D011930","descriptor_name":"Reaction Time","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018685","descriptor_name":"Anesthetics, Inhalation","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1097-4695(200001)42:1<69::aid-neu7>3.3.co;2-r","doi":"https://doi.org/10.1002/(sici)1097-4695(200001)42:1<69::aid-neu7>3.3.co;2-r","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4695(200001)42:1<69::aid-neu7>3.3.co;2-r","pdf_url":null,"source":{"id":"https://openalex.org/S68990794","display_name":"Journal of Neurobiology","issn_l":"0022-3034","issn":["0022-3034","1097-4695"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurobiology","raw_type":"journal-article"},{"id":"pmid:10623902","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10623902","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurobiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W1495302182","https://openalex.org/W1894754493","https://openalex.org/W1957507185","https://openalex.org/W1967632947","https://openalex.org/W1970915837","https://openalex.org/W1974223005","https://openalex.org/W1977943570","https://openalex.org/W1990257793","https://openalex.org/W1990470989","https://openalex.org/W2006067904","https://openalex.org/W2007732633","https://openalex.org/W2010824071","https://openalex.org/W2012911720","https://openalex.org/W2047423425","https://openalex.org/W2057308478","https://openalex.org/W2064363803","https://openalex.org/W2069905101","https://openalex.org/W2084967156","https://openalex.org/W2086332355","https://openalex.org/W2103197717","https://openalex.org/W2103920482","https://openalex.org/W2111447389","https://openalex.org/W2119507794","https://openalex.org/W2119948064","https://openalex.org/W2120064385","https://openalex.org/W2152230276","https://openalex.org/W2158817948","https://openalex.org/W2162207411","https://openalex.org/W2243837007"],"related_works":["https://openalex.org/W2128156181","https://openalex.org/W2064363803","https://openalex.org/W2058533651","https://openalex.org/W1995966245","https://openalex.org/W1853582264","https://openalex.org/W2010824071","https://openalex.org/W2031571254","https://openalex.org/W2027025589","https://openalex.org/W1831992130","https://openalex.org/W2103920482"],"abstract_inverted_index":{"General":[0],"anesthetics":[1,27,135],"are":[2],"known":[3],"to":[4,26,71,129,132],"inhibit":[5],"the":[6,12,17,36,43,82,88,92,97,115,126,152,159,164,167,188,194,201,217,226,242],"electrically":[7],"induced":[8],"escape":[9,98,127],"response":[10,22,128],"of":[11,35,42,66,77,91,125,148,154,166,177,203,228,244],"fruitfly":[13],"through":[14],"action":[15,109],"within":[16],"brain.":[18,94],"We":[19],"examined":[20],"this":[21,140,233,239],"and":[23,39,151],"its":[24],"sensitivity":[25,55,101,124],"in":[28,46,75,139,187,232],"several":[29],"mutants":[30],"that":[31,53,81,163,183,238],"cause":[32],"significant":[33],"disruption":[34],"mushroom":[37,116],"body":[38,117],"other":[40,134],"structures":[41],"central":[44,93,178],"brain":[45,155,179],"adult":[47],"flies.":[48],"Because":[49],"we":[50,61,211],"show":[51],"here":[52],"anesthesia":[54,171,197],"is":[56,73,85,102,136,172,191,198],"influenced":[57],"by":[58,87,200],"genetic":[59],"background,":[60],"have":[62],"used":[63],"a":[64,104,111,204,247],"set":[65],"congenic":[67],"mutant":[68,160],"lines.":[69],"Sensitivity":[70,131],"halothane":[72,245],"normal":[74],"most":[76],"these":[78],"lines,":[79],"indicating":[80],"anesthetic":[83,100,222],"target":[84,223],"unaffected":[86],"gross":[89,175],"status":[90],"Thus,":[95],"for":[96,193],"response,":[99],"not":[103,173,213],"global":[105],"feature":[106],"but":[107],"reflects":[108],"at":[110],"localized":[112],"target.":[113],"Only":[114],"defect":[118],"(mud)":[119],"line":[120,190],"showed":[121],"an":[122,184,221,229],"increased":[123],"halothane.":[130],"two":[133,207],"also":[137],"perturbed":[138],"line,":[141],"albeit":[142],"less":[143],"dramatically":[144],"so.":[145],"The":[146,181],"behavior":[147,202],"mud/+":[149],"heterozygotes":[150],"comparison":[153],"anatomy":[156],"among":[157],"all":[158],"lines":[161],"imply":[162],"effect":[165],"mud":[168,189,208,218],"mutation":[169,186],"on":[170,196,246],"via":[174],"alteration":[176],"structures.":[180],"possibility":[182],"adventitious":[185],"responsible":[192],"effects":[195,243],"disfavored":[199],"heterozygote":[205],"between":[206],"alleles.":[209],"Although":[210],"do":[212],"yet":[214],"know":[215],"whether":[216],"gene":[219,240],"encodes":[220],"or":[224],"influences":[225],"functioning":[227],"anesthetic-sensitive":[230],"neuron":[231],"pathway,":[234],"our":[235],"work":[236],"indicates":[237],"regulates":[241],"circumscribed":[248],"pathway.":[249]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}
