{"id":"https://openalex.org/W4236565104","doi":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3+<633::aid-cncr8>3.3.co;2-w","title":"Activity of gemcitabine in patients with advanced pancreatic carcinoma: A review","display_name":"Activity of gemcitabine in patients with advanced pancreatic carcinoma: A review","publication_year":1996,"publication_date":"1996-08-01","ids":{"openalex":"https://openalex.org/W4236565104","doi":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3+<633::aid-cncr8>3.3.co;2-w"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-0142(19960801)78:3+<633::aid-cncr8>3.3.co;2-w","doi":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3+<633::aid-cncr8>3.3.co;2-w","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3+<633::aid-cncr8>3.3.co;2-w","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110863459","display_name":"Malcolm A.S. Moore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I2802654988","display_name":"Princess Margaret Cancer Centre","ror":"https://ror.org/03zayce58","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1325899441","https://openalex.org/I2802654988"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Malcolm Moore","raw_affiliation_strings":["Departments of Medicine and Pharmacology, Princess Margaret Hospital, University of Toronto, Toronto, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Pharmacology, Princess Margaret Hospital, University of Toronto, Toronto, Canada","institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5110863459"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I2802654988"],"apc_list":{"value":4790,"currency":"USD","value_usd":4790},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.39467879,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"S3","first_page":"633","last_page":"638"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":1.0},{"id":"https://openalex.org/keywords/advanced-pancreatic-cancer","display_name":"advanced pancreatic cancer","score":0.8539999723434448},{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9879999756813049},{"id":"https://openalex.org/keywords/pain-intensity","display_name":"pain intensity","score":0.7390000224113464},{"id":"https://openalex.org/keywords/analgesic-use","display_name":"analgesic use","score":0.9980000257492065},{"id":"https://openalex.org/keywords/performance-status","display_name":"performance status","score":0.996999979019165},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8429999947547913},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5320000052452087},{"id":"https://openalex.org/keywords/treatment-related-toxicity","display_name":"treatment toxicity","score":0.4320000112056732}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9278797507286072},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.9088973999023438},{"id":"https://openalex.org/C3020076753","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic carcinoma","level":4,"score":0.6317642331123352},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5523977279663086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47835773229599},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.4612950086593628},{"id":"https://openalex.org/C61434518","wikidata":"https://www.wikidata.org/wiki/Q932510","display_name":"General surgery","level":1,"score":0.3418549597263336},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.22525116801261902},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.21665939688682556}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/(sici)1097-0142(19960801)78:3+<633::aid-cncr8>3.3.co;2-w","doi":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3+<633::aid-cncr8>3.3.co;2-w","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-0142(19960801)78:3+<633::aid-cncr8>3.3.co;2-w","pdf_url":null,"source":{"id":"https://openalex.org/S126033908","display_name":"Cancer","issn_l":"0008-543X","issn":["0008-543X","1045-7410","1097-0142"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2418564374","https://openalex.org/W2417351619","https://openalex.org/W2329900300","https://openalex.org/W4389802987","https://openalex.org/W2011195685","https://openalex.org/W2050272257","https://openalex.org/W2036449594","https://openalex.org/W2589673404","https://openalex.org/W2387104737","https://openalex.org/W2415381472"],"abstract_inverted_index":{"BACKGROUND":[0],"In":[1,51],"early":[2],"phase":[3],"II":[4],"trials":[5,92],"in":[6,17,27,87,99,128,162],"advanced":[7,102,129],"pancreatic":[8,103,130,166],"cancer,":[9],"gemcitabine":[10,22,113,161],"demonstrated":[11],"modest":[12],"antitumor":[13],"activity.":[14],"The":[15,106,132],"investigators":[16],"these":[18,109],"studies":[19,110,150],"reported":[20],"that":[21,66,112],"should":[23],"be":[24,82,146,152],"studied":[25],"further":[26],"view":[28],"of":[29,34,40,42,61,108,134,160,165],"the":[30,38,43,46,115,158,163],"degree":[31,133],"and":[32,45,74,84,125],"frequency":[33],"symptomatic":[35,56],"improvement":[36,135],"observed,":[37],"durability":[39],"some":[41],"remissions,":[44],"favorable":[47],"toxicity":[48],"profile.":[49],"METHODS":[50],"order":[52],"to":[53,81,145,154],"quantify":[54],"such":[55],"improvement,":[57],"a":[58],"rigorous":[59],"endpoint":[60],"Clinical":[62],"Benefit":[63],"was":[64],"developed":[65],"incorporated":[67],"measures":[68],"including":[69],"pain":[70],"intensity,":[71],"analgesic":[72],"consumption":[73],"performance":[75],"status,":[76],"which":[77,139],"have":[78,93],"been":[79,94],"shown":[80],"reliable":[83],"valid":[85],"endpoints":[86],"other":[88],"studies.":[89],"RESULTS":[90],"Two":[91],"conducted":[95],"using":[96],"this":[97],"methodology":[98],"patients":[100,140],"with":[101,119,141],"carcinoma.":[104],"CONCLUSIONS":[105],"results":[107],"suggest":[111],"is":[114,137],"first":[116],"cytotoxic":[117],"agent":[118],"any":[120],"meaningful":[121],"impact":[122],"on":[123],"survival":[124],"disease-related":[126],"symptoms":[127],"adenocarcinoma.":[131],"seen":[136],"one":[138],"cancer":[142],"often":[143],"consider":[144],"most":[147],"important.":[148],"Further":[149],"will":[151],"required":[153],"define":[155],"more":[156],"fully":[157],"role":[159],"treatment":[164],"cancer.":[167],"Cancer":[168],"1996;78:633-8.":[169]},"counts_by_year":[],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2022-05-12T00:00:00"}
