{"id":"https://openalex.org/W4236476887","doi":"https://doi.org/10.1213/00000539-199112000-00004","title":"Effects of Adenosine on Myocardial Blood Flow and Metabolism After Coronary Artery Bypass Surgery","display_name":"Effects of Adenosine on Myocardial Blood Flow and Metabolism After Coronary Artery Bypass Surgery","publication_year":1991,"publication_date":"1991-12-01","ids":{"openalex":"https://openalex.org/W4236476887","doi":"https://doi.org/10.1213/00000539-199112000-00004","mag":"2005650513","pmid":"https://pubmed.ncbi.nlm.nih.gov/1952168"},"language":"en","primary_location":{"id":"doi:10.1213/00000539-199112000-00004","doi":"https://doi.org/10.1213/00000539-199112000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199112000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077936870","display_name":"S. Z ll","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S. Z??ll","raw_affiliation_strings":["Accepted for publication July 1, 1991","Department of Anesthesia and Intensive Care, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden","This study was supported by grants from the Swedish Medical Research Council (No. 08682) and was presented in part at the annual meeting of the European Association of Cardiothoracic Anesthesiologists in Uppsala, Sweden, June 1989"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Accepted for publication July 1, 1991","institution_ids":[]},{"raw_affiliation_string":"Department of Anesthesia and Intensive Care, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]},{"raw_affiliation_string":"This study was supported by grants from the Swedish Medical Research Council (No. 08682) and was presented in part at the annual meeting of the European Association of Cardiothoracic Anesthesiologists in Uppsala, Sweden, June 1989","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015102071","display_name":"Italo Milocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"I. Milocco","raw_affiliation_strings":["Department of Anesthesia and Intensive Care, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden","to Dr. Ricksten, Department of Anesthesia and Intensive Care, Sahlgren's Hospital, S-413 45 Gothenburg, Sweden","Accepted for publication July 1, 1991","This study was supported by grants from the Swedish Medical Research Council (No. 08682) and was presented in part at the annual meeting of the European Association of Cardiothoracic Anesthesiologists in Uppsala, Sweden, June 1989"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Intensive Care, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]},{"raw_affiliation_string":"to Dr. Ricksten, Department of Anesthesia and Intensive Care, Sahlgren's Hospital, S-413 45 Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Accepted for publication July 1, 1991","institution_ids":[]},{"raw_affiliation_string":"This study was supported by grants from the Swedish Medical Research Council (No. 08682) and was presented in part at the annual meeting of the European Association of Cardiothoracic Anesthesiologists in Uppsala, Sweden, June 1989","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080244085","display_name":"S-E. Ricksten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"S-E. Ricksten","raw_affiliation_strings":["Department of Anesthesia and Intensive Care, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden","to Dr. Ricksten, Department of Anesthesia and Intensive Care, Sahlgren's Hospital, S-413 45 Gothenburg, Sweden","Accepted for publication July 1, 1991","This study was supported by grants from the Swedish Medical Research Council (No. 08682) and was presented in part at the annual meeting of the European Association of Cardiothoracic Anesthesiologists in Uppsala, Sweden, June 1989"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesia and Intensive Care, Sahlgren's Hospital, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"]},{"raw_affiliation_string":"to Dr. Ricksten, Department of Anesthesia and Intensive Care, Sahlgren's Hospital, S-413 45 Gothenburg, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Accepted for publication July 1, 1991","institution_ids":[]},{"raw_affiliation_string":"This study was supported by grants from the Swedish Medical Research Council (No. 08682) and was presented in part at the annual meeting of the European Association of Cardiothoracic Anesthesiologists in Uppsala, Sweden, June 1989","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5080244085"],"corresponding_institution_ids":["https://openalex.org/I2801112325","https://openalex.org/I881427289"],"apc_list":null,"apc_paid":null,"fwci":1.1492,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.76488786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"73","issue":"6","first_page":"689???695","last_page":"689???695"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.7465999722480774,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.044199999421834946,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine","display_name":"adenosine","score":0.9929999709129333},{"id":"https://openalex.org/keywords/coronary-artery-bypass-grafting","display_name":"coronary artery bypass grafting","score":0.8980000019073486},{"id":"https://openalex.org/keywords/myocardial-blood-flow","display_name":"myocardial blood flow","score":0.9869999885559082},{"id":"https://openalex.org/keywords/myocardial-metabolism","display_name":"myocardial metabolism","score":0.9610000252723694},{"id":"https://openalex.org/keywords/intrapulmonary-shunt","display_name":"intrapulmonary shunt","score":0.8730000257492065},{"id":"https://openalex.org/keywords/coronary-vasodilation","display_name":"coronary vasodilation","score":0.628000020980835},{"id":"https://openalex.org/keywords/pulmonary-vasodilation","display_name":"pulmonary vasodilation","score":0.8040000200271606},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.8180000185966492},{"id":"https://openalex.org/keywords/lactate-extraction","display_name":"lactate extraction","score":0.7039999961853027},{"id":"https://openalex.org/keywords/coronary-sinus-flow","display_name":"coronary sinus blood flow","score":0.6949999928474426},{"id":"https://openalex.org/keywords/st-segment-depression","display_name":"ST-segment depression","score":0.6610000133514404},{"id":"https://openalex.org/keywords/postoperative-hemodynamics","display_name":"postoperative hemodynamics","score":0.6579999923706055}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8994349241256714},{"id":"https://openalex.org/C2778259205","wikidata":"https://www.wikidata.org/wiki/Q629460","display_name":"Coronary sinus","level":2,"score":0.6789928674697876},{"id":"https://openalex.org/C31861589","wikidata":"https://www.wikidata.org/wiki/Q618068","display_name":"Cardiac index","level":4,"score":0.6399795413017273},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.6382623314857483},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6021130084991455},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5845338106155396},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.5567794442176819},{"id":"https://openalex.org/C139940330","wikidata":"https://www.wikidata.org/wiki/Q596579","display_name":"Cardiac output","level":3,"score":0.5417646765708923},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5119336843490601},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.47635841369628906},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.45400571823120117},{"id":"https://openalex.org/C78085059","wikidata":"https://www.wikidata.org/wiki/Q641303","display_name":"Ejection fraction","level":3,"score":0.44022437930107117},{"id":"https://openalex.org/C80461066","wikidata":"https://www.wikidata.org/wiki/Q1698533","display_name":"Stroke volume","level":4,"score":0.43154698610305786},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4292443096637726},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.21655437350273132}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001026","descriptor_name":"Coronary Artery Bypass","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003326","descriptor_name":"Coronary Circulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003327","descriptor_name":"Coronary Disease","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1213/00000539-199112000-00004","doi":"https://doi.org/10.1213/00000539-199112000-00004","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-199112000-00004","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:1952168","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1952168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Journal Article"},{"id":"mag:2005650513","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/1952168","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2284652565","https://openalex.org/W2031828501","https://openalex.org/W4301207226","https://openalex.org/W4244646909","https://openalex.org/W2046619690","https://openalex.org/W2315562592","https://openalex.org/W2043859210","https://openalex.org/W2079643962","https://openalex.org/W2145365678","https://openalex.org/W2090684068"],"abstract_inverted_index":{"The":[0,181],"effects":[1],"of":[2,81,90,173,183,214,221],"adenosine":[3,171],"on":[4,141],"myocardial":[5,63,193],"blood":[6,64,98],"flow":[7,65,163,167,187],"and":[8,12,28,52,55,70,85,92,101,109,111,117,123,128,130,135,137,153,164,176,196,201,223],"metabolism,":[9],"central":[10,142],"hemodynamics,":[11],"the":[13,39,149,215],"intrapulmonary":[14,150],"shunt":[15,151],"fraction":[16,32,152],"were":[17,36,73,203],"investigated.":[18],"Fourteen":[19],"patients":[20],"with":[21,29,170,178],"two-":[22],"or":[23],"three-vessel":[24],"coronary":[25,47,165,189],"artery":[26,48],"disease":[27],"an":[30],"ejection":[31],"greater":[33],"than":[34],"0.5":[35],"studied":[37],"in":[38,78],"operating":[40],"room":[41],"following":[42],"sternal":[43],"closure":[44],"after":[45],"elective":[46],"bypass":[49],"grafting.":[50],"Systemic":[51],"pulmonary":[53,112],"hemodynamics":[54],"global":[56],"(coronary":[57],"sinus),":[58],"as":[59,61],"well":[60],"regional":[62,192,198],"(great":[66],"cardiac":[67,120,161,185],"vein":[68,162,186],"flow),":[69],"metabolic":[71],"variables":[72],"measured.":[74],"Adenosine":[75,209],"was":[76],"given":[77],"infusion":[79,146,172,219],"rates":[80,89,147,220],"15,":[82],"30,":[83],"60,":[84],"120":[86,93,179,224],"micrograms.kg-1.min-1.":[87,180],"Infusion":[88],"60":[91,222],"micrograms.kg-1.min-1":[94,175],"decreased":[95,154],"mean":[96,197],"arterial":[97,155],"pressure":[99],"(11%":[100],"16%,":[102],"respectively),":[103],"systemic":[104],"vascular":[105,113],"resistance":[106,114],"index":[107,115,121,133],"(30%":[108],"43%),":[110],"(24%":[116],"31%),":[118],"increased":[119,168],"(25%":[122],"45%),":[124],"heart":[125],"rate":[126],"(14%":[127],"15%),":[129],"stroke":[131],"volume":[132],"(9%":[134],"25%),":[136],"had":[138],"no":[139],"effect":[140],"filling":[143],"pressures.":[144],"These":[145],"doubled":[148],"O2":[156],"tension":[157],"by":[158,207],"26%.":[159],"Great":[160],"sinus":[166,190],"60%":[169],"30-60":[174],"120%":[177],"ratio":[182],"great":[184],"to":[188],"flow,":[191],"oxygen":[194],"consumption,":[195],"lactate":[199],"extraction":[200],"uptake":[202],"not":[204],"significantly":[205],"altered":[206],"adenosine.":[208],"caused":[210],"a":[211],"significant":[212],"depression":[213],"ST":[216],"segment":[217],"at":[218],"micrograms.kg-1.min-1.(ABSTRACT":[225],"TRUNCATED":[226],"AT":[227],"250":[228],"WORDS)":[229]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2022-05-12T00:00:00"}