{"id":"https://openalex.org/W4236418882","doi":"https://doi.org/10.1097/tp.0000000000001488","title":"Research Highlights","display_name":"Research Highlights","publication_year":2016,"publication_date":"2016-10-22","ids":{"openalex":"https://openalex.org/W4236418882","doi":"https://doi.org/10.1097/tp.0000000000001488"},"language":"en","primary_location":{"id":"doi:10.1097/tp.0000000000001488","doi":"https://doi.org/10.1097/tp.0000000000001488","is_oa":false,"landing_page_url":"https://doi.org/10.1097/tp.0000000000001488","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071342347","display_name":"Elmi Muller","orcid":"https://orcid.org/0000-0003-4891-5296","observed_orcids":["https://orcid.org/0000-0003-4891-5296"]},"institutions":[{"id":"https://openalex.org/I157614274","display_name":"University of Cape Town","ror":"https://ror.org/03p74gp79","country_code":"ZA","type":"education","lineage":["https://openalex.org/I157614274"]},{"id":"https://openalex.org/I2802258008","display_name":"Groote Schuur Hospital","ror":"https://ror.org/00c879s84","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I1307091933","https://openalex.org/I2802258008"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Elmi Muller","raw_affiliation_strings":["Elmi Muller, MBChB, MMED, Department of Surgery, University of, Cape Town and Groote Schuur Hospital, Main Road, Observatory, Cape Twon 7925. ([email\u00a0protected])","The author declares no funding or conflicts of interest"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Elmi Muller, MBChB, MMED, Department of Surgery, University of, Cape Town and Groote Schuur Hospital, Main Road, Observatory, Cape Twon 7925. ([email\u00a0protected])","institution_ids":["https://openalex.org/I157614274","https://openalex.org/I2802258008"]},{"raw_affiliation_string":"The author declares no funding or conflicts of interest","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071342347"],"corresponding_institution_ids":["https://openalex.org/I157614274","https://openalex.org/I2802258008"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.26209162,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"100","issue":"11","first_page":"2237","last_page":"2238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6011000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.6011000275611877,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11189","display_name":"Transplantation: Methods and Outcomes","score":0.21459999680519104,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.04809999838471413,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/donor-dendritic-cells","display_name":"donor dendritic cells","score":0.8069999814033508},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8840000033378601},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.9940000176429749},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.7799999713897705},{"id":"https://openalex.org/keywords/heart-transplantation","display_name":"heart transplantation","score":0.6790000200271606},{"id":"https://openalex.org/keywords/mhc-presentation","display_name":"MHC presentation","score":0.6740000247955322},{"id":"https://openalex.org/keywords/antigen-presentation","display_name":"antigen presentation","score":0.8360000252723694},{"id":"https://openalex.org/keywords/alloreactive-t-cells","display_name":"alloreactive T cells","score":0.8339999914169312},{"id":"https://openalex.org/keywords/mucosa-associated-invariant-t-cells","display_name":"mucosal-associated invariant T cells","score":0.8830000162124634},{"id":"https://openalex.org/keywords/chronic-hepatitis-c","display_name":"chronic hepatitis C","score":0.8700000047683716},{"id":"https://openalex.org/keywords/immune-exhaustion","display_name":"immune exhaustion","score":0.5440000295639038},{"id":"https://openalex.org/keywords/interferon-free-therapy","display_name":"interferon-free therapy","score":0.7490000128746033},{"id":"https://openalex.org/keywords/sofosbuvir","display_name":"sofosbuvir","score":0.7210000157356262},{"id":"https://openalex.org/keywords/ribavirin","display_name":"ribavirin","score":0.9890000224113464},{"id":"https://openalex.org/keywords/viral-clearance","display_name":"viral clearance","score":0.6919999718666077},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.574999988079071}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3838208317756653},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.32323992252349854}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1097/tp.0000000000001488","doi":"https://doi.org/10.1097/tp.0000000000001488","is_oa":false,"landing_page_url":"https://doi.org/10.1097/tp.0000000000001488","pdf_url":null,"source":{"id":"https://openalex.org/S11564597","display_name":"Transplantation","issn_l":"0041-1337","issn":["0041-1337","1534-6080"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transplantation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2468654154","https://openalex.org/W24254922","https://openalex.org/W2079156182","https://openalex.org/W2122211980","https://openalex.org/W2489001340","https://openalex.org/W3004441393","https://openalex.org/W2911074674","https://openalex.org/W3106917106","https://openalex.org/W2001739973","https://openalex.org/W2554730647"],"abstract_inverted_index":{"Donor":[0],"Dendritic":[1],"Cell\u2013Derived":[2],"Exosomes":[3],"Promote":[4],"Allograft-Targeting":[5],"Immune":[6],"Response":[7],"Liu":[8],"Q,":[9],"Rojas-Canales":[10],"DM,":[11],"Divito":[12],"SJ,":[13],"et":[14,241,532],"al.":[15,242,533],"J":[16,244],"Clin":[17,546],"Invest.":[18],"2016;126(8):2805\u201320.":[19],"This":[20],"study":[21],"examines":[22],"the":[23,67,76,80,94,109,113,120,131,138,181,207,258,266,269,359,368,376,379,391,458,482],"key":[24],"role":[25,208],"that":[26,135,211,254,336,362,423,442],"donor":[27,70,105,123,161,184],"derived":[28],"extracellular":[29],"vesicles":[30],"(EVs)":[31],"play":[32],"during":[33,397],"alloimmune":[34,499],"responses":[35,500],"explored":[36,66,268],"in":[37,40,196,225,280,354,406,411,465,501,514,542],"transplant":[38,503,517],"models":[39],"mice.":[41,118,197],"The":[42,64,419,432],"authors":[43,65,267,360,420],"extracted":[44],"DNA":[45],"from":[46,108,137],"spleens,":[47],"mediastinal":[48],"and":[49,78,149,163,192,285,299,329,386,389,416,451,475],"retroperitoneal":[50],"lymph":[51],"nodes":[52],"at":[53],"sequential":[54],"intervals":[55],"by":[56],"days":[57],"1,":[58],"2,":[59],"3,":[60],"or":[61,152,218],"7":[62],"days.":[63],"migration":[68],"of":[69,75,88,116,122,133,173,183,203,209,378,435,457,508,511],"dendritic":[71],"cells":[72,91,170,191,316,321,341,364,382,444,472,513,539],"(DC)":[73],"out":[74],"graft":[77,139,194],"into":[79,112],"recipient\u2019s":[81],"lymphoid":[82,114,141,387],"tissue":[83,115],"with":[84,147,322,467,487,505,519],"a":[85,384,506,520],"subsequent":[86,428],"activation":[87],"alloreactive":[89,168,189],"T":[90,169,190,312,320,340,537],"directed":[92],"against":[93],"donor\u2019s":[95],"Major":[96],"Histocompatibility":[97],"Complex":[98],"(MHC)":[99],"molecules.":[100],"Of":[101],"note,":[102],"relatively":[103],"few":[104],"DCs":[106,128,175],"migrated":[107,136],"heart":[110],"allograft":[111],"recipient":[117,127,174],"Moreover,":[119],"passage":[121],"MHC":[124,162,185],"molecules":[125,186],"to":[126,140,155,166,187,251,326,414,429,449,453,481,497,516],"depended":[129],"on":[130,304,308],"transfer":[132],"EVs":[134,144,159,210],"tissues.":[142],"These":[143,198],"shared":[145],"characteristics":[146,324],"exosomes":[148],"were":[150,291,302],"internalized":[151],"remained":[153],"attached":[154],"recipient's":[156],"DCs.":[157],"Interestingly,":[158],"carried":[160],"APC-activating":[164],"signals":[165],"which":[167,479],"responded.":[171],"Depletion":[172],"after":[176,272,297,351,375],"cardiac":[177],"transplantation":[178],"drastically":[179],"compromised":[180],"presentation":[182,205],"directly":[188],"delayed":[193],"rejection":[195],"findings":[199,437],"reveal":[200],"novel":[201],"mechanisms":[202],"antigen":[204],"characterizing":[206],"can":[212],"potentially":[213],"serve":[214],"as":[215,319,342,344,455],"treatment":[216],"targets":[217],"biomarkers":[219],"monitoring":[220],"rejection.":[221],"Nonreversible":[222],"MAIT":[223,315,363,381,443,471,512,522],"Cell-Dysfunction":[224],"Chronic":[226],"Hepatitis":[227],"C":[228,274],"Virus":[229],"Infection":[230],"Despite":[231],"Successful":[232],"Interferon-Free":[233],"Therapy":[234],"Hengst":[235],"J,":[236],"Strunz":[237],"B,":[238],"Deterding":[239],"K,":[240],"Eur":[243],"Immunol.":[245,548],"2016;9:2204\u20132210.":[246],"Viral":[247],"infection":[248],"is":[249,255,261,333,426],"linked":[250],"immune":[252,270,460],"exhaustion":[253],"reversible":[256],"once":[257],"viral":[259,330,352,415,430],"pathogen":[260],"eradicated.":[262],"In":[263],"this":[264,424,488],"study,":[265],"remodulation":[271],"hepatitis":[273],"virus":[275],"(HCV)":[276],"had":[277],"been":[278],"cleared":[279],"patients":[281,306,466],"who":[282],"received":[283],"sofosbuvir":[284],"ribavirin":[286],"for":[287,294,463],"24":[288],"weeks.":[289],"Patients":[290],"followed":[292],"up":[293],"72":[295],"weeks":[296],"therapy":[298],"flow":[300],"cytometry":[301],"performed":[303],"all":[305],"focusing":[307],"functional":[309],"mucosal-associated":[310,535],"invariant":[311,536],"(MAIT)":[313,538],"cells.":[314],"are":[317,390,401,473,540],"defined":[318],"innate-like":[323],"responding":[325],"both":[327,337],"bacterial":[328,417],"infections.":[331],"It":[332],"well":[334,343,374],"known":[335],"HCV-specific":[338],"CD8":[339],"natural":[345],"killer":[346],"cell":[347,396,523],"populations":[348],"become":[349],"reinvigorated":[350],"clearance":[353,377],"HCV":[355,509],"infected":[356],"patients.":[357],"Here,":[358],"demonstrated":[361,422],"do":[365],"not":[366,402],"follow":[367],"same":[369],"pattern:":[370],"counts":[371],"remain":[372,438],"low":[373],"virus.":[380],"have":[383,445],"myeloid":[385],"origin":[388],"most":[392],"severely":[393],"affected":[394],"peripheral":[395],"chronic":[398,483],"infection.":[399],"They":[400],"only":[403],"dramatically":[404],"reduced":[405],"frequency,":[407],"but":[408],"also":[409],"impaired":[410],"their":[412],"response":[413],"triggers.":[418],"clearly":[421],"dysfunction":[425],"nonreversible":[427],"clearance.":[431],"clinical":[433],"implications":[434],"those":[436],"unclear.":[439],"We":[440],"know":[441],"an":[446],"inherent":[447],"capacity":[448],"detect":[450],"respond":[452],"infections":[454],"part":[456],"innate":[459],"response.":[461],"Clinically,":[462],"example,":[464],"inflammatory":[468,484,543],"bowel":[469,544],"disease,":[470],"activated":[474,541],"secrete":[476],"proinflammatory":[477],"cytokines,":[478],"contribute":[480],"state":[485],"associated":[486],"pathology.1":[489],"Among":[490],"other":[491],"aspects,":[492],"it":[493],"will":[494],"be":[495],"interesting":[496],"assess":[498],"liver":[502],"recipients":[504,518],"PMH":[507],"depleted":[510],"comparison":[515],"normal":[521],"populations.":[524],"REFERENCE":[525],"Serriari":[526],"NE,":[527],"Eoche":[528],"M,":[529],"Lamotte":[530],"L,":[531],"Innate":[534],"diseases.":[545],"Exp":[547],"2014;176:266\u201374.":[549]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-09-23T05:00:35.095934","created_date":"2022-05-12T00:00:00"}