{"id":"https://openalex.org/W4236192026","doi":"https://doi.org/10.1210/endo-meetings.2011.part2.or3.or12-6","title":"Determination of the Mechanism by Which IGFBP-2 Regulates PTEN/AKT Signal Transduction in Vascular Smooth Muscle Cells (VSMC)","display_name":"Determination of the Mechanism by Which IGFBP-2 Regulates PTEN/AKT Signal Transduction in Vascular Smooth Muscle Cells (VSMC)","publication_year":2011,"publication_date":"2011-06-01","ids":{"openalex":"https://openalex.org/W4236192026","doi":"https://doi.org/10.1210/endo-meetings.2011.part2.or3.or12-6"},"language":"en","primary_location":{"id":"doi:10.1210/endo-meetings.2011.part2.or3.or12-6","doi":"https://doi.org/10.1210/endo-meetings.2011.part2.or3.or12-6","is_oa":false,"landing_page_url":"http://doi.org/10.1210/endo-meetings.2011.part2.or3.or12-6","pdf_url":null,"source":{"id":"https://openalex.org/S7407089385","display_name":"The Endocrine Society eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Endocrine Society's 93rd Annual Meeting & Expo, June 4\u20137, 2011 - Boston","raw_type":"book-chapter"},"volume":null,"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084540202","display_name":"Xinchun Shen","orcid":"https://orcid.org/0000-0002-0889-1587","observed_orcids":["https://orcid.org/0000-0002-0889-1587"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xinchun Shen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100698886","display_name":"Gang Xi","orcid":"https://orcid.org/0000-0002-7020-1831","observed_orcids":["https://orcid.org/0000-0002-7020-1831"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gang Xi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112869583","display_name":"Laura A. Maile","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Laura A Maile","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047044979","display_name":"Clifford james Rosen","orcid":"https://orcid.org/0000-0003-3436-8199","observed_orcids":["https://orcid.org/0000-0003-3436-8199"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Clifford J Rosen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5000288481","display_name":"David R. Clemmons","orcid":"https://orcid.org/0000-0001-9946-788X","observed_orcids":["https://orcid.org/0000-0001-9946-788X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David R Clemmons","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.44407622,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"OR12","last_page":"6"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.8086000084877014,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.05889999866485596,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.025699999183416367,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igfbp-2","display_name":"IGFBP-2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":0.6660000085830688},{"id":"https://openalex.org/keywords/akt-signaling","display_name":"Akt signaling","score":0.9559999704360962},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9110000133514404},{"id":"https://openalex.org/keywords/signal-transduction-regulation","display_name":"signal transduction regulation","score":0.8669999837875366},{"id":"https://openalex.org/keywords/insulin-like-growth-factor-binding-proteins","display_name":"IGF binding proteins","score":0.8880000114440918}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8954137563705444},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.6790664792060852},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.6439032554626465},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5680927038192749},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5635102391242981},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5576688647270203},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4707508683204651},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.461535781621933},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.37715214490890503},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33310502767562866},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.278544545173645},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2267838418483734},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05870544910430908},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1210/endo-meetings.2011.part2.or3.or12-6","doi":"https://doi.org/10.1210/endo-meetings.2011.part2.or3.or12-6","is_oa":false,"landing_page_url":"http://doi.org/10.1210/endo-meetings.2011.part2.or3.or12-6","pdf_url":null,"source":{"id":"https://openalex.org/S7407089385","display_name":"The Endocrine Society eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Endocrine Society's 93rd Annual Meeting & Expo, June 4\u20137, 2011 - Boston","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7100211603","https://openalex.org/W4299788680","https://openalex.org/W4238080628","https://openalex.org/W2131301215","https://openalex.org/W7100350205","https://openalex.org/W3194734665","https://openalex.org/W2023841557","https://openalex.org/W4233775858","https://openalex.org/W409822990","https://openalex.org/W1979410842"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-10-06T10:28:23.643775","created_date":"2022-05-12T00:00:00"}