{"id":"https://openalex.org/W4236113258","doi":"https://doi.org/10.1097/00000539-200102000-00012","title":"The Use of Lepirudin for Anticoagulation in Patients with Heparin-Induced Thrombocytopenia During Major Vascular Surgery","display_name":"The Use of Lepirudin for Anticoagulation in Patients with Heparin-Induced Thrombocytopenia During Major Vascular Surgery","publication_year":2001,"publication_date":"2001-02-01","ids":{"openalex":"https://openalex.org/W4236113258","doi":"https://doi.org/10.1097/00000539-200102000-00012","pmid":"https://pubmed.ncbi.nlm.nih.gov/11159229"},"language":"en","primary_location":{"id":"doi:10.1097/00000539-200102000-00012","doi":"https://doi.org/10.1097/00000539-200102000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-200102000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and Analgesia","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100715505","display_name":"Yang Sun","orcid":"https://orcid.org/0000-0002-1587-9797","observed_orcids":["https://orcid.org/0000-0002-1587-9797"]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Sun","raw_affiliation_strings":["Department of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas","Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology & Pain Management, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050336059","display_name":"Philip E. Greilich","orcid":"https://orcid.org/0000-0002-5811-601X","observed_orcids":["https://orcid.org/0000-0002-5811-601X"]},"institutions":[{"id":"https://openalex.org/I4210104138","display_name":"VA North Texas Health Care System","ror":"https://ror.org/01nzxq896","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104138","https://openalex.org/I4210144023"]},{"id":"https://openalex.org/I4210136278","display_name":"Dallas VA Medical Center","ror":"https://ror.org/034pdr896","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210104138","https://openalex.org/I4210136278","https://openalex.org/I4210144023"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Philip E. Greilich","raw_affiliation_strings":["Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas","and reprint requests to Philip E. Greilich, MD, Anesthesiology and Pain Management Service (112A), Veterans Affairs North Texas Health Care System, 450. 0 South Lancaster Road, Dallas, TX 75216. Address e-mail to philip. [email\u00a0protected]","reprint requests to Philip E. Greilich, MD, Anesthesiology and Pain Management Service (112A), Veterans Affairs North Texas Health Care System, 450. 0 South Lancaster Road, Dallas, TX 75216. Address e-mail to philip. [email\u00a0protected]"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"and reprint requests to Philip E. Greilich, MD, Anesthesiology and Pain Management Service (112A), Veterans Affairs North Texas Health Care System, 450. 0 South Lancaster Road, Dallas, TX 75216. Address e-mail to philip. [email\u00a0protected]","institution_ids":["https://openalex.org/I4210104138","https://openalex.org/I4210136278"]},{"raw_affiliation_string":"reprint requests to Philip E. Greilich, MD, Anesthesiology and Pain Management Service (112A), Veterans Affairs North Texas Health Care System, 450. 0 South Lancaster Road, Dallas, TX 75216. Address e-mail to philip. [email\u00a0protected]","institution_ids":["https://openalex.org/I4210104138","https://openalex.org/I4210136278"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060086748","display_name":"Steve I. O. Wilson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steve I. O. Wilson","raw_affiliation_strings":["Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103569155","display_name":"Mark R. Jackson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark R. Jackson","raw_affiliation_strings":["Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111611586","display_name":"Charles W. Whitten","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles W. Whitten","raw_affiliation_strings":["Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anesthesiology & Pain Management and Surgery, University of Texas Southwestern Medical Center, Dallas, Texas","institution_ids":["https://openalex.org/I867280407"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5050336059"],"corresponding_institution_ids":["https://openalex.org/I4210104138","https://openalex.org/I4210136278","https://openalex.org/I867280407"],"apc_list":null,"apc_paid":null,"fwci":1.6493,"has_fulltext":false,"cited_by_count":9,"citation_normalized_percentile":{"value":0.85519384,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"92","issue":"2","first_page":"344","last_page":"346"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12352","display_name":"Heparin-Induced Thrombocytopenia and Thrombosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lepirudin","display_name":"lepirudin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/recombinant-hirudin","display_name":"recombinant hirudin","score":0.9340000152587891},{"id":"https://openalex.org/keywords/heparin-induced-thrombocytopenia","display_name":"heparin-induced thrombocytopenia","score":0.9879999756813049},{"id":"https://openalex.org/keywords/anticoagulation","display_name":"anticoagulation","score":0.9819999933242798},{"id":"https://openalex.org/keywords/vascular-surgery","display_name":"vascular surgery","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2780205058","wikidata":"https://www.wikidata.org/wiki/Q3271949","display_name":"Lepirudin","level":5,"score":0.9873417615890503},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9742406606674194},{"id":"https://openalex.org/C2776472838","wikidata":"https://www.wikidata.org/wiki/Q1598365","display_name":"Heparin-induced thrombocytopenia","level":3,"score":0.860675036907196},{"id":"https://openalex.org/C2778271848","wikidata":"https://www.wikidata.org/wiki/Q386715","display_name":"Hirudin","level":4,"score":0.8571228981018066},{"id":"https://openalex.org/C2777557582","wikidata":"https://www.wikidata.org/wiki/Q190016","display_name":"Heparin","level":2,"score":0.7430764436721802},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.5604798197746277},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4478401839733124},{"id":"https://openalex.org/C2778205648","wikidata":"https://www.wikidata.org/wiki/Q215118","display_name":"Anticoagulant","level":2,"score":0.4245389699935913},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.29432666301727295},{"id":"https://openalex.org/C2779612170","wikidata":"https://www.wikidata.org/wiki/Q474880","display_name":"Argatroban","level":4,"score":0.2505394220352173},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.13320079445838928},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.11417320370674133}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000925","descriptor_name":"Anticoagulants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006629","descriptor_name":"Hirudins","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D006629","descriptor_name":"Hirudins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010314","descriptor_name":"Partial Thromboplastin Time","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013921","descriptor_name":"Thrombocytopenia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D014656","descriptor_name":"Vascular Surgical Procedures","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/00000539-200102000-00012","doi":"https://doi.org/10.1097/00000539-200102000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00000539-200102000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and Analgesia","raw_type":"journal-article"},{"id":"doi:10.1213/00000539-200102000-00012","doi":"https://doi.org/10.1213/00000539-200102000-00012","is_oa":false,"landing_page_url":"https://doi.org/10.1213/00000539-200102000-00012","pdf_url":null,"source":{"id":"https://openalex.org/S104698359","display_name":"Anesthesia & Analgesia","issn_l":"0003-2999","issn":["0003-2999","1526-7598"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia & Analgesia","raw_type":"journal-article"},{"id":"pmid:11159229","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11159229","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Anesthesia and analgesia","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W175628560","https://openalex.org/W188744978","https://openalex.org/W1210530719","https://openalex.org/W1968797532","https://openalex.org/W1987710095","https://openalex.org/W2012489492","https://openalex.org/W2023548160","https://openalex.org/W2026783020","https://openalex.org/W2036385266","https://openalex.org/W2039135839","https://openalex.org/W2052920099","https://openalex.org/W2062519001","https://openalex.org/W2080479097","https://openalex.org/W2086150454","https://openalex.org/W2090243525","https://openalex.org/W2109289067","https://openalex.org/W2114155850","https://openalex.org/W2165313346","https://openalex.org/W2298563345","https://openalex.org/W2340070814","https://openalex.org/W2408800704","https://openalex.org/W3125065962"],"related_works":["https://openalex.org/W2121715628","https://openalex.org/W2397901540","https://openalex.org/W2052882899","https://openalex.org/W2885351167","https://openalex.org/W2010502481","https://openalex.org/W2898514237","https://openalex.org/W1988931944","https://openalex.org/W2057880556","https://openalex.org/W1989047283","https://openalex.org/W2109289067"],"abstract_inverted_index":{"The":[0],"method":[1],"of":[2,13],"anticoagulation":[3],"in":[4,23,38],"patients":[5,39],"undergoing":[6],"major":[7],"vascular":[8,44],"surgery":[9],"with":[10,40],"a":[11,25],"history":[12],"heparin-induced":[14],"thrombocytopenia":[15],"(HIT)":[16],"is":[17],"controversial.":[18],"We":[19],"present":[20],"two":[21],"cases":[22],"which":[24],"bolus":[26],"only":[27],"technique":[28],"using":[29],"recombinant":[30],"hirudin":[31],"(Lepirudin":[32],"or":[33],"Refludan)":[34],"was":[35],"used":[36],"successfully":[37],"HIT":[41],"scheduled":[42],"for":[43],"surgery.":[45]},"counts_by_year":[{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}