{"id":"https://openalex.org/W4236012197","doi":"https://doi.org/10.3410/f.725354522.793537645","title":"Faculty Opinions recommendation of Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses.","display_name":"Faculty Opinions recommendation of Phosphatidylserine vesicles enable efficient en bloc transmission of enteroviruses.","publication_year":2017,"publication_date":"2017-10-13","ids":{"openalex":"https://openalex.org/W4236012197","doi":"https://doi.org/10.3410/f.725354522.793537645"},"language":"en","primary_location":{"id":"doi:10.3410/f.725354522.793537645","doi":"https://doi.org/10.3410/f.725354522.793537645","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.725354522.793537645","pdf_url":"https://facultyopinions.com/download/725354522","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"volume":null,"type":"peer-review","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://facultyopinions.com/download/725354522","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089010495","display_name":"Johan H. Neyts","orcid":"https://orcid.org/0000-0002-0033-7514","observed_orcids":["https://orcid.org/0000-0002-0033-7514"]},"institutions":[{"id":"https://openalex.org/I24156275","display_name":"Rega Institute for Medical Research","ror":"https://ror.org/03w5j8p12","country_code":"BE","type":"facility","lineage":["https://openalex.org/I24156275"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Johan Neyts","raw_affiliation_strings":["Department of Virology, Rega Institute for Medical Research, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Virology, Rega Institute for Medical Research, Belgium","institution_ids":["https://openalex.org/I24156275"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5089010495"],"corresponding_institution_ids":["https://openalex.org/I24156275"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11112","display_name":"Viral Infections and Immunology Research","score":0.6855000257492065,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.060600001364946365,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10617","display_name":"Cellular transport and secretion","score":0.05350000038743019,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylserine-vesicles","display_name":"phosphatidylserine vesicles","score":0.9169999957084656},{"id":"https://openalex.org/keywords/enterovirus","display_name":"enterovirus","score":0.9760000109672546},{"id":"https://openalex.org/keywords/virus-transmission","display_name":"virus transmission","score":0.5540000200271606},{"id":"https://openalex.org/keywords/cell-to-cell-spread","display_name":"cell-to-cell transmission","score":0.7730000019073486},{"id":"https://openalex.org/keywords/membrane-vesicles","display_name":"membrane vesicles","score":0.6129999756813049},{"id":"https://openalex.org/keywords/virus-receptor","display_name":"viral receptor","score":0.5350000262260437},{"id":"https://openalex.org/keywords/human-macrophages","display_name":"human macrophages","score":0.9340000152587891},{"id":"https://openalex.org/keywords/viral-replication","display_name":"viral replication","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.5115257501602173},{"id":"https://openalex.org/C14500911","wikidata":"https://www.wikidata.org/wiki/Q3413375","display_name":"Viral quasispecies","level":4,"score":0.4863000810146332},{"id":"https://openalex.org/C106358424","wikidata":"https://www.wikidata.org/wiki/Q1662346","display_name":"Infectivity","level":3,"score":0.45415252447128296},{"id":"https://openalex.org/C2779637612","wikidata":"https://www.wikidata.org/wiki/Q2354337","display_name":"Phosphatidylserine","level":4,"score":0.4485463500022888},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4100393056869507},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32931023836135864},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.21635767817497253},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20918571949005127},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.08696439862251282},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.0},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3410/f.725354522.793537645","doi":"https://doi.org/10.3410/f.725354522.793537645","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.725354522.793537645","pdf_url":"https://facultyopinions.com/download/725354522","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"}],"best_oa_location":{"id":"doi:10.3410/f.725354522.793537645","doi":"https://doi.org/10.3410/f.725354522.793537645","is_oa":true,"landing_page_url":"https://doi.org/10.3410/f.725354522.793537645","pdf_url":"https://facultyopinions.com/download/725354522","source":{"id":"https://openalex.org/S4363604054","display_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Faculty Opinions \u2013 Post-Publication Peer Review of the Biomedical Literature","raw_type":"dataset"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4236012197.pdf","grobid_xml":"https://content.openalex.org/works/W4236012197.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W125106425","https://openalex.org/W1940692702","https://openalex.org/W1969103349","https://openalex.org/W1970821321","https://openalex.org/W1979661536","https://openalex.org/W1994527574","https://openalex.org/W1996969128","https://openalex.org/W2000454359","https://openalex.org/W2001045944","https://openalex.org/W2003574450","https://openalex.org/W2012620164","https://openalex.org/W2016964866","https://openalex.org/W2020009024","https://openalex.org/W2022626924","https://openalex.org/W2028776321","https://openalex.org/W2033281996","https://openalex.org/W2040141788","https://openalex.org/W2051245442","https://openalex.org/W2051943484","https://openalex.org/W2055654995","https://openalex.org/W2073576660","https://openalex.org/W2076497166","https://openalex.org/W2078921115","https://openalex.org/W2079046408","https://openalex.org/W2080799466","https://openalex.org/W2094241924","https://openalex.org/W2099133435","https://openalex.org/W2115403023","https://openalex.org/W2123391493","https://openalex.org/W2123436498","https://openalex.org/W2123799993","https://openalex.org/W2131394102","https://openalex.org/W2133161896","https://openalex.org/W2135404101","https://openalex.org/W2139756641","https://openalex.org/W2156910240","https://openalex.org/W2159516959","https://openalex.org/W2159791657","https://openalex.org/W2167105834","https://openalex.org/W4240521712","https://openalex.org/W4256266823","https://openalex.org/W4299678239"],"related_works":["https://openalex.org/W2170585188","https://openalex.org/W2006516312","https://openalex.org/W2396516078","https://openalex.org/W7047380837","https://openalex.org/W2159613172","https://openalex.org/W2887691821","https://openalex.org/W2923925623","https://openalex.org/W4213200006","https://openalex.org/W3178562812","https://openalex.org/W4414938702"],"abstract_inverted_index":{"A":[0],"central":[1],"paradigm":[2],"within":[3,26,78],"virology":[4],"is":[5],"that":[6,19,31,48,72],"each":[7],"viral":[8,45,76,82,98,125,131],"particle":[9],"largely":[10],"behaves":[11],"as":[12,127,129],"an":[13],"independent":[14,116],"infectious":[15],"unit.Here":[16],"we":[17],"demonstrate":[18,71],"clusters":[20],"of":[21,75,97,114],"enteroviral":[22,101],"particles":[23,77],"are":[24,32,52,103],"packaged":[25],"phosphatidylserine":[27],"(PS)":[28],"lipid-enriched":[29],"vesicles":[30,79,112],"non-lytically":[33],"released":[34],"from":[35,105],"cells":[36],"and":[37,63],"provide":[38],"greater":[39],"infection":[40],"efficiency":[41],"than":[42],"free":[43],"single":[44,90,115],"particles.We":[46],"show":[47],"vesicular":[49],"PS":[50,111],"lipids":[51],"co-factors":[53],"to":[54,67,85],"the":[55],"relevant":[56],"enterovirus":[57],"receptors":[58],"in":[59,65,109],"mediating":[60],"subsequent":[61],"infectivity":[62],"transmission,":[64,99],"particular":[66],"primary":[68],"human":[69],"macrophages.We":[70],"clustered":[73],"packaging":[74],"enables":[80],"multiple":[81],"RNA":[83],"genomes":[84,102],"be":[86],"collectively":[87],"transferred":[88],"into":[89],"cells.This":[91],"study":[92],"reveals":[93],"a":[94],"novel":[95],"mode":[96],"where":[100],"transmitted":[104],"cell-to-cell":[106],"en":[107],"bloc":[108],"membrane-bound":[110],"instead":[113],"genomes.This":[117],"has":[118],"implications":[119],"for":[120],"facilitating":[121],"genetic":[122],"cooperativity":[123],"among":[124],"quasispecies":[126],"well":[128],"enhancing":[130],"replication.":[132]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-05-12T00:00:00"}