{"id":"https://openalex.org/W4235835333","doi":"https://doi.org/10.1158/1538-7445.sabcs18-4863","title":"Abstract 4863: Discovery of novel metabolomic plasma biomarkers predictive of radiation induced cardiac toxicity","display_name":"Abstract 4863: Discovery of novel metabolomic plasma biomarkers predictive of radiation induced cardiac toxicity","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4235835333","doi":"https://doi.org/10.1158/1538-7445.sabcs18-4863"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-4863","doi":"https://doi.org/10.1158/1538-7445.sabcs18-4863","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-4863","pdf_url":null,"source":{"id":"https://openalex.org/S4306506411","display_name":"Clinical Research (Excluding Clinical Trials)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Research (Excluding Clinical Trials)","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110576063","display_name":"Keith Robert Unger","orcid":"https://orcid.org/0009-0006-5963-2565","observed_orcids":["https://orcid.org/0009-0006-5963-2565"]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Keith Unger","raw_affiliation_strings":["MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051811339","display_name":"Michael J. Girgis","orcid":"https://orcid.org/0000-0003-0310-8829","observed_orcids":["https://orcid.org/0000-0003-0310-8829","https://orcid.org/0000-0001-6419-8974"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Girgis","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075708272","display_name":"Meena U. Rajagopal","orcid":"https://orcid.org/0000-0003-2778-1831","observed_orcids":["https://orcid.org/0000-0003-2778-1831"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meena Rajagopal","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079476210","display_name":"Yeline Ceh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802534011","display_name":"MedStar Georgetown University Hospital","ror":"https://ror.org/03ja1ak26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802534011","https://openalex.org/I86755215"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yeline Ceh","raw_affiliation_strings":["MedStar Georgetown University Hospital, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MedStar Georgetown University Hospital, Washington, DC","institution_ids":["https://openalex.org/I2802534011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024289248","display_name":"Meth M. Jayatilake","orcid":"https://orcid.org/0000-0002-5780-9391","observed_orcids":["https://orcid.org/0000-0002-5780-9391"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meth Jayatilake","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066177824","display_name":"Yaoxiang Li","orcid":"https://orcid.org/0000-0001-9200-1016","observed_orcids":["https://orcid.org/0000-0001-9200-1016"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yaoxiang Li","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003800447","display_name":"Amrita K. Cheema","orcid":"https://orcid.org/0000-0003-4877-7583","observed_orcids":["https://orcid.org/0000-0003-4877-7583"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amrita K. Cheema","raw_affiliation_strings":["Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"4863","last_page":"4863"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.8515999913215637,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.1151999980211258,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiation-induced-cardiotoxicity","display_name":"radiation-induced cardiotoxicity","score":0.781000018119812},{"id":"https://openalex.org/keywords/radiation-induced-heart-disease","display_name":"radiation-induced heart disease","score":0.7760000228881836},{"id":"https://openalex.org/keywords/lipidomics","display_name":"lipidomics","score":0.8040000200271606},{"id":"https://openalex.org/keywords/esophageal-cancer","display_name":"esophageal cancer","score":0.8880000114440918},{"id":"https://openalex.org/keywords/thoracic-radiotherapy","display_name":"thoracic radiotherapy","score":0.7900000214576721},{"id":"https://openalex.org/keywords/myocardial-ischemia","display_name":"myocardial ischemia","score":0.5490000247955322},{"id":"https://openalex.org/keywords/myocardial-fibrosis","display_name":"myocardial fibrosis","score":0.925000011920929},{"id":"https://openalex.org/keywords/cardiotoxicity-risk-prediction","display_name":"cardiotoxicity risk prediction","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cancer-survivors","display_name":"cancer survivors","score":0.6349999904632568},{"id":"https://openalex.org/keywords/cardiac-mri","display_name":"cardiac MRI","score":0.7049999833106995},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.3970000147819519}],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.7048074007034302},{"id":"https://openalex.org/C2910163948","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiac toxicity","level":3,"score":0.5219963788986206},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.49247798323631287},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39512187242507935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33972153067588806},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3271111845970154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.25789737701416016},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.25777366757392883},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19801238179206848}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-4863","doi":"https://doi.org/10.1158/1538-7445.sabcs18-4863","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-4863","pdf_url":null,"source":{"id":"https://openalex.org/S4306506411","display_name":"Clinical Research (Excluding Clinical Trials)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Research (Excluding Clinical Trials)","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3019893219","https://openalex.org/W7204919695","https://openalex.org/W3001912101","https://openalex.org/W4362670147","https://openalex.org/W7167330325","https://openalex.org/W4304812353","https://openalex.org/W4379983921","https://openalex.org/W7166878796","https://openalex.org/W4411679540","https://openalex.org/W4308772235"],"abstract_inverted_index":{"Introduction:":[0],"Although":[1],"advancements":[2],"in":[3,38,90,108,128,182,286,384],"cancer":[4,29,69,109,153,331,344],"treatment":[5],"have":[6,51,59,272],"led":[7],"to":[8,43,66,85,245,293,334,355,375,387],"increased":[9],"survivorship,":[10],"radiation":[11,146,176,244,263,363,432],"induced":[12,264,433],"heart":[13,178,189],"disease":[14],"(RIHD)":[15],"remains":[16],"a":[17,136,170,253],"major":[18],"source":[19],"of":[20,56,63,75,80,105,132,172,187,241,258,289,299,315,372,389,425,431,439],"acute":[21],"and":[22,26,180,214,269,297,303,309,337,396,404],"long":[23],"term":[24],"morbidity":[25,336],"mortality":[27],"for":[28,31,102,135,149,256,276,443],"survivors,":[30],"which":[32],"there":[33,380],"are":[34,72,285,353,371,381],"no":[35],"diagnostic":[36],"tests":[37],"routine":[39],"clinical":[40,392],"use":[41],"due":[42],"lack":[44],"efficacy":[45],"or":[46,230],"excessive":[47],"cost.":[48],"Several":[49],"studies":[50],"documented":[52],"RIHD;":[53],"however,":[54],"none":[55],"these":[57],"investigations":[58],"examined":[60],"the":[61,91,129,183,188,192,246,287,295,300,312,316,325,348,376,440],"utility":[62],"using":[64],"metabolomics":[65,268],"prospectively":[67],"identify":[68],"survivors":[70],"who":[71,161,174],"at":[73,143,324],"risk":[74,104],"cardiotoxicity.":[76],"The":[77],"overarching":[78],"goal":[79],"this":[81,369],"pilot":[82],"study":[83,370],"is":[84],"determine":[86,294],"whether":[87],"biomolecules":[88],"secreted":[89],"circulation":[92],"by":[93,307,398],"latent":[94],"yet":[95],"developing":[96,277],"cardiotoxic":[97],"processes":[98],"can":[99],"be":[100,322],"leveraged":[101],"predicting":[103],"cardiac":[106,164,200,215,265,349,390,434],"dysfunction":[107,329],"survivors.Approach:":[110],"We":[111,168,210,284,365],"used":[112,251],"metabolomics/lipidomics":[113],"analysis,":[114],"an":[115],"emerging":[116],"field":[117],"that":[118,225],"provides":[119],"information":[120],"on":[121,125,311],"biological":[122],"perturbations":[123],"based":[124],"relative":[126],"changes":[127],"plasma":[130,213,428],"levels":[131],"endogenous":[133],"metabolites,":[134],"retrospective":[137],"outcome":[138],"analysis":[139,249],"study.":[140],"Patients":[141],"treated":[142],"GUH":[144],"with":[145,191,262,280],"therapy":[147,332],"(RT)":[148],"locally":[150],"advanced":[151],"esophageal":[152,343],"(n":[154,203],"=":[155,204],"11":[156],"x":[157,206,238],"3":[158,207],"time":[159,208],"points),":[160],"underwent":[162],"serial":[163],"MRI\u2019s":[165],"were":[166,226],"selected.":[167],"identified":[169],"subset":[171],"patients":[173],"developed":[175],"related":[177,386],"ischemia":[179],"fibrosis":[181],"inferior/":[184],"basal":[185],"segment":[186],"associated":[190,199,261],"high":[193,281,360],"dose":[194,361],"region,":[195],"as":[196,198,252],"well":[197],"functional":[201],"impairments":[202],"6":[205],"points).":[209],"also":[211],"analyzed":[212],"tissue":[216],"samples":[217],"from":[218,368],"groups":[219],"male":[220],"Sprague":[221],"Dawley":[222],"(SD)":[223],"rats":[224],"either":[227],"sham":[228],"irradiated":[229],"received":[231],"fractionated":[232],"doses":[233],"(9":[234],"Gy":[235],"per":[236],"day":[237],"5":[239],"days)":[240],"targeted":[242],"X-ray":[243],"heart.":[247],"Metabolomic":[248],"was":[250],"correlative":[254],"approach":[255],"delineation":[257],"novel":[259,426],"biomarkers":[260,429],"toxicity.Results:":[266],"Global":[267],"lipidomics":[270],"analyses":[271,292],"yielded":[273],"important":[274],"data":[275,320],"classification":[278],"algorithms":[279],"predictive":[282,313,430],"accuracy.":[283],"process":[288],"performing":[290],"statistical":[291],"sensitivity":[296],"specificity":[298],"resultant":[301],"panel,":[302],"any":[304],"influence":[305],"provided":[306],"age":[308],"gender":[310],"performance":[314],"biomarker":[317],"panel.":[318],"These":[319],"will":[321],"presented":[323],"AACR":[326],"meeting.Conclusion:":[327],"Cardiac":[328],"following":[330],"leads":[333],"significant":[335,373],"mortality.":[338],"While":[339],"our":[340],"cohort":[341],"includes":[342],"patients,":[345],"we":[346],"believe":[347,366],"toxicities":[350],"detailed":[351],"previously":[352],"applicable":[354],"other":[356],"patient":[357],"populations":[358],"receiving":[359],"thoracic":[362],"therapy.":[364],"findings":[367],"interest":[374],"scientific":[377],"community":[378],"since":[379],"critical":[382],"gaps":[383],"knowledge":[385],"mechanisms":[388],"injury,":[391],"prediction,":[393],"screening,":[394],"prevention,":[395],"treatment.Supported":[397],"Cancer":[399,444,458],"Center":[400],"Support":[401],"Grant":[402],"(CCSG/NCI/NIH)":[403],"funding":[405],"Ruesch":[406],"FoundationCitation":[407],"Format:":[408],"Keith":[409],"Unger,":[410],"Michael":[411],"Girgis,":[412],"Meena":[413],"Rajagopal,":[414],"Yeline":[415],"Ceh,":[416],"Meth":[417],"Jayatilake,":[418],"Yaoxiang":[419],"Li,":[420],"Amrita":[421],"K.":[422],"Cheema.":[423],"Discovery":[424],"metabolomic":[427],"toxicity":[435],"[abstract].":[436],"In:":[437],"Proceedings":[438],"American":[441],"Association":[442],"Research":[445],"Annual":[446],"Meeting":[447],"2019;":[448],"2019":[449],"Mar":[450],"29-Apr":[451],"3;":[452],"Atlanta,":[453],"GA.":[454],"Philadelphia":[455],"(PA):":[456],"AACR;":[457],"Res":[459],"2019;79(13":[460],"Suppl):Abstract":[461],"nr":[462],"4863.":[463]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}