{"id":"https://openalex.org/W4235741007","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct199","title":"Abstract CT199: IMpower133: Primary efficacy and safety + CNS-related adverse events in a Ph1/3 study of first-line (1L) atezolizumab (atezo) + carboplatin + etoposide in extensive-stage SCLC (ES-SCLC)","display_name":"Abstract CT199: IMpower133: Primary efficacy and safety + CNS-related adverse events in a Ph1/3 study of first-line (1L) atezolizumab (atezo) + carboplatin + etoposide in extensive-stage SCLC (ES-SCLC)","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4235741007","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct199"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.sabcs18-ct199","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct199","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-ct199","pdf_url":null,"source":{"id":"https://openalex.org/S59378366","display_name":"Clinical Trials","issn_l":"1740-7745","issn":["1740-7745","1740-7753"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Trials","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071440718","display_name":"Aaron Scott Mansfield","orcid":"https://orcid.org/0000-0002-9483-6903","observed_orcids":["https://orcid.org/0000-0002-9483-6903"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron S. Mansfield","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;","Mayo Clinic, Rochester, MN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Mayo Clinic, Rochester, MN","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043871151","display_name":"Stephen V. Liu","orcid":"https://orcid.org/0000-0002-4852-3914","observed_orcids":["https://orcid.org/0000-0002-4852-3914"]},"institutions":[{"id":"https://openalex.org/I184565670","display_name":"Georgetown University","ror":"https://ror.org/05vzafd60","country_code":"US","type":"education","lineage":["https://openalex.org/I184565670"]},{"id":"https://openalex.org/I2799903593","display_name":"Georgetown University Medical Center","ror":"https://ror.org/00hjz7x27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799903593"]},{"id":"https://openalex.org/I4390039356","display_name":"Georgetown Lombardi Comprehensive Cancer Center","ror":"https://ror.org/035zrb927","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen V. Liu","raw_affiliation_strings":["Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC;","Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC;","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I4390039356"]},{"raw_affiliation_string":"Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC","institution_ids":["https://openalex.org/I184565670","https://openalex.org/I2799903593","https://openalex.org/I4390039356"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113629540","display_name":"Aleksandra Szcz\u0119sna","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aleksandra Szcz\u0119sna","raw_affiliation_strings":["Mazowieckie Centrum Leczenia Chor\u00f3b P\u0142uc i Gru\u017alicy, Otwock, Poland;","Mazowieckie Centrum Leczenia Chor\u00f3b P\u0142uc i Gru\u017alicy, Otwock, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mazowieckie Centrum Leczenia Chor\u00f3b P\u0142uc i Gru\u017alicy, Otwock, Poland;","institution_ids":[]},{"raw_affiliation_string":"Mazowieckie Centrum Leczenia Chor\u00f3b P\u0142uc i Gru\u017alicy, Otwock, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007665505","display_name":"Libor Havel","orcid":"https://orcid.org/0009-0007-9131-226X","observed_orcids":["https://orcid.org/0009-0007-9131-226X"]},"institutions":[{"id":"https://openalex.org/I4210144209","display_name":"Thomayer University Hospital","ror":"https://ror.org/04hyq8434","country_code":"CZ","type":"healthcare","lineage":["https://openalex.org/I4210144209"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Libor Havel","raw_affiliation_strings":["Thomayerova Neomicnice, Pneumologick\u00e1 Klinika 1. LF UK, Prague, Czech Republic;","Thomayerova Neomicnice, Pneumologick\u00e1 Klinika 1. LF UK, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thomayerova Neomicnice, Pneumologick\u00e1 Klinika 1. LF UK, Prague, Czech Republic;","institution_ids":["https://openalex.org/I4210144209"]},{"raw_affiliation_string":"Thomayerova Neomicnice, Pneumologick\u00e1 Klinika 1. LF UK, Prague, Czech Republic","institution_ids":["https://openalex.org/I4210144209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020097422","display_name":"Maciej Kzrakowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150880","display_name":"The Maria Sklodowska-Curie National Research Institute of Oncology","ror":"https://ror.org/04qcjsm24","country_code":"PL","type":"healthcare","lineage":["https://openalex.org/I4210150880"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Maciej Kzrakowski","raw_affiliation_strings":["Centrum Onkologii-Instytut Im. M. Sk\u0142odowskiej-Curie w Warszawie, Warsaw, Poland;","Centrum Onkologii-Instytut Im. M. Sk\u0142odowskiej-Curie w Warszawie, Warsaw, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centrum Onkologii-Instytut Im. M. Sk\u0142odowskiej-Curie w Warszawie, Warsaw, Poland;","institution_ids":["https://openalex.org/I4210150880"]},{"raw_affiliation_string":"Centrum Onkologii-Instytut Im. M. Sk\u0142odowskiej-Curie w Warszawie, Warsaw, Poland","institution_ids":["https://openalex.org/I4210150880"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012226414","display_name":"Maximilian Johannes Hochmair","orcid":"https://orcid.org/0000-0002-8673-2450","observed_orcids":["https://orcid.org/0000-0002-8673-2450"]},"institutions":[{"id":"https://openalex.org/I4210107853","display_name":"Ludwig Boltzmann Institute for Lung Health","ror":"https://ror.org/01tf5aq62","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210107853"]},{"id":"https://openalex.org/I4210139931","display_name":"Otto Wagner Hospital","ror":"https://ror.org/041jk5w53","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134","https://openalex.org/I4210139931"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Maximilian J. Hochmair","raw_affiliation_strings":["Department of Respiratory and Critical Care Medicine & Ludwig Boltzmann Institute for COPD & Respiratory Epidemiology \u2013 Baumgartner H\u00f6he, Otto-Wagner-Spital, Vienna, Austria;","Department of Respiratory and Critical Care Medicine & Ludwig Boltzmann Institute for COPD & Respiratory Epidemiology \u2013 Baumgartner H\u00f6he, Otto-Wagner-Spital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine & Ludwig Boltzmann Institute for COPD & Respiratory Epidemiology \u2013 Baumgartner H\u00f6he, Otto-Wagner-Spital, Vienna, Austria;","institution_ids":["https://openalex.org/I4210107853","https://openalex.org/I4210139931"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine & Ludwig Boltzmann Institute for COPD & Respiratory Epidemiology \u2013 Baumgartner H\u00f6he, Otto-Wagner-Spital, Vienna, Austria","institution_ids":["https://openalex.org/I4210107853","https://openalex.org/I4210139931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036764789","display_name":"Florian Huemer","orcid":"https://orcid.org/0000-0001-9184-4038","observed_orcids":["https://orcid.org/0000-0001-9184-4038"]},"institutions":[{"id":"https://openalex.org/I4210107853","display_name":"Ludwig Boltzmann Institute for Lung Health","ror":"https://ror.org/01tf5aq62","country_code":"AT","type":"facility","lineage":["https://openalex.org/I2799334681","https://openalex.org/I4210107853"]},{"id":"https://openalex.org/I4210139931","display_name":"Otto Wagner Hospital","ror":"https://ror.org/041jk5w53","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210117134","https://openalex.org/I4210139931"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Florian Huemer","raw_affiliation_strings":["2nd Department of Respiratory and Critical Care Medicine & Ludwig Boltzmann Institute for COPD & Respiratory Epidemiology \u2013 Baumgartner H\u00f6he, Otto-Wagner-Spital, Vienna, Austria;","2nd Department of Respiratory and Critical Care Medicine & Ludwig Boltzmann Institute for COPD & Respiratory Epidemiology \u2013 Baumgartner H\u00f6he, Otto-Wagner-Spital, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2nd Department of Respiratory and Critical Care Medicine & Ludwig Boltzmann Institute for COPD & Respiratory Epidemiology \u2013 Baumgartner H\u00f6he, Otto-Wagner-Spital, Vienna, Austria;","institution_ids":["https://openalex.org/I4210107853","https://openalex.org/I4210139931"]},{"raw_affiliation_string":"2nd Department of Respiratory and Critical Care Medicine & Ludwig Boltzmann Institute for COPD & Respiratory Epidemiology \u2013 Baumgartner H\u00f6he, Otto-Wagner-Spital, Vienna, Austria","institution_ids":["https://openalex.org/I4210107853","https://openalex.org/I4210139931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054842148","display_name":"Gy\u00f6rgy Losonczy","orcid":"https://orcid.org/0000-0002-0211-5237","observed_orcids":["https://orcid.org/0000-0002-0211-5237"]},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Gy\u00f6rgy Losonczy","raw_affiliation_strings":["Semmelweis Egyetem \u00c1OK, Pulmonol\u00f3giai Klinika, Budapest, Hungary;","Semmelweis Egyetem \u00c1OK, Pulmonol\u00f3giai Klinika, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Semmelweis Egyetem \u00c1OK, Pulmonol\u00f3giai Klinika, Budapest, Hungary;","institution_ids":["https://openalex.org/I101202996"]},{"raw_affiliation_string":"Semmelweis Egyetem \u00c1OK, Pulmonol\u00f3giai Klinika, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049294543","display_name":"Melissa Lynne Johnson","orcid":"https://orcid.org/0000-0001-9874-1314","observed_orcids":["https://orcid.org/0000-0001-9874-1314"]},"institutions":[{"id":"https://openalex.org/I4210100810","display_name":"Sarah Cannon","ror":"https://ror.org/014t21j89","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210100810"]},{"id":"https://openalex.org/I4210135086","display_name":"Tennessee Oncology","ror":"https://ror.org/03754ky26","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210135086"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melissa L. Johnson","raw_affiliation_strings":["Sarah Cannon Research Institute/Tennessee Oncology PLLC, Nashville, TN;","Sarah Cannon Research Institute/Tennessee Oncology PLLC, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sarah Cannon Research Institute/Tennessee Oncology PLLC, Nashville, TN;","institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"]},{"raw_affiliation_string":"Sarah Cannon Research Institute/Tennessee Oncology PLLC, Nashville, TN","institution_ids":["https://openalex.org/I4210100810","https://openalex.org/I4210135086"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078287634","display_name":"Makoto Nishio","orcid":"https://orcid.org/0000-0003-4969-4165","observed_orcids":["https://orcid.org/0000-0003-4969-4165"]},"institutions":[{"id":"https://openalex.org/I4210137039","display_name":"The Cancer Institute Hospital","ror":"https://ror.org/03md8p445","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210137039"]},{"id":"https://openalex.org/I42570316","display_name":"Japanese Foundation For Cancer Research","ror":"https://ror.org/00bv64a69","country_code":"JP","type":"nonprofit","lineage":["https://openalex.org/I42570316"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Nishio","raw_affiliation_strings":["The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;","The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan;","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]},{"raw_affiliation_string":"The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan","institution_ids":["https://openalex.org/I4210137039","https://openalex.org/I42570316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060572768","display_name":"Martin Reck","orcid":"https://orcid.org/0000-0002-5336-9739","observed_orcids":["https://orcid.org/0000-0002-5336-9739"]},"institutions":[{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210140903","display_name":"LungenClinic Grosshansdorf","ror":"https://ror.org/041wfjw90","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210140903"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Reck","raw_affiliation_strings":["LungClinic Grosshansdorf, German Center for Lung Research, Grosshansdorf, Germany;","LungClinic Grosshansdorf, German Center for Lung Research, Grosshansdorf, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LungClinic Grosshansdorf, German Center for Lung Research, Grosshansdorf, Germany;","institution_ids":["https://openalex.org/I4210129183","https://openalex.org/I4210140903"]},{"raw_affiliation_string":"LungClinic Grosshansdorf, German Center for Lung Research, Grosshansdorf, Germany","institution_ids":["https://openalex.org/I4210129183","https://openalex.org/I4210140903"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066717752","display_name":"Tony S.K. Mok","orcid":"https://orcid.org/0000-0002-8251-0551","observed_orcids":["https://orcid.org/0000-0002-8251-0551"]},"institutions":[{"id":"https://openalex.org/I177725633","display_name":"Chinese University of Hong Kong","ror":"https://ror.org/00t33hh48","country_code":"HK","type":"education","lineage":["https://openalex.org/I177725633"]}],"countries":["HK"],"is_corresponding":false,"raw_author_name":"Tony S. Mok","raw_affiliation_strings":["State Key Laboratory of South China, The Chinese University of Hong Kong, Hong Kong, Hong Kong;","State Key Laboratory of South China, The Chinese University of Hong Kong, Hong Kong, Hong Kong"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of South China, The Chinese University of Hong Kong, Hong Kong, Hong Kong;","institution_ids":["https://openalex.org/I177725633"]},{"raw_affiliation_string":"State Key Laboratory of South China, The Chinese University of Hong Kong, Hong Kong, Hong Kong","institution_ids":["https://openalex.org/I177725633"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019770739","display_name":"Sivuonthanh Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Sivuonthanh Lam","raw_affiliation_strings":["Genentech, Inc., San Francisco, CA;","Genentech, Inc., San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech, Inc., San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049192558","display_name":"David S. Shames","orcid":"https://orcid.org/0000-0002-5900-1177","observed_orcids":["https://orcid.org/0000-0002-5900-1177"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"David S. Shames","raw_affiliation_strings":["Genentech, Inc., San Francisco, CA;","Genentech, Inc., San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech, Inc., San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100446315","display_name":"Juan Liu","orcid":"https://orcid.org/0000-0002-8693-4271","observed_orcids":["https://orcid.org/0000-0002-8693-4271"]},"institutions":[{"id":"https://openalex.org/I4210119458","display_name":"Roche (China)","ror":"https://ror.org/02hv5e369","country_code":"CN","type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I4210119458"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Liu","raw_affiliation_strings":["F. Hoffmann-La Roche, Ltd., Shanghai, China;","F. Hoffmann-La Roche, Ltd., Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"F. Hoffmann-La Roche, Ltd., Shanghai, China;","institution_ids":["https://openalex.org/I4210119458"]},{"raw_affiliation_string":"F. Hoffmann-La Roche, Ltd., Shanghai, China","institution_ids":["https://openalex.org/I4210119458"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006496749","display_name":"Fairooz F. Kabbinavar","orcid":"https://orcid.org/0009-0003-2552-4935","observed_orcids":["https://orcid.org/0009-0003-2552-4935"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Fairooz Kabbinavar","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA;","Genentech, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078389632","display_name":"Alan B. Sandler","orcid":"https://orcid.org/0009-0004-5397-5247","observed_orcids":["https://orcid.org/0009-0004-5397-5247"]},"institutions":[{"id":"https://openalex.org/I183934855","display_name":"Genentech","ror":"https://ror.org/04gndp242","country_code":null,"type":"company","lineage":["https://openalex.org/I118019719","https://openalex.org/I129302853","https://openalex.org/I183934855"]}],"countries":[],"is_corresponding":false,"raw_author_name":"Alan Sandler","raw_affiliation_strings":["Genentech, Inc., South San Francisco, CA;","Genentech, Inc., South San Francisco, CA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA;","institution_ids":["https://openalex.org/I183934855"]},{"raw_affiliation_string":"Genentech, Inc., South San Francisco, CA","institution_ids":["https://openalex.org/I183934855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062894702","display_name":"Leora Horn","orcid":"https://orcid.org/0000-0003-2070-2547","observed_orcids":["https://orcid.org/0000-0003-2070-2547"]},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]},{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leora Horn","raw_affiliation_strings":["Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN","institution_ids":["https://openalex.org/I200719446","https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":20,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"CT199","last_page":"CT199"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.9452999830245972,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.020800000056624413,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.012299999594688416,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atezolizumab","display_name":"atezolizumab","score":0.9570000171661377},{"id":"https://openalex.org/keywords/extensive-stage-small-cell-lung-cancer","display_name":"extensive-stage small cell lung cancer","score":0.9160000085830688},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.765999972820282},{"id":"https://openalex.org/keywords/carboplatin","display_name":"carboplatin","score":0.9539999961853027},{"id":"https://openalex.org/keywords/etoposide","display_name":"etoposide","score":1.0},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.9039999842643738},{"id":"https://openalex.org/keywords/prophylactic-cranial-irradiation","display_name":"prophylactic cranial irradiation","score":0.7680000066757202},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.875},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.996999979019165},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.7649999856948853},{"id":"https://openalex.org/keywords/impower133","display_name":"IMpower133","score":0.8080000281333923},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.5130000114440918},{"id":"https://openalex.org/keywords/thoracic-radiation","display_name":"thoracic radiation","score":0.6060000061988831}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8610045909881592},{"id":"https://openalex.org/C2781451048","wikidata":"https://www.wikidata.org/wiki/Q415588","display_name":"Carboplatin","level":4,"score":0.8522670269012451},{"id":"https://openalex.org/C2775949291","wikidata":"https://www.wikidata.org/wiki/Q20707748","display_name":"Atezolizumab","level":5,"score":0.811025857925415},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.6557354927062988},{"id":"https://openalex.org/C2779562246","wikidata":"https://www.wikidata.org/wiki/Q16918881","display_name":"Prophylactic cranial irradiation","level":4,"score":0.6325944662094116},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.5393728017807007},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.539313554763794},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5248558521270752},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5020971298217773},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4374036192893982},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.4122332036495209},{"id":"https://openalex.org/C45393284","wikidata":"https://www.wikidata.org/wiki/Q191012","display_name":"Conventional PCI","level":3,"score":0.37088581919670105},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.356867253780365},{"id":"https://openalex.org/C2778239845","wikidata":"https://www.wikidata.org/wiki/Q412415","display_name":"Cisplatin","level":3,"score":0.2844412922859192},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.22970089316368103},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.062055230140686035},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.05264565348625183},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.sabcs18-ct199","doi":"https://doi.org/10.1158/1538-7445.sabcs18-ct199","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.sabcs18-ct199","pdf_url":null,"source":{"id":"https://openalex.org/S59378366","display_name":"Clinical Trials","issn_l":"1740-7745","issn":["1740-7745","1740-7753"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Trials","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1994546669","https://openalex.org/W2134044915","https://openalex.org/W3094743317","https://openalex.org/W1982203825","https://openalex.org/W1989308867","https://openalex.org/W2767645483","https://openalex.org/W2001663274","https://openalex.org/W2017836189","https://openalex.org/W2048847191","https://openalex.org/W155247356"],"abstract_inverted_index":{"Background":[0],"Platinum":[1],"chemotherapy":[2],"(carboplatin":[3],"or":[4,51,103,108,114,291],"cisplatin)":[5],"+":[6,88,174,264,294,296,307,309,313,315,442,455,457],"etoposide":[7,89,175,265,297,458],"is":[8,32,41],"the":[9,43,258,380,467],"current":[10],"1L":[11,54,185,275],"standard":[12,302],"of":[13,47,80,116,230,235,247,386,450,466],"care":[14],"treatment":[15],"(tx)":[16],"for":[17,56,65,304,470],"ES-SCLC.":[18],"Despite":[19],"high":[20],"response":[21],"rates":[22],"on":[23],"this":[24,274],"regimen,":[25],"patient":[26],"(pt)":[27],"outcomes":[28,147],"remain":[29],"poor.":[30],"IMpower133":[31,59],"a":[33,268,300,384,447],"Ph1/3,":[34],"double-blind,":[35],"randomized,":[36],"placebo":[37],"(PBO)-controlled":[38],"trial":[39],"that":[40],"evaluating":[42],"efficacy":[44,180,340,439],"and":[45,139,163,182,195,209,440],"safety":[46,283,369,441],"adding":[48],"PD-L1-inhibitor":[49],"atezo":[50,97,107,171,213,231,261],"PBO":[52,109,217,236],"to":[53,76,172,262,373,379],"tx":[55,64,374],"ES-SCLC":[57,186,276],"(NCT02763579).Methods":[58],"enrolled":[60],"pts":[61,200,232,251,287,349],"without":[62],"prior":[63],"ES-SCLC;":[66],"PD-L1":[67],"testing":[68],"was":[69,124,133,146],"not":[70],"required.":[71],"Pts":[72],"were":[73,137,190,280],"randomized":[74,378],"1:1":[75],"four":[77],"21-day":[78],"cycles":[79],"carboplatin":[81,173,263,295,308,314,456],"(AUC":[82],"5":[83],"mg/mL/min":[84],"IV,":[85,92,100],"Day":[86,101],"1)":[87,102],"(100":[90],"mg/m2":[91],"Days":[93],"1-3)":[94],"with":[95],"either":[96],"(1200":[98],"mg":[99],"PBO,":[104],"then":[105],"maintenance":[106],"until":[110],"PD,":[111],"unacceptable":[112],"toxicity":[113],"loss":[115],"clinical":[117],"benefit.":[118],"Maintenance":[119],"prophylactic":[120],"cranial":[121],"irradiation":[122],"(PCI)":[123],"allowed":[125],"per":[126],"protocol,":[127],"while":[128],"definitive":[129],"thoracic":[130],"radiation":[131],"(TR)":[132],"not.":[134],"Coprimary":[135],"endpoints":[136],"OS":[138],"investigator-assessed":[140],"PFS.":[141],"A":[142],"key":[143,193],"exploratory":[144],"endpoint":[145],"by":[148],"blood":[149],"tumor":[150],"mutation":[151],"burden":[152],"(bTMB)":[153],"analyzed":[154],"at":[155],"prespecified":[156,196],"cutoffs":[157],"(\u2265":[158],"16":[159,162],"vs":[160,166,233,244],"<":[161,167],"\u2265":[164,391],"10":[165,168],"mutations/Mb).Results":[169],"Adding":[170,260],"demonstrated":[176],"significant":[177,269],"improvement":[178,270],"in":[179,184,202,212,216,228,242,250,257,267,271,273,286,348,390,446,459],"(OS":[181],"PFS)":[183],"(Table).":[187],"Survival":[188],"benefits":[189],"consistent":[191],"across":[192],"subgroups":[194],"bTMB":[197],"cutoffs.":[198],"44":[199],"(22":[201],"each":[203],"arm":[204,382],"[per":[205],"ITT])":[206],"received":[207,219,289,375,383],"PCI,":[208,352],"7":[210],"(3":[211],"arm,":[214],"4":[215],"arm)":[218],"TR.":[220,292],"Gr":[221],"3-4":[222],"tx-related":[223,239],"adverse":[224,444],"events":[225,445],"(AEs)":[226],"occurred":[227,241],"57%":[229],"56%":[234],"pts;":[237],"serious":[238],"AEs":[240,249,347,388],"23%":[243],"19%.":[245],"Occurrence":[246],"CNS-related":[248,443],"who":[252,288,350],"had":[253,351],"PCI":[254,290],"are":[255],"shown":[256],"Table.Conclusion":[259],"resulted":[266],"survival":[272],"all-comers":[277],"population.":[278],"There":[279],"no":[281],"new":[282,301],"signals,":[284],"including":[285],"Atezo":[293],"may":[298],"represent":[299],"regimen":[303],"untreated":[305],"ES-SCLC.Atezo":[306],"etoposiden":[310,316],"=":[311,317,328,338,355,357],"201PBO":[312],"202Co-primary":[318],"endpointsMedian":[319],"OS,":[320],"mo12.310.3HR":[321],"0.70":[322],"(95%":[323,333],"CI:":[324,334],"0.54,":[325],"0.91);":[326],"P":[327,337],"0.0069Median":[329],"PFS,":[330],"mo5.24.3HR":[331],"0.77":[332],"0.62,":[335],"0.96)":[336],"0.017Secondary":[339],"endpointsInvestigator-assessed":[341],"confirmed":[342],"ORR,":[343],"%60.264.4Median":[344],"DoR,":[345],"mo4.23.9CNS-related":[346],"n":[353],"(%)a,bn":[354],"23n":[356],"21Headache8":[358],"(34.8)4":[359],"(19.0)Asthenia5":[360],"(21.7)2":[361],"(9.5)Dizziness2":[362],"(8.7)0Insomnia2":[363],"(8.7)1":[364,366],"(4.8)Fall2":[365],"(4.8)aSafety":[367],"population;":[368],"analyses":[370],"conducted":[371],"according":[372],"(1":[376],"pt":[377],"control":[381],"dose":[385],"atezo).bIncludes":[387],"occurring":[389],"2":[392],"patients.Citation":[393],"Format:":[394],"Aaron":[395],"S.":[396,422,427],"Mansfield,":[397],"Stephen":[398],"V.":[399],"Liu,":[400,430],"Aleksandra":[401],"Szcz\u0119sna,":[402],"Libor":[403],"Havel,":[404],"Maciej":[405],"Kzrakowski,":[406],"Maximilian":[407],"J.":[408],"Hochmair,":[409],"Florian":[410],"Huemer,":[411],"Gy\u00f6rgy":[412],"Losonczy,":[413],"Melissa":[414],"L.":[415],"Johnson,":[416],"Makoto":[417],"Nishio,":[418],"Martin":[419],"Reck,":[420],"Tony":[421],"Mok,":[423],"Sivuonthanh":[424],"Lam,":[425],"David":[426],"Shames,":[428],"Juan":[429],"Fairooz":[431],"Kabbinavar,":[432],"Alan":[433],"Sandler,":[434],"Leora":[435],"Horn.":[436],"IMpower133:":[437],"Primary":[438],"Ph1/3":[448],"study":[449],"first-line":[451],"(1L)":[452],"atezolizumab":[453],"(atezo)":[454],"extensive-stage":[460],"SCLC":[461],"(ES-SCLC)":[462],"[abstract].":[463],"In:":[464],"Proceedings":[465],"American":[468],"Association":[469],"Cancer":[471,485],"Research":[472],"Annual":[473],"Meeting":[474],"2019;":[475],"2019":[476],"Mar":[477],"29-Apr":[478],"3;":[479],"Atlanta,":[480],"GA.":[481],"Philadelphia":[482],"(PA):":[483],"AACR;":[484],"Res":[486],"2019;79(13":[487],"Suppl):Abstract":[488],"nr":[489],"CT199.":[490]},"counts_by_year":[],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2025-10-10T00:00:00"}