{"id":"https://openalex.org/W4235630331","doi":"https://doi.org/10.1161/res.121.suppl_1.341","title":"Abstract 341: Disturbance of p53-indcued Long Noncoding RNA Meg3 - FUS Complex by AAV9 System Preserves Heart Function in Myocardial Infarction","display_name":"Abstract 341: Disturbance of p53-indcued Long Noncoding RNA Meg3 - FUS Complex by AAV9 System Preserves Heart Function in Myocardial Infarction","publication_year":2017,"publication_date":"2017-07-21","ids":{"openalex":"https://openalex.org/W4235630331","doi":"https://doi.org/10.1161/res.121.suppl_1.341"},"language":"en","primary_location":{"id":"doi:10.1161/res.121.suppl_1.341","doi":"https://doi.org/10.1161/res.121.suppl_1.341","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.121.suppl_1.341","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108446585","display_name":"Hongchun Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongchun Wu","raw_affiliation_strings":["Soochow Univ, Suzhou, China","Hongchun Wu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow Univ, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Hongchun Wu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037015064","display_name":"Kaili Hao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kaili Hao","raw_affiliation_strings":["Soochow Univ, Suzhou, China","Kaili Hao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow Univ, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Kaili Hao","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089462099","display_name":"Yu You","orcid":"https://orcid.org/0000-0002-8983-6378","observed_orcids":["https://orcid.org/0000-0002-8983-6378"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"You Yu","raw_affiliation_strings":["Soochow Univ, Suzhou, China","You Yu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow Univ, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"You Yu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066737055","display_name":"Xinglong Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinglong Han","raw_affiliation_strings":["Soochow Univ, Suzhou, China","Xinglong Han"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow Univ, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Xinglong Han","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338397","display_name":"Jingjing Li","orcid":"https://orcid.org/0000-0003-0600-7097","observed_orcids":["https://orcid.org/0000-0003-0600-7097"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Li","raw_affiliation_strings":["Soochow Univ, Suzhou, China","Jingjing Li"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow Univ, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Jingjing Li","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039306381","display_name":"Zhen\u2010Ao Zhao","orcid":"https://orcid.org/0000-0002-9868-2534","observed_orcids":["https://orcid.org/0000-0002-9868-2534"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-Ao Zhao","raw_affiliation_strings":["Soochow Univ, Suzhou, China","Zhen-Ao Zhao"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow Univ, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Zhen-Ao Zhao","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422491","display_name":"Junwei Liu","orcid":"https://orcid.org/0000-0002-1320-4024","observed_orcids":["https://orcid.org/0000-0002-1320-4024"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junwei Liu","raw_affiliation_strings":["Huazhong Univ of Science and Technology, Wuhan, China","Junwei Liu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huazhong Univ of Science and Technology, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Junwei Liu","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047561254","display_name":"Joseph C. Wu","orcid":"https://orcid.org/0000-0002-6068-8041","observed_orcids":["https://orcid.org/0000-0002-6068-8041","https://orcid.org/0000-0003-4274-0413"]},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph C Wu","raw_affiliation_strings":["Stanford Univ, Stanford, CA","Joseph C Wu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stanford Univ, Stanford, CA","institution_ids":["https://openalex.org/I97018004"]},{"raw_affiliation_string":"Joseph C Wu","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035131138","display_name":"Shijun Hu","orcid":"https://orcid.org/0000-0002-0068-8429","observed_orcids":["https://orcid.org/0000-0002-0068-8429"]},"institutions":[{"id":"https://openalex.org/I3923682","display_name":"Soochow University","ror":"https://ror.org/05t8y2r12","country_code":"CN","type":"education","lineage":["https://openalex.org/I3923682"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shijun Hu","raw_affiliation_strings":["Soochow Univ, Suzhou, China","Shijun Hu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Soochow Univ, Suzhou, China","institution_ids":["https://openalex.org/I3923682"]},{"raw_affiliation_string":"Shijun Hu","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"121","issue":"suppl_1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.38600000739097595,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.38600000739097595,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.16300000250339508,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11677","display_name":"Congenital heart defects research","score":0.07769999653100967,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/meg3","display_name":"MEG3","score":0.8100000023841858},{"id":"https://openalex.org/keywords/long-non-coding-rna","display_name":"long non-coding RNA","score":0.9739999771118164},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9739999771118164},{"id":"https://openalex.org/keywords/fus","display_name":"FUS","score":0.9670000076293945},{"id":"https://openalex.org/keywords/cardiomyocyte-apoptosis","display_name":"cardiomyocyte apoptosis","score":0.9580000042915344},{"id":"https://openalex.org/keywords/myocardial-infarction","display_name":"myocardial infarction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cardiac-remodeling","display_name":"cardiac remodeling","score":0.6430000066757202},{"id":"https://openalex.org/keywords/aav9-gene-therapy","display_name":"AAV9 gene therapy","score":0.7699999809265137},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.9259999990463257}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.789664089679718},{"id":"https://openalex.org/C2781369401","wikidata":"https://www.wikidata.org/wiki/Q18041809","display_name":"MEG3","level":5,"score":0.7739409804344177},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6616188883781433},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5547778606414795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5421231389045715},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.43118536472320557},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38984209299087524},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.36755359172821045},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.3271447420120239},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11605438590049744},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07852548360824585}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1161/res.121.suppl_1.341","doi":"https://doi.org/10.1161/res.121.suppl_1.341","is_oa":false,"landing_page_url":"https://doi.org/10.1161/res.121.suppl_1.341","pdf_url":null,"source":{"id":"https://openalex.org/S10652568","display_name":"Circulation Research","issn_l":"0009-7330","issn":["0009-7330","1524-4571"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Circulation Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2894967305","https://openalex.org/W2980341630","https://openalex.org/W2897790387","https://openalex.org/W4381308173","https://openalex.org/W3025565108","https://openalex.org/W4245418655","https://openalex.org/W2944910822","https://openalex.org/W3022039290","https://openalex.org/W2989843273","https://openalex.org/W4387492391"],"abstract_inverted_index":{"Introduction:":[0],"The":[1,81,92,183],"injured":[2,148],"heart":[3,149,193],"undergoes":[4],"a":[5,237],"major":[6],"process":[7],"of":[8,15,40,94],"cellular":[9,73],"apoptosis":[10,53,74,225],"in":[11,58,101,121,123,145,158,174,186,195,205,231],"the":[12,18,37,55,126,146,155],"initial":[13],"stage":[14],"MI,":[16,151],"therefore,":[17],"most":[19],"fundamental":[20],"method":[21,239],"to":[22,27,70,117,240],"prevent":[23],"post-MI":[24],"remodeling":[25],"is":[26],"suppress":[28],"cardiomyocyte":[29,52,224],"apoptosis.":[30],"In":[31],"this":[32],"study,":[33],"we":[34],"have":[35],"illustrated":[36],"key":[38],"role":[39,222],"long":[41],"noncoding":[42],"RNA,":[43],"Maternally":[44],"expressed":[45],"gene":[46],"3":[47],"(":[48],"Meg3":[49,82,95,120,141,161,184,215],"),":[50],"on":[51,223],"and":[54,64,72,96,107,125,133,152,171,227],"underlying":[56],"mechanisms":[57],"heart.":[59],"Methods:":[60],"Neonatal":[61],"murine":[62,147,196],"cardiomyocytes":[63,67,122,187,232],"human":[65,206],"ESC-derived":[66],"were":[68],"subjected":[69],"hypoxia,":[71],"was":[75,86,103,115,129,142,172,203],"evaluated":[76,130],"with":[77,181,233],"Annexin":[78],"V":[79],"assay.":[80,91],"regulation":[83,176],"by":[84,88,105,131,166,188],"p53":[85,167],"measured":[87],"luciferase":[89],"reporter":[90],"complex":[93,218],"RNA-binding":[97],"protein":[98],"FUS":[99,217],"(Fused":[100],"sarcoma)":[102],"determined":[104],"EMSA":[106],"RIP.":[108],"Adeno-Associated":[109],"Virus":[110],"serotype":[111],"9":[112],"(AAV9)":[113],"system":[114,190,235],"employed":[116],"knock":[118],"down":[119],"vivo,":[124],"cardiac":[127],"function":[128,194,202],"echocardiography":[132],"ex-vivo":[134],"assays.":[135],"Results:":[136],"We":[137],"first":[138],"found":[139],"that":[140,213],"progressively":[143],"upregulated":[144,165],"after":[150],"it":[153],"showed":[154],"pro-apoptotic":[156,201],"functions":[157],"primary":[159],"cardiomyocytes.":[160,207],"could":[162,191],"be":[163],"directly":[164],"during":[168],"hypoxia":[169],"condition,":[170],"involved":[173],"apoptotic":[175],"via":[177],"its":[178,200,228],"direct":[179],"binding":[180],"FUS.":[182],"knockdown":[185,230],"AAV9":[189,234],"preserve":[192],"myocardial":[197,242],"infarction.":[198,243],"Moreover,":[199],"conserved":[204],"Conclusion:":[208],"Together,":[209],"these":[210],"results":[211],"indicate":[212],"p53-induced":[214],"-":[216],"plays":[219],"an":[220],"important":[221],"post-MI,":[226],"specific":[229],"represents":[236],"promising":[238],"treat":[241]},"counts_by_year":[],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2022-05-12T00:00:00"}
