{"id":"https://openalex.org/W4235596679","doi":"https://doi.org/10.1517/13543784.10.5.825","title":"Development and therapeutic indications of orally-active non-peptide vasopressin receptor antagonists","display_name":"Development and therapeutic indications of orally-active non-peptide vasopressin receptor antagonists","publication_year":2001,"publication_date":"2001-05-01","ids":{"openalex":"https://openalex.org/W4235596679","doi":"https://doi.org/10.1517/13543784.10.5.825","pmid":"https://pubmed.ncbi.nlm.nih.gov/11322860"},"language":"en","primary_location":{"id":"doi:10.1517/13543784.10.5.825","doi":"https://doi.org/10.1517/13543784.10.5.825","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.10.5.825","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113996092","display_name":"Sudhan Paranjape","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suvinay B Paranjape","raw_affiliation_strings":["Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, Ohio 44106-4951, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University School of Medicine and University Hospitals of Cleveland, 10900 Euclid Avenue, Cleveland, Ohio 44106-4951, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I58956616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089077794","display_name":"Marc Thibonnier","orcid":"https://orcid.org/0000-0002-4546-180X","observed_orcids":["https://orcid.org/0000-0002-4546-180X"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marc Thibonnier","raw_affiliation_strings":["Room BRB431, Department of Medicine, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106-4951, USA. mxt10@po.cwru.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Room BRB431, Department of Medicine, Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, Ohio 44106-4951, USA. mxt10@po.cwru.edu","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.4109,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.8322877,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"10","issue":"5","first_page":"825","last_page":"834"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11967","display_name":"Electrolyte and hormonal disorders","score":0.9824000000953674,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14486","display_name":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.004100000020116568,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vasopressin-receptor-antagonists","display_name":"vasopressin receptor antagonists","score":0.9769999980926514},{"id":"https://openalex.org/keywords/oral-drug-development","display_name":"oral drug development","score":0.5680000185966492},{"id":"https://openalex.org/keywords/v1a-receptor","display_name":"V1a receptor","score":0.6069999933242798},{"id":"https://openalex.org/keywords/vasopressin-v2-receptor","display_name":"V2 receptor","score":0.9829999804496765},{"id":"https://openalex.org/keywords/syndrome-of-inappropriate-antidiuretic-hormone-secretion","display_name":"syndrome of inappropriate antidiuretic hormone secretion","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8399999737739563},{"id":"https://openalex.org/keywords/congestive-heart-failure","display_name":"congestive heart failure","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dysmenorrhea","display_name":"dysmenorrhea","score":0.7210000157356262},{"id":"https://openalex.org/keywords/hyponatremia","display_name":"hyponatremia","score":0.7369999885559082},{"id":"https://openalex.org/keywords/acth-secreting-adenoma","display_name":"ACTH-secreting tumor","score":0.7850000262260437},{"id":"https://openalex.org/keywords/drug-screening","display_name":"drug screening","score":0.3400000035762787},{"id":"https://openalex.org/keywords/lead-optimization","display_name":"lead optimization","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.7392469048500061},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6861435770988464},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6820360422134399},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6702013611793518},{"id":"https://openalex.org/C90474776","wikidata":"https://www.wikidata.org/wiki/Q24784390","display_name":"Vasopressin receptor","level":4,"score":0.5746057629585266},{"id":"https://openalex.org/C2779881253","wikidata":"https://www.wikidata.org/wiki/Q1587028","display_name":"Vasopressin Antagonists","level":4,"score":0.5647399425506592},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.509842574596405},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.48243841528892517},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.41788727045059204},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.06846612691879272}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003919","descriptor_name":"Diabetes Insipidus","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004412","descriptor_name":"Dysmenorrhea","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D007010","descriptor_name":"Hyponatremia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D065092","descriptor_name":"Antidiuretic Hormone Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1517/13543784.10.5.825","doi":"https://doi.org/10.1517/13543784.10.5.825","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.10.5.825","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},{"id":"pmid:11322860","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11322860","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on investigational drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W120370463","https://openalex.org/W298378610","https://openalex.org/W1729808602","https://openalex.org/W1944772484","https://openalex.org/W1959892471","https://openalex.org/W1968611495","https://openalex.org/W1974365124","https://openalex.org/W1983911029","https://openalex.org/W1986620839","https://openalex.org/W1991705297","https://openalex.org/W1994690457","https://openalex.org/W1994859626","https://openalex.org/W1994890126","https://openalex.org/W2001912905","https://openalex.org/W2011820327","https://openalex.org/W2024435623","https://openalex.org/W2027467507","https://openalex.org/W2030725425","https://openalex.org/W2047140979","https://openalex.org/W2048083002","https://openalex.org/W2056355686","https://openalex.org/W2057640040","https://openalex.org/W2061538500","https://openalex.org/W2061977229","https://openalex.org/W2074330505","https://openalex.org/W2078607192","https://openalex.org/W2082215793","https://openalex.org/W2090971571","https://openalex.org/W2091666217","https://openalex.org/W2101653844","https://openalex.org/W2103209316","https://openalex.org/W2104748479","https://openalex.org/W2109393969","https://openalex.org/W2110802189","https://openalex.org/W2112317854","https://openalex.org/W2117999820","https://openalex.org/W2130645824","https://openalex.org/W2133515585","https://openalex.org/W2150028972","https://openalex.org/W2157907012","https://openalex.org/W2164254604","https://openalex.org/W2300369442","https://openalex.org/W2346028701"],"related_works":["https://openalex.org/W2104748479","https://openalex.org/W2008522101","https://openalex.org/W2144939206","https://openalex.org/W1970443530","https://openalex.org/W2313613389","https://openalex.org/W1994388355","https://openalex.org/W2003470142","https://openalex.org/W755254467","https://openalex.org/W2426192062","https://openalex.org/W2126358811"],"abstract_inverted_index":{"Vasopressin":[0],"(AVP)":[1],"is":[2],"a":[3,25],"cyclic":[4],"nonapeptide":[5],"hormone":[6,21],"that":[7],"exhibits":[8],"many":[9],"physiological":[10],"effects":[11],"including":[12],"free":[13,193],"water":[14,194],"reabsorption,":[15],"vasoconstriction,":[16],"cellular":[17],"proliferation":[18],"and":[19,39,68,94,106,162,186,195,220],"adrenocorticotrophic":[20],"(ACTH)":[22],"secretion.":[23],"In":[24],"healthy":[26],"organism,":[27],"AVP":[28,56,71,83,108,113,140,149,169,204,217],"plays":[29],"an":[30,74],"important":[31,75],"role":[32,76],"in":[33,43,77,151,171,206],"the":[34,50,104,172,212],"homeostasis":[35],"of":[36,52,55,91,96,121,147,167,174,177,189,192,202,214],"fluid":[37],"osmolality":[38],"volume":[40],"status.":[41],"However,":[42],"several":[44],"diseases":[45],"or":[46],"conditions":[47],"such":[48],"as":[49],"syndrome":[51,173,185],"inappropriate":[53,175],"secretion":[54,176],"(SIADH),":[57],"congestive":[58,154,179],"heart":[59,155],"failure,":[60,156,181],"arterial":[61,152],"hypertension,":[62,70,153],"liver":[63,182],"cirrhosis,":[64,183],"nephrotic":[65,184],"syndrome,":[66,158],"dysmenorrhoea":[67],"ocular":[69],"may":[72],"play":[73],"their":[78,221],"pathophysiology.":[79],"Recently,":[80],"orally-active":[81,215],"non-peptide":[82,123,216],"receptor":[84,109,114,124,141,218],"antagonists":[85,115,125,142,219],"were":[86],"developed":[87],"by":[88],"random":[89],"screening":[90],"chemical":[92],"entities":[93],"optimisation":[95],"lead":[97],"compounds.":[98],"These":[99],"include":[100],"agents":[101],"specific":[102],"for":[103,139],"V(1)-vascular":[105,148],"V(2)-renal":[107,168],"subtypes.":[110],"Dual":[111],"V(1)/V(2)":[112],"are":[116,132],"also":[117],"being":[118],"studied.":[119],"Some":[120],"these":[122],"have":[126],"been":[127],"studied":[128],"extensively,":[129],"while":[130],"others":[131],"currently":[133],"under":[134],"investigation.":[135],"Potential":[136],"therapeutic":[137],"indications":[138],"comprise:":[143],"1)":[144],"The":[145,165,200],"blockade":[146,166,201],"receptors":[150,170,205],"Raynaud's":[157],"peripheral":[159],"vascular":[160],"disease":[161],"dysmenorrhea.":[163],"2)":[164],"vasopressin,":[178],"hart":[180],"any":[187],"state":[188],"excessive":[190],"retention":[191],"subsequent":[196],"dilutional":[197],"hyponatraemia.":[198],"3)":[199],"V(3)-pituitary":[203],"ACTH-secreting":[207],"tumours.":[208],"This":[209],"review":[210],"examines":[211],"pharmacology":[213],"clinical":[222],"applications.":[223]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}
