{"id":"https://openalex.org/W4235476255","doi":"https://doi.org/10.1007/978-1-60761-283-4_12","title":"Abacavir","display_name":"Abacavir","publication_year":2010,"publication_date":"2010-11-02","ids":{"openalex":"https://openalex.org/W4235476255","doi":"https://doi.org/10.1007/978-1-60761-283-4_12"},"language":"en","primary_location":{"id":"doi:10.1007/978-1-60761-283-4_12","doi":"https://doi.org/10.1007/978-1-60761-283-4_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-283-4_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomic Testing in Current Clinical Practice","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W2496486112","display_name":"Pharmacogenomic Testing in Current Clinical Practice"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080985934","display_name":"Elizabeth Jane Phillips","orcid":"https://orcid.org/0000-0002-7623-3383","observed_orcids":["https://orcid.org/0000-0002-7623-3383"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]},{"id":"https://openalex.org/I2802220196","display_name":"Sir Charles Gairdner Hospital","ror":"https://ror.org/01hhqsm59","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159","https://openalex.org/I2802220196","https://openalex.org/I4210133657","https://openalex.org/I4396570646"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Elizabeth J. Phillips","raw_affiliation_strings":["Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia","Royal Perth Hospital, Perth, Western Australia, Australia","School of Pathology & Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia","Sir Charles Gairdner Hospital, Nedlands, Perth, Western Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia","institution_ids":["https://openalex.org/I176790772"]},{"raw_affiliation_string":"Royal Perth Hospital, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I2799740997"]},{"raw_affiliation_string":"School of Pathology & Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"Sir Charles Gairdner Hospital, Nedlands, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I2802220196"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070165631","display_name":"Simon Alexander Mallal","orcid":"https://orcid.org/0000-0002-7036-1309","observed_orcids":["https://orcid.org/0000-0002-7036-1309"]},"institutions":[{"id":"https://openalex.org/I176790772","display_name":"Murdoch University","ror":"https://ror.org/00r4sry34","country_code":"AU","type":"education","lineage":["https://openalex.org/I176790772"]},{"id":"https://openalex.org/I177877127","display_name":"The University of Western Australia","ror":"https://ror.org/047272k79","country_code":"AU","type":"education","lineage":["https://openalex.org/I177877127"]},{"id":"https://openalex.org/I2799740997","display_name":"Royal Perth Hospital","ror":"https://ror.org/00zc2xc51","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2799740997","https://openalex.org/I2800882159","https://openalex.org/I4388446364","https://openalex.org/I4405257575"]},{"id":"https://openalex.org/I2802220196","display_name":"Sir Charles Gairdner Hospital","ror":"https://ror.org/01hhqsm59","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2799506148","https://openalex.org/I2800882159","https://openalex.org/I2802220196","https://openalex.org/I4210133657","https://openalex.org/I4396570646"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Simon A. Mallal","raw_affiliation_strings":["Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia","Royal Perth Hospital, Perth, Western Australia, Australia","School of Pathology & Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia","Sir Charles Gairdner Hospital, Nedlands, Perth, Western Australia, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Immunology & Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia","institution_ids":["https://openalex.org/I176790772"]},{"raw_affiliation_string":"Royal Perth Hospital, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I2799740997"]},{"raw_affiliation_string":"School of Pathology & Laboratory Medicine, University of Western Australia, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I177877127"]},{"raw_affiliation_string":"Sir Charles Gairdner Hospital, Nedlands, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I2802220196"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5080985934"],"corresponding_institution_ids":["https://openalex.org/I176790772","https://openalex.org/I177877127","https://openalex.org/I2799740997","https://openalex.org/I2802220196"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.51435221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"201","last_page":"212"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10082","display_name":"HIV/AIDS Research and Interventions","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abacavir","display_name":"abacavir","score":1.0},{"id":"https://openalex.org/keywords/hiv","display_name":"HIV","score":0.7400000095367432},{"id":"https://openalex.org/keywords/reverse-transcriptase-inhibitors","display_name":"reverse transcriptase inhibitors","score":0.9210000038146973},{"id":"https://openalex.org/keywords/nucleoside-analogs","display_name":"nucleoside analogues","score":0.8610000014305115},{"id":"https://openalex.org/keywords/highly-active-antiretroviral-therapy","display_name":"highly active antiretroviral therapy","score":0.9520000219345093},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9739999771118164},{"id":"https://openalex.org/keywords/drug-metabolism","display_name":"drug metabolism","score":0.6129999756813049},{"id":"https://openalex.org/keywords/alcohol-dehydrogenase","display_name":"alcohol dehydrogenase","score":0.8529999852180481},{"id":"https://openalex.org/keywords/uridine-diphosphate-glucuronosyltransferase","display_name":"uridine diphosphate glucuronosyltransferase","score":0.9129999876022339},{"id":"https://openalex.org/keywords/once-daily-dosing","display_name":"once-daily dosing","score":0.7889999747276306},{"id":"https://openalex.org/keywords/lamivudine","display_name":"lamivudine","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fixed-dose-combination","display_name":"fixed-dose combination","score":0.8299999833106995},{"id":"https://openalex.org/keywords/therapeutic-drug-monitoring","display_name":"therapeutic drug monitoring","score":0.8330000042915344},{"id":"https://openalex.org/keywords/drug-interactions","display_name":"drug interactions","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.9632563591003418},{"id":"https://openalex.org/C2777869810","wikidata":"https://www.wikidata.org/wiki/Q422631","display_name":"Lamivudine","level":4,"score":0.721468448638916},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7011104822158813},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5462056398391724},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.49740341305732727},{"id":"https://openalex.org/C2909970146","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Nucleoside Reverse Transcriptase Inhibitor","level":5,"score":0.4770333468914032},{"id":"https://openalex.org/C156719811","wikidata":"https://www.wikidata.org/wiki/Q28774","display_name":"Reverse transcriptase","level":4,"score":0.46563616394996643},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4455893933773041},{"id":"https://openalex.org/C2777351918","wikidata":"https://www.wikidata.org/wiki/Q421559","display_name":"Reverse-transcriptase inhibitor","level":5,"score":0.4437256455421448},{"id":"https://openalex.org/C97320921","wikidata":"https://www.wikidata.org/wiki/Q718753","display_name":"Drug interaction","level":3,"score":0.43245238065719604},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.290627658367157},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2748945355415344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26641860604286194},{"id":"https://openalex.org/C2780593183","wikidata":"https://www.wikidata.org/wiki/Q6844","display_name":"Hepatitis B virus","level":3,"score":0.12850439548492432},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.1252237856388092},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1007/978-1-60761-283-4_12","doi":"https://doi.org/10.1007/978-1-60761-283-4_12","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-1-60761-283-4_12","pdf_url":null,"source":{"id":"https://openalex.org/S4306463399","display_name":"Humana Press eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310315801","host_organization_name":"Humana Press","host_organization_lineage":["https://openalex.org/P4310315801","https://openalex.org/P4310319900"],"host_organization_lineage_names":["Humana Press","Springer Science+Business Media"],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacogenomic Testing in Current Clinical Practice","raw_type":"book-chapter"},{"id":"pmh:oai:alma.61MUN_INST:11136436040007891","doi":null,"is_oa":false,"landing_page_url":"https://researchportal.murdoch.edu.au/esploro/outputs/bookChapter/Abacavir/991005544636307891","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Book Section"},{"id":"pmh:oai:researchrepository.murdoch.edu.au:14857","doi":null,"is_oa":false,"landing_page_url":"http://researchrepository.murdoch.edu.au/id/eprint/14857/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400274","display_name":"Murdoch University Research Portal","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I176790772","host_organization_name":"Murdoch University","host_organization_lineage":["https://openalex.org/I176790772"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Phillips, E.J. <http://researchrepository.murdoch.edu.au/view/author/Phillips, Elizabeth.html> and Mallal, S.A. <http://researchrepository.murdoch.edu.au/view/author/Mallal, Simon.html> (2010) Abacavir. In: Wu, A.H.B. and Kiang-Teck, J.Y., (eds.) Pharmacogenomic Testing in Current Clinical Practice. Humana Press, New York, U.S.A, pp. 201-212.","raw_type":"Book Chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W71091497","https://openalex.org/W1898025448","https://openalex.org/W1972242699","https://openalex.org/W2009516154","https://openalex.org/W2009674096","https://openalex.org/W2021318193","https://openalex.org/W2023655765","https://openalex.org/W2026666645","https://openalex.org/W2032039529","https://openalex.org/W2035312251","https://openalex.org/W2035476310","https://openalex.org/W2036030829","https://openalex.org/W2049501844","https://openalex.org/W2052332986","https://openalex.org/W2053896303","https://openalex.org/W2061857819","https://openalex.org/W2064387902","https://openalex.org/W2069455040","https://openalex.org/W2089378839","https://openalex.org/W2098330191","https://openalex.org/W2101761365","https://openalex.org/W2102942667","https://openalex.org/W2111047626","https://openalex.org/W2112182958","https://openalex.org/W2117678059","https://openalex.org/W2122329447","https://openalex.org/W2135068975","https://openalex.org/W2140055542","https://openalex.org/W2153529108","https://openalex.org/W2168733361","https://openalex.org/W2169362147","https://openalex.org/W2170804912","https://openalex.org/W2410517707","https://openalex.org/W2889331915","https://openalex.org/W4240615046","https://openalex.org/W4248823399"],"related_works":["https://openalex.org/W4247262784","https://openalex.org/W2395065655","https://openalex.org/W2098330191","https://openalex.org/W1965481039","https://openalex.org/W7097676972","https://openalex.org/W2028678640","https://openalex.org/W3203006910","https://openalex.org/W2134728837","https://openalex.org/W4301072998","https://openalex.org/W2161935034"],"abstract_inverted_index":{"Abacavir":[0,50,96],"is":[1,18,51,71,81,97,129,147,181,200,229,263,294],"a":[2,59,85,120,290],"guanosine":[3],"analog":[4,176],"that":[5,48,155,213],"competitively":[6],"inhibits":[7],"the":[8,12,25,33,116,185,204,217,264],"reverse":[9,177,222],"transcriptase":[10,178,223],"of":[11,27,58,76,104,124,139,152,267],"human":[13],"immunodefiency":[14],"virus":[15],"(HIV)":[16],"and":[17,36,41,88,106,163,193,225,281,285,304],"used":[19,55],"in":[20,39,44,64,94,203],"combination":[21,65,77],"antiretroviral":[22,78,211],"therapy":[23],"for":[24,92,259],"treatment":[26],"HIV.":[28],"It":[29,80,146,238],"was":[30],"approved":[31,91],"by":[32,168,184,187,216,233],"US":[34],"Food":[35],"Drug":[37],"Administration":[38],"1998":[40],"has":[42,89,119,135,165,255],"been":[43,90,166,256],"clinical":[45,169,308],"use":[46,93],"since":[47],"time.":[49],"currently":[52],"most":[53,273],"commonly":[54],"as":[56,74,84,220,261],"part":[57,75],"fixed-dose":[60],"combination,":[61],"600":[62],"mg":[63,69],"with":[66,100,278,307],"lamivudine":[67],"300":[68],"which":[70,134,247,270],"given":[72],"once-daily":[73,161],"therapy.":[79],"also":[82,239,295],"available":[83],"liquid":[86],"formulation":[87],"children.":[95],"well":[98],"absorbed":[99],"an":[101,136],"absolute":[102],"bioavailability":[103],"83%":[105],"can":[107],"be":[108,272,276],"taken":[109],"without":[110],"regard":[111],"to":[112,131,160,275,287],"food":[113],"[1].":[114,206],"Although":[115],"parent":[117],"drug":[118,249,253,279],"short":[121],"plasma":[122],"half-life":[123,138,151],"only":[125],"2":[126],"h,":[127],"abacavir":[128,157,180,228,260],"metabolized":[130,182,215,232],"carbovir":[132,153,268],"triphosphate":[133,154,269],"intracellular":[137,150,265,301],"20":[140],"h":[141],"or":[142,243],"longer":[143],"[1,":[144],"2].":[145],"this":[148,164],"long":[149],"makes":[156],"pharmacokinetically":[158],"amenable":[159],"dosing":[162],"supported":[167],"data":[170],"[3,":[171],"4].":[172],"Unlike":[173],"other":[174,210],"nucleoside":[175],"inhibitors,":[179,227],"predominantly":[183],"liver":[186,218],"two":[188],"major":[189],"pathways:":[190],"alcohol":[191],"dehydrogenase":[192],"uridine":[194],"diphosphate":[195],"glucruonyltransferase.":[196],"Less":[197],"than":[198],"2%":[199],"excreted":[201],"unchanged":[202],"urine":[205],"In":[207],"addition,":[208],"unlike":[209],"drugs":[212],"are":[214,283],"such":[219],"nonnucleoside":[221],"inhibitors":[224],"protease":[226],"not":[230,241],"significantly":[231],"cytochrome":[234],"(CYP)":[235],"P450":[236],"enzymes.":[237],"does":[240],"inhibit":[242],"induce":[244],"CYP":[245],"enzymes":[246],"make":[248],"interactions":[250],"unlikely.":[251],"Therapeutic":[252],"monitoring":[254],"infrequently":[257],"employed":[258],"it":[262],"concentrations":[266,303],"would":[271],"likely":[274],"associated":[277],"effect":[280],"these":[282],"difficult":[284],"costly":[286],"measure":[288],"on":[289,299],"routine":[291],"basis.":[292],"There":[293],"very":[296],"little":[297],"information":[298],"validated":[300],"target":[302],"their":[305],"association":[306],"efficacy.":[309]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2022-05-12T00:00:00"}