{"id":"https://openalex.org/W4235147263","doi":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","title":"Eugenol and liposome-based nanocarriers loaded with eugenol protect against anxiolytic disorder via down regulation of neurokinin-1 receptors in mice","display_name":"Eugenol and liposome-based nanocarriers loaded with eugenol protect against anxiolytic disorder via down regulation of neurokinin-1 receptors in mice","publication_year":2020,"publication_date":"2020-09-01","ids":{"openalex":"https://openalex.org/W4235147263","doi":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","mag":"3148056055","pmid":"https://pubmed.ncbi.nlm.nih.gov/33832901"},"language":"en","primary_location":{"id":"doi:10.36721/pjps.2020.33.5.sup.2275-2284.1","doi":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049172785","display_name":"Fahad Jibran Siyal","orcid":"https://orcid.org/0000-0003-0318-6659","observed_orcids":["https://orcid.org/0000-0003-0318-6659"]},"institutions":[{"id":"https://openalex.org/I3131820683","display_name":"Shaheed Mohtarma Benazir Bhutto Medical University","ror":"https://ror.org/03nw0tx25","country_code":"PK","type":"education","lineage":["https://openalex.org/I3131820683"]},{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Fahad Jibran Siyal","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi/Institute of Pharmacy, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi/Institute of Pharmacy, Shaheed Mohtarma Benazir Bhutto Medical University, Larkana","institution_ids":["https://openalex.org/I3131820683","https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113521071","display_name":"Zahida Memon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zahida Memon","raw_affiliation_strings":["Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Ziauddin Medical College, Ziauddin University, Karachi","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102767053","display_name":"Rehan Ahmed Siddiqui","orcid":"https://orcid.org/0000-0003-0099-3156","observed_orcids":["https://orcid.org/0000-0003-0099-3156"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rehan Ahmed Siddiqui","raw_affiliation_strings":["Department of Research, Ziauddin University, Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Ziauddin University, Karachi","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059345136","display_name":"Zara Aslam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Zara Aslam","raw_affiliation_strings":["HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064465130","display_name":"Uzair Nisar","orcid":"https://orcid.org/0000-0001-5956-0828","observed_orcids":["https://orcid.org/0000-0001-5956-0828"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Uzair Nisar","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Ziauddin University, Karachi","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031431793","display_name":"Rehan Imad","orcid":"https://orcid.org/0000-0003-0560-0171","observed_orcids":["https://orcid.org/0000-0003-0560-0171"]},"institutions":[{"id":"https://openalex.org/I923305593","display_name":"Ziauddin University","ror":"https://ror.org/03vz8ns51","country_code":"PK","type":"education","lineage":["https://openalex.org/I923305593"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Rehan Imad","raw_affiliation_strings":["Department of Research, Ziauddin University, Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Research, Ziauddin University, Karachi","institution_ids":["https://openalex.org/I923305593"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091775788","display_name":"Muhammad Raza Shah","orcid":"https://orcid.org/0000-0003-4978-3627","observed_orcids":["https://orcid.org/0000-0003-4978-3627"]},"institutions":[{"id":"https://openalex.org/I193670377","display_name":"University of Karachi","ror":"https://ror.org/05bbbc791","country_code":"PK","type":"education","lineage":["https://openalex.org/I193670377"]},{"id":"https://openalex.org/I4210121526","display_name":"International Center for Chemical and Biological Sciences","ror":"https://ror.org/024ghrf67","country_code":"PK","type":"facility","lineage":["https://openalex.org/I4210121526"]}],"countries":["PK"],"is_corresponding":false,"raw_author_name":"Muhammad Raza Shah","raw_affiliation_strings":["HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi","institution_ids":["https://openalex.org/I193670377","https://openalex.org/I4210121526"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.775,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.88941113,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"33","issue":"5(Supplementary)","first_page":"2275","last_page":"2284"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13090","display_name":"Medicinal Plant Extracts Effects","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13202","display_name":"Pharmacology and Nanomedicine Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eugenol","display_name":"eugenol","score":1.0},{"id":"https://openalex.org/keywords/neurokinin-1-receptor","display_name":"neurokinin-1 receptor","score":0.8809999823570251},{"id":"https://openalex.org/keywords/anxiolytic-effects","display_name":"anxiolytic effects","score":0.9430000185966492},{"id":"https://openalex.org/keywords/anxiety-disorders","display_name":"anxiety disorders","score":0.9779999852180481},{"id":"https://openalex.org/keywords/restraint-stress","display_name":"restraint stress","score":0.9610000252723694},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8519999980926514},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.5830000042915344}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3238176703453064}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001007","descriptor_name":"Anxiety","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D005054","descriptor_name":"Eugenol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008081","descriptor_name":"Liposomes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014151","descriptor_name":"Anti-Anxiety Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018040","descriptor_name":"Receptors, Neurokinin-1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018040","descriptor_name":"Receptors, Neurokinin-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018040","descriptor_name":"Receptors, Neurokinin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064729","descriptor_name":"Neurokinin-1 Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D064729","descriptor_name":"Neurokinin-1 Receptor Antagonists","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.36721/pjps.2020.33.5.sup.2275-2284.1","doi":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},{"id":"pmid:33832901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33832901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan journal of pharmaceutical sciences","raw_type":"Journal Article"},{"id":"mag:3148056055","doi":null,"is_oa":true,"landing_page_url":"https://europepmc.org/article/MED/33832901","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":null}],"best_oa_location":{"id":"doi:10.36721/pjps.2020.33.5.sup.2275-2284.1","doi":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","is_oa":true,"landing_page_url":"https://doi.org/10.36721/pjps.2020.33.5.sup.2275-2284.1","pdf_url":null,"source":{"id":"https://openalex.org/S24112332","display_name":"Pakistan Journal of Pharmaceutical Sciences","issn_l":"1011-601X","issn":["1011-601X","3105-9686"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-40","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319291","host_organization_name":"University of Karachi","host_organization_lineage":["https://openalex.org/P4310319291"],"host_organization_lineage_names":["University of Karachi"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pakistan Journal of Pharmaceutical Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4391389865","https://openalex.org/W3205659697","https://openalex.org/W7058353758","https://openalex.org/W3128971586","https://openalex.org/W4385996719","https://openalex.org/W1993558445","https://openalex.org/W7120602230","https://openalex.org/W4399671623","https://openalex.org/W2001988196","https://openalex.org/W2287361950"],"abstract_inverted_index":{"Anxiety":[0],"disorder":[1,5],"is":[2,13,22,32,58,207],"a":[3,33,186],"psychiatric":[4],"characterized":[6],"by":[7,128,140,219],"extreme":[8],"fear":[9],"or":[10],"worry.":[11],"It":[12,206],"highly":[14],"prevalent":[15],"worldwide":[16],"which":[17],"affects":[18],"daily":[19],"life":[20],"and":[21,42,56,84,145,152,181,212],"also":[23,59,138],"an":[24,60],"enormous":[25],"health":[26],"burden.":[27],"Neurokinin":[28],"1":[29],"receptor":[30],"(NK1R)":[31],"G":[34],"protein":[35,135,153,222],"coupled":[36],"receptor,":[37],"expressed":[38],"in":[39,47,54,73,142,160,175,185,195,224],"both":[40],"central":[41],"peripheral":[43],"nervous":[44],"system,":[45],"involved":[46],"affective":[48],"behaviors.":[49],"NK1R":[50,80,125,134,221],"has":[51,70],"established":[52],"role":[53],"anxiety":[55,66,163],"it":[57,69],"important":[61],"target":[62],"for":[63],"pathogenesis":[64],"of":[65,79,95,98,124],"disorder.":[67,102],"Therefore,":[68],"been":[71],"hypothesized":[72],"previous":[74],"studies":[75],"that":[76,209],"the":[77,92,133,167,171,176,191,203,210],"blockades":[78],"may":[81],"have":[82],"antidepressant":[83],"anxiolytic":[85,101,217],"effects.":[86],"The":[87,121,150],"present":[88],"study":[89,106],"deals":[90],"with":[91,179,198],"molecular":[93],"mechanism":[94],"protective":[96],"activity":[97,218],"eugenol":[99,180,211],"against":[100],"A":[103],"pre-clinical":[104],"animal":[105],"was":[107,126,137,148],"performed":[108],"on":[109],"42":[110],"BALB/c":[111],"mice.":[112,225],"Animals":[113],"were":[114,155,173,193],"given":[115,162],"stress":[116],"through":[117],"conventional":[118],"restrain":[119],"model.":[120],"mRNA":[122,151],"expression":[123,136,223],"analyzed":[127],"real":[129],"time":[130],"RT-PCR.":[131],"Moreover,":[132],"examined":[139],"immunohistochemistry":[141],"whole":[143],"brain":[144],"mean":[146],"density":[147],"calculated.":[149],"expressions":[154,172],"found":[156],"to":[157,166,202],"be":[158],"increased":[159],"animals":[161,177,196],"as":[164,200],"compared":[165,201],"normal":[168],"control.":[169],"Whereas,":[170],"decreased":[174],"treated":[178,197],"its":[182,213],"liposome-based":[183,214],"nanocarriers":[184,199,215],"dose":[187],"dependent":[188],"manner.":[189],"However,":[190],"results":[192],"better":[194],"compound":[204],"alone.":[205],"concluded":[208],"exert":[216],"down-regulating":[220]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2022-05-12T00:00:00"}