{"id":"https://openalex.org/W4234896918","doi":"https://doi.org/10.1002/9781119245193.ch8","title":"Pathophysiology of Urinary Tract Obstruction","display_name":"Pathophysiology of Urinary Tract Obstruction","publication_year":2018,"publication_date":"2018-12-30","ids":{"openalex":"https://openalex.org/W4234896918","doi":"https://doi.org/10.1002/9781119245193.ch8"},"language":"en","primary_location":{"id":"doi:10.1002/9781119245193.ch8","doi":"https://doi.org/10.1002/9781119245193.ch8","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781119245193.ch8","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Smith's Textbook of Endourology","raw_type":"other"},"volume":{"id":"https://openalex.org/W1544698936","display_name":"Smith's Textbook of Endourology"},"type":"other","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053188863","display_name":"Frederick A. Gulmi","orcid":"https://orcid.org/0000-0002-0683-2698","observed_orcids":["https://orcid.org/0000-0002-0683-2698"]},"institutions":[{"id":"https://openalex.org/I4210086933","display_name":"NYU Langone Health","ror":"https://ror.org/005dvqh91","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210086933"]},{"id":"https://openalex.org/I57206974","display_name":"New York University","ror":"https://ror.org/0190ak572","country_code":"US","type":"education","lineage":["https://openalex.org/I57206974"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frederick A. Gulmi","raw_affiliation_strings":["Department of Urology, NYU School of Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology, NYU School of Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4210086933","https://openalex.org/I57206974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068682755","display_name":"Diane Felsen","orcid":"https://orcid.org/0000-0003-1190-9626","observed_orcids":["https://orcid.org/0000-0003-1190-9626"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Diane Felsen","raw_affiliation_strings":["Weill Cornell Medicine, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Weill Cornell Medicine, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"124","last_page":"142"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.013799999840557575,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12634","display_name":"Ureteral procedures and complications","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urinary-tract-obstruction","display_name":"urinary tract obstruction","score":0.9520000219345093},{"id":"https://openalex.org/keywords/interstitial-fibrosis","display_name":"interstitial fibrosis","score":0.8360000252723694},{"id":"https://openalex.org/keywords/unilateral-ureteral-obstruction","display_name":"unilateral ureteral obstruction","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tubular-cell-apoptosis","display_name":"tubular apoptosis","score":0.6349999904632568},{"id":"https://openalex.org/keywords/epithelial-mesenchymal-transition","display_name":"epithelial-mesenchymal transition","score":0.8489999771118164},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.9369999766349792},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ss-31","display_name":"SS-31","score":0.8029999732971191},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.9120000004768372},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.6240000128746033},{"id":"https://openalex.org/keywords/glomerular-filtration-rate-decline","display_name":"glomerular filtration rate decline","score":0.8009999990463257},{"id":"https://openalex.org/keywords/extracellular-matrix-accumulation","display_name":"extracellular matrix accumulation","score":0.7200000286102295},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.8050000071525574},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.5569999814033508}],"concepts":[{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.7995393872261047},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.7116550207138062},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.6963373422622681},{"id":"https://openalex.org/C2780829873","wikidata":"https://www.wikidata.org/wiki/Q374000","display_name":"Peritubular capillaries","level":3,"score":0.6190206408500671},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5610020160675049},{"id":"https://openalex.org/C2778305430","wikidata":"https://www.wikidata.org/wiki/Q26261754","display_name":"Glomerulus","level":3,"score":0.5470524430274963},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.4859253466129303},{"id":"https://openalex.org/C159641895","wikidata":"https://www.wikidata.org/wiki/Q108377937","display_name":"Renal function","level":2,"score":0.4482828676700592},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42132675647735596},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.331061452627182},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.31825152039527893},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.21845144033432007}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/9781119245193.ch8","doi":"https://doi.org/10.1002/9781119245193.ch8","is_oa":false,"landing_page_url":"https://doi.org/10.1002/9781119245193.ch8","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Smith's Textbook of Endourology","raw_type":"other"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":97,"referenced_works":["https://openalex.org/W179945565","https://openalex.org/W316286216","https://openalex.org/W887436300","https://openalex.org/W1722845210","https://openalex.org/W1949377242","https://openalex.org/W1964177773","https://openalex.org/W1968002331","https://openalex.org/W1969291377","https://openalex.org/W1970088621","https://openalex.org/W1976765944","https://openalex.org/W1977437151","https://openalex.org/W1985727654","https://openalex.org/W1991564855","https://openalex.org/W1992044002","https://openalex.org/W2000748410","https://openalex.org/W2002077845","https://openalex.org/W2006733931","https://openalex.org/W2009346194","https://openalex.org/W2012046401","https://openalex.org/W2015141049","https://openalex.org/W2019628175","https://openalex.org/W2021017423","https://openalex.org/W2021242633","https://openalex.org/W2023548286","https://openalex.org/W2024358778","https://openalex.org/W2026543228","https://openalex.org/W2026786136","https://openalex.org/W2027667893","https://openalex.org/W2028823314","https://openalex.org/W2030024461","https://openalex.org/W2031535129","https://openalex.org/W2032667836","https://openalex.org/W2033144243","https://openalex.org/W2036044995","https://openalex.org/W2039714220","https://openalex.org/W2043486948","https://openalex.org/W2044075983","https://openalex.org/W2044982400","https://openalex.org/W2046650092","https://openalex.org/W2052410694","https://openalex.org/W2059952390","https://openalex.org/W2060036842","https://openalex.org/W2063523864","https://openalex.org/W2063926390","https://openalex.org/W2067135666","https://openalex.org/W2070674743","https://openalex.org/W2071470608","https://openalex.org/W2078657995","https://openalex.org/W2079227242","https://openalex.org/W2083228624","https://openalex.org/W2087429403","https://openalex.org/W2088491604","https://openalex.org/W2104046861","https://openalex.org/W2106887481","https://openalex.org/W2111731443","https://openalex.org/W2111994713","https://openalex.org/W2117299485","https://openalex.org/W2121339421","https://openalex.org/W2122905657","https://openalex.org/W2125589586","https://openalex.org/W2128725121","https://openalex.org/W2129874430","https://openalex.org/W2133356988","https://openalex.org/W2134159913","https://openalex.org/W2141180121","https://openalex.org/W2143750325","https://openalex.org/W2159999776","https://openalex.org/W2161326284","https://openalex.org/W2167528075","https://openalex.org/W2170143992","https://openalex.org/W2239996304","https://openalex.org/W2285693312","https://openalex.org/W2317846978","https://openalex.org/W2327030716","https://openalex.org/W2329145383","https://openalex.org/W2335236539","https://openalex.org/W2339528391","https://openalex.org/W2403702251","https://openalex.org/W2404145251","https://openalex.org/W2406620873","https://openalex.org/W2408765400","https://openalex.org/W2409161629","https://openalex.org/W2409540958","https://openalex.org/W2409975155","https://openalex.org/W2414175313","https://openalex.org/W2415223688","https://openalex.org/W2415881708","https://openalex.org/W2417333826","https://openalex.org/W2417888268","https://openalex.org/W2417939225","https://openalex.org/W2418071373","https://openalex.org/W2420374468","https://openalex.org/W2426973307","https://openalex.org/W2471737829","https://openalex.org/W2555623892","https://openalex.org/W2729722698","https://openalex.org/W4244774747"],"related_works":["https://openalex.org/W4384120022","https://openalex.org/W2125589586","https://openalex.org/W2026686441","https://openalex.org/W4385307466","https://openalex.org/W7096611912","https://openalex.org/W2045376250","https://openalex.org/W2021242633","https://openalex.org/W2587544867","https://openalex.org/W2078657995","https://openalex.org/W1968002331"],"abstract_inverted_index":{"The":[0,276],"obstructed":[1,42,80,212,222,289],"kidney":[2],"is":[3,35,69,83,101,148,171,217,246,351],"characterized":[4],"by":[5,150],"accumulation":[6,48,125],"of":[7,15,19,49,63,91,98,105,113,126,142,146,167,187,202,205,220,230,260,330,334,347,358,389],"collagen-rich":[8],"scar":[9],"tissue,":[10],"the":[11,20,26,32,40,47,57,60,64,79,86,96,111,124,154,161,168,176,185,211,221,253,288,296,328,345,356,377],"most":[12],"common":[13],"feature":[14],"fibrotic":[16],"organs.":[17],"Most":[18],"microscopic":[21],"changes":[22,152,380],"are":[23,117,183],"confined":[24],"to":[25,119,252,256,362],"tubules":[27,131],"with":[28,44,85,239],"little":[29],"effect":[30],"on":[31,327,391,397],"glomeruli.":[33],"Fibrosis":[34,170],"a":[36,70,89,102,172,200,218,250],"rapid":[37],"occurrence":[38],"in":[39,56,73,78,88,140,153,160,196,210,224,241,274,287,318,344,365,381,400],"experimentally":[41],"kidney,":[43],"studies":[45,227,306,322],"demonstrating":[46,228],"collagens":[50],"and":[51,136,158,164,175,180,190,268,284,295,336,394],"other":[52],"extracellular":[53,127],"matrix":[54,128],"components":[55],"interstitium.":[58],"Despite":[59],"relative":[61],"sparing":[62],"glomerulus":[65],"from":[66,110,132],"fibrosis,":[67,282],"there":[68],"clear":[71],"decline":[72],"glomerular":[74,162],"filtration":[75,163],"rate":[76],"(GFR)":[77],"kidney.":[81,169,213,290],"This":[82,373],"consistent":[84],"finding":[87],"variety":[90],"chronic":[92],"renal":[93,398],"diseases":[94],"that":[95,309],"presence":[97,112],"interstitial":[99,392],"fibrosis":[100,198,317,346,364,393],"major":[103],"determinant":[104],"GFR;":[106],"this":[107,147,245],"may":[108,137],"result":[109,139,195],"atubular":[114],"glomeruli,":[115],"which":[116,178,206],"unable":[118],"filter":[120],"properly.":[121],"In":[122],"addition,":[123],"can":[129,194],"isolate":[130],"their":[133],"oxygen":[134],"supply":[135],"also":[138,302,341],"obliteration":[141],"peritubular":[143],"capillaries.":[144],"All":[145],"accompanied":[149],"physiologic":[151,379],"intrarenal":[155],"hormonal":[156],"environment":[157],"consequently":[159],"tubular":[165,234],"functions":[166],"complex":[173],"process,":[174],"mechanisms":[177],"initiate":[179],"sustain":[181],"it":[182],"both":[184],"subject":[186],"much":[188],"investigation":[189],"controversy.":[191],"Epithelial":[192,214],"injury":[193],"tissue":[197],"through":[199],"number":[201],"mechanisms,":[203],"all":[204],"have":[207,271,301,307,323,340],"been":[208,272,303,342],"found":[209,273],"cell":[215],"apoptosis":[216,235],"hallmark":[219],"kidney;":[223],"many":[225],"experimental":[226],"effectiveness":[229],"various":[231],"antifibrotic":[232],"strategies,":[233],"was":[236],"decreased":[237,281],"along":[238],"decreases":[240],"fibrosis.":[242],"However,":[243],"whether":[244],"causative":[247],"or":[248,314],"merely":[249],"response":[251],"treatments":[254],"remains":[255],"be":[257],"determined.":[258],"Dysregulation":[259],"metabolic":[261],"pathways,":[262],"including":[263],"excessive":[264],"endoplasmic":[265],"reticulum":[266],"stress":[267,286],"mitochondrial":[269,277],"dysfunction,":[270],"obstruction.":[275,348],"targeted":[278,360],"peptide":[279],"SS-31":[280],"apoptosis,":[283],"oxidative":[285],"Transforming":[291],"growth":[292],"actor-\u03b2":[293],"(TGF-\u03b2)":[294],"epithelial-mesenchymal":[297],"transition":[298],"(EMT)":[299],"process":[300],"implicated.":[304],"Many":[305],"shown":[308],"inhibiting":[310],"either":[311],"TGF-\u03b2's":[312],"action":[313],"EMT":[315],"reduced":[316],"obstruction,":[319],"although":[320],"recent":[321],"cast":[324],"some":[325],"doubt":[326],"importance":[329],"EMT.":[331],"Finally,":[332],"infiltration":[333],"macrophages":[335],"increased":[337],"cytokine":[338],"expression":[339],"implicated":[343],"As":[349],"more":[350,371],"understood":[352],"about":[353],"these":[354],"processes,":[355],"prospect":[357],"developing":[359],"therapies":[361],"attenuate":[363],"unilateral":[366],"ureteral":[367],"occlusion":[368],"(UUO)":[369],"becomes":[370],"feasible.":[372],"chapter":[374],"will":[375],"discuss":[376],"traditional":[378],"UUO":[382],"as":[383,385],"well":[384],"an":[386],"updated":[387],"focus":[388],"information":[390],"its":[395],"effects":[396],"function":[399],"UUO.":[401]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-05-12T00:00:00"}
