{"id":"https://openalex.org/W4234615508","doi":"https://doi.org/10.1158/1538-7445.am2019-4616","title":"Abstract 4616: Establishment of a metastatic orthotopic model of pancreatic ductal adenocarcinoma (PDAC) for drug development","display_name":"Abstract 4616: Establishment of a metastatic orthotopic model of pancreatic ductal adenocarcinoma (PDAC) for drug development","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4234615508","doi":"https://doi.org/10.1158/1538-7445.am2019-4616"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-4616","doi":"https://doi.org/10.1158/1538-7445.am2019-4616","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4616","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089063973","display_name":"Justyna Zdrojewska","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124546","display_name":"Pharmatest (Finland)","ror":"https://ror.org/02fkt1r75","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210124546"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Justyna Zdrojewska","raw_affiliation_strings":["Pharmatest Services, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmatest Services, Turku, Finland","institution_ids":["https://openalex.org/I4210124546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069690323","display_name":"Jenni H. M\u00e4ki-Jouppila","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124546","display_name":"Pharmatest (Finland)","ror":"https://ror.org/02fkt1r75","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210124546"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jenni H.E. M\u00e4ki-Jouppila","raw_affiliation_strings":["Pharmatest Services, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmatest Services, Turku, Finland","institution_ids":["https://openalex.org/I4210124546"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111580829","display_name":"Jussi M. Halleen","orcid":"https://orcid.org/0000-0002-1965-9265","observed_orcids":["https://orcid.org/0000-0002-1965-9265"]},"institutions":[{"id":"https://openalex.org/I4210124546","display_name":"Pharmatest (Finland)","ror":"https://ror.org/02fkt1r75","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210124546"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jussi M. Halleen","raw_affiliation_strings":["Pharmatest Services, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmatest Services, Turku, Finland","institution_ids":["https://openalex.org/I4210124546"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013170089","display_name":"Jenni Bernoulli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124546","display_name":"Pharmatest (Finland)","ror":"https://ror.org/02fkt1r75","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210124546"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jenni Bernoulli","raw_affiliation_strings":["Pharmatest Services, Turku, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmatest Services, Turku, Finland","institution_ids":["https://openalex.org/I4210124546"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210124546"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"4616","last_page":"4616"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10760","display_name":"Pancreatitis Pathology and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":1.0},{"id":"https://openalex.org/keywords/nude-mice","display_name":"nude mice","score":0.9330000281333923},{"id":"https://openalex.org/keywords/bioluminescence-imaging","display_name":"bioluminescence imaging","score":0.878000020980835},{"id":"https://openalex.org/keywords/nab-paclitaxel","display_name":"nab-paclitaxel","score":0.875},{"id":"https://openalex.org/keywords/gemcitabine","display_name":"gemcitabine","score":1.0},{"id":"https://openalex.org/keywords/micrometastasis","display_name":"micrometastases","score":0.7829999923706055},{"id":"https://openalex.org/keywords/liver-metastases","display_name":"liver metastasis","score":0.7480000257492065},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5609999895095825},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.4779999852180481},{"id":"https://openalex.org/keywords/tumor-take-rate","display_name":"tumor take rate","score":0.4339999854564667},{"id":"https://openalex.org/keywords/chemotherapy-response","display_name":"chemotherapy response","score":0.40299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8546655178070068},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.7843806743621826},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.5600550174713135},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5503954291343689},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5227218270301819},{"id":"https://openalex.org/C2778764654","wikidata":"https://www.wikidata.org/wiki/Q9618","display_name":"Pancreas","level":2,"score":0.5043972730636597},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5037204623222351},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49578365683555603},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.46586206555366516},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4495778977870941},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.43805497884750366},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.42889973521232605},{"id":"https://openalex.org/C161997846","wikidata":"https://www.wikidata.org/wiki/Q4915066","display_name":"Bioluminescence imaging","level":5,"score":0.41721445322036743},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.0},{"id":"https://openalex.org/C111335760","wikidata":"https://www.wikidata.org/wiki/Q95385166","display_name":"Luciferase","level":4,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-4616","doi":"https://doi.org/10.1158/1538-7445.am2019-4616","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-4616","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1819065859","https://openalex.org/W4213008022","https://openalex.org/W2317179939","https://openalex.org/W4398222511","https://openalex.org/W2255759435","https://openalex.org/W4399630670","https://openalex.org/W2740117548","https://openalex.org/W4390698354","https://openalex.org/W7149007969","https://openalex.org/W4285266622"],"abstract_inverted_index":{"Abstract":[0],"Ductal":[1],"adenocarcinoma":[2,418],"of":[3,13,47,75,84,95,99,127,136,145,172,178,185,197,250,262,283,410,415,426],"the":[4,8,28,39,45,48,55,62,80,96,108,173,176,180,189,191,204,212,217,234,251,263,302,305,311,325,333,349,373,427],"pancreas":[5],"(PDAC)":[6,419],"has":[7,30],"worst":[9],"survival":[10,46,115],"prognosis":[11,109],"(<5%)":[12],"all":[14],"common":[15],"gastrointestinal":[16],"malignancies.":[17],"PDAC":[18,100,137,163,365,394],"is":[19,54,64,122],"typically":[20],"diagnosed":[21,76],"at":[22,36,66,337,347],"a":[23,67,278,281,362,386,411],"very":[24,68],"late":[25],"stage":[26],"when":[27,331],"tumor":[29,97,206,231,288,295],"already":[31],"metastasized":[32],"to":[33,131,142,167,243,310,340,354],"other":[34,355],"organs,":[35],"which":[37],"point":[38],"treatment":[40,195,244,267,307,327,375],"can":[41],"no":[42,318],"longer":[43],"prolong":[44],"patients.":[49],"To":[50,187],"date,":[51],"surgical":[52,235],"resection":[53],"only":[56],"curative":[57],"approach":[58],"present,":[59],"provided":[60],"that":[61,138,376],"cancer":[63],"detected":[65],"early":[69],"stage.":[70],"Nonetheless,":[71],"less":[72,329],"than":[73],"20%":[74],"patients":[77,86],"qualify":[78],"for":[79,389,420,430],"surgery":[81,118],"and":[82,199,274,297,370],"majority":[83],"these":[85],"will":[87],"eventually":[88],"develop":[89],"recurrence.":[90],"Despite":[91],"our":[92],"advancing":[93],"knowledge":[94],"biology":[98],"as":[101,103,308],"well":[102],"recent":[104],"improvements":[105],"in":[106,158,229,233,301,320,395],"diagnosis,":[107],"remains":[110],"strikingly":[111],"poor.":[112],"The":[113,239,265,286],"median":[114],"observed":[116,287],"after":[117,260],"followed":[119],"by":[120,210,216,344],"chemotherapy":[121],"about":[123],"20":[124],"months.The":[125],"aim":[126],"this":[128,159,382],"study":[129,143],"was":[130,201,208,237,255,268,275,291,367],"establish":[132],"an":[133],"orthotopic":[134,364,383,413],"model":[135,366,384,414],"could":[139],"be":[140],"used":[141,157],"efficacy":[144],"new":[146,391],"potential":[147],"treatments.":[148],"Female":[149],"athymic":[150],"nude":[151],"mice":[152,240,323],"(Hsd:":[153],"Athymic":[154],"Nude-Foxn1nu)":[155],"were":[156,165,182,241,299,317],"study.":[160],"MiaPaCa-2-Luc":[161],"human":[162],"cells":[164,219,351],"injected":[166],"surgically":[168],"exposed":[169],"caudal":[170],"part":[171],"pancreas.":[174],"At":[175,293],"time":[177],"inoculation,":[179],"animals":[181],"4-5":[183,284],"weeks":[184,271],"age.":[186],"validate":[188],"model,":[190],"current":[192],"standard-of-care":[193],"(SOC)":[194],"(combination":[196],"nab-paclitaxel":[198],"gemcitabine)":[200],"used.":[202],"During":[203],"study,":[205,230],"burden":[207],"quantified":[209],"imaging":[211,224],"bioluminescence":[213],"signal":[214],"emitted":[215],"MiaPaCa-2-luc":[218,350],"using":[220],"IVIS":[221],"Lumina":[222],"II":[223],"system.":[225],"After":[226],"30":[227],"days":[228],"growth":[232],"area":[236],"observed.":[238],"stratified":[242],"groups":[245],"based":[246],"on":[247],"similar":[248],"intensity":[249],"bioluminescent":[252],"readout.":[253],"Imaging":[254],"performed":[256],"every":[257],"second":[258],"week":[259,279],"inoculation":[261,273],"cells.":[264],"SOC":[266,306,326,374],"initiated":[269],"two":[270],"post":[272],"administered":[276],"twice":[277],"over":[280],"period":[282],"weeks.":[285],"take":[289],"rate":[290],"100%.":[292],"sacrifice,":[294],"weight":[296,330],"volume":[298],"lower":[300],"group":[303],"receiving":[304,324],"compared":[309],"vehicle":[312],"treated":[313],"group.":[314],"Although":[315],"there":[316],"differences":[319],"body":[321,334],"weights,":[322],"gained":[328],"comparing":[332],"weights":[335],"obtained":[336],"endpoint":[338],"relative":[339],"baseline.":[341],"As":[342],"confirmed":[343],"histological":[345],"analyses":[346],"endpoint,":[348],"induced":[352],"micrometastasis":[353],"visceral":[356],"organs":[357],"including":[358],"liver.":[359],"In":[360],"conclusion,":[361],"metastatic":[363,412],"established":[368],"successfully":[369],"validated":[371],"with":[372],"slowed":[377],"down":[378],"disease":[379],"progression.":[380],"Therefore,":[381],"provides":[385],"promising":[387],"tool":[388],"testing":[390],"treatments":[392],"against":[393],"vivo.":[396],"Citation":[397],"Format:":[398],"Justyna":[399],"Zdrojewska,":[400],"Jenni":[401,407],"H.E.":[402],"M\u00e4ki-Jouppila,":[403],"Jussi":[404],"M.":[405],"Halleen,":[406],"Bernoulli.":[408],"Establishment":[409],"pancreatic":[416],"ductal":[417],"drug":[421],"development":[422],"[abstract].":[423],"In:":[424],"Proceedings":[425],"American":[428],"Association":[429],"Cancer":[431,445],"Research":[432],"Annual":[433],"Meeting":[434],"2019;":[435],"2019":[436],"Mar":[437],"29-Apr":[438],"3;":[439],"Atlanta,":[440],"GA.":[441],"Philadelphia":[442],"(PA):":[443],"AACR;":[444],"Res":[446],"2019;79(13":[447],"Suppl):Abstract":[448],"nr":[449],"4616.":[450]},"counts_by_year":[],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2022-05-12T00:00:00"}
