{"id":"https://openalex.org/W4234579231","doi":"https://doi.org/10.1093/geroni/igz038.2158","title":"FRAILTY AND THE COMPARATIVE EFFECTIVENESS AND SAFETY OF SGLT2I AND GLP1-RA IN OLDER ADULTS WITH TYPE 2 DIABETES","display_name":"FRAILTY AND THE COMPARATIVE EFFECTIVENESS AND SAFETY OF SGLT2I AND GLP1-RA IN OLDER ADULTS WITH TYPE 2 DIABETES","publication_year":2019,"publication_date":"2019-11-01","ids":{"openalex":"https://openalex.org/W4234579231","doi":"https://doi.org/10.1093/geroni/igz038.2158"},"language":"en","primary_location":{"id":"doi:10.1093/geroni/igz038.2158","doi":"https://doi.org/10.1093/geroni/igz038.2158","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igz038.2158","pdf_url":"https://academic.oup.com/innovateage/article-pdf/3/Supplement_1/S582/32997575/igz038.2158.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://academic.oup.com/innovateage/article-pdf/3/Supplement_1/S582/32997575/igz038.2158.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044474781","display_name":"Elisabetta Patorno","orcid":"https://orcid.org/0000-0002-8809-9898","observed_orcids":["https://orcid.org/0000-0002-8809-9898"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elisabetta Patorno","raw_affiliation_strings":["Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and Women\u2019s Hospital and Harvard Medical School, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102890723","display_name":"Ajinkya M Pawar","orcid":"https://orcid.org/0000-0002-8585-9505","observed_orcids":["https://orcid.org/0000-0002-8585-9505"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ajinkya Pawar","raw_affiliation_strings":["Brigham and women\u2019s hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and women\u2019s hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100615887","display_name":"Seoyoung C. Kim","orcid":"https://orcid.org/0000-0002-2517-3579","observed_orcids":["https://orcid.org/0000-0002-2517-3579"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Seoyoung Kim","raw_affiliation_strings":["Brigham and women\u2019s hospital, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brigham and women\u2019s hospital, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023135047","display_name":"Dae Hyun Kim","orcid":"https://orcid.org/0000-0001-7290-6838","observed_orcids":["https://orcid.org/0000-0001-7290-6838","https://orcid.org/0000-0003-4315-9145"]},"institutions":[{"id":"https://openalex.org/I4210123879","display_name":"Hebrew SeniorLife","ror":"https://ror.org/02vptss42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210123879"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dae Kim","raw_affiliation_strings":["hebrew SeniorLife, Boston, Massachusetts, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"hebrew SeniorLife, Boston, Massachusetts, United States","institution_ids":["https://openalex.org/I4210123879"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3977,"currency":"USD","value_usd":3977},"apc_paid":{"value":3977,"currency":"USD","value_usd":3977},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"3","issue":"Supplement_1","first_page":"S582","last_page":"S582"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10401","display_name":"Diabetes Treatment and Management","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10198","display_name":"Heart Failure Treatment and Management","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11011","display_name":"Frailty in Older Adults","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/frailty","display_name":"frailty","score":0.9020000100135803},{"id":"https://openalex.org/keywords/sglt2-inhibitors","display_name":"SGLT2 inhibitors","score":0.878000020980835},{"id":"https://openalex.org/keywords/glp-1-receptor-agonists","display_name":"GLP-1 receptor agonists","score":0.9950000047683716},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9929999709129333},{"id":"https://openalex.org/keywords/cardiovascular-outcomes","display_name":"cardiovascular outcomes","score":0.6570000052452087},{"id":"https://openalex.org/keywords/severe-hypoglycemia","display_name":"severe hypoglycemia","score":0.9789999723434448},{"id":"https://openalex.org/keywords/comparative-effectiveness","display_name":"comparative effectiveness","score":0.902999997138977},{"id":"https://openalex.org/keywords/comparative-safety","display_name":"comparative safety","score":0.5450000166893005},{"id":"https://openalex.org/keywords/frailty-index","display_name":"frailty index","score":0.5440000295639038}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8293739557266235},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.70637047290802},{"id":"https://openalex.org/C2780668416","wikidata":"https://www.wikidata.org/wiki/Q202758","display_name":"Hypoglycemia","level":3,"score":0.6781768798828125},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.5599431991577148},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.5305725932121277},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5086041688919067},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.44109103083610535},{"id":"https://openalex.org/C17923572","wikidata":"https://www.wikidata.org/wiki/Q7250160","display_name":"Propensity score matching","level":2,"score":0.42758041620254517},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.42509496212005615},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.15086033940315247},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.14206162095069885},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.1262112557888031},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1093/geroni/igz038.2158","doi":"https://doi.org/10.1093/geroni/igz038.2158","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igz038.2158","pdf_url":"https://academic.oup.com/innovateage/article-pdf/3/Supplement_1/S582/32997575/igz038.2158.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5814717","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6841064","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6841064","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6841064","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innov Aging","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/geroni/igz038.2158","doi":"https://doi.org/10.1093/geroni/igz038.2158","is_oa":true,"landing_page_url":"https://doi.org/10.1093/geroni/igz038.2158","pdf_url":"https://academic.oup.com/innovateage/article-pdf/3/Supplement_1/S582/32997575/igz038.2158.pdf","source":{"id":"https://openalex.org/S2735557189","display_name":"Innovation in Aging","issn_l":"2399-5300","issn":["2399-5300"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311647","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/P4310311647"],"host_organization_lineage_names":["University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Innovation in Aging","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.7699999809265137,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4234579231.pdf","grobid_xml":"https://content.openalex.org/works/W4234579231.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4235551561","https://openalex.org/W2985562410","https://openalex.org/W4281610848","https://openalex.org/W4386520753","https://openalex.org/W2948907953","https://openalex.org/W4200500045","https://openalex.org/W2984272600","https://openalex.org/W3124074039","https://openalex.org/W4402518986","https://openalex.org/W4323036937"],"abstract_inverted_index":{"Abstract":[0],"We":[1,33],"conducted":[2],"a":[3,25,28,39,85],"1:1":[4],"propensity":[5],"score-matched":[6],"retrospective":[7],"cohort":[8],"study":[9],"of":[10,69,88,93,120],"87,218":[11],"patients":[12,114,140],"with":[13,61,66],"type":[14],"2":[15],"diabetes":[16],"(mean":[17],"age,":[18],"71.5":[19],"years":[20],"[standard":[21],"deviation,":[22],"5.1])":[23],"initiating":[24],"SGLT2i":[26,63,102],"or":[27],"GLP1-RA":[29,104],"in":[30,50],"Medicare":[31],"data.":[32],"estimated":[34],"HRs":[35],"(95%":[36],"CIs)":[37],"for":[38],"composite":[40,71,94],"cardiovascular":[41,72,95],"endpoint":[42,73,96],"and":[43,54,79,103,112,138],"severe":[44,80,121],"hypoglycemia":[45,81,122],"comparing":[46],"the":[47,51,56,70,118,128],"two":[48,129],"treatments":[49,130],"entire":[52],"population":[53],"by":[55],"CFI-based":[57],"frailty":[58],"subgroups.":[59],"Compared":[60],"GLP1-RA,":[62],"were":[64],"associated":[65],"similar":[67],"rates":[68],"(HR,":[74],"0.94":[75],"[95%":[76],"CI,":[77],"0.86-1.03])":[78],"(0.87":[82,115],"[0.71-1.07])":[83],"over":[84],"mean":[86],"follow-up":[87],"8.6":[89],"months.":[90],"The":[91],"rate":[92,119],"was":[97,123],"not":[98,124],"meaningfully":[99,125],"different":[100,126],"between":[101,127],"across":[105],"non-frail":[106,132],"(1.33":[107],"[0.80-2.23]),":[108],"pre-frail":[109,135],"(0.96":[110],"[0.85-1.08]),":[111],"frail":[113,139],"[0.73-1.04]).":[116],"Similarly,":[117],"among":[131],"(0.97":[133],"[0.20-4.80]),":[134],"(0.83":[136],"[0.64-1.08]),":[137],"(0.95":[141],"[0.67-1.34]).":[142]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}
