{"id":"https://openalex.org/W4234464312","doi":"https://doi.org/10.1016/j.febslet.2005.02.030","title":"Interactome modeling","display_name":"Interactome modeling","publication_year":2005,"publication_date":"2005-02-24","ids":{"openalex":"https://openalex.org/W4234464312","doi":"https://doi.org/10.1016/j.febslet.2005.02.030","pmid":"https://pubmed.ncbi.nlm.nih.gov/15763560"},"language":"en","primary_location":{"id":"doi:10.1016/j.febslet.2005.02.030","doi":"https://doi.org/10.1016/j.febslet.2005.02.030","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2005.02.030","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040546953","display_name":"Marc Vidal","orcid":"https://orcid.org/0000-0003-3391-5410","observed_orcids":["https://orcid.org/0000-0003-3391-5410"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I4210134579","display_name":"Dana-Farber/Harvard Cancer Center","ror":"https://ror.org/03pvyf116","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc Vidal","raw_affiliation_strings":["Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. marc_vidal@dfci.harvard.edu","Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA","Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. marc_vidal@dfci.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"]},{"raw_affiliation_string":"Department of Genetics, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5040546953"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I4210134579"],"apc_list":{"value":3980,"currency":"USD","value_usd":3980},"apc_paid":null,"fwci":1.2488,"has_fulltext":false,"cited_by_count":100,"citation_normalized_percentile":{"value":0.76902633,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"579","issue":"8","first_page":"1834","last_page":"1838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10064","display_name":"Complex Network Analysis Techniques","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3109","display_name":"Statistical and Nonlinear Physics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.9309999942779541},{"id":"https://openalex.org/keywords/macromolecular-networks","display_name":"macromolecular networks","score":0.9100000262260437},{"id":"https://openalex.org/keywords/network-topology","display_name":"network topology","score":0.7070000171661377},{"id":"https://openalex.org/keywords/disease-mechanisms","display_name":"disease mechanisms","score":0.5329999923706055},{"id":"https://openalex.org/keywords/network-based-prediction","display_name":"network-based prediction","score":0.3889999985694885}],"concepts":[{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.9570796489715576},{"id":"https://openalex.org/C74318829","wikidata":"https://www.wikidata.org/wiki/Q36458","display_name":"Multicellular organism","level":3,"score":0.6360542178153992},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6203812956809998},{"id":"https://openalex.org/C9652623","wikidata":"https://www.wikidata.org/wiki/Q190109","display_name":"Field (mathematics)","level":2,"score":0.5811055302619934},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.41483357548713684},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3461196720600128},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18444421887397766},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C202444582","wikidata":"https://www.wikidata.org/wiki/Q837863","display_name":"Pure mathematics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.febslet.2005.02.030","doi":"https://doi.org/10.1016/j.febslet.2005.02.030","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.febslet.2005.02.030","pdf_url":null,"source":{"id":"https://openalex.org/S104830714","display_name":"FEBS Letters","issn_l":"0014-5793","issn":["0014-5793","1873-3468"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS Letters","raw_type":"journal-article"},{"id":"pmid:15763560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15763560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FEBS letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4043000042438507,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1525091092","https://openalex.org/W1563231805","https://openalex.org/W1588911128","https://openalex.org/W1602611649","https://openalex.org/W1964833504","https://openalex.org/W1965893904","https://openalex.org/W1971925662","https://openalex.org/W1973129665","https://openalex.org/W1974863459","https://openalex.org/W1974906719","https://openalex.org/W1977186059","https://openalex.org/W1982035848","https://openalex.org/W1986508375","https://openalex.org/W1989952069","https://openalex.org/W1992194142","https://openalex.org/W2006062026","https://openalex.org/W2008942114","https://openalex.org/W2012852001","https://openalex.org/W2014519647","https://openalex.org/W2018619092","https://openalex.org/W2022032029","https://openalex.org/W2025999411","https://openalex.org/W2028872736","https://openalex.org/W2032579724","https://openalex.org/W2037036397","https://openalex.org/W2040941311","https://openalex.org/W2050981769","https://openalex.org/W2051628416","https://openalex.org/W2052093902","https://openalex.org/W2061439657","https://openalex.org/W2065304353","https://openalex.org/W2074027785","https://openalex.org/W2076710572","https://openalex.org/W2076762827","https://openalex.org/W2079818352","https://openalex.org/W2080115238","https://openalex.org/W2081617218","https://openalex.org/W2081702874","https://openalex.org/W2090286778","https://openalex.org/W2094049721","https://openalex.org/W2094131214","https://openalex.org/W2096810446","https://openalex.org/W2098999612","https://openalex.org/W2104315543","https://openalex.org/W2110563630","https://openalex.org/W2113019448","https://openalex.org/W2119630070","https://openalex.org/W2120596623","https://openalex.org/W2124463526","https://openalex.org/W2136316164","https://openalex.org/W2144993348","https://openalex.org/W2145080853","https://openalex.org/W2146803229","https://openalex.org/W2151326548","https://openalex.org/W2155758168","https://openalex.org/W2167869241","https://openalex.org/W2169788158","https://openalex.org/W2183798833","https://openalex.org/W4230501579","https://openalex.org/W7047723641","https://openalex.org/W7055455646","https://openalex.org/W7112136558"],"related_works":["https://openalex.org/W4210369481","https://openalex.org/W2009405916","https://openalex.org/W1515641456","https://openalex.org/W4230229339","https://openalex.org/W2211041313","https://openalex.org/W2172687151","https://openalex.org/W7101004844","https://openalex.org/W7099227209","https://openalex.org/W3160983356","https://openalex.org/W7038569838"],"abstract_inverted_index":{"A":[0],"long-term":[1],"goal":[2],"of":[3,6,17,43,45,54],"the":[4,46,52,94],"field":[5,47],"interactome":[7,90],"modeling":[8],"is":[9],"to":[10,34,71],"understand":[11],"how":[12,27],"global":[13,57],"and":[14,26,58,92],"local":[15,59],"properties":[16,31],"complex":[18],"macromolecular":[19],"networks":[20],"impact":[21],"on":[22,82,93],"observable":[23],"biological":[24],"properties,":[25,60],"changes":[28],"in":[29],"such":[30,55],"can":[32],"lead":[33],"human":[35],"diseases.":[36],"The":[37],"information":[38],"available":[39],"at":[40,86],"this":[41],"stage":[42],"development":[44],"provides":[48],"strong":[49],"evidence":[50],"for":[51],"existence":[53],"interesting":[56],"but":[61],"also":[62],"demonstrates":[63],"that":[64,98],"many":[65],"more":[66],"datasets":[67],"will":[68],"be":[69],"needed":[70],"provide":[72],"accurate":[73],"models":[74],"with":[75],"increasingly":[76],"predictive":[77],"capacity.":[78],"This":[79],"review":[80],"focuses":[81],"an":[83],"early":[84],"attempt":[85],"mapping":[87],"a":[88],"multicellular":[89],"network":[91],"lessons":[95],"learned":[96],"from":[97],"attempt.":[99]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}