{"id":"https://openalex.org/W4234430282","doi":"https://doi.org/10.1093/neuonc/noab090.210","title":"EPCT-24 THE REMIND TRIAL: MULTI-ANTIGEN TARGETED T CELLS FOR PEDIATRIC CNS TUMORS","display_name":"EPCT-24 THE REMIND TRIAL: MULTI-ANTIGEN TARGETED T CELLS FOR PEDIATRIC CNS TUMORS","publication_year":2021,"publication_date":"2021-06-01","ids":{"openalex":"https://openalex.org/W4234430282","doi":"https://doi.org/10.1093/neuonc/noab090.210"},"language":"en","primary_location":{"id":"doi:10.1093/neuonc/noab090.210","doi":"https://doi.org/10.1093/neuonc/noab090.210","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noab090.210","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/23/Supplement_1/i52/38378331/noab090.210.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/neuro-oncology/article-pdf/23/Supplement_1/i52/38378331/noab090.210.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077132028","display_name":"Melanie Grant","orcid":"https://orcid.org/0000-0002-5421-5889","observed_orcids":["https://orcid.org/0000-0002-5421-5889"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Melanie Grant","raw_affiliation_strings":["Emory University School of Medicine, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Emory University School of Medicine, Atlanta, GA, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044759108","display_name":"Maria Fernanda Fortiz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Fortiz","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100364529","display_name":"Lu Wang","orcid":"https://orcid.org/0009-0001-0470-1694","observed_orcids":["https://orcid.org/0009-0001-0470-1694"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lu Wang","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110399552","display_name":"Haili Lang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haili Lang","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042431577","display_name":"Anushree A. Datar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anushree Datar","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066937973","display_name":"Emily Reynolds","orcid":"https://orcid.org/0000-0002-3546-2622","observed_orcids":["https://orcid.org/0000-0002-3546-2622"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Reynolds","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006101269","display_name":"Madeleine Terpilowski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Madeleine Terpilowski","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104045091","display_name":"Ashley E. Geiger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ashley Geiger","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069722678","display_name":"Chris Lazarski","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chris Lazarski","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080987226","display_name":"Jay Tanna","orcid":"https://orcid.org/0009-0001-3381-5105","observed_orcids":["https://orcid.org/0009-0001-3381-5105"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jay Tanna","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010156605","display_name":"Adriana Pitino","orcid":"https://orcid.org/0000-0003-3772-6430","observed_orcids":["https://orcid.org/0000-0003-3772-6430"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana Pitino","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100331228","display_name":"Nan Zhang","orcid":"https://orcid.org/0000-0001-7667-0615","observed_orcids":["https://orcid.org/0000-0001-7667-0615"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Zhang","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057892885","display_name":"Fahmida Hoq","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fahmida Hoq","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066139971","display_name":"Patrick J. Hanley","orcid":"https://orcid.org/0000-0002-0102-7892","observed_orcids":["https://orcid.org/0000-0002-0102-7892"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick Hanley","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033997937","display_name":"Carolina Colli Cruz","orcid":"https://orcid.org/0000-0001-7065-3769","observed_orcids":["https://orcid.org/0000-0001-7065-3769"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C Russell Cruz","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044312349","display_name":"Lindsay Baker Kilburn","orcid":"https://orcid.org/0000-0003-1478-3619","observed_orcids":["https://orcid.org/0000-0003-1478-3619"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lindsay Kilburn","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025567999","display_name":"Roger J. Packer","orcid":"https://orcid.org/0000-0001-9413-7531","observed_orcids":["https://orcid.org/0000-0001-9413-7531"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger Packer","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083480223","display_name":"Brian Rood","orcid":"https://orcid.org/0000-0003-3221-9421","observed_orcids":["https://orcid.org/0000-0003-3221-9421"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Rood","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006134549","display_name":"Catherine M. Bollard","orcid":"https://orcid.org/0000-0001-5140-9090","observed_orcids":["https://orcid.org/0000-0001-5140-9090"]},"institutions":[{"id":"https://openalex.org/I1336742384","display_name":"Children's National","ror":"https://ror.org/03wa2q724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1336742384"]},{"id":"https://openalex.org/I193531525","display_name":"George Washington University","ror":"https://ror.org/00y4zzh67","country_code":"US","type":"education","lineage":["https://openalex.org/I193531525"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Bollard","raw_affiliation_strings":["Children\u2019s National Hospital, Washington, DC, USA","George Washington University, Washington, DC, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Children\u2019s National Hospital, Washington, DC, USA","institution_ids":["https://openalex.org/I1336742384"]},{"raw_affiliation_string":"George Washington University, Washington, DC, USA","institution_ids":["https://openalex.org/I193531525"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4326,"currency":"USD","value_usd":4326},"apc_paid":{"value":4326,"currency":"USD","value_usd":4326},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"23","issue":"Supplement_1","first_page":"i52","last_page":"i52"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.48069998621940613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.48069998621940613,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.3686999976634979,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.12409999966621399,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-immunotherapy","display_name":"T cell therapy","score":0.5260000228881836},{"id":"https://openalex.org/keywords/autologous-t-cell-therapy","display_name":"autologous T cell therapy","score":0.6589999794960022},{"id":"https://openalex.org/keywords/tumor-associated-antigens","display_name":"tumor-associated antigens","score":0.7590000033378601},{"id":"https://openalex.org/keywords/wt1","display_name":"WT1","score":0.8730000257492065},{"id":"https://openalex.org/keywords/prame","display_name":"PRAME","score":1.0},{"id":"https://openalex.org/keywords/survivin","display_name":"survivin","score":1.0},{"id":"https://openalex.org/keywords/diffuse-intrinsic-pontine-glioma","display_name":"diffuse intrinsic pontine glioma","score":0.9670000076293945},{"id":"https://openalex.org/keywords/pediatric-cns-tumors","display_name":"pediatric central nervous system tumors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/dose-escalation","display_name":"dose escalation","score":0.45100000500679016},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.7649999856948853},{"id":"https://openalex.org/keywords/plasma-proteomics","display_name":"plasma proteomics","score":0.8460000157356262},{"id":"https://openalex.org/keywords/t-cell-receptor-clonality","display_name":"T-cell receptor clonality","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ifn-gamma-elispot","display_name":"IFN-gamma ELISPOT","score":0.7429999709129333},{"id":"https://openalex.org/keywords/safety-and-toxicity","display_name":"safety and toxicity","score":0.609000027179718},{"id":"https://openalex.org/keywords/cd40-ligand","display_name":"CD40 ligand","score":0.6859999895095825},{"id":"https://openalex.org/keywords/interleukin-7","display_name":"IL-7","score":0.9810000061988831}],"concepts":[{"id":"https://openalex.org/C2779053233","wikidata":"https://www.wikidata.org/wiki/Q731235","display_name":"ELISPOT","level":4,"score":0.842454195022583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6448403596878052},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6155605316162109},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.5816143155097961},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5498549342155457},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5374667048454285},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4811909794807434},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.4486713707447052},{"id":"https://openalex.org/C2775975398","wikidata":"https://www.wikidata.org/wiki/Q906904","display_name":"Survivin","level":3,"score":0.43935972452163696},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.33756086230278015},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.332179456949234},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.14257094264030457}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/neuonc/noab090.210","doi":"https://doi.org/10.1093/neuonc/noab090.210","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noab090.210","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/23/Supplement_1/i52/38378331/noab090.210.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8168094","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8168094","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro Oncol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/neuonc/noab090.210","doi":"https://doi.org/10.1093/neuonc/noab090.210","is_oa":true,"landing_page_url":"https://doi.org/10.1093/neuonc/noab090.210","pdf_url":"https://academic.oup.com/neuro-oncology/article-pdf/23/Supplement_1/i52/38378331/noab090.210.pdf","source":{"id":"https://openalex.org/S106908163","display_name":"Neuro-Oncology","issn_l":"1522-8517","issn":["1522-8517","1523-5866"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuro-Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4234430282.pdf","grobid_xml":"https://content.openalex.org/works/W4234430282.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4245833338","https://openalex.org/W3113294877","https://openalex.org/W4281700672","https://openalex.org/W7135029113","https://openalex.org/W4380355695","https://openalex.org/W7166690226","https://openalex.org/W2964620721","https://openalex.org/W2892200488","https://openalex.org/W2910692741","https://openalex.org/W2972546061"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Patients":[2,35],"with":[3,85,110,161],"relapsed":[4],"CNS":[5,55],"malignancies":[6,56],"or":[7,53],"DIPG":[8,50],"face":[9],"terrible":[10],"prognoses.":[11],"We":[12],"hypothesized":[13],"that":[14],"T":[15,41,104,173,234],"cells":[16,42,100,105],"specific":[17],"for":[18,47,69,124],"3":[19],"tumor-associated":[20],"antigens":[21],"(TAA),":[22],"WT1,":[23],"PRAME":[24],"and":[25,30,66,71,112,118,139,141,149,157,177,190,195,218,225,229,240,256,263],"survivin,":[26],"would":[27],"be":[28],"safe":[29,255],"elicit":[31,257],"anti-tumor":[32],"immunity.":[33],"Methods":[34],"(n=18)":[36],"received":[37,77],"autologous":[38],"tumor":[39],"antigen-associated":[40],"(TAAT)":[43],"(up":[44],"to":[45],"8x107/m2)":[46],"newly":[48],"diagnosed":[49],"(Group":[51,57],"A)":[52],"recurrent":[54],"B)":[58],"on":[59],"a":[60],"Phase":[61],"I":[62],"dose-escalation":[63],"study":[64],"(NCT03652545)":[65],"were":[67,91,101],"monitored":[68],"safety":[70,82],"response.":[72],"Results/Discussion":[73],"16/18":[74],"patients":[75,167,203],"who":[76,204],"TAAT":[78,131,250],"completed":[79],"the":[80],"45-day":[81],"monitoring":[83],"phase":[84],"no":[86],"dose-limiting":[87],"toxicities.":[88],"Adverse":[89],"events":[90],"minimal":[92],"despite":[93],"multiple":[94],"pretreatments":[95],"in":[96,129,168,245,260],"Group":[97],"B.":[98],"Infused":[99],"predominantly":[102],"CD3+":[103],"(median":[106],"96%;":[107],"range:":[108],"87\u201399%),":[109],"CD4+":[111],"CD8+":[113],"comprising":[114],"16%":[115],"(range:":[116,120],"5\u201387%)":[117],"40%":[119],"4\u201367%)":[121],"respectively.":[122],"Specificity":[123],"1\u20133":[125],"TAAs":[126],"was":[127],"demonstrated":[128,152],"11/18":[130],"by":[132],"a-IFN-\u03b3":[133],"ELISPOT.":[134],"Dose":[135],"escalation":[136],"is":[137],"complete,":[138],"clinical":[140],"immunologic":[142,264],"response":[143,165,265],"assessments":[144,266],"are":[145,267],"ongoing.":[146,268],"Plasma":[147],"cytokine":[148,156],"proteomic":[150],"analyses":[151],"dynamic":[153],"post-infusion":[154,197],"immune":[155,164,258],"protein":[158],"responses.":[159],"Consistent":[160],"an":[162],"infusion-mediated":[163],"all":[166],"Grp":[169],"A":[170],"showed":[171,211,238],"increased":[172,221],"cell":[174,235],"effector,":[175],"inflammatory":[176],"immune-stimulatory":[178],"cytokines":[179],"IFN-\u03b3,":[180],"TNF-\u03b1,":[181],"IL-2,":[182],"IL-5,":[183],"IL-7,":[184],"IL-1\u03b2,":[185],"IL-6,":[186],"IL-8,":[187],"IL-12p70,":[188],"IL-17A":[189],"GM-CSF":[191],"at":[192],"Weeks":[193],"1":[194,217],"2":[196],"(n":[198],"=":[199],"6).":[200],"Of":[201],"9":[202],"have":[205,251],"been":[206,254],"tested,":[207],"29/92":[208],"plasma":[209],"proteins":[210],"significant":[212],"differences":[213],"between":[214],"dose":[215],"levels":[216],"2,":[219],"including":[220],"IL-7":[222],"(p":[223,227,232],"<0.0004)":[224],"CD40L":[226],"<0.046)":[228],"reduced":[230],"IL-4":[231],"<0.0004).":[233],"receptor":[236],"sequencing":[237],"expansion":[239],"persistence":[241],"of":[242],"clones":[243],"detected":[244],"infusion":[246],"products.":[247],"In":[248],"summary,":[249],"thus":[252],"far":[253],"responses":[259],"vivo.":[261],"Clinical":[262]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2022-05-12T00:00:00"}