{"id":"https://openalex.org/W4234089101","doi":"https://doi.org/10.1021/acs.jmedchem.9b01498","title":"Correction to Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway","display_name":"Correction to Discovery of 3-Oxabicyclo[4.1.0]heptane, a Non-nitrogen Containing Morpholine Isostere, and Its Application in Novel Inhibitors of the PI3K-AKT-mTOR Pathway","publication_year":2019,"publication_date":"2019-09-25","ids":{"openalex":"https://openalex.org/W4234089101","doi":"https://doi.org/10.1021/acs.jmedchem.9b01498"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jmedchem.9b01498","doi":"https://doi.org/10.1021/acs.jmedchem.9b01498","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b01498","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"erratum","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003694962","display_name":"Heather Hobbs","orcid":"https://orcid.org/0000-0001-8474-9016","observed_orcids":["https://orcid.org/0000-0001-8474-9016"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Heather Hobbs","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-8474-9016","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058775651","display_name":"Gianpaolo Bravi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gianpaolo Bravi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070762803","display_name":"Ian M. Campbell","orcid":"https://orcid.org/0000-0002-3749-2884","observed_orcids":["https://orcid.org/0000-0002-3749-2884"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ian Campbell","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063907103","display_name":"M.A. Convery","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maire Convery","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006644511","display_name":"Hannah Davies","orcid":"https://orcid.org/0000-0002-9503-4427","observed_orcids":["https://orcid.org/0000-0002-9503-4427"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hannah Davies","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060046847","display_name":"Graham G. A. Inglis","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Graham Inglis","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111594781","display_name":"Sandeep Pal","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sandeep Pal","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062525496","display_name":"Simon Peace","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Simon Peace","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032048772","display_name":"Joanna M. Redmond","orcid":"https://orcid.org/0000-0002-3200-4087","observed_orcids":["https://orcid.org/0000-0002-3200-4087"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joanna Redmond","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5074553597","display_name":"Declan M. Summers","orcid":"https://orcid.org/0000-0001-7181-8764","observed_orcids":["https://orcid.org/0000-0001-7181-8764"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Declan Summers","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7181-8764","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5003694962"],"corresponding_institution_ids":[],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"62","issue":"19","first_page":"8880","last_page":"8880"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pi3k-akt-mtor-inhibitors","display_name":"PI3K/AKT/mTOR inhibitors","score":0.8799999952316284},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.7300000190734863},{"id":"https://openalex.org/keywords/anticancer-drug-discovery","display_name":"anticancer drug discovery","score":0.6759999990463257},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.6159999966621399},{"id":"https://openalex.org/keywords/molecular-dynamics-simulation","display_name":"molecular dynamics simulation","score":0.5360000133514404},{"id":"https://openalex.org/keywords/molecular-dynamics-free-energy-calculation","display_name":"molecular dynamics free energy calculation","score":0.35600000619888306}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8823363780975342},{"id":"https://openalex.org/C2781056017","wikidata":"https://www.wikidata.org/wiki/Q410243","display_name":"Morpholine","level":2,"score":0.8101882934570312},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.7513318061828613},{"id":"https://openalex.org/C180000673","wikidata":"https://www.wikidata.org/wiki/Q899268","display_name":"Isostere","level":2,"score":0.7114871144294739},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.4995272159576416},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3479963541030884},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.33028343319892883},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2855892777442932},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.25457340478897095},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.21333491802215576}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jmedchem.9b01498","doi":"https://doi.org/10.1021/acs.jmedchem.9b01498","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jmedchem.9b01498","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2958781078","https://openalex.org/W4405801159","https://openalex.org/W2019652935","https://openalex.org/W2740110401","https://openalex.org/W2083508995","https://openalex.org/W2912841954","https://openalex.org/W2977140060","https://openalex.org/W6888759241","https://openalex.org/W7104736520","https://openalex.org/W1975958715"],"abstract_inverted_index":{"ADVERTISEMENT":[0],"RETURN":[1],"TO":[2],"ISSUEPREVAddition/CorrectionNEXTORIGINAL":[3],"ARTICLEThis":[4],"notice":[5],"is":[6,117,129,204,256],"a":[7,13,205,212,225],"correctionCorrection":[8],"to":[9,131,169,174],"Discovery":[10],"of":[11,24,122,147,182,208],"3-Oxabicyclo[4.1.0]heptane,":[12],"Non-nitrogen":[14],"Containing":[15],"Morpholine":[16],"Isostere,":[17],"and":[18,81,157,162,191,235,252,268,270],"Its":[19],"Application":[20],"in":[21],"Novel":[22],"Inhibitors":[23],"the":[25,144,175,180,209,220,233,236,241,248,254],"PI3K-AKT-mTOR":[26],"PathwayHeather":[27],"Hobbs*Heather":[28],"HobbsMore":[29],"by":[30,36,42,48,54,60,66,72,78,85,189],"Heather":[31],"Hobbshttp://orcid.org/0000-0001-8474-9016,":[32],"Gianpaolo":[33,37],"BraviGianpaolo":[34],"BraviMore":[35],"Bravi,":[38],"Ian":[39,43],"CampbellIan":[40],"CampbellMore":[41],"Campbell,":[44],"Maire":[45,49],"ConveryMaire":[46],"ConveryMore":[47],"Convery,":[50],"Hannah":[51,55],"DaviesHannah":[52],"DaviesMore":[53],"Davies,":[56],"Graham":[57,61],"InglisGraham":[58],"InglisMore":[59],"Inglis,":[62],"Sandeep":[63,67],"PalSandeep":[64],"PalMore":[65],"Pal,":[68],"Simon":[69,73],"PeaceSimon":[70],"PeaceMore":[71],"Peace,":[74],"Joanna":[75,79],"RedmondJoanna":[76],"RedmondMore":[77],"Redmond,":[80],"Declan":[82,86],"SummersDeclan":[83],"SummersMore":[84],"Summershttp://orcid.org/0000-0001-7181-8764Cite":[87],"this:":[88],"J.":[89],"Med.":[90],"Chem.":[91],"2019,":[92],"62,":[93],"19,":[94],"8880Publication":[95],"Date":[96],"(Web):September":[97],"25,":[98],"2019Publication":[99],"History":[100],"Published":[101],"online25":[102],"September":[103],"2019Published":[104],"inissue":[105],"10":[106],"October":[107],"2019https://pubs.acs.org/doi/10.1021/acs.jmedchem.9b01498https://doi.org/10.1021/acs.jmedchem.9b01498correctionACS":[108],"PublicationsCopyright":[109],"\u00a9":[110],"2019":[111],"American":[112],"Chemical":[113],"Society.":[114],"This":[115,127],"publication":[116,128],"available":[118],"under":[119],"these":[120],"Terms":[121],"Use.":[123],"Request":[124],"reuse":[125],"permissions":[126],"free":[130],"access":[132],"through":[133],"this":[134,186],"site.":[135],"Learn":[136],"MoreArticle":[137],"Views1652Altmetric-Citations-LEARN":[138],"ABOUT":[139],"THESE":[140],"METRICSArticle":[141],"Views":[142],"are":[143,166,179],"COUNTER-compliant":[145],"sum":[146],"full":[148],"text":[149],"article":[150,214],"downloads":[151],"since":[152],"November":[153],"2008":[154],"(both":[155],"PDF":[156,276],"HTML)":[158],"across":[159],"all":[160],"institutions":[161],"individuals.":[163],"These":[164],"metrics":[165],"regularly":[167],"updated":[168,192],"reflect":[170],"usage":[171],"leading":[172],"up":[173],"last":[176],"few":[177],"days.Citations":[178],"number":[181],"other":[183],"articles":[184],"citing":[185],"article,":[187],"calculated":[188],"Crossref":[190,198],"daily.":[193],"Find":[194,244],"more":[195,245],"information":[196,246],"about":[197,232],"citation":[199],"counts.The":[200],"Altmetric":[201,249],"Attention":[202,250],"Score":[203,251],"quantitative":[206],"measure":[207],"attention":[210],"that":[211],"research":[213],"has":[215],"received":[216],"online.":[217],"Clicking":[218],"on":[219,247],"donut":[221],"icon":[222],"will":[223],"load":[224],"page":[226],"at":[227],"altmetric.com":[228],"with":[229,264],"additional":[230],"details":[231],"score":[234,255],"social":[237],"media":[238],"presence":[239],"for":[240],"given":[242],"article.":[243],"how":[253],"calculated.":[257],"Share":[258,273],"Add":[259],"toView":[260],"InAdd":[261],"Full":[262],"Text":[263],"ReferenceAdd":[265],"Description":[266],"ExportRISCitationCitation":[267],"abstractCitation":[269],"referencesMore":[271],"Options":[272],"onFacebookTwitterWechatLinked":[274],"InRedditEmail":[275],"(205":[277],"KB)":[278],"Get":[279,281],"e-Alertsclose":[280],"e-Alerts":[282]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2022-05-12T00:00:00"}