{"id":"https://openalex.org/W4234086293","doi":"https://doi.org/10.1111/j.1399-0039.1989.tb01745.x","title":"A simple and rapid method for HLA\u2010DQA1 genotyping by digestion of PCR\u2010amplified DNA with allele specific restriction endonucleases","display_name":"A simple and rapid method for HLA\u2010DQA1 genotyping by digestion of PCR\u2010amplified DNA with allele specific restriction endonucleases","publication_year":1989,"publication_date":"1989-11-01","ids":{"openalex":"https://openalex.org/W4234086293","doi":"https://doi.org/10.1111/j.1399-0039.1989.tb01745.x"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-0039.1989.tb01745.x","doi":"https://doi.org/10.1111/j.1399-0039.1989.tb01745.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-0039.1989.tb01745.x","pdf_url":null,"source":{"id":"https://openalex.org/S141055564","display_name":"Tissue Antigens","issn_l":"0001-2815","issn":["0001-2815","1399-0039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Antigens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006692829","display_name":"Masahiro Maeda","orcid":"https://orcid.org/0000-0002-9086-7657","observed_orcids":["https://orcid.org/0000-0002-9086-7657"]},"institutions":[{"id":"https://openalex.org/I4405265026","display_name":"Nichirei Corporation (Japan)","ror":"https://ror.org/03n9gk658","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265026"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"M. Maeda","raw_affiliation_strings":["Research Institute, NICHIREI Corporation, Tokyo, Japan","Research Institute, NICHIREI Corporation, Kumegawa, Higashimurayama, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, NICHIREI Corporation, Tokyo, Japan","institution_ids":["https://openalex.org/I4405265026"]},{"raw_affiliation_string":"Research Institute, NICHIREI Corporation, Kumegawa, Higashimurayama, Tokyo","institution_ids":["https://openalex.org/I4405265026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007752920","display_name":"Noriko Murayama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265026","display_name":"Nichirei Corporation (Japan)","ror":"https://ror.org/03n9gk658","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265026"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Murayama","raw_affiliation_strings":["Research Institute, NICHIREI Corporation, Kumegawa, Higashimurayama, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, NICHIREI Corporation, Kumegawa, Higashimurayama, Tokyo","institution_ids":["https://openalex.org/I4405265026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076088322","display_name":"Hiroko Ishii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265026","display_name":"Nichirei Corporation (Japan)","ror":"https://ror.org/03n9gk658","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265026"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Ishii","raw_affiliation_strings":["Research Institute, NICHIREI Corporation, Kumegawa, Higashimurayama, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, NICHIREI Corporation, Kumegawa, Higashimurayama, Tokyo","institution_ids":["https://openalex.org/I4405265026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019241098","display_name":"Noboru Uryu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405265026","display_name":"Nichirei Corporation (Japan)","ror":"https://ror.org/03n9gk658","country_code":"JP","type":"company","lineage":["https://openalex.org/I4405265026"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"N. Uryu","raw_affiliation_strings":["Research Institute, NICHIREI Corporation, Kumegawa, Higashimurayama, Tokyo"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research Institute, NICHIREI Corporation, Kumegawa, Higashimurayama, Tokyo","institution_ids":["https://openalex.org/I4405265026"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055880583","display_name":"Masao \u00d4ta","orcid":"https://orcid.org/0000-0002-6400-5658","observed_orcids":["https://orcid.org/0000-0002-6400-5658"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"M. Ota","raw_affiliation_strings":["Department of Legal Medicine, Shinsyu University School of Medicine, Asahi, Matsumoto, Nagano"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Legal Medicine, Shinsyu University School of Medicine, Asahi, Matsumoto, Nagano","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108445887","display_name":"K. Tsuji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"K. Tsuji","raw_affiliation_strings":["Department of Transplantation, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052702717","display_name":"Hidetoshi Inoko","orcid":"https://orcid.org/0000-0002-5176-2561","observed_orcids":["https://orcid.org/0000-0002-5176-2561"]},"institutions":[{"id":"https://openalex.org/I1314466530","display_name":"Tokai University","ror":"https://ror.org/01p7qe739","country_code":"JP","type":"education","lineage":["https://openalex.org/I1314466530"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"H. Inoko","raw_affiliation_strings":["Department of Transplantation, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Transplantation, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, Japan","institution_ids":["https://openalex.org/I1314466530"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006692829"],"corresponding_institution_ids":["https://openalex.org/I4405265026"],"apc_list":null,"apc_paid":null,"fwci":6.6611,"has_fulltext":false,"cited_by_count":104,"citation_normalized_percentile":{"value":0.97640548,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"34","issue":"5","first_page":"290","last_page":"298"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.7656000256538391,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.0828000009059906,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.021700000390410423,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hla-dqa1","display_name":"HLA-DQA1","score":0.9150000214576721},{"id":"https://openalex.org/keywords/pcr-rflp","display_name":"PCR-RFLP","score":0.8429999947547913},{"id":"https://openalex.org/keywords/restriction-fragment-polymorphism","display_name":"restriction fragment polymorphism","score":0.7390000224113464}],"concepts":[{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.8144092559814453},{"id":"https://openalex.org/C128319531","wikidata":"https://www.wikidata.org/wiki/Q219715","display_name":"Restriction enzyme","level":3,"score":0.7238025665283203},{"id":"https://openalex.org/C2889275","wikidata":"https://www.wikidata.org/wiki/Q7316313","display_name":"Restriction digest","level":4,"score":0.5713819861412048},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.5297031402587891},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5079899430274963},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.4941399395465851},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4890759587287903},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4843827188014984},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.43224501609802246},{"id":"https://openalex.org/C33935397","wikidata":"https://www.wikidata.org/wiki/Q7915779","display_name":"Variants of PCR","level":4,"score":0.4209573268890381},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.268309086561203},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16019904613494873}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/j.1399-0039.1989.tb01745.x","doi":"https://doi.org/10.1111/j.1399-0039.1989.tb01745.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-0039.1989.tb01745.x","pdf_url":null,"source":{"id":"https://openalex.org/S141055564","display_name":"Tissue Antigens","issn_l":"0001-2815","issn":["0001-2815","1399-0039"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Tissue Antigens","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W1997521650","https://openalex.org/W2001412093","https://openalex.org/W2030903599","https://openalex.org/W2032118018","https://openalex.org/W2036178285","https://openalex.org/W2045150724","https://openalex.org/W2050179219","https://openalex.org/W2063392648","https://openalex.org/W2079490247","https://openalex.org/W2080824017","https://openalex.org/W4313347581"],"related_works":["https://openalex.org/W2084952943","https://openalex.org/W4247464924","https://openalex.org/W2141248241","https://openalex.org/W2092636293","https://openalex.org/W2078298372","https://openalex.org/W2088518311","https://openalex.org/W2066120818","https://openalex.org/W2039642496","https://openalex.org/W2067360524","https://openalex.org/W2044482921"],"abstract_inverted_index":{"The":[0,88],"second":[1,48],"exon":[2],"of":[3,13,45,62,102,123],"the":[4,20,42,46,75,96,100,108,124,128,132],"HLA\u2010DQA1":[5],"genes":[6],"was":[7],"selectively":[8],"amplified":[9],"from":[10,74,95],"genomic":[11],"DNAs":[12,26],"72":[14],"HLA\u2010homozygous":[15],"B":[16],"cell":[17],"lines":[18],"by":[19,85],"polymerase":[21],"chain":[22],"reaction":[23],"(PCR).":[24],"Amplified":[25],"were":[27,65,69],"digested":[28],"with":[29,80],"HaeIII,":[30],"Ddel,":[31],"ScrFI,":[32],"FokI":[33],"and":[34,50,67,117,143,147],"RsaI,":[35],"which":[36],"recognize":[37],"allelic":[38],"sequence":[39,97],"variations":[40],"in":[41,55],"polymorphic":[43,60],"segments":[44],"DQA1":[47,105],"exon,":[49],"then":[51],"subjected":[52],"to":[53,71,149],"electrophoresis":[54],"polyacrylamide":[56],"gels.":[57],"Eight":[58],"different":[59],"patterns":[61,72],"restriction":[63],"fragments":[64],"obtained,":[66],"seven":[68],"identical":[70],"predicted":[73],"known":[76],"DNA":[77],"sequences,":[78],"correlating":[79],"each":[81],"HLA\u2010DQw":[82],"type":[83],"defined":[84],"serological":[86],"typing.":[87,153],"remaining":[89],"one":[90],"pattern":[91],"cannot":[92],"be":[93,145],"explained":[94],"data,":[98],"suggesting":[99],"presence":[101],"a":[103,115],"novel":[104],"allele":[106,139],"at":[107,127],"nucleotide":[109,129],"level.":[110],"This":[111],"PCR\u2010RFLP":[112],"method":[113],"provides":[114],"simple":[116],"rapid":[118],"technique":[119],"for":[120,134],"accurate":[121],"definition":[122],"HLA\u2010DQ":[125],"types":[126],"level,":[130],"eliminating":[131],"need":[133],"radioisotope":[135],"as":[136,138],"well":[137],"specific":[140],"oligonucleotide":[141],"probes":[142],"can":[144],"extended":[146],"applied":[148],"HLA\u2010DR,":[150],"\u2010Dw":[151],"DP":[152]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2022-05-12T00:00:00"}
