{"id":"https://openalex.org/W4234076156","doi":"https://doi.org/10.1134/s199075081104010x","title":"The induction of Guerin\u2019s carcinoma cytochrome P450 hydroxylase activity by retinoids","display_name":"The induction of Guerin\u2019s carcinoma cytochrome P450 hydroxylase activity by retinoids","publication_year":2011,"publication_date":"2011-11-08","ids":{"openalex":"https://openalex.org/W4234076156","doi":"https://doi.org/10.1134/s199075081104010x"},"language":"en","primary_location":{"id":"doi:10.1134/s199075081104010x","doi":"https://doi.org/10.1134/s199075081104010x","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s199075081104010x","pdf_url":null,"source":{"id":"https://openalex.org/S4210194599","display_name":"Biochemistry (Moscow) Supplement Series B Biomedical Chemistry","issn_l":"1990-7508","issn":["1990-7508","1990-7516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037978929","display_name":"Igor O Shmarakov","orcid":"https://orcid.org/0000-0002-4073-9585","observed_orcids":["https://orcid.org/0000-0002-4073-9585"]},"institutions":[{"id":"https://openalex.org/I130701412","display_name":"Yuriy Fedkovych Chernivtsi National University","ror":"https://ror.org/044n25186","country_code":"UA","type":"education","lineage":["https://openalex.org/I130701412"]}],"countries":["UA"],"is_corresponding":true,"raw_author_name":"I. A. Shmarakov","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, Yuri Fed\u2019kovich Chernivtsi National University, ul. Kotsyubynskogo 2, Chernivtsi, 58000, Ukraine","Department of Biochemistry and Biotechnology, Yuri Fed\u2019kovich Chernivtsi National University, Chernivtsi, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Yuri Fed\u2019kovich Chernivtsi National University, ul. Kotsyubynskogo 2, Chernivtsi, 58000, Ukraine","institution_ids":["https://openalex.org/I130701412"]},{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Yuri Fed\u2019kovich Chernivtsi National University, Chernivtsi, Ukraine","institution_ids":["https://openalex.org/I130701412"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010711916","display_name":"Niv Katan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130701412","display_name":"Yuriy Fedkovych Chernivtsi National University","ror":"https://ror.org/044n25186","country_code":"UA","type":"education","lineage":["https://openalex.org/I130701412"]}],"countries":["UA"],"is_corresponding":false,"raw_author_name":"N. V. Katan","raw_affiliation_strings":["Department of Biochemistry and Biotechnology, Yuri Fed\u2019kovich Chernivtsi National University, ul. Kotsyubynskogo 2, Chernivtsi, 58000, Ukraine","Department of Biochemistry and Biotechnology, Yuri Fed\u2019kovich Chernivtsi National University, Chernivtsi, Ukraine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Yuri Fed\u2019kovich Chernivtsi National University, ul. Kotsyubynskogo 2, Chernivtsi, 58000, Ukraine","institution_ids":["https://openalex.org/I130701412"]},{"raw_affiliation_string":"Department of Biochemistry and Biotechnology, Yuri Fed\u2019kovich Chernivtsi National University, Chernivtsi, Ukraine","institution_ids":["https://openalex.org/I130701412"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5037978929"],"corresponding_institution_ids":["https://openalex.org/I130701412"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.34069672,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"5","issue":"4","first_page":"369","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11559","display_name":"Retinoids in leukemia and cellular processes","score":0.951200008392334,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.02850000001490116,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14135","display_name":"Cancer and biochemical research","score":0.012799999676644802,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/guerin-s-carcinoma","display_name":"Guerin's carcinoma","score":0.8899999856948853},{"id":"https://openalex.org/keywords/retinoids","display_name":"retinoids","score":0.9309999942779541},{"id":"https://openalex.org/keywords/vitamin-a-supplementation","display_name":"vitamin A supplementation","score":0.6890000104904175},{"id":"https://openalex.org/keywords/cytochrome-p450","display_name":"cytochrome P450","score":0.8539999723434448},{"id":"https://openalex.org/keywords/demethylase-activity","display_name":"demethylase activity","score":0.8980000019073486},{"id":"https://openalex.org/keywords/tumor-growth","display_name":"tumor growth","score":0.8360000252723694},{"id":"https://openalex.org/keywords/retinyl-acetate","display_name":"retinyl acetate","score":0.7870000004768372},{"id":"https://openalex.org/keywords/all-trans-retinoic-acid","display_name":"all-trans retinoic acid","score":0.9789999723434448},{"id":"https://openalex.org/keywords/liposomal-drug-delivery","display_name":"liposomal drug delivery","score":0.7139999866485596},{"id":"https://openalex.org/keywords/vitamin-deficiency","display_name":"vitamin deficiency","score":0.6290000081062317},{"id":"https://openalex.org/keywords/microsomal-enzymes","display_name":"microsomal enzymes","score":0.7120000123977661}],"concepts":[{"id":"https://openalex.org/C2776940978","wikidata":"https://www.wikidata.org/wiki/Q34956","display_name":"Vitamin","level":2,"score":0.6841599345207214},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6775108575820923},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.656743586063385},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.6476478576660156},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.6428492665290833},{"id":"https://openalex.org/C87644729","wikidata":"https://www.wikidata.org/wiki/Q547502","display_name":"Microsome","level":3,"score":0.6348453760147095},{"id":"https://openalex.org/C2779573558","wikidata":"https://www.wikidata.org/wiki/Q424976","display_name":"Retinol","level":3,"score":0.5414609313011169},{"id":"https://openalex.org/C2781364455","wikidata":"https://www.wikidata.org/wiki/Q2531584","display_name":"Demethylase","level":4,"score":0.5358368754386902},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.5261811017990112},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.49752500653266907},{"id":"https://openalex.org/C2775954498","wikidata":"https://www.wikidata.org/wiki/Q420418","display_name":"Retinoid","level":4,"score":0.46773701906204224},{"id":"https://openalex.org/C2779185683","wikidata":"https://www.wikidata.org/wiki/Q7316808","display_name":"Retinyl acetate","level":4,"score":0.42481160163879395},{"id":"https://openalex.org/C2777326149","wikidata":"https://www.wikidata.org/wiki/Q7316807","display_name":"Retinyl palmitate","level":4,"score":0.42164346575737},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.416444331407547},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41478079557418823},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3091011047363281},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.28602510690689087},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2698700428009033},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23079189658164978},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s199075081104010x","doi":"https://doi.org/10.1134/s199075081104010x","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s199075081104010x","pdf_url":null,"source":{"id":"https://openalex.org/S4210194599","display_name":"Biochemistry (Moscow) Supplement Series B Biomedical Chemistry","issn_l":"1990-7508","issn":["1990-7508","1990-7516"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1832039973","https://openalex.org/W1899383916","https://openalex.org/W1927684145","https://openalex.org/W1979517867","https://openalex.org/W1981398318","https://openalex.org/W2019378745","https://openalex.org/W2049343950","https://openalex.org/W2072145718","https://openalex.org/W2073032065","https://openalex.org/W2079080809","https://openalex.org/W2083018390","https://openalex.org/W2104995445","https://openalex.org/W2118001999","https://openalex.org/W2141478391","https://openalex.org/W2160478917","https://openalex.org/W2162481906","https://openalex.org/W2782045341"],"related_works":["https://openalex.org/W2068906155","https://openalex.org/W1996415442","https://openalex.org/W1987739543","https://openalex.org/W103923758","https://openalex.org/W2993190751","https://openalex.org/W2412500911","https://openalex.org/W2572271320","https://openalex.org/W2273389346","https://openalex.org/W1969985717","https://openalex.org/W624465868"],"abstract_inverted_index":{"Using":[0],"Guerin\u2019s":[1,37,82,108],"carcinoma":[2,38,83,109],"as":[3],"a":[4,42],"model":[5],"the":[6,9,16,36,81,90,96,107,131],"interrelationship":[7],"between":[8],"tumor":[10,32,54,91,137],"growth":[11,39,55,92],"process":[12],"and":[13,73,100],"supplementation":[14,59],"of":[15,26,30,53,58,80,98,103,116,125,134],"body":[17],"with":[18,60,67,95],"vitamin":[19,27,61],"A":[20,28,62],"has":[21],"been":[22],"studied.":[23],"The":[24,50,87],"replenishment":[25],"resources":[29],"vitamin-deficient":[31],"bearing":[33],"animals":[34],"modulated":[35],"rate":[40,93],"in":[41,89,106],"dose":[43],"dependent":[44],"manner":[45],"(":[46,69,75],"r":[47,70,76],"=":[48,71,77],"0.83).":[49],"morphological":[51],"parameters":[52],"under":[56,114],"conditions":[57,115],"(0\u20133000":[63],"IU)":[64],"positively":[65],"correlated":[66],"hydroxylase":[68,99],"0.81)":[72],"demethylase":[74,101],"0.49)":[78],"activities":[79,102],"cytochrome":[84,104],"P450":[85,105],"system.":[86],"increase":[88],"together":[94],"induction":[97],"microsomal":[110],"fraction,":[111],"observed":[112],"either":[113],"retinyl":[117],"acetate":[118],"overdose":[119],"supplementation,":[120],"or":[121],"selective":[122],"liposomal":[123],"form":[124],"all-":[126],"trans":[127],"-retinoic":[128],"acid,":[129],"suggests":[130],"stimulatory":[132],"effect":[133],"retinoids":[135],"on":[136],"growth.":[138]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2022-05-12T00:00:00"}