{"id":"https://openalex.org/W4234047775","doi":"https://doi.org/10.1002/(sici)1097-4547(19980215)51:4<541::aid-jnr14>3.3.co;2-e","title":"Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat \u03b11\u2010 and \u03b12\u2010macroglobulins","display_name":"Inhibition of dopamine and choline acetyltransferase concentrations in rat CNS neurons by rat \u03b11\u2010 and \u03b12\u2010macroglobulins","publication_year":1998,"publication_date":"1998-02-15","ids":{"openalex":"https://openalex.org/W4234047775","doi":"https://doi.org/10.1002/(sici)1097-4547(19980215)51:4<541::aid-jnr14>3.3.co;2-e"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1097-4547(19980215)51:4<541::aid-jnr14>3.3.co;2-e","doi":"https://doi.org/10.1002/(sici)1097-4547(19980215)51:4<541::aid-jnr14>3.3.co;2-e","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4547(19980215)51:4<541::aid-jnr14>3.3.co;2-e","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102837904","display_name":"Yiqun Hu","orcid":"https://orcid.org/0000-0001-9157-7865","observed_orcids":["https://orcid.org/0000-0001-9157-7865"]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yi\u2010Qun Hu","raw_affiliation_strings":["Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067425254","display_name":"Daniel J. Liebl","orcid":"https://orcid.org/0000-0003-2680-1220","observed_orcids":["https://orcid.org/0000-0003-2680-1220","https://orcid.org/0000-0001-5851-5363"]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Liebl","raw_affiliation_strings":["Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029887779","display_name":"Dean E. Dluzen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dean E. Dluzen","raw_affiliation_strings":["Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Northeastern Ohio Universities College of Medicine, Rootstown","institution_ids":["https://openalex.org/I95240055"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112769712","display_name":"Peter H. Koo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95240055","display_name":"Northeast Ohio Medical University","ror":"https://ror.org/04q9qf557","country_code":"US","type":"education","lineage":["https://openalex.org/I95240055"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Peter H. Koo","raw_affiliation_strings":["Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown","institution_ids":["https://openalex.org/I95240055"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5112769712"],"corresponding_institution_ids":["https://openalex.org/I95240055"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.1347,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.44993352,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"51","issue":"4","first_page":"541","last_page":"550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.5166000127792358,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.20759999752044678,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.10509999841451645,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alpha-1-macroglobulin","display_name":"alpha1-macroglobulin","score":0.9710000157356262},{"id":"https://openalex.org/keywords/alpha-2-macroglobulin","display_name":"alpha2-macroglobulin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.9419999718666077},{"id":"https://openalex.org/keywords/choline-acetyltransferase","display_name":"choline acetyltransferase","score":0.9890000224113464},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.8629999756813049},{"id":"https://openalex.org/keywords/neurotransmitter-modulation","display_name":"neurotransmitter modulation","score":0.6880000233650208},{"id":"https://openalex.org/keywords/monoamine-signaling","display_name":"monoamine signaling","score":0.30300000309944153}],"concepts":[{"id":"https://openalex.org/C198399640","wikidata":"https://www.wikidata.org/wiki/Q14863671","display_name":"Choline acetyltransferase","level":3,"score":0.8165501356124878},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.6956605911254883},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5643390417098999},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.4969229996204376},{"id":"https://openalex.org/C2779649592","wikidata":"https://www.wikidata.org/wiki/Q2655970","display_name":"Acetyltransferase","level":4,"score":0.49274924397468567},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45117607712745667},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4096826910972595},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3076998293399811},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2623103857040405},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23000037670135498},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1002/(sici)1097-4547(19980215)51:4<541::aid-jnr14>3.3.co;2-e","doi":"https://doi.org/10.1002/(sici)1097-4547(19980215)51:4<541::aid-jnr14>3.3.co;2-e","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1097-4547(19980215)51:4<541::aid-jnr14>3.3.co;2-e","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8199999928474426,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2043554424","https://openalex.org/W2021186252","https://openalex.org/W2030473421","https://openalex.org/W2064233821","https://openalex.org/W1990730648","https://openalex.org/W1964170309","https://openalex.org/W2031614449","https://openalex.org/W2054213050","https://openalex.org/W1518994648","https://openalex.org/W4255315232"],"abstract_inverted_index":{"Previous":[0],"studies":[1],"have":[2],"implicated":[3],"human":[4,27,119,134],"alpha-2-macroglobulin":[5,21],"(\u03b12M)":[6,22],"as":[7],"a":[8,95,175],"potential":[9,176],"regulator":[10],"of":[11,26,36,46,58,83,126,179],"neuronal":[12],"development":[13],"and":[14,19,55,62,115,136,165,172],"function.":[15],"Rat":[16],"alpha-1-macroglobulin":[17],"(\u03b11M)":[18],"acute-phase":[20],"are":[23],"murine":[24],"homologues":[25],"\u03b12M.":[28],"In":[29,111],"this":[30,146,173],"report,":[31],"we":[32],"tested":[33],"the":[34,44,50,56,65,89,170],"effect":[35,57],"intracranially":[37],"infused":[38],"serotonin-activated":[39],"rat":[40,60,86,91,113,116,128,137,149,162],"\u03b11M":[41,61,150],"(5HT-\u03b11M)":[42],"on":[43,64],"concentration":[45],"dopamine":[47],"(DA)":[48],"in":[49,53,75,145,169,182],"corpus":[51,92],"striatum":[52,93],"vivo":[54],"5HT-activated":[59],"\u03b12M":[63,135,138],"choline":[66],"acetyltransferase":[67],"(ChAT)":[68],"activity":[69,125],"upon":[70,98],"embryonic":[71,127],"basal":[72],"forebrain":[73],"neurons":[74],"culture.":[76],"The":[77],"results":[78,156],"show":[79],"that":[80,158],"direct":[81],"infusion":[82],"0.65":[84],"nmole":[85],"5HT-\u03b11M":[87,114],"into":[88],"adult":[90],"produced":[94],"consistent":[96],"attenuation":[97],"striatal":[99],"DA":[100],"concentrations.":[101],"This":[102],"decrease":[103],"was":[104],"particularly":[105],"prominent":[106],"at":[107],"5\u20137":[108],"days":[109],"post-infusion.":[110],"addition,":[112],"5HT-\u03b12M,":[117,120],"like":[118],"all":[121],"significantly":[122],"inhibited":[123,152],"ChAT":[124,153],"cerebral":[129],"cortex":[130],"neurons.":[131],"Although":[132],"normal":[133,148],"were":[139],"either":[140],"marginally":[141],"or":[142],"insignificantly":[143],"inhibitory":[144],"preparation,":[147],"dose-dependently":[151],"activity.":[154],"These":[155],"demonstrate":[157],"monoamine-activated":[159],"\u03b1-macroglobulins":[160],"from":[161],"depress":[163],"dopaminergic":[164],"cholinergic":[166],"neurotransmitter":[167,183],"systems":[168],"CNS,":[171],"suggests":[174],"regulatory":[177],"role":[178],"these":[180],"alpha-macroglobulins":[181],"metabolism.":[184],"J.":[185],"Neurosci.":[186],"Res.":[187],"51:541\u2013550,":[188],"1998.":[189],"\u00a9":[190],"1998":[191],"Wiley-Liss,":[192],"Inc.":[193]},"counts_by_year":[],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-05-12T00:00:00"}
