{"id":"https://openalex.org/W4234035004","doi":"https://doi.org/10.26434/chemrxiv.13106069","title":"A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers","display_name":"A Mega-High-Throughput Screening Platform for the Discovery of Biologically Relevant Sequence-Defined Non-Natural Polymers","publication_year":2020,"publication_date":"2020-10-19","ids":{"openalex":"https://openalex.org/W4234035004","doi":"https://doi.org/10.26434/chemrxiv.13106069"},"language":"en","primary_location":{"id":"doi:10.26434/chemrxiv.13106069","doi":"https://doi.org/10.26434/chemrxiv.13106069","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.13106069","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c750f8bdbb89c19ea39fb6/original/a-mega-high-throughput-screening-platform-for-the-discovery-of-biologically-relevant-sequence-defined-non-natural-polymers.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c750f8bdbb89c19ea39fb6/original/a-mega-high-throughput-screening-platform-for-the-discovery-of-biologically-relevant-sequence-defined-non-natural-polymers.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078210381","display_name":"Michal Avital\u2010Shmilovici","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michal Avital-Shmilovici","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053373754","display_name":"Xiaohe Liu","orcid":"https://orcid.org/0000-0003-1297-9597","observed_orcids":["https://orcid.org/0000-0003-1297-9597"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaohe Liu","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024928471","display_name":"Thomas A. Shaler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Shaler","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010399551","display_name":"Andrew C. Lowenthal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrew Lowenthal","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000142237","display_name":"Pauline Bourbon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pauline Bourbon","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074488909","display_name":"Janey Snider","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janey Snider","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047465748","display_name":"Arlyn Tambo-ong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Arlyn Tambo-ong","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003812416","display_name":"Claire E. Repellin","orcid":"https://orcid.org/0000-0002-6552-3318","observed_orcids":["https://orcid.org/0000-0002-6552-3318"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Claire Repellin","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042464228","display_name":"Kenya Yniguez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenya Yniguez","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085226365","display_name":"Lidia C. Sambucetti","orcid":"https://orcid.org/0000-0001-9686-5444","observed_orcids":["https://orcid.org/0000-0001-9686-5444"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lidia Sambucetti","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025984430","display_name":"Peter B. Madrid","orcid":"https://orcid.org/0000-0002-4895-5610","observed_orcids":["https://orcid.org/0000-0002-4895-5610"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Madrid","raw_affiliation_strings":["SRI International"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI International","institution_ids":["https://openalex.org/I1298353152"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044337418","display_name":"Nathan Collins","orcid":"https://orcid.org/0000-0002-5793-4870","observed_orcids":["https://orcid.org/0000-0002-5793-4870"]},"institutions":[{"id":"https://openalex.org/I1298353152","display_name":"SRI International","ror":"https://ror.org/05s570m15","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1298353152"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Collins","raw_affiliation_strings":["SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SRI Biosciences Division, SRI International, Menlo Park, CA 94025 USA","institution_ids":["https://openalex.org/I1298353152"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1298353152"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9726999998092651,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12867","display_name":"Advanced Biosensing Techniques and Applications","score":0.005100000184029341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10405","display_name":"Advanced Polymer Synthesis and Characterization","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ultra-high-throughput-screening","display_name":"ultra-high-throughput screening","score":0.8820000290870667},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"combinatorial chemistry","score":0.6320000290870667},{"id":"https://openalex.org/keywords/raf","display_name":"Raf","score":0.3919999897480011},{"id":"https://openalex.org/keywords/asialoglycoprotein-receptor","display_name":"asialoglycoprotein receptor","score":0.7170000076293945},{"id":"https://openalex.org/keywords/il-6-receptor","display_name":"IL-6 receptor","score":0.8360000252723694},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8759999871253967},{"id":"https://openalex.org/keywords/intracellular-delivery","display_name":"intracellular delivery","score":0.5920000076293945},{"id":"https://openalex.org/keywords/high-resolution-mass-spectrometry","display_name":"high-resolution mass spectrometry","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.6481406092643738},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.6237497925758362},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.562771201133728},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49898624420166016},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4882402718067169},{"id":"https://openalex.org/C2780513914","wikidata":"https://www.wikidata.org/wiki/Q18210350","display_name":"Bottleneck","level":2,"score":0.48111575841903687},{"id":"https://openalex.org/C11569505","wikidata":"https://www.wikidata.org/wiki/Q727265","display_name":"Asialoglycoprotein receptor","level":4,"score":0.472277969121933},{"id":"https://openalex.org/C161624437","wikidata":"https://www.wikidata.org/wiki/Q1988322","display_name":"Small molecule","level":2,"score":0.45120275020599365},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.4320662021636963},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.4225448966026306},{"id":"https://openalex.org/C99726746","wikidata":"https://www.wikidata.org/wiki/Q906396","display_name":"Chemical space","level":3,"score":0.41410520672798157},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.25206804275512695},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25085094571113586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23574116826057434},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.19036880135536194},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1275026500225067},{"id":"https://openalex.org/C2776200302","wikidata":"https://www.wikidata.org/wiki/Q827450","display_name":"Hepatocyte","level":3,"score":0.0},{"id":"https://openalex.org/C149635348","wikidata":"https://www.wikidata.org/wiki/Q193040","display_name":"Embedded system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26434/chemrxiv.13106069","doi":"https://doi.org/10.26434/chemrxiv.13106069","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.13106069","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c750f8bdbb89c19ea39fb6/original/a-mega-high-throughput-screening-platform-for-the-discovery-of-biologically-relevant-sequence-defined-non-natural-polymers.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.26434/chemrxiv.13106069","doi":"https://doi.org/10.26434/chemrxiv.13106069","is_oa":true,"landing_page_url":"https://doi.org/10.26434/chemrxiv.13106069","pdf_url":"https://chemrxiv.org/engage/api-gateway/chemrxiv/assets/orp/resource/item/60c750f8bdbb89c19ea39fb6/original/a-mega-high-throughput-screening-platform-for-the-discovery-of-biologically-relevant-sequence-defined-non-natural-polymers.pdf","source":{"id":"https://openalex.org/S4393918830","display_name":"ChemRxiv","issn_l":"2573-2293","issn":["2573-2293"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G6288219026","display_name":null,"funder_award_id":"N66001-14-C-4059","funder_id":"https://openalex.org/F4320332180","funder_display_name":"Defense Advanced Research Projects Agency"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320314430","display_name":"Ionis Pharmaceuticals","ror":"https://ror.org/00t8bew53"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4234035004.pdf","grobid_xml":"https://content.openalex.org/works/W4234035004.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W153979151","https://openalex.org/W1981513975","https://openalex.org/W1981572734","https://openalex.org/W1983482250","https://openalex.org/W1997564906","https://openalex.org/W2006446936","https://openalex.org/W2018145486","https://openalex.org/W2022208537","https://openalex.org/W2022877555","https://openalex.org/W2023096047","https://openalex.org/W2029948741","https://openalex.org/W2031929695","https://openalex.org/W2041719513","https://openalex.org/W2055321137","https://openalex.org/W2056188780","https://openalex.org/W2057306577","https://openalex.org/W2060089085","https://openalex.org/W2062774044","https://openalex.org/W2071378581","https://openalex.org/W2078890343","https://openalex.org/W2087186774","https://openalex.org/W2095066949","https://openalex.org/W2114559046","https://openalex.org/W2127455662","https://openalex.org/W2130007201","https://openalex.org/W2142350160","https://openalex.org/W2158151243","https://openalex.org/W2299310257","https://openalex.org/W2318821151","https://openalex.org/W2398350456","https://openalex.org/W2519539312","https://openalex.org/W2565924714","https://openalex.org/W2591344998","https://openalex.org/W2765408218","https://openalex.org/W2792138005","https://openalex.org/W2804806053","https://openalex.org/W2806468320","https://openalex.org/W2963418941","https://openalex.org/W2973137732","https://openalex.org/W3035579699","https://openalex.org/W6600210674","https://openalex.org/W6600459194"],"related_works":["https://openalex.org/W4206305868","https://openalex.org/W4385693793","https://openalex.org/W4413127729","https://openalex.org/W2059328037","https://openalex.org/W2804806053","https://openalex.org/W4388384330","https://openalex.org/W4407230669","https://openalex.org/W4206088079","https://openalex.org/W4235855415","https://openalex.org/W2052843828"],"abstract_inverted_index":{"Combinatorial":[0],"methods":[1],"enable":[2],"the":[3,17,116,136],"synthesis":[4],"of":[5,10,14,45,48,68,74,92,115,124,130,161],"chemical":[6,105],"libraries":[7,26,44,67,91,123],"on":[8],"scales":[9],"millions":[11],"to":[12,19,50,64,89,164],"billions":[13],"compounds,":[15],"but":[16],"ability":[18],"efficiently":[20],"screen":[21,65,90],"and":[22,42,107,113,132,146,166],"sequence":[23],"such":[24],"large":[25],"has":[27,86],"remained":[28],"a":[29,37,51,72],"major":[30],"bottleneck":[31],"for":[32,40,171],"molecular":[33],"discovery.":[34],"We":[35],"developed":[36],"novel":[38],"technology":[39],"screening":[41,84,121],"sequencing":[43],"synthetic":[46,69,93],"molecules":[47],"up":[49],"billion":[52],"compounds":[53,70,77,134],"in":[54],"size.":[55],"This":[56,82],"method":[57],"utilizes":[58],"Fiber-optic":[59],"Array":[60],"Scanning":[61],"Technology":[62],"(FAST)":[63],"bead-based":[66],"at":[71,101],"rate":[73],"5":[75],"million":[76],"per":[78],"minute":[79],"(~83,000":[80],"Hz).":[81],"ultra-high-throughput":[83],"platform":[85,117],"been":[87],"used":[88],"\u201cself-readable\u201d":[94],"non-natural":[95,125],"polymers":[96,127],"that":[97],"can":[98],"be":[99],"sequenced":[100],"femtomole":[102],"scale":[103],"by":[104,120],"fragmentation":[106],"highresolution":[108],"mass":[109],"spectrometry.":[110],"The":[111],"versatility":[112],"throughput":[114],"was":[118],"demonstrated":[119],"two":[122],"polyamide":[126],"with":[128,149],"sizes":[129],"1.77M":[131],"1B":[133],"against":[135,155],"protein":[137],"targets":[138],"K-Ras,":[139],"asialoglycoprotein":[140],"receptor":[141,145],"(ASGPR),":[142],"IL-6,":[143],"IL-6":[144],"TNF\u03b1.":[147],"Hits":[148],"nanomolar":[150],"binding":[151,163],"affinities":[152],"were":[153],"found":[154],"all":[156],"targets,":[157],"including":[158],"competitive":[159],"inhibitors":[160],"K-Ras":[162],"Raf":[165],"functionally":[167],"active":[168],"uptake":[169],"ligands":[170],"ASGPR":[172],"facilitating":[173],"intracellular":[174],"delivery.":[175]},"counts_by_year":[],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2022-05-12T00:00:00"}