{"id":"https://openalex.org/W4234020294","doi":"https://doi.org/10.1158/1538-7445.am2019-3803","title":"Abstract 3803: Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer","display_name":"Abstract 3803: Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer","publication_year":2019,"publication_date":"2019-07-01","ids":{"openalex":"https://openalex.org/W4234020294","doi":"https://doi.org/10.1158/1538-7445.am2019-3803"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.am2019-3803","doi":"https://doi.org/10.1158/1538-7445.am2019-3803","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-3803","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101562905","display_name":"Yunhua Liu","orcid":"https://orcid.org/0000-0002-2631-795X","observed_orcids":["https://orcid.org/0000-0002-2631-795X","https://orcid.org/0000-0003-2017-3059"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunhua Liu","raw_affiliation_strings":["1Indiana University, Indianapolis, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Indiana University, Indianapolis, IN;","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021686580","display_name":"Xiaoming He","orcid":"https://orcid.org/0000-0003-0125-6086","observed_orcids":["https://orcid.org/0000-0003-0125-6086"]},"institutions":[{"id":"https://openalex.org/I66946132","display_name":"University of Maryland, College Park","ror":"https://ror.org/047s2c258","country_code":"US","type":"education","lineage":["https://openalex.org/I66946132"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaoming He","raw_affiliation_strings":["2University of Maryland, College Park, MD"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2University of Maryland, College Park, MD","institution_ids":["https://openalex.org/I66946132"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081753593","display_name":"Xiongbin Lu","orcid":"https://orcid.org/0000-0002-7987-9825","observed_orcids":["https://orcid.org/0000-0002-7987-9825"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiongbin Lu","raw_affiliation_strings":["1Indiana University, Indianapolis, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Indiana University, Indianapolis, IN;","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072661022","display_name":"Xinna Zhang","orcid":"https://orcid.org/0000-0003-4118-2245","observed_orcids":["https://orcid.org/0000-0003-4118-2245"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinna Zhang","raw_affiliation_strings":["1Indiana University, Indianapolis, IN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Indiana University, Indianapolis, IN;","institution_ids":["https://openalex.org/I4388446366"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"79","issue":"13_Supplement","first_page":"3803","last_page":"3803"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.8428000211715698,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.03550000116229057,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9869999885559082},{"id":"https://openalex.org/keywords/trastuzumab-resistance","display_name":"trastuzumab resistance","score":0.8970000147819519},{"id":"https://openalex.org/keywords/wip1","display_name":"Wip1","score":0.7110000252723694},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9409999847412109},{"id":"https://openalex.org/keywords/ph-sensitive-nanoparticles","display_name":"pH-responsive nanoparticles","score":0.9589999914169312},{"id":"https://openalex.org/keywords/co-delivery","display_name":"co-delivery","score":0.6620000004768372},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6359999775886536},{"id":"https://openalex.org/keywords/dna-damage-response","display_name":"DNA damage response","score":0.6959999799728394},{"id":"https://openalex.org/keywords/tumor-targeting","display_name":"tumor targeting","score":0.33899998664855957}],"concepts":[{"id":"https://openalex.org/C8185291","wikidata":"https://www.wikidata.org/wiki/Q2844457","display_name":"Amplicon","level":4,"score":0.7361268997192383},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6303749680519104},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5979917049407959},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.549755334854126},{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.5486725568771362},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5395429134368896},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.46747279167175293},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.43288007378578186},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39484384655952454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3622085750102997},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3285902440547943},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2590788006782532},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12456852197647095},{"id":"https://openalex.org/C49105822","wikidata":"https://www.wikidata.org/wiki/Q176996","display_name":"Polymerase chain reaction","level":3,"score":0.10357359051704407}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.am2019-3803","doi":"https://doi.org/10.1158/1538-7445.am2019-3803","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.am2019-3803","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2045413188","https://openalex.org/W2591960783","https://openalex.org/W2145848169","https://openalex.org/W2059012985","https://openalex.org/W2791452587","https://openalex.org/W4381930657","https://openalex.org/W2081653697","https://openalex.org/W2321922702","https://openalex.org/W2113165452","https://openalex.org/W3092804779"],"abstract_inverted_index":{"Abstract":[0],"Amplification":[1],"of":[2,15,61,76,90,102,142,155,169,181,195,227,248,260,264,305],"chromosome":[3],"17q23":[4,20,69,96,148,289],"is":[5,22,29,163],"a":[6,51,88,245],"frequent":[7],"genomic":[8],"event":[9],"that":[10],"occurs":[11],"in":[12,24,45,54,66,87,99,152,159,172,221,252,298],"~":[13],"11%":[14],"human":[16,77],"breast":[17,26,78,110,144,186,240,272,300],"cancers.":[18],"The":[19,188,223],"amplification":[21,97],"enriched":[23],"HER2+":[25,143,239,271,299],"cancers,":[27],"which":[28,48,106],"significantly":[30],"correlated":[31],"with":[32],"poor":[33],"clinical":[34],"outcomes.":[35],"Previous":[36],"studies":[37],"have":[38],"identified":[39],"the":[40,46,59,67,91,95,136,151,156,167,182,192,206,210,218,249,257,261,270,293,306],"oncogenic":[41,83],"phosphatase":[42],"WIP1":[43,103,121,129,265],"gene":[44],"amplicon,":[47],"functions":[49],"as":[50],"master":[52],"inhibitor":[53,127],"DNA":[55],"damage":[56],"response.":[57],"While":[58],"possibility":[60],"any":[62],"other":[63],"protein-coding":[64],"oncogenes":[65],"WIP1-containing":[68,92],"amplicon":[70,290],"was":[71],"ruled":[72],"out,":[73],"our":[74],"analysis":[75],"cancer":[79,145,241,301],"genomics":[80],"uncovered":[81],"an":[82],"microRNA":[84],"gene,":[85],"MIR21,":[86],"majority":[89],"amplicons.":[93],"Accordingly,":[94],"results":[98,255],"aberrant":[100],"expression":[101],"and":[104,122,131,139,229,266],"miR-21,":[105],"not":[107],"only":[108],"promotes":[109],"tumorigenesis,":[111],"but":[112,198],"also":[113,199],"leads":[114],"to":[115,117,208,235,244,275,291,295],"resistance":[116,168,294],"anti-HER2":[118,296],"therapies.":[119,277],"Inhibiting":[120],"miR-21":[123,228,267],"using":[124],"small":[125],"molecular":[126],"against":[128],"(GSK2830371)":[130],"anti-miR-21":[132,196],"oligonucleotides":[133,197],"selectively":[134],"inhibits":[135],"proliferation,":[137],"survival":[138],"tumorigenic":[140],"potential":[141,259],"cells":[146],"harboring":[147],"amplification.":[149],"However,":[150],"vivo":[153],"bioavailability":[154],"two":[157,183,224],"agents":[158,184,225],"their":[160],"free":[161],"form":[162],"poor.":[164],"To":[165],"overcome":[166,292],"trastuzumab-based":[170],"therapies":[171],"vivo,":[173],"we":[174],"developed":[175],"pH-sensitive":[176],"nanoparticles":[177,189,231],"for":[178,213,269,309],"specific":[179],"co-delivery":[180],"into":[185,205],"tumors.":[187,222],"can":[190,232],"improve":[191],"encapsulation":[193],"efficiency":[194],"effectively":[200],"capture":[201],"carbon":[202],"dioxide":[203],"(CO2)":[204],"nanoparticle":[207],"achieve":[209],"\u2018nano-bomb\u2019":[211],"effect":[212],"triggered":[214],"drug":[215],"release":[216],"under":[217],"reduced":[219],"pH":[220],"(inhibitors":[226],"WIP1)-laden":[230],"be":[233],"used":[234],"efficiently":[236],"kill":[237],"trastuzumab-resistant":[238],"cells,":[242],"leading":[243],"profound":[246],"reduction":[247],"tumor":[250],"growth":[251],"vivo.":[253],"These":[254],"demonstrate":[256],"great":[258],"combined":[262],"treatment":[263],"inhibitors":[268],"cancers":[273],"resistant":[274],"anti-HER2-based":[276],"Citation":[278],"Format:":[279],"Yunhua":[280],"Liu,":[281],"Xiaoming":[282],"He,":[283],"Xiongbin":[284],"Lu,":[285],"Xinna":[286],"Zhang.":[287],"Targeting":[288],"therapy":[297],"[abstract].":[302],"In:":[303],"Proceedings":[304],"American":[307],"Association":[308],"Cancer":[310,324],"Research":[311],"Annual":[312],"Meeting":[313],"2019;":[314],"2019":[315],"Mar":[316],"29-Apr":[317],"3;":[318],"Atlanta,":[319],"GA.":[320],"Philadelphia":[321],"(PA):":[322],"AACR;":[323],"Res":[325],"2019;79(13":[326],"Suppl):Abstract":[327],"nr":[328],"3803.":[329]},"counts_by_year":[],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2022-05-12T00:00:00"}
