{"id":"https://openalex.org/W4233941633","doi":"https://doi.org/10.1080/00034983.2001.11813610","title":"Clinical characteristics and disposition kinetics of the hepatomegaly associated with acute, uncomplicated,Plasmodium falciparummalaria in children","display_name":"Clinical characteristics and disposition kinetics of the hepatomegaly associated with acute, uncomplicated,Plasmodium falciparummalaria in children","publication_year":2001,"publication_date":"2001-01-01","ids":{"openalex":"https://openalex.org/W4233941633","doi":"https://doi.org/10.1080/00034983.2001.11813610"},"language":"en","primary_location":{"id":"doi:10.1080/00034983.2001.11813610","doi":"https://doi.org/10.1080/00034983.2001.11813610","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00034983.2001.11813610","pdf_url":null,"source":{"id":"https://openalex.org/S135866459","display_name":"Annals of Tropical Medicine and Parasitology","issn_l":"0003-4983","issn":["0003-4983","1364-8594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Medicine &amp; Parasitology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108091127","display_name":"A. Sowunmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":true,"raw_author_name":"A. Sowunmi","raw_affiliation_strings":["Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069574228","display_name":"Ahmed Adebowale Adedeji","orcid":"https://orcid.org/0000-0002-8058-4098","observed_orcids":["https://orcid.org/0000-0002-8058-4098"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"A. A. Adedeji","raw_affiliation_strings":["Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043079577","display_name":"C.O.A. Sowunmi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800598127","display_name":"University College Hospital, Ibadan","ror":"https://ror.org/022yvqh08","country_code":"NG","type":"healthcare","lineage":["https://openalex.org/I2800598127"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C. O. Sowunmi","raw_affiliation_strings":["Federal Training Centre for Teachers of Health Sciences, University College Hospital, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Federal Training Centre for Teachers of Health Sciences, University College Hospital, Ibadan, Nigeria","institution_ids":["https://openalex.org/I2800598127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109617695","display_name":"CO Falade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"C. O. Falade","raw_affiliation_strings":["Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022808978","display_name":"Adegoke Gbadegesin Falade","orcid":"https://orcid.org/0000-0001-8216-2924","observed_orcids":["https://orcid.org/0000-0001-8216-2924"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"A. G. Falade","raw_affiliation_strings":["Department of Paediatrics, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Paediatrics, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109148906","display_name":"Beatrice Mgboro Ohaeri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"B. Ohaeri","raw_affiliation_strings":["Department of Nursing, University of Ibadan, Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nursing, University of Ibadan, Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078539061","display_name":"Christian Tientcha Happi","orcid":"https://orcid.org/0000-0002-3056-6705","observed_orcids":["https://orcid.org/0000-0002-3056-6705"]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"T. C. Happi","raw_affiliation_strings":["Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5106034838","display_name":"AYOADE M. J. ODUOLA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181631907","display_name":"University of Ibadan","ror":"https://ror.org/03wx2rr30","country_code":"NG","type":"education","lineage":["https://openalex.org/I181631907"]}],"countries":["NG"],"is_corresponding":false,"raw_author_name":"A. M. J. Oduola","raw_affiliation_strings":["Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology and Therapeutics and Postgraduate Institute for Medical Research & Training, University of Ibadan, Nigeria","institution_ids":["https://openalex.org/I181631907"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5108091127"],"corresponding_institution_ids":["https://openalex.org/I181631907"],"apc_list":null,"apc_paid":null,"fwci":0.3855,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.73354848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"95","issue":"1","first_page":"7","last_page":"18"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10091","display_name":"Malaria Research and Control","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12178","display_name":"Bird parasitology and diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmodium-falciparum","display_name":"Plasmodium falciparum","score":0.8849999904632568},{"id":"https://openalex.org/keywords/uncomplicated-malaria","display_name":"uncomplicated malaria","score":0.6990000009536743},{"id":"https://openalex.org/keywords/pediatric-malaria","display_name":"pediatric malaria","score":0.6309999823570251},{"id":"https://openalex.org/keywords/hepatomegaly","display_name":"hepatomegaly","score":0.9869999885559082},{"id":"https://openalex.org/keywords/liver-size","display_name":"liver size","score":0.7070000171661377},{"id":"https://openalex.org/keywords/parasitaemia-clearance","display_name":"parasitaemia clearance","score":0.8320000171661377},{"id":"https://openalex.org/keywords/antimalarial-drug-resistance","display_name":"antimalarial drug resistance","score":0.5870000123977661},{"id":"https://openalex.org/keywords/nigeria","display_name":"Nigeria","score":0.6389999985694885},{"id":"https://openalex.org/keywords/malaria-endemic-areas","display_name":"malaria endemic areas","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.7367339134216309},{"id":"https://openalex.org/C138944611","wikidata":"https://www.wikidata.org/wiki/Q1163287","display_name":"Clearance","level":2,"score":0.7243533730506897},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5471623539924622},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5302714109420776},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5042761564254761},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.5002765655517578},{"id":"https://openalex.org/C18206936","wikidata":"https://www.wikidata.org/wiki/Q378749","display_name":"Clearance rate","level":2,"score":0.4792221188545227},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.41691166162490845},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.35275769233703613},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34421372413635254},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.13664525747299194}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/00034983.2001.11813610","doi":"https://doi.org/10.1080/00034983.2001.11813610","is_oa":false,"landing_page_url":"https://doi.org/10.1080/00034983.2001.11813610","pdf_url":null,"source":{"id":"https://openalex.org/S135866459","display_name":"Annals of Tropical Medicine and Parasitology","issn_l":"0003-4983","issn":["0003-4983","1364-8594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320442","host_organization_name":"Maney Publishing","host_organization_lineage":["https://openalex.org/P4310320442"],"host_organization_lineage_names":["Maney Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Tropical Medicine &amp; Parasitology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8500000238418579,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W47970597","https://openalex.org/W1964528848","https://openalex.org/W1985024767","https://openalex.org/W1992978024","https://openalex.org/W2035160668","https://openalex.org/W2039326543","https://openalex.org/W2053154970","https://openalex.org/W2105817519","https://openalex.org/W2110768563","https://openalex.org/W2137649897","https://openalex.org/W4211010162","https://openalex.org/W4246120931"],"related_works":["https://openalex.org/W2035160668","https://openalex.org/W1997746909","https://openalex.org/W2028104775","https://openalex.org/W990435171","https://openalex.org/W2038714923","https://openalex.org/W1996309924","https://openalex.org/W3089332749","https://openalex.org/W3176843060","https://openalex.org/W2039326543","https://openalex.org/W3176606269"],"abstract_inverted_index":{"The":[0,387],"clinical":[1,358],"characteristics":[2],"and":[3,135,165,170,193,207,229,317,326,328,349,380,407],"the":[4,7,10,36,40,52,69,101,118,127,145,163,166,171,191,194,199,204,215,222,235,245,248,260,264,281,288,297,300,307,312,322,329,361,382,409,412,421],"kinetics":[5,298],"of":[6,9,28,65,82,89,100,114,133,137,149,156,162,177,184,190,250,272,283,290,299,302,311,315,324,360,385,389,393,399,411,423],"disposition":[8],"hepatomegaly":[11,56,83,192,232,251,284,303,316,327,346,367],"associated":[12,79,110],"with":[13,80,111,224,366,403],"acute,":[14,369],"uncomplicated":[15],"Plasmodium":[16],"falciparum":[17,227,372,405],"malaria":[18,373],"were":[19,210,304,333],"investigated":[20],"in":[21,24,35,39,46,54,62,93,198,230,257,280,287,306,344,364,378,401,425],"162":[22],"children":[23,53,128,223,365,402],"an":[25],"endemic":[26,426],"area":[27,236,246],"Nigeria.":[29],"Hepatomegaly":[30],"was":[31,72,78,109,121,140,276,336],"significantly":[32],"more":[33],"common":[34],"younger":[37],"than":[38],"older":[41],"children.":[42],"Complete":[43],"resolution":[44,136,183,301,388],"occurred":[45],"48%":[47],"following":[48],"antimalarial":[49],"chemotherapy.":[50],"In":[51,126],"whom":[55,231,345],"did":[57],"not":[58],"resolve,":[59],"a":[60,112,391,416],"reduction":[61],"liver":[63,94,178,216,240,261,291,362,413],"size":[64,95,179,241,262,292,363],"<":[66,123],"17%":[67],"by":[68,84,104,238],"time":[70,153,168,181,196,243],"parasitaemia":[71,134,318,325,350,400],"cleared":[73],"(usually":[74],"on":[75],"day":[76,105],"3)":[77],"non-resolution":[81],"days":[85],"7":[86],"or":[87,107,159,187,254,286],"14":[88],"follow-up.":[90],"An":[91],"increase":[92],"to":[96,154,259,293],"at":[97],"least":[98],"125%":[99],"baseline":[102],"value":[103],"4":[106],"5":[108,124],"lack":[113],"therapeutic":[115,150,220,383],"response,":[116],"providing":[117],"child":[119],"involved":[120],"aged":[122],"years.":[125],"who":[129],"had":[130],"complete":[131],"clearance":[132,155,331,398],"hepatomegaly,":[138,390],"there":[139,275,335],"no":[141,277,337],"significant":[142,278],"relationship":[143],"between":[144,339],"parasitaemia-derived":[146],"conventional":[147],"indices":[148,314],"response":[151],"[i.e.":[152,180],"50%":[157,185],"(PC50)":[158],"90%":[160,188],"(PC90)":[161],"parasitaemia,":[164],"parasite-clearance":[167],"(PCT)]":[169],"corresponding":[172,330],"parameters":[173,217,341],"derived":[174],"from":[175,270],"measurement":[176,359],"for":[182,419],"(HR50)":[186],"(HR90)":[189],"hepatomegaly-resolution":[195],"(HRT)]":[197],"same":[200],"patients.":[201],"However,":[202],"as":[203,415],"HR50:PC50,":[205],"HR90:PC90":[206],"HRT:PCT":[208],"ratios":[209,289],"similar":[211],"(range":[212],"=":[213,268],"1.6\u20132.1),":[214],"may":[218,374],"have":[219,375],"application.In":[221],"drug-sensitive":[225],"P.":[226,371,404],"infections":[228],"completely":[233,347,351],"resolved,":[234],"produced":[237],"plotting":[239],"against":[242],"(i.e.":[244],"under":[247],"curve":[249],"v.":[252],"time,":[253],"AUChp)":[255],"increased":[256],"proportion":[258],"below":[263],"costal":[265],"margin":[266],"(P":[267],"0.02,":[269],"analysis":[271],"variance),":[273],"but":[274],"difference":[279],"half-lives":[282,323],"(t\u00bdhp)":[285],"AUChp,":[294],"indicating":[295],"that":[296,356],"linear":[305],"range":[308],"examined.":[309],"Comparison":[310],"kinetic":[313],"showed":[319],"that,":[320],"although":[321],"values":[332],"similar,":[334],"correlation":[338],"these":[340],"among":[342],"those":[343],"resolved":[348],"cleared.":[352],"These":[353],"results":[354],"indicate":[355],"routine":[357],"during":[368],"uncomplicated,":[370],"some":[376],"use":[377,410],"evaluating":[379],"monitoring":[381],"responses":[384],"infections.":[386],"reflection":[392],"pathological":[394],"changes,":[395],"lags":[396],"behind":[397],"malaria,":[406],"supports":[408],"\u2018rate\u2019":[414],"malariometric":[417],"index":[418],"assessing":[420],"intensity":[422],"transmission":[424],"areas.":[427]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2022-05-12T00:00:00"}